Case Reports in Dermatology最新文献

Keratoderma-Like T-Cell Dyscrasia: A Case Report. 角化病样 T 细胞瘤：病例报告

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Case Reports in Dermatology Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.1159/000541258

Asem Shadid, Sukaina Al Haddad, Rua'a Alharithy, Tariq J Al-Zaid

{"title":"Keratoderma-Like T-Cell Dyscrasia: A Case Report.","authors":"Asem Shadid, Sukaina Al Haddad, Rua'a Alharithy, Tariq J Al-Zaid","doi":"10.1159/000541258","DOIUrl":"10.1159/000541258","url":null,"abstract":"Introduction: Cutaneous T-cell dyscrasia (CTCD) encompasses a heterogeneous group of T-cell infiltrates, often clonal and epitheliotropic. While the etiology remains unclear, certain medications, including statins, have been linked to cutaneous T-cell lymphocytic infiltrate development.Case description: A patient presented with a pruritic, scaly eruption on her palms and soles unresponsive to topical steroids for 1 month. Histopathological examination revealed compact orthokeratosis, mild lymphocytic infiltrate with focal exocytosis, and atypical lymphocytes. Immunophenotyping demonstrated a predominance of CD3+ T cells with a 1:1 CD4/CD8 ratio and reduced CD7 expression. The clinical presentation, histopathology, and immunophenotype supported a diagnosis of statin-induced CTCD.Conclusion: Statin discontinuation led to complete symptom resolution, emphasizing the reversibility of drug-induced T-cell dyscrasia. This case highlights the importance of a detailed medication history as drug-induced T-cell dyscrasia, unlike classic CTCD with its characteristic lymphoid atypia, phenotypic abnormalities, and clonality leading to a refractory course, can be reversed by drug withdrawal.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syringotropic Lichen Planus: An Unusual Presentation of a Common Dermatosis - A Report of 2 Cases. 注射性扁平苔藓：常见皮肤病的不寻常表现--2 例报告。

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Case Reports in Dermatology Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI: 10.1159/000541695

Fatemeh Mohaghegh, Zohre Khodashenas, Mina Saber, Haniyeh Sohrabi

引用次数: 0

DRESS Syndrome That Resembles Graft-Versus-Host Disease after Chemotherapy in a Pediatric Patient: A Case Report. 一名儿科患者化疗后出现类似移植物抗宿主病的 DRESS 综合征：病例报告。

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Case Reports in Dermatology Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.1159/000541046

Marian Rolón, Mateo Barros, Clara Ortiz, Sergio Danilo Cruz Romero, Johanna Álvarez

{"title":"DRESS Syndrome That Resembles Graft-Versus-Host Disease after Chemotherapy in a Pediatric Patient: A Case Report.","authors":"Marian Rolón, Mateo Barros, Clara Ortiz, Sergio Danilo Cruz Romero, Johanna Álvarez","doi":"10.1159/000541046","DOIUrl":"https://doi.org/10.1159/000541046","url":null,"abstract":"Introduction: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening, drug-induced adverse reaction characterized by skin eruptions, lymphadenopathy, fever, and a broad range of other bodily manifestations. The spectrum of histopathologic and clinical presentations is wide; therefore, DRESS syndrome can mimic other diseases.Case presentation: We present a case of a 4-year-old male patient who started chemotherapy with vincristine, cytarabine, and etoposide. The first clinical signs were fever, hemodynamic in-stability, and maculopapular erythema. Biopsies of skin lesions were taken, and hyperkeratosis, focal parakeratosis, acanthosis with slight spongiosis, and intraepithelial dyskeratotic cells were observed. There was a perivascular lymphoid infiltrate with abundant eosinophils in the dermis, and eosinophil permeations to the acrosyringium and epithelium were found.Conclusion: DRESS syndrome is a drug-induced reaction that shares histopathological findings in skin biopsies with those seen in graft-versus-host disease. Although the histological findings are non-pathognomonic, they were characteristic enough to be of importance in the differential diagnosis.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Nodulocystic Acne Induced by Mercury-Containing Skin-Whitening Cream: A Case Report and Call for Public Awareness. 含汞美白霜诱发的严重结节囊肿性痤疮：病例报告和提高公众认识的呼吁。

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Case Reports in Dermatology Pub Date : 2024-09-19 eCollection Date: 2024-01-01 DOI: 10.1159/000541141

Sami Alsuwaidan, Khalid Nabil Nagshabandi, Abdulmajeed Alajlan

引用次数: 0

Treatment of a Complex Case of Scleromyxedema Using a Novel Intravenous Immunoglobulin Preparation. 使用新型静脉注射免疫球蛋白制剂治疗复杂的硬肌水肿病例

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Case Reports in Dermatology Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.1159/000540519

Anastasia Sophie Vollmer, Nadine Wiedenmayer, Julia K Winkler, Alexander H Enk

{"title":"Treatment of a Complex Case of Scleromyxedema Using a Novel Intravenous Immunoglobulin Preparation.","authors":"Anastasia Sophie Vollmer, Nadine Wiedenmayer, Julia K Winkler, Alexander H Enk","doi":"10.1159/000540519","DOIUrl":"https://doi.org/10.1159/000540519","url":null,"abstract":"Introduction: We provide a case report on a patient with scleromyxedema treated with high-dose intravenous immunoglobulins (IVIgs) who reported less fatigue and fewer headaches after transitioning to Yimmugo, a novel IVIg preparation. Scleromyxedema is a rare and chronic cutaneous mucinosis, frequently associated with monoclonal gammopathy and systemic complications, which may be life-threatening. The disease is characterized by papular eruptions and sclerosis of the skin. Treatment of scleromyxedema is challenging because of its unclear pathogenesis. High-dose IVIgs are a promising treatment option to improve cutaneous manifestations.Case presentation: We present the case of a 57-year-old patient with scleromyxedema and monoclonal gammopathy with end-stage renal failure on hemodialysis (3 times a week). Stabilization of skin symptoms was finally achieved by high-dose IVIg therapy administered at 2 g per kg bodyweight distributed over 2 days every 3 weeks. However, disease stabilization came at the expense of flu-like side effects that significantly affected daily life. After transitioning to Yimmugo®, the patient reported an improved quality of life.Conclusion: Further follow-up is essential to conclusively evaluate effectiveness and tolerability of this novel IVIg preparation.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Spontaneous Subcutaneous Abscess Formation due to Finegoldia magna in a Diabetic Patient: A Case Report. 糖尿病患者因细金丝桃而自发形成大面积皮下脓肿：病例报告。

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Case Reports in Dermatology Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI: 10.1159/000540636

Toshiyuki Sato, Mayuka Tomita, Atsuhiro Kohno, Satomi Chujo, Yuma Waki, Yoshimasa Nobeyama, Masaaki Kawase, Akihiko Asahina

{"title":"Large Spontaneous Subcutaneous Abscess Formation due to Finegoldia magna in a Diabetic Patient: A Case Report.","authors":"Toshiyuki Sato, Mayuka Tomita, Atsuhiro Kohno, Satomi Chujo, Yuma Waki, Yoshimasa Nobeyama, Masaaki Kawase, Akihiko Asahina","doi":"10.1159/000540636","DOIUrl":"https://doi.org/10.1159/000540636","url":null,"abstract":"Introduction: Finegoldia magna is a member of the Gram-positive anaerobic cocci group and constitutes the flora of the skin and other parts of the body. It sometimes colonizes diabetic foot and rarely infects skin or soft tissue of non-immunocompromised patients.Case presentation: Here, we report the case of a severe subcutaneous abscess on the back caused by F. magna involving an immunocompromised patient with poorly controlled diabetes. A 48-year-old woman with diabetes mellitus and anemia associated with uterine fibroids was referred to us with a 1-month history of a skin manifestation on her back, with a body temperature of 35.9°C and blood pressure of 115/73 mm Hg. The manifestation involved a subcutaneous mass of 36 × 45 cm with a foul odor, partly covered with necrotic tissue, which had the appearance of a tortoiseshell-like pattern. Blood examination revealed C-reactive protein of 21.4 mg/dL and hemoglobin A1c of 9.1%. Contrast-enhanced computed tomography showed a subcutaneous abscess with internal emphysema. Emergency debridement was performed, resulting in drainage of foul-smelling gray-green pus. F. magna was detected in the pus and skin tissue.Conclusion: Skin and soft tissue infectious disease caused by F. magna is extremely rare, but the disease tends to become severe once developing in an immunocompromised patient, such as a patient with poorly controlled diabetes. Therefore, physicians should consider F. magna as a causative agent when poorly controlled diabetic patients suffer from severe infectious cutaneous manifestations.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First Case of Eruptive Pyogenic Granuloma following COVID-19 Vaccination. 首例接种 COVID-19 疫苗后出现爆发性化脓性肉芽肿的病例。

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Case Reports in Dermatology Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI: 10.1159/000539849

Saman Al-Zahawi, Alireza Ghanadan, Fatema Saberi, Kamran Balighi, Zahra Razavi

引用次数: 0

A Challenging Case of Reactive Angioendotheliomatosis. 反应性血管内皮瘤病的棘手病例

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Case Reports in Dermatology Pub Date : 2024-07-05 eCollection Date: 2024-01-01 DOI: 10.1159/000539775

Georgios Kravvas, Lola Meghoma, Victoria Vilenchik, Jon Oxley, Daniel J Keith

{"title":"A Challenging Case of Reactive Angioendotheliomatosis.","authors":"Georgios Kravvas, Lola Meghoma, Victoria Vilenchik, Jon Oxley, Daniel J Keith","doi":"10.1159/000539775","DOIUrl":"10.1159/000539775","url":null,"abstract":"Introduction: Reactive angioendotheliomatosis (RAE) is a rare, benign, angioproliferative disorder with poorly understood aetiopathogenesis. It is characterised by vascular occlusion that occurs in patients with coexistent systemic or autoimmune disease.Case presentation: A 60-year-old female presented with an 8-week history of a painful, non-healing, and non-traumatic ulcer on the left thigh. Her past medical history included smoking, peripheral vascular disease (PVD) and previously treated rectal squamous cell carcinoma. The diagnosis of pyoderma gangrenosum with superimposed cellulitis was considered and treatment with oral antibiotics was initiated. Following failure to improve, a biopsy was undertaken leading to the diagnosis of RAE. The patient was referred for urgent consideration of surgical correction of PVD, but was deemed unsuitable for surgical treatment due to a poor performance status. The patient was treated with conservative measures, but her condition rapidly deteriorated and she passed away a few weeks later.Conclusion: RAE is notorious for mimicking a wide spectrum of diseases. It is an important differential diagnosis to consider in patients with non-healing ulceration and underlying systemic or autoimmune disorders. Our case raises awareness of this rare condition and the mortality that it carries if left untreated. In an attempt to reverse disease progression and mortality, we urge clinicians to attempt surgical correction of PVD even when faced with multiple comorbidities and poor performance status.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisystem Langerhans Cell Histiocytosis following Treatment of Initially Presumed Atopic Dermatitis with Dupilumab: A Case Report of an Extremely Confusing Scenario. 用杜匹单抗治疗最初假定的特应性皮炎后出现的多系统朗格汉斯细胞组织细胞增生症：极易混淆的病例报告。

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Case Reports in Dermatology Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.1159/000539704

Wenhao Cheng, Hong Ren, Wenlong Hu

引用次数: 0

Hedgehog Pathway and Programmed Cell Death Protein-1 Inhibitors for Advanced Basal Cell Carcinoma. 治疗晚期基底细胞癌的刺猬蛋白通路和程序性细胞死亡蛋白-1抑制剂

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Case Reports in Dermatology Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI: 10.1159/000539592

Babette J A Verkouteren, An K L Reyners, Maureen J B Aarts, Klara Mosterd

{"title":"Hedgehog Pathway and Programmed Cell Death Protein-1 Inhibitors for Advanced Basal Cell Carcinoma.","authors":"Babette J A Verkouteren, An K L Reyners, Maureen J B Aarts, Klara Mosterd","doi":"10.1159/000539592","DOIUrl":"10.1159/000539592","url":null,"abstract":"Introduction: Basal cell carcinoma (BCC) is treated with local surgery or noninvasive treatment modalities. If a BCC remains untreated, it can develop into a locally advanced BCC or a metastatic BCC.Case presentation: Here we report in detail the management of three complex advanced BCC (aBCC) after treatment failure with vismodegib. On all tumors, next generation DNA sequencing in the Center for Personalized Cancer Treatment-02 (CPCT-02) study was performed; subsequently, patients were included in the Drug Rediscovery Protocol (DRUP) trial, in which treatment was started with commercially available targeted anticancer drugs based on the molecular tumor profile. All patients showed partial response or stable disease following treatment with second line PD-1 inhibitors with an average duration of response of 12.3 months.Discussion/conclusion: Immunotherapy can be a treatment option for aBCC resistant to hedgehog pathway inhibitor treatment. However, despite the high tumor mutational burden of aBCCs, immunotherapy does not always lead to a long response. Rechallenge or combining treatment of hedgehog inhibitors and PD-1 inhibitors by parallel or alternating cycles may be a strategy to lengthen the treatment response.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0