Case Reports in Dermatology最新文献

Cutaneous Rosai-Dorfman Disease: A Report of 2 Cases and a Review of Recent Literature (2018-2023). 皮肤Rosai-Dorfman病2例报告及近期文献回顾（2018-2023）

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Case Reports in Dermatology Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.1159/000546382

Fatemeh Mohaghegh, Mina Saber, Parvin Rajabi, Haniyeh Sohrabi

{"title":"Cutaneous Rosai-Dorfman Disease: A Report of 2 Cases and a Review of Recent Literature (2018-2023).","authors":"Fatemeh Mohaghegh, Mina Saber, Parvin Rajabi, Haniyeh Sohrabi","doi":"10.1159/000546382","DOIUrl":"10.1159/000546382","url":null,"abstract":"Introduction: Rosai-Dorfman disease (RDD) is a rare, benign histiocytic disorder that can present as isolated cutaneous RDD (CRDD), often mimicking other dermatologic conditions and complicating diagnosis.Case presentation: We report two cases of CRDD: one with palms and soles involvement, and another as an exophytic facial mass, initially misdiagnosed and unsuccessfully treated. Dermoscopy revealed distinctive features, including yellow ovoid structures, linear vessels, and cotton-like white globules. Histopathological and immunohistochemical analyses confirmed CRDD with histiocytic infiltration and emperipolesis, key histological markers of CRDD.Conclusion: A review of 53 cases (2018-2023) highlights CRDD's clinical variability, common anatomical sites, and diverse treatment responses, emphasizing the need for individualized management and early recognition for optimal treatment. These findings contribute to a broader understanding of CRDD and support a multidisciplinary approach to optimizing patient care.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"204-223"},"PeriodicalIF":0.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erosive Pustular Dermatosis and Amivantamab for Lung Cancer: A Case Report. 糜烂性脓疱性皮肤病与阿米万他单抗治疗肺癌1例报告。

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Case Reports in Dermatology Pub Date : 2025-06-13 eCollection Date: 2025-01-01 DOI: 10.1159/000546616

Yseult Senterre, Amandine Bouillenne, Murielle Sabatiello, Anne-Sophie Demoulin, Arjen F Nikkels

引用次数: 0

Primary Aquagenic Pruritus Successfully Treated by β-Alanine: A Case Report. β-丙氨酸成功治疗原发性水源性瘙痒1例。

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Case Reports in Dermatology Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI: 10.1159/000545842

Farzad Alinaghi, Jesper Elberling

引用次数: 0

Malignant Hidroacanthoma Simplex: A Case Report. 恶性单纯性汗腺瘤1例。

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Case Reports in Dermatology Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI: 10.1159/000546700

Xiangxiang Ren, Tianhao Xie, Lingyun Liu, Fan Yang, Meng Zhang

{"title":"Malignant Hidroacanthoma Simplex: A Case Report.","authors":"Xiangxiang Ren, Tianhao Xie, Lingyun Liu, Fan Yang, Meng Zhang","doi":"10.1159/000546700","DOIUrl":"10.1159/000546700","url":null,"abstract":"Introduction: Malignant hidroacanthoma simplex (MHS) is an exceedingly rare cutaneous neoplasm with limited documented cases. This report highlights a distinctive case of MHS with prolonged clinical evolution, emphasizing its diagnostic challenges and management outcomes.Case presentation: A 64-year-old female presented with a right lumbar mass persisting for over 2 decades, exhibiting progressive enlargement in the past 5 years. Clinical examination revealed a solitary reddish-brown proliferative plaque (3.5 cm × 4.0 cm) on the right waist, characterized by irregular borders, a rough surface, and reddish-brown crusts. Histopathological findings included hyperkeratosis, irregular epidermal hyperplasia, hypertrophic stratum spinosum, and tumor cells displaying pale eosinophilic cytoplasm, vacuolated nuclei, small nucleoli, and atypical mitotic figures. Notably, tumor cells were confined to the epidermis without dermal invasion. The patient underwent local extended excision, and postoperative surveillance over 15 months demonstrated no evidence of recurrence or lymph node metastasis.Conclusion: This case underscores the indolent yet locally persistent nature of MHS. Complete surgical excision remains the cornerstone of management, with favorable outcomes achievable in the absence of dermal infiltration. Long-term follow-up is critical to monitor potential recurrence.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"246-251"},"PeriodicalIF":0.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different Course of Nonpigmented Skin Cancers in Patients Treated with Immunosuppression after Organ Transplantation: A Case Series. 器官移植后免疫抑制治疗非色素性皮肤癌患者的不同病程：一个病例系列。

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Case Reports in Dermatology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000545836

Monika Łącka, Paulina Bernecka, Karolina Kondej, Jerzy Jankau

{"title":"Different Course of Nonpigmented Skin Cancers in Patients Treated with Immunosuppression after Organ Transplantation: A Case Series.","authors":"Monika Łącka, Paulina Bernecka, Karolina Kondej, Jerzy Jankau","doi":"10.1159/000545836","DOIUrl":"10.1159/000545836","url":null,"abstract":"Introduction: In 2023, solid organs were transplanted in 1,400 patients in Poland. Nonmelanoma skin cancer such as squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) is the most common malignancy in solid organ transplant recipients. Aims of the study were to present cases and discuss the possible course of skin cancer in patients after organ transplantation.Case presentation: The study involved 3 patients after organ transplantation treated for skin cancer in the Department of Plastic Surgery of the University of Gdańsk in the years 2020-2023. Each patient is an example of a different course of the disease. In the case of patients treated with immunosuppression, a more aggressive course of the cancer should be considered, which may take various forms. One of the variants that we are dealing with in the first patient is the occurrence of multiple lesions, the co-occurrence of SCC and BCC, and frequent local recurrences. In the case of the second patient, we are dealing with a very aggressive course despite the early initiation of appropriate treatment. Another example of a different course is an atypical clinical picture that makes it difficult to make the correct diagnosis, which we observe in the third patient.Conclusions: Our study demonstrates that due to the much higher morbidity, aggressive, rapid progression of the skin cancer disease, and unfavorable prognosis, population after transplantation requires a special oncological approach.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"196-203"},"PeriodicalIF":0.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Resistant Herpetic Whitlow: A Case of Recurrent Herpetic Whitlow Resistant to Standard Therapy. 耐药疱疹Whitlow的治疗：1例复发性疱疹Whitlow对标准治疗耐药。

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Case Reports in Dermatology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546664

Amit Singal, Ting Ting Wong, Shari R Lipner

{"title":"Management of Resistant Herpetic Whitlow: A Case of Recurrent Herpetic Whitlow Resistant to Standard Therapy.","authors":"Amit Singal, Ting Ting Wong, Shari R Lipner","doi":"10.1159/000546664","DOIUrl":"10.1159/000546664","url":null,"abstract":"Introduction: Herpetic whitlow, due to herpes simplex virus (HSV) type 1 or 2, typically presents with vesicles that may coalesce into bullae. Herpetic whitlow often resolves without intervention but can be treated with antiviral medications.Case presentation: Herein is a report of a 68-year-old female patient with a history of well-controlled human immunodeficiency virus (HIV) infection and a 4-year history of recurrent HSV-2 herpes genitalis who failed multiple trials of standard antiviral therapy clinically confirming a case of resistant HSV-2 infection, with recurrent tender lesions on her digits. Physical examination showed bullae involving the nail folds of her right thumb and left index finger. Initial PCR was negative for HSV-1 and HSV-2, but repeat PCR was positive for HSV-2. Treatment with foscarnet resulted in clinical improvement of both herpetic whitlow and herpes genitalis.Conclusion: Though herpetic whitlow typically resolves without intervention, a case is described of recurrent lesions in an HIV-positive patient unresponsive to multiple first-line antiviral treatment regimens and an interdisciplinary approach to treatment in a challenging case.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"224-230"},"PeriodicalIF":0.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupilumab's Successful Journey in Pityriasis Lichenoides Chronica Followed by the Intriguing Reemergence of Vitiligo after Monobenzone Depigmentation: A Case Report. Dupilumab在慢性苔藓样糠疹的成功之旅，随后是单苯酮脱色后白癜风的有趣复发：一例报告。

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Case Reports in Dermatology Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.1159/000545212

Khalid Nabil Nagshabandi, Mohammed Aljughayman, Asem Shadid, Salman Almalki, Nouf Almuhanna

{"title":"Dupilumab's Successful Journey in Pityriasis Lichenoides Chronica Followed by the Intriguing Reemergence of Vitiligo after Monobenzone Depigmentation: A Case Report.","authors":"Khalid Nabil Nagshabandi, Mohammed Aljughayman, Asem Shadid, Salman Almalki, Nouf Almuhanna","doi":"10.1159/000545212","DOIUrl":"10.1159/000545212","url":null,"abstract":"Introduction: Pityriasis lichenoides (PL) is an inflammatory skin disorder encompassing both acute (PLEVA) and chronic (PLC) subtypes, which share overlapping clinical and histopathological features. Standard treatment modalities include oral antibiotics, phototherapy, and immunosuppressive agents. Dupilumab, an IL-4Rα antagonist approved for atopic dermatitis, has been used off-label for various inflammatory skin conditions. However, its role in PLC management remains poorly documented.Case presentation: We report a case of PLC successfully treated with dupilumab. The patient had a history of vitiligo and had previously undergone monobenzone depigmentation therapy. Due to concerns regarding potential pigmentary changes, dupilumab was initiated with a loading dose of 600 mg, followed by 300 mg biweekly. After 3 months of therapy, there was significant improvement in PLC lesions and pruritus, with only residual erythematous plaques. Unexpectedly, spontaneous skin repigmentation occurred, contrasting with previous reports of vitiligo exacerbation following dupilumab use. The patient resumed monobenzone therapy without experiencing PLC recurrence or worsening pruritus.Conclusion: This case highlights dupilumab's potential as an effective treatment for PLC and its possible role in promoting skin repigmentation in a patient with prior vitiligo. These findings suggest a potential link between type 2 inflammation and PLC pathogenesis, warranting further investigation. Dupilumab may represent a promising therapeutic alternative for refractory PLC.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"231-239"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Acrodermatitis Enteropathica in a Pediatric Patient: A Rare Case Report with Zinc Deficiency and Complications. 小儿复发性肠病性肢端皮炎：缺锌和并发症的罕见病例报告。

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Case Reports in Dermatology Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI: 10.1159/000544874

Abdul Hanan, Atiq Ul Rehman, Fnu Abdullah, Amna Anwar, Muhammad Umar, Saba Shafiq, Abdur Rehman, Javed Iqbal

{"title":"Recurrent Acrodermatitis Enteropathica in a Pediatric Patient: A Rare Case Report with Zinc Deficiency and Complications.","authors":"Abdul Hanan, Atiq Ul Rehman, Fnu Abdullah, Amna Anwar, Muhammad Umar, Saba Shafiq, Abdur Rehman, Javed Iqbal","doi":"10.1159/000544874","DOIUrl":"10.1159/000544874","url":null,"abstract":"Introduction: Acrodermatitis enteropathica (AE) is a rare genetic disorder that results in impaired zinc absorption due to a mutation in the SLC39A4 gene, leading to systemic zinc deficiency with characteristic dermatologic, immunologic, and gastrointestinal manifestations.Case presentation: This case report presents a 6-year-old boy with recurrent AE, exhibiting widespread vesiculopustular lesions, alopecia, chronic diarrhea, and poor growth, symptoms typical of zinc deficiency syndromes. Initial diagnosis was supported by low serum zinc levels, elevated C-reactive protein, and IgE, indicating an inflammatory process. Despite the absence of genetic confirmation, the clinical and laboratory findings were consistent with AE. Treatment with oral zinc supplementation resulted in rapid symptomatic improvement, underscoring the essential role of zinc in skin integrity and immune function.Conclusion: This case highlights AE's diagnostic challenges, especially in resource-limited settings lacking access to genetic testing, and the critical need for long-term zinc monitoring to manage recurrent symptoms and prevent toxicity. AE's rare incidence and overlapping symptoms with other dermatologic and metabolic disorders necessitate a high degree of clinical suspicion, emphasizing the importance of zinc in pediatric growth and immune health. This report contributes valuable insights for managing recurrent AE presentations, particularly in contexts with limited diagnostic resources.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"255-262"},"PeriodicalIF":0.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood Linear IgA Dermatosis Successfully Treated with the Combination of Dapsone and Sulfasalazine. 氨苯砜联合柳氮磺胺吡啶成功治疗儿童线性IgA皮肤病。

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Case Reports in Dermatology Pub Date : 2025-05-03 eCollection Date: 2025-01-01 DOI: 10.1159/000546155

Ashley S Kim, Olav Sundnes

{"title":"Childhood Linear IgA Dermatosis Successfully Treated with the Combination of Dapsone and Sulfasalazine.","authors":"Ashley S Kim, Olav Sundnes","doi":"10.1159/000546155","DOIUrl":"10.1159/000546155","url":null,"abstract":"Introduction: Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune blistering skin disorder characterized by the linear deposition of IgA along the basal membrane. It affects primarily young children and adults, and is the most common bullous disease in the paediatric population. Dapsone represents the mainstay of treatment, to which the majority of patients show excellent initial responses with long-term remission. In recalcitrant cases, sulfonamides (sulfapyridine, sulfasalazine, sulfamethoxypyridazine) are considered second-line options either as monotherapy or in conjunction with dapsone. Most published cases of sulfonamides in childhood LAD report use of sulfapyridine or sulfamethoxypyridazine, with no published reports on sulfasalazine use in young children.Case presentation: We present a case of a 1-year-old child with confirmed LAD who did not respond adequately to dapsone alone. Sulfapyridine is not available in Norway, while sulfasalazine is accessible and considered a safe option for other autoimmune disorders. The addition of sulfasalazine resulted in rapid complete remission.Conclusion: This case thus supports sulfasalazine as a pragmatic, accessible alternative to sulfapyridine as the second-line treatment in childhood LAD.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"185-190"},"PeriodicalIF":0.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapy-Resistant Erosions in the Genital Area of Elderly Patients: A Differential Diagnostic Challenge - A Case Report. 治疗抵抗糜烂在老年患者生殖器区域：鉴别诊断的挑战-一个病例报告。

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Case Reports in Dermatology Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546135

Martin Gschnell, Iris Hennighausen, Can Alpagut, Julia Nadina Föhr, Jacqueline Kussini, Lisa Krönig

{"title":"Therapy-Resistant Erosions in the Genital Area of Elderly Patients: A Differential Diagnostic Challenge - A Case Report.","authors":"Martin Gschnell, Iris Hennighausen, Can Alpagut, Julia Nadina Föhr, Jacqueline Kussini, Lisa Krönig","doi":"10.1159/000546135","DOIUrl":"10.1159/000546135","url":null,"abstract":"Introduction: Genital erosions occur in many dermatological conditions and can sometimes be difficult to classify, especially in older patients with multiple morbidities.Case presentation: We report the case of an 81-year-old patient with therapy-resistant genital erythema. Under topical antifungal therapy for a suspected diagnosis of Candida intrigue, the scrotal findings continued to progress, accompanied by genital erosions and new erosions on the nose and right knee. With evidence of IgG and C3 deposition on the basement membrane on direct immunofluorescence and subepidermal cleft formation on histology, a diagnosis of bullous pemphigoid with predominant genital involvement was made.Conclusion: In conclusion, this case study illustrates that skin biopsies should be taken in cases of therapy-resistant erythema with erosions in order to clarify the dignity and ultimately to be able to adapt the treatment. In addition, it is important to examine the entire integument, including the mucous membranes close to the skin, to avoid overlooking groundbreaking findings. Bullous pemphigoid is the most common blistering autoimmune skin disease and occurs mainly in older people. However, the classic picture of bulging blisters is not always present. Bullous pemphigoid may masquerade clinically as pruritic eczema, erythroderma, or erosions. Predominant genital involvement has only been described in a few case reports.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"191-195"},"PeriodicalIF":0.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0