Case Reports in Dermatology最新文献

Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review. 广泛的指甲变化是儿童朗格汉斯细胞组织细胞增多症多系统参与的可能线索：一个病例报告和文献复习。

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Case Reports in Dermatology Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI: 10.1159/000545567

Xiaofei Gao, Bin Yu, Jiaotian Huang, Haixia Yang, Zhu Wei

{"title":"Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review.","authors":"Xiaofei Gao, Bin Yu, Jiaotian Huang, Haixia Yang, Zhu Wei","doi":"10.1159/000545567","DOIUrl":"10.1159/000545567","url":null,"abstract":"Introduction: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm that can involve nearly any organ, leading to multisystem damage. Nail involvement in LCH is particularly uncommon. Here we report a case of a young boy with multisystem LCH initially presenting with nail changes.Case presentation: We described a boy who presented with a 2-year history of asymptomatic changes characterized by onycholysis, subungual hyperkeratosis, and purpuric striae affecting most fingernails and toenails, initially attributed to onychomycosis. Two years later, he developed multisystem involvement affecting the pituitary gland, lungs, skin, liver, and spleen. The patient succumbed shortly after histopathological confirmation via skin biopsy due to massive gastrointestinal hemorrhage secondary to cirrhosis-induced portal hypertension.Discussion: Nail lesions may serve as the initial manifestation of LCH, often preceding other characteristic disease symptoms. This early presentation provides critical diagnostic opportunities for timely intervention. Consideration of LCH, biopsy, and comprehensive evaluation of organ involvement is essential to reduce the rate of misdiagnosis and the potential for unrecognized high-risk disease.Conclusion: Nail involvement in LCH, while rare, may serve as an early clinical indicator of multisystem disease.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"165-173"},"PeriodicalIF":0.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Primary Cutaneous CD4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab. 一例罕见的原发性皮肤CD4+小/中型t细胞增生性疾病对利妥昔单抗有反应。

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Case Reports in Dermatology Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.1159/000545747

Saman Al-Zahawi, Sara Masoomi, Alireza Ghanadan, Yasaman Sadeghi, Maryam Daneshpazhooh, Hamidreza Mahmoudi

引用次数: 0

Acquired Reactive Perforating Collagenosis Complicated by Diabetes Mellitus and Hypertension: A Case Report. 获得性反应性穿孔性胶原沉积合并糖尿病和高血压1例。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.1159/000545693

Meng Zhang, Ruiqi Chu, Junping Shen, Chunmei Liu, Yanan Wang, Shun Zhang, Xiangxiang Ren

{"title":"Acquired Reactive Perforating Collagenosis Complicated by Diabetes Mellitus and Hypertension: A Case Report.","authors":"Meng Zhang, Ruiqi Chu, Junping Shen, Chunmei Liu, Yanan Wang, Shun Zhang, Xiangxiang Ren","doi":"10.1159/000545693","DOIUrl":"https://doi.org/10.1159/000545693","url":null,"abstract":"Introduction: Acquired reactive perforating collagenosis (ARPC) is a rare cutaneous disorder frequently associated with systemic diseases such as diabetes mellitus and chronic kidney disease. Its diagnosis remains challenging due to clinical overlap with other perforating dermatoses, necessitating advanced diagnostic tools for confirmation.Case presentation: A 55-year-old male with a 15-year history of diabetes mellitus and hypertension developed progressively pruritic papules and nodules on both lower limbs over 2 months. Initial misdiagnosis as a fungal infection led to unsuccessful antifungal therapy. Dermatoscopy revealed keratotic plugs with peripheral erythema, while histopathology demonstrated transepidermal elimination of degenerated collagen, confirming ARPC. Topical retinoic acid cream achieved marked symptomatic relief.Conclusion: This case highlights ARPC's strong association with metabolic comorbidities and underscores the necessity of dermatoscopic and histopathological evaluation to avoid diagnostic pitfalls. The therapeutic success of topical retinoids in resource-constrained settings reinforces their role as a pragmatic first-line intervention. Clinicians should consider ARPC in patients with chronic pruritic eruptions and systemic metabolic disorders, advocating for multidisciplinary collaboration to address underlying comorbidities.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"143-149"},"PeriodicalIF":0.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trauma-Induced Psoriatic Arthritis: A Deep Köbner Phenomenon. 创伤性银屑病关节炎：深层Köbner现象。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.1159/000545694

Yoshihito Mima, Masako Yamamoto, Naoki Nishida, Yuta Norimatsu, Ken Iozumi

{"title":"Trauma-Induced Psoriatic Arthritis: A Deep Köbner Phenomenon.","authors":"Yoshihito Mima, Masako Yamamoto, Naoki Nishida, Yuta Norimatsu, Ken Iozumi","doi":"10.1159/000545694","DOIUrl":"https://doi.org/10.1159/000545694","url":null,"abstract":"Introduction: Psoriasis is a chronic systemic inflammatory disorder resulting from complex interactions between genetic and environmental factors. In addition to cutaneous manifestations, psoriasis is associated with psoriatic arthritis (PsA). Among the recognized mechanisms of disease exacerbation, the Köbner phenomenon (KP) plays a crucial role. KP refers to the appearance of new psoriatic lesions on previously healthy skin following trauma. A deeper variant of this phenomenon, the deep Köbner phenomenon (DKP), involves severe trauma triggering systemic inflammation, including the onset of PsA. Trauma-induced DKP represents unique disease mechanisms, linking external mechanical stress to immune-mediated joint pathology.Case presentation: We present a case of a 60-year-old male with psoriasis, who initially responded well to ixekizumab, an IL-17A inhibitor but subsequently developed PsA following a wrist injury. The PsA exacerbation was attributed to increased mechanical stress from daily activities and rehabilitation efforts. Adjustments were made to rehabilitation intensity and joint movement restrictions, leading to gradual symptom improvement over 3 months without intensifying biological therapy.Conclusion: This case highlights the pathophysiological relationship between trauma, DKP, and PsA. The rapid onset of PsA following trauma suggests that inflammatory mediators and neuropeptides triggered by DKP play significant roles. Given that rehabilitation plays crucial roles in recovery but may also exacerbate symptoms if improperly managed, tailored rehabilitation strategies are essential in managing trauma-induced PsA. This case also underscores the importance of comprehensive management, including biological therapy and personalized rehabilitation approaches. Further studies are needed to optimize inflammation control and joint function in patients experiencing post-trauma PsA.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"137-142"},"PeriodicalIF":0.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital Malalignment of the Great Toenails with Secondary Retronychia: A Tale of Twin Toenails. 先天性大趾甲畸形伴继发性后甲：双趾甲的故事。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.1159/000545462

Carrie A Forman, Noelle Desir, Michael M Ong, Shari R Lipner

{"title":"Congenital Malalignment of the Great Toenails with Secondary Retronychia: A Tale of Twin Toenails.","authors":"Carrie A Forman, Noelle Desir, Michael M Ong, Shari R Lipner","doi":"10.1159/000545462","DOIUrl":"https://doi.org/10.1159/000545462","url":null,"abstract":"Introduction: Congenital malalignment of the great toenail (CMGT) is characterized by deviation of the nail plate due to rotation of the nail matrix. CMGT may be complicated by secondary retronychia.Case presentation: We report a case of twin 14-year-old females who presented with CMGT with secondary retronychia with no clear inciting event. Physical examination demonstrated lateral deviation of the great toenails with yellowed, thickened, and layered nail plates, consistent with a diagnosis of CMGT with secondary retronychia. The patients were advised to make relevant lifestyle changes and treated with clobetasol proprionate 0.05% ointment to use on all toenails daily for 3 months, with 1 week off per month, under occlusion.Conclusion: We hypothesize that both genetic and environmental factors likely contributed to the development of CMGT with secondary retronychia in these twins. Increased awareness and recognition of this underdiagnosed condition, particularly in the pediatric population, is important for timely and effective management.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"157-164"},"PeriodicalIF":0.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focal Hypertrichosis during Topical Tacrolimus Therapy for Vitiligo: A Case Report. 局部他克莫司治疗白癜风期间局灶性多毛：1例报告。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.1159/000545115

Lingyu Mao, Yan Lin, Xueping Yu, Huaxu Liu

{"title":"Focal Hypertrichosis during Topical Tacrolimus Therapy for Vitiligo: A Case Report.","authors":"Lingyu Mao, Yan Lin, Xueping Yu, Huaxu Liu","doi":"10.1159/000545115","DOIUrl":"10.1159/000545115","url":null,"abstract":"Introduction: Tacrolimus is widely used in treating vitiligo. Drug-induced hypertrichosis is a well-known side effect of cyclosporine. It is less commonly associated with tacrolimus or with topical calcineurin inhibitors. Four reports of hypertrichosis attributed to topical or systemic tacrolimus have been previously reported in the literature. In this report, we describe a case of focal hypertrichosis due to long-term use of topical tacrolimus for vitiligo.Case presentation: We present a 15-year-old boy with focal hypertrichosis of white hair for 4 months, after treatment with topical tacrolimus 0.1% ointment. He denied ever using other ointment to the area. After he stopped using tacrolimus for half a month, the focal hypertrichosis improved.Conclusion: We propose that the focal hypertrichosis was induced by tacrolimus. The hair growth-stimulating effects of tacrolimus have been established. It is reported that tacrolimus directly stimulates mouse whiskers in vitro and prolongs the anagen phase of hair growth when it is applied topically in mice. We believe that a greater awareness of this rare side effect of tacrolimus is warranted as tacrolimus is widely used in treating vitiligo.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"106-109"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome following Dalbavancin and Oritavancin Administration in a Patient with Osteomyelitis. 1例骨髓炎患者服用达尔巴万星和奥利塔万星后嗜酸性粒细胞增多和全身症状综合征的药物反应。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.1159/000545359

Jina Bai, Emily Frech Preciado, Mary Baxter Harlow, Nina Blank

{"title":"Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome following Dalbavancin and Oritavancin Administration in a Patient with Osteomyelitis.","authors":"Jina Bai, Emily Frech Preciado, Mary Baxter Harlow, Nina Blank","doi":"10.1159/000545359","DOIUrl":"https://doi.org/10.1159/000545359","url":null,"abstract":"Introduction: Dalbavancin and oritavancin are newer long-acting antibiotics with potent activity against gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA). To our knowledge, there have been no reported cases of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with dalbavancin and oritavancin.Patient presentation: A woman in her 20s presented with a right thumb abscess and cellulitis that failed to respond to several courses of oral antibiotics, resulting in recurrent emergency room visits over 3 weeks. Approximately 1 month after the initial skin infection, magnetic resonance imaging revealed osteomyelitis of the right thumb. She was treated with a single dose of oritavancin followed by two weekly doses of dalbavancin, which successfully resolved the infection. However, she subsequently developed fever and a rash consistent with DRESS syndrome, likely triggered by oritavancin or dalbavancin. Given the prolonged half-life of these medications, she required treatment with high-dose steroids for an extended duration.Conclusion: Dalbavancin and oritavancin are second-generation lipoglycopeptide antibiotics that provide coverage for gram-positive organisms, including MRSA. They are approved for the treatment of acute bacterial skin and skin structure infections and are used off-label for bacteremia, endocarditis, and osteomyelitis. Their prolonged half-lives - 257 h for dalbavancin and 195 h for oritavancin - allow for less frequent dosing. However, a long half-life also leads to prolonged drug exposure in the event of adverse effects. Here, we report the first case of DRESS syndrome in a patient treated with dalbavancin and oritavancin.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"128-136"},"PeriodicalIF":0.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amelanotic Melanoma Arising in Surgical Cicatrix: A Case Report. 手术瘢痕无色素黑色素瘤一例报告。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.1159/000545287

Anna Louise Norling, Christian Beltoft Brøchner, Linnea Langhans

{"title":"Amelanotic Melanoma Arising in Surgical Cicatrix: A Case Report.","authors":"Anna Louise Norling, Christian Beltoft Brøchner, Linnea Langhans","doi":"10.1159/000545287","DOIUrl":"https://doi.org/10.1159/000545287","url":null,"abstract":"Introduction: Amelanotic melanoma (AM) is a rare subtype of melanoma characterized by the absence of pigmentation, making it difficult to diagnose. This case report describes AM arising in a cicatrix following cardiac surgery, highlighting diagnostic challenges and the importance of reassessment when the clinical findings do not fit the initial diagnosis.Case presentation: A 76-year-old male underwent coronary artery bypass grafting in March 2022. Nine months later, he noticed a mass with ulceration in the sternal cicatrix. A punch biopsy showed inflammation and fibrosis, leading to a diagnosis of suture granuloma. Despite the lesion's progression over 8 months, no further biopsies or treatments were performed. In September 2023, the patient was referred to the Department of Plastic Surgery at Copenhagen University Hospital, Rigshospitalet, where an excision biopsy revealed an AM with a thickness of 20 mm. Preoperative PET-CT showed no evidence of metastasis, and re-excision with sentinel lymph node biopsy was performed. Adjuvant oncologic treatment was administered due to a positive sentinel node.Conclusion: This case emphasizes the diagnostic challenges of AM, especially when arising in a cicatrix. When the clinical picture does not align with the initial diagnosis, it is crucial to reconsider and conduct further evaluations to avoid delays in treatment.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"123-127"},"PeriodicalIF":0.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guillain-Barré Syndrome Secondary to Herpes Zoster: A Rare Case Report of Death and Literature Review. 带状疱疹继发格林-巴利综合征1例死亡报告及文献复习。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI: 10.1159/000544954

Jingyu Wang, Xinyi Hou, Jin Zhang, Bo Ren, Bin Lu

引用次数: 0

Disabling Plantar Keloids Treated with Brachytherapy and Free Flap Reconstruction: A Case Report. 近距离治疗和游离皮瓣重建致残性足底瘢痕1例报告。

IF 0.9

Case Reports in Dermatology Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.1159/000545053

Andrea Varazzani, Pierre Petolat, Louis Brochet, Alice Prevost, Nicolas Graillon, Antoine Pierrefeu

{"title":"Disabling Plantar Keloids Treated with Brachytherapy and Free Flap Reconstruction: A Case Report.","authors":"Andrea Varazzani, Pierre Petolat, Louis Brochet, Alice Prevost, Nicolas Graillon, Antoine Pierrefeu","doi":"10.1159/000545053","DOIUrl":"10.1159/000545053","url":null,"abstract":"Introduction: Keloids result from a disorganized fibroproliferative collagen response that extends beyond the original wound margins and fails to regress. They are associated with a high recurrence rate despite various treatment options. Keloids on the sole of the foot are exceedingly rare and pose significant challenges for both patients and surgeons. To date, only 15 cases of plantar keloids have been described in the English literature. Management options for this region include observation with custom-made footwear, steroid injections, surgery alone, or surgery followed by multimodal therapy. This report presents the first documented case of a plantar keloid treated with surgical excision, brachytherapy, and free flap reconstruction.Case presentation: We describe the case of a plantar keloid treated with surgical excision followed by high-dose-rate brachytherapy and free flap reconstruction. At 18 months postoperatively, the patient was ambulating independently without crutches, though hypersensitivity persisted. The scars at the donor site and the medial ankle exhibited keloids, but all scars subjected to brachytherapy were normal.Conclusion: The free flap approach may not be the optimal reconstruction method for plantar keloids, as skin grafts appear to have better outcomes, according to the literature. Also, in our patient, brachytherapy has proven its effectiveness in preventing further keloid formation as shown in the literature.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"96-105"},"PeriodicalIF":0.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0