Case Reports in Dermatology最新文献_第10页

Development of Pyoderma Gangrenosum in a Patient with Acquired Reactive Perforating Collagenosis. 获得性反应性穿孔性胶原病患者坏疽性脓皮病的发展。

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Case Reports in Dermatology Pub Date : 2026-01-26 eCollection Date: 2026-01-01 DOI: 10.1159/000550460

Yuki Mizutani, Kyoko Sugioka, Tomoko Akeda, Akinobu Hayashi, Keiichi Yamanaka

{"title":"Development of Pyoderma Gangrenosum in a Patient with Acquired Reactive Perforating Collagenosis.","authors":"Yuki Mizutani, Kyoko Sugioka, Tomoko Akeda, Akinobu Hayashi, Keiichi Yamanaka","doi":"10.1159/000550460","DOIUrl":"10.1159/000550460","url":null,"abstract":"Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis associated with systemic diseases, but its pathogenesis remains unclear. Acquired reactive perforating collagenosis (ARPC) is characterized by transepidermal elimination of degenerated collagen and is usually linked to diabetes mellitus or renal dysfunction. ARPC is not recognized as a precursor to PG. We report a rare case of PG occurring in a patient with ARPC, successfully treated with adalimumab.Case presentation: An 80-year-old woman with diabetes presented with generalized erythema and later developed multiple papules and nodules with central crusting. Histology confirmed ARPC. Despite topical corticosteroids, lesions ulcerated and progressed into painful necrotic ulcers on her extremities. Laboratory findings showed neutrophilia and elevated C-reactive protein, but no infection or autoimmune markers. Histopathology of the ulcers revealed dense neutrophilic infiltration with transepidermal elimination of collagen, consistent with PG. Diagnostic criteria (Delphi, Su, Paracelsus) supported PG secondary to ARPC. Topical corticosteroids were ineffective. Due to comorbid diabetes, high-dose systemic corticosteroids were avoided; instead, low-dose prednisolone with adalimumab was initiated. The patient received adalimumab induction (160 mg at week 0, 80 mg at week 2) followed by 40 mg weekly. The ulcers rapidly improved, and by 12 weeks, near-complete epithelialization was achieved without recurrence during steroid tapering.Conclusion: This case represents PG occurring in a patient with ARPC, suggesting that persistent epidermal injury in ARPC may trigger neutrophilic dermatosis. Adalimumab proved effective, offering a safe therapeutic option in PG patients with comorbidities limiting corticosteroid use. Recognition of this association may aid earlier diagnosis and optimize treatment strategies.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"123-129"},"PeriodicalIF":0.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Film-Forming Wound Gel for Preterm Infant Skin Injuries: A Case Series. 成膜伤口凝胶用于早产儿皮肤损伤：一个案例系列。

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Case Reports in Dermatology Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.1159/000550642

Rachael Fleming, Tobias Strunk

引用次数: 0

A Rare Adverse Effect of Methotrexate Mimicking Disease Progression in Folliculotropic Mycosis Fungoides: A Case Report. 甲氨蝶呤模拟嗜滤泡真菌病进展的罕见不良反应：1例报告。

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Case Reports in Dermatology Pub Date : 2026-01-20 eCollection Date: 2026-01-01 DOI: 10.1159/000550569

Surachanee Likittanasombat, Manasmon Chairatchaneeboon

{"title":"A Rare Adverse Effect of Methotrexate Mimicking Disease Progression in Folliculotropic Mycosis Fungoides: A Case Report.","authors":"Surachanee Likittanasombat, Manasmon Chairatchaneeboon","doi":"10.1159/000550569","DOIUrl":"10.1159/000550569","url":null,"abstract":"Introduction: Cutaneous ulceration is an uncommon adverse effect of methotrexate (MTX). This complication has been rarely described in cutaneous T-cell lymphoma and, to date, has not been reported in folliculotropic mycosis fungoides (FMF).Case report: A 66-year-old Thai man with stage IB FMF achieved excellent clinical improvement with low-dose MTX therapy for 13 months. He subsequently developed disseminated erythematous papules, plaques, and necrotic ulcers on the extremities. Laboratory evaluation revealed mild anemia, and microbial cultures were negative. Histopathologic examination demonstrated epidermal dysmaturation with necrotic keratinocytes, infiltration by eosinophils and neutrophils, and atypical lymphocytes with features consistent with FMF - findings suggestive of MTX-induced ulceration rather than tumor progression. Discontinuation of MTX led to dramatic resolution within 2 weeks, after which the patient was transitioned to acitretin, resulting in sustained disease control.Conclusion: This case highlights MTX-induced cutaneous ulceration as a rare adverse event in FMF that can mimic disease progression. Recognition of the characteristic histopathologic features facilitates accurate diagnosis. Early discontinuation of MTX leads to rapid resolution, underscoring the importance of prompt recognition and management.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"108-114"},"PeriodicalIF":0.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Presentation of Plexiform Neurofibroma Embedded with Large Comedones: A Case Report. 丛状神经纤维瘤嵌入大秃发的罕见表现：1例报告。

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Case Reports in Dermatology Pub Date : 2026-01-14 eCollection Date: 2026-01-01 DOI: 10.1159/000548908

Waseem Alhawsawi, Wafa Alghamdi, Maria AlSulami, Afnan Aljawi, Houriah Nukaly, Yassir Alotaibi

{"title":"Unusual Presentation of Plexiform Neurofibroma Embedded with Large Comedones: A Case Report.","authors":"Waseem Alhawsawi, Wafa Alghamdi, Maria AlSulami, Afnan Aljawi, Houriah Nukaly, Yassir Alotaibi","doi":"10.1159/000548908","DOIUrl":"10.1159/000548908","url":null,"abstract":"Introduction: Plexiform neurofibromas (PNFs) represent benign neoplasms associated with neurofibromatosis type 1 (NF1), a genetic disorder characterized by mutations in the NF1 gene that lead to dysregulated Ras signaling and uncontrolled cell growth. NF1 manifests with various cutaneous features, including café-au-lait macules and axillary freckling, as well as the development of neurofibromas. PNFs are particularly complex due to their extensive involvement of nerve plexuses and their potential for malignant transformation.Case presentation: This case report documents a 42-year-old male who presented with numerous neurofibromas, café-au-lait macules, and axillary freckling. Notably, the patient had a large PNF on the right lower back, measuring 10 × 15 cm, which exhibited a \"bag of worms\" sensation upon palpation. Remarkably, this PNF contained multiple large comedones, each approximately 0.5 × 0.5 cm. Although histopathologic confirmation would have been valuable, a biopsy was not performed because the clinical appearance was clearly consistent with comedones, and the patient strongly refused the procedure due to pain at the lesion site.Conclusion: This case highlights an unusual presentation of PNF with large comedones, a manifestation not previously reported in the literature. The presence of comedones within a PNF emphasizes the need for thorough clinical evaluation and awareness of atypical manifestations in NF1 patients. This report contributes to the existing knowledge and underscores the importance of recognizing rare dermatological presentations to prevent misdiagnosis and ensure appropriate management.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"103-107"},"PeriodicalIF":0.7,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Hypertrophic Lichen Planus Mimicking Squamous Cell Carcinoma: A Case Report. 多发性增生性扁平苔藓模拟鳞状细胞癌1例报告。

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Case Reports in Dermatology Pub Date : 2026-01-13 eCollection Date: 2026-01-01 DOI: 10.1159/000550461

Sho Hirata, Daisuke Watabe, Toshihide Akasaka, Hiroo Amano

{"title":"Multiple Hypertrophic Lichen Planus Mimicking Squamous Cell Carcinoma: A Case Report.","authors":"Sho Hirata, Daisuke Watabe, Toshihide Akasaka, Hiroo Amano","doi":"10.1159/000550461","DOIUrl":"10.1159/000550461","url":null,"abstract":"Introduction: Hypertrophic lichen planus (HLP) with pseudoepitheliomatous hyperplasia (PEH) can closely mimic well-differentiated squamous cell carcinoma (SCC), creating a clinically important diagnostic pitfall. Fewer than 26 case reports in the literature describe HLP initially misdiagnosed as SCC, underscoring the need for careful clinicopathologic correlation.Case presentation: A 77-year-old woman developed multiple hyperkeratotic nodules and plaques on both legs and feet over 4 months. A punch biopsy led to an initial diagnosis of well-differentiated SCC. An additional elliptical incisional biopsy from a separate plaque showed irregular acanthosis with hypergranulosis, endophytic well-differentiated squamous epithelium, and a dense lichenoid interface infiltrate with focal basal vacuolar change and Max-Joseph spaces, without destructive invasion or significant atypia - findings consistent with HLP with PEH. The lesions flattened with topical clobetasol propionate under occlusion for 6 weeks, and no recurrence was observed during a 3-month follow-up.Conclusion: HLP can closely mimic well-differentiated SCC, making adequate tissue sampling and clinicopathologic correlation essential to avoid unnecessary surgery. This case adds to the limited literature on HLP misdiagnosed as SCC and highlights the need to also consider inflammatory mimickers.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"89-95"},"PeriodicalIF":0.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of Vitiligo during Treatment with Risankizumab-Rzaa for Plaque Psoriasis: A Case Report. 利尚单抗- rzaa治疗斑块型银屑病期间出现白癜风1例报告

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Case Reports in Dermatology Pub Date : 2025-12-20 eCollection Date: 2026-01-01 DOI: 10.1159/000548980

Kevin V Thomas, Jennifer M Tran, Lisa M Cotter

{"title":"Emergence of Vitiligo during Treatment with Risankizumab-Rzaa for Plaque Psoriasis: A Case Report.","authors":"Kevin V Thomas, Jennifer M Tran, Lisa M Cotter","doi":"10.1159/000548980","DOIUrl":"10.1159/000548980","url":null,"abstract":"Introduction: Risankizumab-rzaa (Skyrizi) is a humanized monoclonal antibody (IgG1) approved for the treatment of severe plaque psoriasis. It selectively blocks the p19 subunit of the IL-23 pathway, leading to reduced keratinocyte proliferation reducing the inflammatory response.Case presentation: We present a case of de novo vitiligo in a patient being treated with risankizumab-rzaa (Skyrizi) for plaque psoriasis. Our patient had extensive plaque psoriasis affecting his trunk, upper extremities, and scalp, encompassing 30% of his total body surface area. He was treated with risankizumab-rzaa, an IL-23 inhibitor, with significant improvement of his psoriasis and residual hyperpigmented, post-inflammatory patches. In addition, he developed new-onset vitiligo, for which he declined treatment and was continued on risankizumab-rzaa. On subsequent follow-up over a year later, there were extensive areas of vitiligo now with a trichrome pattern suggestive of active vitiligo.Conclusion: To our knowledge, no cases of de novo vitiligo associated with risankizumab-rzaa have been reported in the literature, and our patient may represent the first reported case. The role of IL-23 remains unclear, and our case represents the importance of further research to better elucidate IL-23's role in vitiligo.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"64-69"},"PeriodicalIF":0.8,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic Syringocystadenocarcinoma Papilliferum Treated with Enzalutamide: A Case Report and a Review of the Literature. 恩杂鲁胺治疗转移性乳头状囊腺癌1例报告及文献复习。

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Case Reports in Dermatology Pub Date : 2025-12-12 eCollection Date: 2026-01-01 DOI: 10.1159/000548401

Antonino Colloca, Domenico Michele D'Angiolella, Gabriele Laezza, Chiara Cesaro, Maria Cristina Giugliano, Filippo Sepe, Francesco Caraglia, Miriam Forte, Silvana Cozzolino, Alfonso Esposito, Vincenzo Terrano, Andrea Ronchi, Francesca Pagliuca, Vincenzo De Falco, Stefania Napolitano, Teresa Troiani, Lorenzo Lobianco

{"title":"Metastatic Syringocystadenocarcinoma Papilliferum Treated with Enzalutamide: A Case Report and a Review of the Literature.","authors":"Antonino Colloca, Domenico Michele D'Angiolella, Gabriele Laezza, Chiara Cesaro, Maria Cristina Giugliano, Filippo Sepe, Francesco Caraglia, Miriam Forte, Silvana Cozzolino, Alfonso Esposito, Vincenzo Terrano, Andrea Ronchi, Francesca Pagliuca, Vincenzo De Falco, Stefania Napolitano, Teresa Troiani, Lorenzo Lobianco","doi":"10.1159/000548401","DOIUrl":"10.1159/000548401","url":null,"abstract":"Introduction: Syringocystadenocarcinoma papilliferum (SCACP) is a rare malignancy of the elderly originating from apocrine adnexal glands, mostly developing in the head and neck district. To date, there is no established treatment for metastatic SCACP, leaving affected patients with small therapeutic opportunities.Case presentation: Herein, it is described the case of a 70-year-old man affected by metastatic SCACP, treated with three different sequential therapy lines: carboplatin plus paclitaxel, epirubicin, and an off-label protocol with enzalutamide, achieving 41 months overall survival. Off-label enzalutamide treatment has been justified by androgen receptor expression by SCACP cells, a common feature of apocrine glands derived tumors. Interestingly, SCACP demonstrated to be responsive to enzalutamide treatment, even though the patient precociously stopped the treatment due to severe toxicity.Conclusion: This case represents the first evidence of hormonotherapy administration in a SCACP patient, possibly providing the base for a new therapeutic opportunity for this rare malignancy.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"25-31"},"PeriodicalIF":0.8,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Familial Annular Erythema Effectively Responded to Phototherapy: A Case Report of an Extremely Rare Entity and Literature Review. 家族性环状红斑对光疗有效：一罕见病例报告及文献复习。

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Case Reports in Dermatology Pub Date : 2025-12-11 eCollection Date: 2026-01-01 DOI: 10.1159/000549976

Waseem Alhawsawi, Houriah Nukaly, Abdulhadi Jfri, Razan S Al-Luhaibi, Abdulmajeed Aljarallah, Sarah M Fageeh, Khalid Al Hawsawi

{"title":"Familial Annular Erythema Effectively Responded to Phototherapy: A Case Report of an Extremely Rare Entity and Literature Review.","authors":"Waseem Alhawsawi, Houriah Nukaly, Abdulhadi Jfri, Razan S Al-Luhaibi, Abdulmajeed Aljarallah, Sarah M Fageeh, Khalid Al Hawsawi","doi":"10.1159/000549976","DOIUrl":"10.1159/000549976","url":null,"abstract":"Introduction: Familial annular erythema is the inherited form of erythema annular centrifugum, in an autosomal dominant fashion. It is an extremely rare cutaneous condition characterized by asymptomatic or mildly itchy annular, arcuate or polycyclic erythematous plaques that appears few days after birth with no systemic manifestations. Histopathological features are consistent with erythema annular centrifugum. To this date, only five families have been reported to the literature.Case presentation: Herein, we report a family with three generations of affected individuals. The index patient was a 23-year-old female, presented with mildly itchy non-scaly annular and arcuate erythematous plaques that appeared since birth. Her paternal grandmother, father, sister and two male cousins have similar condition. Review of system and laboratory workup was unremarkable. Skin biopsy showed focal compact orthohyperkeratosis, spongiosis, basal cell degeneration, prominent papillary edema with moderate superficial and deep perivascular eosinophilic infiltrate. The index patient was started on narrowband ultraviolet B therapy and showed complete clearance for at least 3 months.Conclusion: This extremely rare entity is not known to be associated with other organ involvement, apart from the skin. It poses diagnostic difficulty as it resembles other annular conditions during infancy. The presence of similar cases within her family underscores the genetic component of this condition, warranting further investigation and discussion. Possible effective therapeutic options include phototherapy.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"70-80"},"PeriodicalIF":0.8,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatofibroma with Hypopigmented Meyerson Halo: A Case Report and Review of Non-Melanocytic Hosts. 皮肤纤维瘤伴低色素迈耶森晕：非黑素细胞宿主1例报告及回顾。

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Case Reports in Dermatology Pub Date : 2025-12-10 eCollection Date: 2026-01-01 DOI: 10.1159/000549986

Mohammed Shanshal, Muna M Abuayyash

{"title":"Dermatofibroma with Hypopigmented Meyerson Halo: A Case Report and Review of Non-Melanocytic Hosts.","authors":"Mohammed Shanshal, Muna M Abuayyash","doi":"10.1159/000549986","DOIUrl":"10.1159/000549986","url":null,"abstract":"Introduction: Meyerson phenomenon denotes a perilesional, classically eczematous halo around a pre-existing lesion, most often melanocytic. Non-melanocytic halos are uncommon and can mimic regression in a melanocytic lesion, including melanoma, leading to urgent referrals.Case presentation: We report a 37-year-old woman with a \"mole with a halo\" on her arm. Examination revealed a 5-mm pink papule with a thin whitish collarette and a faint, ill-defined hypopigmented ring. Dermoscopy showed a structureless pink centre with a pinpoint crust and delicate collarette, but no pigment network or organised vascular pattern. Excisional biopsy revealed a dermal spindle-cell proliferation characteristic of dermatofibroma; the diagnosis was confirmed by negative SOX10 and positive Factor XIIIa staining. Notably, there was no spongiotic perilesional dermatitis. A targeted literature review confirmed the rarity of halos around dermatofibromas, which are typically eczematous.Conclusion: Our case expands the clinicopathologic spectrum to include a hypopigmented, non-eczematous Meyerson-like (\"forme-fruste\") halo variant and supports a dermoscopy-first approach to avoid over-triage to melanoma and help streamline care.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"56-63"},"PeriodicalIF":0.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudoephedrine-Associated Erythromelalgia: A Case Report of a Rare Drug Reaction. 伪麻黄碱相关性红斑性肢痛症：一例罕见药物反应报告。

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Case Reports in Dermatology Pub Date : 2025-12-09 eCollection Date: 2026-01-01 DOI: 10.1159/000549963

Liang Zhi Wong, Georgios Kravvas

引用次数: 0