Case Reports in Dermatology最新文献_第10页

Scleroderma-like Syndrome in the Setting of Pembrolizumab Therapy for Non-Small Cell Lung Cancer: Diagnosis and Dermatologic Management. 派姆单抗治疗非小细胞肺癌的硬皮病样综合征:诊断和皮肤病学管理。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-08-19 eCollection Date: 2022-05-01 DOI: 10.1159/000525887

Davide Fattore, Teresa Battista, Mario De Lucia, Maria Carmela Annunziata, Gabriella Fabbrocini

{"title":"Scleroderma-like Syndrome in the Setting of Pembrolizumab Therapy for Non-Small Cell Lung Cancer: Diagnosis and Dermatologic Management.","authors":"Davide Fattore, Teresa Battista, Mario De Lucia, Maria Carmela Annunziata, Gabriella Fabbrocini","doi":"10.1159/000525887","DOIUrl":"https://doi.org/10.1159/000525887","url":null,"abstract":"Immune checkpoint inhibitors play an important role in the treatment of malignancies. ICIs consist of monoclonal antibodies directed against inhibitory immune receptors cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), or programmed cell death-ligand 1 (PD-L1). PD-1 is a receptor expressed by T lymphocytes and has the role of inhibiting their activation. Pembrolizumab is a humanized anti-PD-1 monoclonal antibody. It can improve the immune function of T-cells, which results in significant clinical benefit in the treatment of cancer. Despite its wide use, immunotherapy is associated with a spectrum of side effects known as immune-related adverse events. We present a case of an 82-year-old patient with widespread fibroatrophic skin areas that occurred during a treatment with pembrolizumab for non-small cell lung cancer. Clinical, serological, and histopathological examinations led to the diagnosis of generalized morphea. The patient discontinued pembrolizumab and switched to chemotherapy with pemetrexed and carboplatin. A good therapeutic response was obtained with phototherapy, corticosteroids, and topical calcineurin inhibitors. A focus on the therapeutic management of this skin toxicity in oncological patients is provided.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/e0/cde-0014-0225.PMC9459594.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33483785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

UltraPulse Carbon Dioxide Laser Plus Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Penile Cancer. 超脉冲二氧化碳激光加甲基氨基乙酰丙酸光动力疗法治疗阴茎癌。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-08-05 eCollection Date: 2022-05-01 DOI: 10.1159/000524963

Santo Raffaele Mercuri, Giovanni Paolino, Pina Brianti, Matteo Riccardo Di Nicola, Alberto Martini, Andrea Necchi, Francesco Montorsi

引用次数: 0

Leukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist. 透皮多巴胺激动剂罗替戈汀贴剂致白皮病。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-08-05 eCollection Date: 2022-05-01 DOI: 10.1159/000525894

Ronan Talty, Goran Micevic, Alice Wang, Christine J Ko, William Damsky

引用次数: 0

Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report. Benralizumab治疗严重中毒性表皮坏死松解及嗜酸性粒细胞增多和全身症状重叠综合征的药物反应:1例报告

IF 0.9

Case Reports in Dermatology Pub Date : 2022-07-14 eCollection Date: 2022-05-01 DOI: 10.1159/000525752

Felix K Zeller, Patrick R Bader, Mirjam C Nägeli, Philipp K Buehler, Reto A Schuepbach

引用次数: 0

Tuberculous Dactylitis in a Case of Multiple Scrofuloderma. 多发性阴囊皮病结核性趾炎1例。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-07-08 eCollection Date: 2022-05-01 DOI: 10.1159/000525464

Sri Linuwih S W Menaldi, Farah Faulin Lubis, Jhauharina Rizki Fadhilla, Sandra Widaty

{"title":"Tuberculous Dactylitis in a Case of Multiple Scrofuloderma.","authors":"Sri Linuwih S W Menaldi, Farah Faulin Lubis, Jhauharina Rizki Fadhilla, Sandra Widaty","doi":"10.1159/000525464","DOIUrl":"https://doi.org/10.1159/000525464","url":null,"abstract":"This paper reports a case of tuberculous dactylitis and multiple scrofuloderma spreading through the lymph nodes. Scrofuloderma, also known as tuberculosis colliquativa cutis, is a form of cutaneous tuberculosis (TB) that occurs most often in children and young adults and involves the skin over the infection focus (i.e., lymph nodes, bones, or joints). Scrofuloderma can affect the lower limbs and upper arms by spreading osteomyelitis TB on the humerus, wrist, and elbow. This study reports the case of a 19-year-old man who initially developed painful and swollen skin, followed by the appearance of numerous recurring lumps on the left arm and hand and the right foot, as well as the folding right hamstring, over 3 years. The patient had no clinical improvement with antibiotics and excision. Radiography of the left hand showed tuberculous dactylitis. A biopsy of the left arm was performed, and Ziehl-Neelsen staining showed acid-fast bacilli. Mycobacterium tuberculosis was confirmed by a real-time polymerase chain reaction. Anti-TB drug treatment was initiated with rifampicin, isoniazid, pyrazinamide, and ethambutol, and debridement was performed on the left hand, which resulted in significant improvement of the lesion. Atypical clinical manifestations and unawareness of M. tuberculosis as an underlying disease delayed the diagnosis and treatment of this patient with tuberculous dactylitis and multiple scrofuloderma.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/ff/cde-0014-0194.PMC9386432.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33484745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nonhealing Ulcers with Rimming of the Adipose Tissues. 带脂肪组织边缘的不愈合溃疡。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-07-05 eCollection Date: 2022-05-01 DOI: 10.1159/000525348

Kittipong Wantavornprasert, Thiti Asawapanumas, Pravit Asawanonda

引用次数: 0

A Young Boy with Brittle Hair. 一个头发脆弱的小男孩。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-06-28 eCollection Date: 2022-05-01 DOI: 10.1159/000525383

Nassim Tootoonchi, Vahideh Azhari, Zahra Razavi, Shadab Seraji, Nika Kianfar, Hamidreza Mahmoudi, Maryam Daneshpazooh

{"title":"A Young Boy with Brittle Hair.","authors":"Nassim Tootoonchi, Vahideh Azhari, Zahra Razavi, Shadab Seraji, Nika Kianfar, Hamidreza Mahmoudi, Maryam Daneshpazooh","doi":"10.1159/000525383","DOIUrl":"https://doi.org/10.1159/000525383","url":null,"abstract":"Trichothiodystrophy (TTD) is a rare multisystem disorder with an autosomal recessive mode of inheritance. TTD presentations vary from only hair abnormalities like brittle, fragile hair to physical and mental retardation. Mutations of DNA repair genes have been identified as responsible for the disease. A 5-year-old boy presented with sparse, short, and brittle hair to our clinic. He was born to consanguineous parents. Trichoscopy and light microscopy revealed broken hairs with no specific shaft defect. Due to the inaccessibility of the polarized microscopy, a bedside technique was employed. We used a polarized dermatoscope and a mirror in order of achieving transillumination of the hair shafts, which revealed striking bright and dark bands. These bands are referred to as \"tiger tail,\" which is the pathognomonic sign of TTD. Subsequent polarizing microscopy also confirmed the clinical diagnosis. This highlighted a feasible method for observing the tiger tail, which expanded the known clinical diagnostic tools of TTD.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/59/cde-0014-0184.PMC9294941.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and a Systematic Review. 发热性溃疡坏死Mucha-Habermann病1例报告及系统回顾。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-06-27 eCollection Date: 2022-05-01 DOI: 10.1159/000525008

Ping Tang, Jing-Si Chen, Hua Wang, Huan Yang

{"title":"Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and a Systematic Review.","authors":"Ping Tang, Jing-Si Chen, Hua Wang, Huan Yang","doi":"10.1159/000525008","DOIUrl":"https://doi.org/10.1159/000525008","url":null,"abstract":"The characteristics and treatments of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) are not well-understood. We reported a FUMHD case, and searched Medline, Embase, Pubmed, Scopus, and Web of Science from inception to June 16, 2021, to perform a systematic review to synthesize its characteristics and treatments. Seventy-eight reports, including 84 people were eligible. Most of them were male (62/83, 74.7%), with high fever state (50/80, 62.5% had a high fever of 39°C or above), and with more positive skin bacterial cultures (31/41, 75.6%). Adults were associated with a higher risk of death (OR = 12.976, 95% CI: 1.049, 160.504, p = 0.046), but not positive blood bacterial cultures (p = 0.102). Systematic corticosteroids combination with other immunosuppressants (methotrexate or cyclosporine) were associated with significantly more effective cases (26/31 = 83.9%, χ2 = 4.065, p = 0.044). Furthermore, no significant differences between the low-dose and high-dose systematic corticosteroid groups were detected in treatment validation (p > 0.05). Overall, FUMHD was associated with male patients, high fever, and positive skin bacterial cultures. Early combination therapy with lower doses of corticosteroids and methotrexate or cyclosporine may be an optimal choice for the treatment of FUMHD.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/e6/cde-0014-0169.PMC9294953.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Varicella-Zoster Virus Encephalitis in an Immunocompetent Adult with Disseminated Cutaneous Herpes Zoster after Testosterone Booster Supplements: Case Report. 水痘-带状疱疹病毒性脑炎的免疫功能正常的成人播散性皮肤带状疱疹后补充睾酮增强剂:病例报告。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-06-27 eCollection Date: 2022-05-01 DOI: 10.1159/000525252

Ghada Alhayaza, Abdullah Al-Omair, Hind M Almohanna

{"title":"Varicella-Zoster Virus Encephalitis in an Immunocompetent Adult with Disseminated Cutaneous Herpes Zoster after Testosterone Booster Supplements: Case Report.","authors":"Ghada Alhayaza, Abdullah Al-Omair, Hind M Almohanna","doi":"10.1159/000525252","DOIUrl":"https://doi.org/10.1159/000525252","url":null,"abstract":"Disseminated zoster affects immunocompromised individuals and has a nondermatomal distribution. We report a 28-year-old male who initially presented to the dermatology clinic with pinprick sensation over the right side of his face that was followed by vesicular eruption. Upon which he was diagnosed with herpes zoster and discharged on topical mupirocin ointment three times a day for 7 days and valacyclovir 1 g oral three times a day. A few hours later, he presented to the emergency department with drowsiness and an episode of loss of consciousness. He was then admitted by neurology and found to have herpetic encephalitis. During admission, he was started on intravenous acyclovir 10 mg/kg three times a day. After 3 weeks of intravenous acyclovir, the patient improved clinically; and all the vesicular lesions have crusted. Up to this date, there are only a few cases of immunocompetent adult patients with disseminated cutaneous herpes zoster (DCHZ), most of whom were over the age of 65 years or taking immunosuppressive medication. We report a case of DCHZ and varicella-zoster virus encephalitis in a young immunocompetent patient using daily testosterone supplements and a history of emotional and physical stress, in contrast to all previously reported cases, which presented significant risk.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/7e/cde-0014-0164.PMC9294947.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clinical Characteristics and Treatment Outcomes of Scleromyxedema: A 10-Year Retrospective Survey. 硬黏液水肿的临床特点和治疗结果:一项10年回顾性调查。

IF 0.9

Case Reports in Dermatology Pub Date : 2022-06-27 eCollection Date: 2022-05-01 DOI: 10.1159/000525211

Abtin Ansari, Zohre Erfani, Maryam Daneshpazhooh, Leila Mahmoudi, Zahra Saffarian, Kambiz Kamyab, Hamidreza Mahmoudi

{"title":"Clinical Characteristics and Treatment Outcomes of Scleromyxedema: A 10-Year Retrospective Survey.","authors":"Abtin Ansari, Zohre Erfani, Maryam Daneshpazhooh, Leila Mahmoudi, Zahra Saffarian, Kambiz Kamyab, Hamidreza Mahmoudi","doi":"10.1159/000525211","DOIUrl":"https://doi.org/10.1159/000525211","url":null,"abstract":"Scleromyxedema is a rare but important mucinosis disorder of the skin that is presented with dermatological manifestations such as waxy papules, diffuse induration, and nondermatologic involvements like neurological and renal disorders. We report a case series of the data regarding the characteristics and treatment of 14 patients diagnosed with scleromyxedema and their follow-up. Patients entered the study based on scleromyxedema diagnosis criteria. Comorbidities were also recorded to evaluate their effect on the treatment process. Clinicopathological and laboratory findings and responses to their treatment were evaluated separately. There was a significant improvement after administering intravenous immunoglobulin (IVIG). Despite the lack of a definite treatment for this condition, the present study shows that the application of IVIG can improve both cutaneous and systemic symptoms. Younger patients, in particular, responded significantly to the use of IVIG. More studies are required to investigate the potential efficacy of IVIG in the treatment of scleromyxedema.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/d1/cde-0014-0178.PMC9294944.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0