Case Reports in Dermatology最新文献

Childhood Linear IgA Dermatosis Successfully Treated with the Combination of Dapsone and Sulfasalazine. 氨苯砜联合柳氮磺胺吡啶成功治疗儿童线性IgA皮肤病。

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Case Reports in Dermatology Pub Date : 2025-05-03 eCollection Date: 2025-01-01 DOI: 10.1159/000546155

Ashley S Kim, Olav Sundnes

{"title":"Childhood Linear IgA Dermatosis Successfully Treated with the Combination of Dapsone and Sulfasalazine.","authors":"Ashley S Kim, Olav Sundnes","doi":"10.1159/000546155","DOIUrl":"10.1159/000546155","url":null,"abstract":"Introduction: Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune blistering skin disorder characterized by the linear deposition of IgA along the basal membrane. It affects primarily young children and adults, and is the most common bullous disease in the paediatric population. Dapsone represents the mainstay of treatment, to which the majority of patients show excellent initial responses with long-term remission. In recalcitrant cases, sulfonamides (sulfapyridine, sulfasalazine, sulfamethoxypyridazine) are considered second-line options either as monotherapy or in conjunction with dapsone. Most published cases of sulfonamides in childhood LAD report use of sulfapyridine or sulfamethoxypyridazine, with no published reports on sulfasalazine use in young children.Case presentation: We present a case of a 1-year-old child with confirmed LAD who did not respond adequately to dapsone alone. Sulfapyridine is not available in Norway, while sulfasalazine is accessible and considered a safe option for other autoimmune disorders. The addition of sulfasalazine resulted in rapid complete remission.Conclusion: This case thus supports sulfasalazine as a pragmatic, accessible alternative to sulfapyridine as the second-line treatment in childhood LAD.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"185-190"},"PeriodicalIF":0.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapy-Resistant Erosions in the Genital Area of Elderly Patients: A Differential Diagnostic Challenge - A Case Report. 治疗抵抗糜烂在老年患者生殖器区域：鉴别诊断的挑战-一个病例报告。

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Case Reports in Dermatology Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546135

Martin Gschnell, Iris Hennighausen, Can Alpagut, Julia Nadina Föhr, Jacqueline Kussini, Lisa Krönig

{"title":"Therapy-Resistant Erosions in the Genital Area of Elderly Patients: A Differential Diagnostic Challenge - A Case Report.","authors":"Martin Gschnell, Iris Hennighausen, Can Alpagut, Julia Nadina Föhr, Jacqueline Kussini, Lisa Krönig","doi":"10.1159/000546135","DOIUrl":"10.1159/000546135","url":null,"abstract":"Introduction: Genital erosions occur in many dermatological conditions and can sometimes be difficult to classify, especially in older patients with multiple morbidities.Case presentation: We report the case of an 81-year-old patient with therapy-resistant genital erythema. Under topical antifungal therapy for a suspected diagnosis of Candida intrigue, the scrotal findings continued to progress, accompanied by genital erosions and new erosions on the nose and right knee. With evidence of IgG and C3 deposition on the basement membrane on direct immunofluorescence and subepidermal cleft formation on histology, a diagnosis of bullous pemphigoid with predominant genital involvement was made.Conclusion: In conclusion, this case study illustrates that skin biopsies should be taken in cases of therapy-resistant erythema with erosions in order to clarify the dignity and ultimately to be able to adapt the treatment. In addition, it is important to examine the entire integument, including the mucous membranes close to the skin, to avoid overlooking groundbreaking findings. Bullous pemphigoid is the most common blistering autoimmune skin disease and occurs mainly in older people. However, the classic picture of bulging blisters is not always present. Bullous pemphigoid may masquerade clinically as pruritic eczema, erythroderma, or erosions. Predominant genital involvement has only been described in a few case reports.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"191-195"},"PeriodicalIF":0.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Necrobiosis Lipoidica with Abrocitinib: A Case Report. 阿布替尼成功治疗脂质坏死性坏死1例。

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Case Reports in Dermatology Pub Date : 2025-04-26 eCollection Date: 2025-01-01 DOI: 10.1159/000546134

Yuping Zhang, Yirong Li, Fengjiao Meng, Chen Li

引用次数: 0

Kasabach-Merritt Phenomenon: Diagnosis, Management, and Outcome on Two Cases in a Sub-Saharan Country (Senegal). Kasabach-Merritt现象：撒哈拉以南国家（塞内加尔）两例病例的诊断、管理和结果。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI: 10.1159/000546020

Khadim Diop, Mame Téné Ndiaye Diop, Ibrahima Diop, Ines Mejri, Lana Yassine, Fatou Diassé, Fatime Tall, Idrissa Demba Ba, Maodo Ndiaye, Ousmane Ndiaye

{"title":"Kasabach-Merritt Phenomenon: Diagnosis, Management, and Outcome on Two Cases in a Sub-Saharan Country (Senegal).","authors":"Khadim Diop, Mame Téné Ndiaye Diop, Ibrahima Diop, Ines Mejri, Lana Yassine, Fatou Diassé, Fatime Tall, Idrissa Demba Ba, Maodo Ndiaye, Ousmane Ndiaye","doi":"10.1159/000546020","DOIUrl":"10.1159/000546020","url":null,"abstract":"Introduction: Kasabach-Merritt phenomenon (KMP) is a rare and life-threatening disease, characterized by the profound thrombocytopenia and consumptive coagulopathy associated with vascular tumors. In sub-Saharan Africa, KMP-related data are scarce and it poses significant challenges in management, particularly due to limited availability of treatment resources. We report 2 cases of KMP observed in a sub-Saharan Africa country (Dakar, Senegal).Case presentation: Case 1: a 45-day-old male infant was admitted for a tumor lesion located in the axillary fold that has been evolving since birth. The lesion had rapidly become aggressive, inflammatory, and purpuric. Blood tests showed normocytic normochromic anemia with severe thrombocytopenia and high D-dimer levels. The diagnosis of a kaposiform hemangioendothelioma complicated by a KMP was retained. Treatment with betamethasone was initiated, but death occurred 6 days later secondary to cerebral hemorrhage. Case 2: a 2-month-old female infant was admitted for a rapidly aggressive, inflammatory, infiltrating tumor lesion on the face that had been progressing for 1 month. Blood tests showed normocytic normochromic anemia with severe thrombocytopenia and high D-dimer levels. The diagnosis of a KMP was retained. Treatment with corticosteroids, then combined with vincristine, was administered. The outcome was favorable with a considerable regression of the mass and improvement in biological parameters after 6 months.Conclusion: To our knowledge, we report the first case report on KMP in sub-Saharan Africa, particularly in pediatric dermatology in Dakar. Besides their rarity, these cases highlight the challenges in the management of KMP in a country with limited therapeutic resources.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"174-180"},"PeriodicalIF":0.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review. 广泛的指甲变化是儿童朗格汉斯细胞组织细胞增多症多系统参与的可能线索：一个病例报告和文献复习。

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Case Reports in Dermatology Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI: 10.1159/000545567

Xiaofei Gao, Bin Yu, Jiaotian Huang, Haixia Yang, Zhu Wei

{"title":"Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review.","authors":"Xiaofei Gao, Bin Yu, Jiaotian Huang, Haixia Yang, Zhu Wei","doi":"10.1159/000545567","DOIUrl":"10.1159/000545567","url":null,"abstract":"Introduction: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm that can involve nearly any organ, leading to multisystem damage. Nail involvement in LCH is particularly uncommon. Here we report a case of a young boy with multisystem LCH initially presenting with nail changes.Case presentation: We described a boy who presented with a 2-year history of asymptomatic changes characterized by onycholysis, subungual hyperkeratosis, and purpuric striae affecting most fingernails and toenails, initially attributed to onychomycosis. Two years later, he developed multisystem involvement affecting the pituitary gland, lungs, skin, liver, and spleen. The patient succumbed shortly after histopathological confirmation via skin biopsy due to massive gastrointestinal hemorrhage secondary to cirrhosis-induced portal hypertension.Discussion: Nail lesions may serve as the initial manifestation of LCH, often preceding other characteristic disease symptoms. This early presentation provides critical diagnostic opportunities for timely intervention. Consideration of LCH, biopsy, and comprehensive evaluation of organ involvement is essential to reduce the rate of misdiagnosis and the potential for unrecognized high-risk disease.Conclusion: Nail involvement in LCH, while rare, may serve as an early clinical indicator of multisystem disease.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"165-173"},"PeriodicalIF":0.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Primary Cutaneous CD4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab. 一例罕见的原发性皮肤CD4+小/中型t细胞增生性疾病对利妥昔单抗有反应。

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Case Reports in Dermatology Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.1159/000545747

Saman Al-Zahawi, Sara Masoomi, Alireza Ghanadan, Yasaman Sadeghi, Maryam Daneshpazhooh, Hamidreza Mahmoudi

引用次数: 0

Acquired Reactive Perforating Collagenosis Complicated by Diabetes Mellitus and Hypertension: A Case Report. 获得性反应性穿孔性胶原沉积合并糖尿病和高血压1例。

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Case Reports in Dermatology Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.1159/000545693

Meng Zhang, Ruiqi Chu, Junping Shen, Chunmei Liu, Yanan Wang, Shun Zhang, Xiangxiang Ren

{"title":"Acquired Reactive Perforating Collagenosis Complicated by Diabetes Mellitus and Hypertension: A Case Report.","authors":"Meng Zhang, Ruiqi Chu, Junping Shen, Chunmei Liu, Yanan Wang, Shun Zhang, Xiangxiang Ren","doi":"10.1159/000545693","DOIUrl":"https://doi.org/10.1159/000545693","url":null,"abstract":"Introduction: Acquired reactive perforating collagenosis (ARPC) is a rare cutaneous disorder frequently associated with systemic diseases such as diabetes mellitus and chronic kidney disease. Its diagnosis remains challenging due to clinical overlap with other perforating dermatoses, necessitating advanced diagnostic tools for confirmation.Case presentation: A 55-year-old male with a 15-year history of diabetes mellitus and hypertension developed progressively pruritic papules and nodules on both lower limbs over 2 months. Initial misdiagnosis as a fungal infection led to unsuccessful antifungal therapy. Dermatoscopy revealed keratotic plugs with peripheral erythema, while histopathology demonstrated transepidermal elimination of degenerated collagen, confirming ARPC. Topical retinoic acid cream achieved marked symptomatic relief.Conclusion: This case highlights ARPC's strong association with metabolic comorbidities and underscores the necessity of dermatoscopic and histopathological evaluation to avoid diagnostic pitfalls. The therapeutic success of topical retinoids in resource-constrained settings reinforces their role as a pragmatic first-line intervention. Clinicians should consider ARPC in patients with chronic pruritic eruptions and systemic metabolic disorders, advocating for multidisciplinary collaboration to address underlying comorbidities.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"143-149"},"PeriodicalIF":0.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trauma-Induced Psoriatic Arthritis: A Deep Köbner Phenomenon. 创伤性银屑病关节炎：深层Köbner现象。

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Case Reports in Dermatology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.1159/000545694

Yoshihito Mima, Masako Yamamoto, Naoki Nishida, Yuta Norimatsu, Ken Iozumi

{"title":"Trauma-Induced Psoriatic Arthritis: A Deep Köbner Phenomenon.","authors":"Yoshihito Mima, Masako Yamamoto, Naoki Nishida, Yuta Norimatsu, Ken Iozumi","doi":"10.1159/000545694","DOIUrl":"https://doi.org/10.1159/000545694","url":null,"abstract":"Introduction: Psoriasis is a chronic systemic inflammatory disorder resulting from complex interactions between genetic and environmental factors. In addition to cutaneous manifestations, psoriasis is associated with psoriatic arthritis (PsA). Among the recognized mechanisms of disease exacerbation, the Köbner phenomenon (KP) plays a crucial role. KP refers to the appearance of new psoriatic lesions on previously healthy skin following trauma. A deeper variant of this phenomenon, the deep Köbner phenomenon (DKP), involves severe trauma triggering systemic inflammation, including the onset of PsA. Trauma-induced DKP represents unique disease mechanisms, linking external mechanical stress to immune-mediated joint pathology.Case presentation: We present a case of a 60-year-old male with psoriasis, who initially responded well to ixekizumab, an IL-17A inhibitor but subsequently developed PsA following a wrist injury. The PsA exacerbation was attributed to increased mechanical stress from daily activities and rehabilitation efforts. Adjustments were made to rehabilitation intensity and joint movement restrictions, leading to gradual symptom improvement over 3 months without intensifying biological therapy.Conclusion: This case highlights the pathophysiological relationship between trauma, DKP, and PsA. The rapid onset of PsA following trauma suggests that inflammatory mediators and neuropeptides triggered by DKP play significant roles. Given that rehabilitation plays crucial roles in recovery but may also exacerbate symptoms if improperly managed, tailored rehabilitation strategies are essential in managing trauma-induced PsA. This case also underscores the importance of comprehensive management, including biological therapy and personalized rehabilitation approaches. Further studies are needed to optimize inflammation control and joint function in patients experiencing post-trauma PsA.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"137-142"},"PeriodicalIF":0.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital Malalignment of the Great Toenails with Secondary Retronychia: A Tale of Twin Toenails. 先天性大趾甲畸形伴继发性后甲：双趾甲的故事。

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Case Reports in Dermatology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.1159/000545462

Carrie A Forman, Noelle Desir, Michael M Ong, Shari R Lipner

{"title":"Congenital Malalignment of the Great Toenails with Secondary Retronychia: A Tale of Twin Toenails.","authors":"Carrie A Forman, Noelle Desir, Michael M Ong, Shari R Lipner","doi":"10.1159/000545462","DOIUrl":"https://doi.org/10.1159/000545462","url":null,"abstract":"Introduction: Congenital malalignment of the great toenail (CMGT) is characterized by deviation of the nail plate due to rotation of the nail matrix. CMGT may be complicated by secondary retronychia.Case presentation: We report a case of twin 14-year-old females who presented with CMGT with secondary retronychia with no clear inciting event. Physical examination demonstrated lateral deviation of the great toenails with yellowed, thickened, and layered nail plates, consistent with a diagnosis of CMGT with secondary retronychia. The patients were advised to make relevant lifestyle changes and treated with clobetasol proprionate 0.05% ointment to use on all toenails daily for 3 months, with 1 week off per month, under occlusion.Conclusion: We hypothesize that both genetic and environmental factors likely contributed to the development of CMGT with secondary retronychia in these twins. Increased awareness and recognition of this underdiagnosed condition, particularly in the pediatric population, is important for timely and effective management.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"157-164"},"PeriodicalIF":0.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focal Hypertrichosis during Topical Tacrolimus Therapy for Vitiligo: A Case Report. 局部他克莫司治疗白癜风期间局灶性多毛：1例报告。

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Case Reports in Dermatology Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.1159/000545115

Lingyu Mao, Yan Lin, Xueping Yu, Huaxu Liu

{"title":"Focal Hypertrichosis during Topical Tacrolimus Therapy for Vitiligo: A Case Report.","authors":"Lingyu Mao, Yan Lin, Xueping Yu, Huaxu Liu","doi":"10.1159/000545115","DOIUrl":"10.1159/000545115","url":null,"abstract":"Introduction: Tacrolimus is widely used in treating vitiligo. Drug-induced hypertrichosis is a well-known side effect of cyclosporine. It is less commonly associated with tacrolimus or with topical calcineurin inhibitors. Four reports of hypertrichosis attributed to topical or systemic tacrolimus have been previously reported in the literature. In this report, we describe a case of focal hypertrichosis due to long-term use of topical tacrolimus for vitiligo.Case presentation: We present a 15-year-old boy with focal hypertrichosis of white hair for 4 months, after treatment with topical tacrolimus 0.1% ointment. He denied ever using other ointment to the area. After he stopped using tacrolimus for half a month, the focal hypertrichosis improved.Conclusion: We propose that the focal hypertrichosis was induced by tacrolimus. The hair growth-stimulating effects of tacrolimus have been established. It is reported that tacrolimus directly stimulates mouse whiskers in vitro and prolongs the anagen phase of hair growth when it is applied topically in mice. We believe that a greater awareness of this rare side effect of tacrolimus is warranted as tacrolimus is widely used in treating vitiligo.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"106-109"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0