Case Reports in Dermatology最新文献_第2页

Management of Resistant Herpetic Whitlow: A Case of Recurrent Herpetic Whitlow Resistant to Standard Therapy. 耐药疱疹Whitlow的治疗：1例复发性疱疹Whitlow对标准治疗耐药。

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Case Reports in Dermatology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546664

Amit Singal, Ting Ting Wong, Shari R Lipner

{"title":"Management of Resistant Herpetic Whitlow: A Case of Recurrent Herpetic Whitlow Resistant to Standard Therapy.","authors":"Amit Singal, Ting Ting Wong, Shari R Lipner","doi":"10.1159/000546664","DOIUrl":"10.1159/000546664","url":null,"abstract":"Introduction: Herpetic whitlow, due to herpes simplex virus (HSV) type 1 or 2, typically presents with vesicles that may coalesce into bullae. Herpetic whitlow often resolves without intervention but can be treated with antiviral medications.Case presentation: Herein is a report of a 68-year-old female patient with a history of well-controlled human immunodeficiency virus (HIV) infection and a 4-year history of recurrent HSV-2 herpes genitalis who failed multiple trials of standard antiviral therapy clinically confirming a case of resistant HSV-2 infection, with recurrent tender lesions on her digits. Physical examination showed bullae involving the nail folds of her right thumb and left index finger. Initial PCR was negative for HSV-1 and HSV-2, but repeat PCR was positive for HSV-2. Treatment with foscarnet resulted in clinical improvement of both herpetic whitlow and herpes genitalis.Conclusion: Though herpetic whitlow typically resolves without intervention, a case is described of recurrent lesions in an HIV-positive patient unresponsive to multiple first-line antiviral treatment regimens and an interdisciplinary approach to treatment in a challenging case.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"224-230"},"PeriodicalIF":0.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupilumab's Successful Journey in Pityriasis Lichenoides Chronica Followed by the Intriguing Reemergence of Vitiligo after Monobenzone Depigmentation: A Case Report. Dupilumab在慢性苔藓样糠疹的成功之旅，随后是单苯酮脱色后白癜风的有趣复发：一例报告。

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Case Reports in Dermatology Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.1159/000545212

Khalid Nabil Nagshabandi, Mohammed Aljughayman, Asem Shadid, Salman Almalki, Nouf Almuhanna

{"title":"Dupilumab's Successful Journey in Pityriasis Lichenoides Chronica Followed by the Intriguing Reemergence of Vitiligo after Monobenzone Depigmentation: A Case Report.","authors":"Khalid Nabil Nagshabandi, Mohammed Aljughayman, Asem Shadid, Salman Almalki, Nouf Almuhanna","doi":"10.1159/000545212","DOIUrl":"10.1159/000545212","url":null,"abstract":"Introduction: Pityriasis lichenoides (PL) is an inflammatory skin disorder encompassing both acute (PLEVA) and chronic (PLC) subtypes, which share overlapping clinical and histopathological features. Standard treatment modalities include oral antibiotics, phototherapy, and immunosuppressive agents. Dupilumab, an IL-4Rα antagonist approved for atopic dermatitis, has been used off-label for various inflammatory skin conditions. However, its role in PLC management remains poorly documented.Case presentation: We report a case of PLC successfully treated with dupilumab. The patient had a history of vitiligo and had previously undergone monobenzone depigmentation therapy. Due to concerns regarding potential pigmentary changes, dupilumab was initiated with a loading dose of 600 mg, followed by 300 mg biweekly. After 3 months of therapy, there was significant improvement in PLC lesions and pruritus, with only residual erythematous plaques. Unexpectedly, spontaneous skin repigmentation occurred, contrasting with previous reports of vitiligo exacerbation following dupilumab use. The patient resumed monobenzone therapy without experiencing PLC recurrence or worsening pruritus.Conclusion: This case highlights dupilumab's potential as an effective treatment for PLC and its possible role in promoting skin repigmentation in a patient with prior vitiligo. These findings suggest a potential link between type 2 inflammation and PLC pathogenesis, warranting further investigation. Dupilumab may represent a promising therapeutic alternative for refractory PLC.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"231-239"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratitis, Ichthyosis, and Deafness Syndrome with Endocarditis and Myelitis: A Rare Case Report. 角膜炎、鱼鳞病和耳聋综合征合并心内膜炎和脊髓炎：一例罕见病例报告。

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Case Reports in Dermatology Pub Date : 2025-05-14 eCollection Date: 2025-01-01 DOI: 10.1159/000546019

Gianluca Gizzi, Dario Didona, Giulia Pascolini, Michael Gores, Mohamed Ishaq Amer, Serge C Thal, Luca Scarsella

{"title":"Keratitis, Ichthyosis, and Deafness Syndrome with Endocarditis and Myelitis: A Rare Case Report.","authors":"Gianluca Gizzi, Dario Didona, Giulia Pascolini, Michael Gores, Mohamed Ishaq Amer, Serge C Thal, Luca Scarsella","doi":"10.1159/000546019","DOIUrl":"10.1159/000546019","url":null,"abstract":"Introduction: Keratitis-ichthyosis-deafness (KID) syndrome (MIM#148210) is a rare autosomal dominant genodermatosis caused by monoallelic deleterious variants in the GJB2 gene (MIM*121011). The syndrome is characterized by congenital neurosensory deafness, keratitis, and palmoplantar keratoderma.Case presentation: We report on a 32-year-old Caucasian male with KID syndrome who presented to the emergency department with high fever, severe headache, and chest pain exacerbated by coughing and deep breathing. His symptoms rapidly progressed to sepsis, and diagnostic evaluations confirmed endocarditis, complicated by parainfectious myelitis. Despite the severity of his condition, the patient achieved significant recovery, with minimal residual neurological deficits affecting the left leg.Conclusion: We attribute the sepsis to systemic dissemination of Staphylococcus aureus, probably facilitated by impaired skin barrier due to KID syndrome. This case highlights the importance of comprehensive interprofessional management in managing rare genodermatoses and their complications.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"291-298"},"PeriodicalIF":0.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosai-Dorfman Disease Case Report. 罗赛-多夫曼病病例报告。

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Case Reports in Dermatology Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.1159/000546278

Naif M Altamimi, Vivian Li, Hershel Kahn, Gibran Shaikh

{"title":"Rosai-Dorfman Disease Case Report.","authors":"Naif M Altamimi, Vivian Li, Hershel Kahn, Gibran Shaikh","doi":"10.1159/000546278","DOIUrl":"10.1159/000546278","url":null,"abstract":"Introduction: Rosai-Dorfman disease (RDD) is a rare histiocytic disorder that is characterized by the accumulation of histiocytes in various tissues, most commonly the lymph nodes. Cutaneous RDD is a rare presentation, accounting for less than 10% of all RDD cases.Case presentation: An 18-year-old female presented for the first time with a dome-like lesion over an indurated plaque. Both lesions were biopsied, and findings suggested RDD. The patient was referred to an oncologist with a subsequent positron emission tomography scan showing hypermetabolic subcutaneous uptake on bilateral thighs and bilateral lumbar lesions, likely corresponding to the patient's biopsy-proven histiocytosis in addition to a diffuse increased tracer uptake in the thoracic aorta and atria.Conclusion: A high degree of suspicion is necessary when dermatologists notice two different morphologies present in proximity to rule out a single pathological process. This case is unique because of the rarity of the condition as well as the clinical presentation of two different morphologies of an indurated plaque and a dome-like lesion on the same area of the body.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"299-303"},"PeriodicalIF":0.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Acrodermatitis Enteropathica in a Pediatric Patient: A Rare Case Report with Zinc Deficiency and Complications. 小儿复发性肠病性肢端皮炎：缺锌和并发症的罕见病例报告。

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Case Reports in Dermatology Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI: 10.1159/000544874

Abdul Hanan, Atiq Ul Rehman, Fnu Abdullah, Amna Anwar, Muhammad Umar, Saba Shafiq, Abdur Rehman, Javed Iqbal

{"title":"Recurrent Acrodermatitis Enteropathica in a Pediatric Patient: A Rare Case Report with Zinc Deficiency and Complications.","authors":"Abdul Hanan, Atiq Ul Rehman, Fnu Abdullah, Amna Anwar, Muhammad Umar, Saba Shafiq, Abdur Rehman, Javed Iqbal","doi":"10.1159/000544874","DOIUrl":"10.1159/000544874","url":null,"abstract":"Introduction: Acrodermatitis enteropathica (AE) is a rare genetic disorder that results in impaired zinc absorption due to a mutation in the SLC39A4 gene, leading to systemic zinc deficiency with characteristic dermatologic, immunologic, and gastrointestinal manifestations.Case presentation: This case report presents a 6-year-old boy with recurrent AE, exhibiting widespread vesiculopustular lesions, alopecia, chronic diarrhea, and poor growth, symptoms typical of zinc deficiency syndromes. Initial diagnosis was supported by low serum zinc levels, elevated C-reactive protein, and IgE, indicating an inflammatory process. Despite the absence of genetic confirmation, the clinical and laboratory findings were consistent with AE. Treatment with oral zinc supplementation resulted in rapid symptomatic improvement, underscoring the essential role of zinc in skin integrity and immune function.Conclusion: This case highlights AE's diagnostic challenges, especially in resource-limited settings lacking access to genetic testing, and the critical need for long-term zinc monitoring to manage recurrent symptoms and prevent toxicity. AE's rare incidence and overlapping symptoms with other dermatologic and metabolic disorders necessitate a high degree of clinical suspicion, emphasizing the importance of zinc in pediatric growth and immune health. This report contributes valuable insights for managing recurrent AE presentations, particularly in contexts with limited diagnostic resources.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"255-262"},"PeriodicalIF":0.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood Linear IgA Dermatosis Successfully Treated with the Combination of Dapsone and Sulfasalazine. 氨苯砜联合柳氮磺胺吡啶成功治疗儿童线性IgA皮肤病。

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Case Reports in Dermatology Pub Date : 2025-05-03 eCollection Date: 2025-01-01 DOI: 10.1159/000546155

Ashley S Kim, Olav Sundnes

{"title":"Childhood Linear IgA Dermatosis Successfully Treated with the Combination of Dapsone and Sulfasalazine.","authors":"Ashley S Kim, Olav Sundnes","doi":"10.1159/000546155","DOIUrl":"10.1159/000546155","url":null,"abstract":"Introduction: Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune blistering skin disorder characterized by the linear deposition of IgA along the basal membrane. It affects primarily young children and adults, and is the most common bullous disease in the paediatric population. Dapsone represents the mainstay of treatment, to which the majority of patients show excellent initial responses with long-term remission. In recalcitrant cases, sulfonamides (sulfapyridine, sulfasalazine, sulfamethoxypyridazine) are considered second-line options either as monotherapy or in conjunction with dapsone. Most published cases of sulfonamides in childhood LAD report use of sulfapyridine or sulfamethoxypyridazine, with no published reports on sulfasalazine use in young children.Case presentation: We present a case of a 1-year-old child with confirmed LAD who did not respond adequately to dapsone alone. Sulfapyridine is not available in Norway, while sulfasalazine is accessible and considered a safe option for other autoimmune disorders. The addition of sulfasalazine resulted in rapid complete remission.Conclusion: This case thus supports sulfasalazine as a pragmatic, accessible alternative to sulfapyridine as the second-line treatment in childhood LAD.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"185-190"},"PeriodicalIF":0.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapy-Resistant Erosions in the Genital Area of Elderly Patients: A Differential Diagnostic Challenge - A Case Report. 治疗抵抗糜烂在老年患者生殖器区域：鉴别诊断的挑战-一个病例报告。

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Case Reports in Dermatology Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546135

Martin Gschnell, Iris Hennighausen, Can Alpagut, Julia Nadina Föhr, Jacqueline Kussini, Lisa Krönig

{"title":"Therapy-Resistant Erosions in the Genital Area of Elderly Patients: A Differential Diagnostic Challenge - A Case Report.","authors":"Martin Gschnell, Iris Hennighausen, Can Alpagut, Julia Nadina Föhr, Jacqueline Kussini, Lisa Krönig","doi":"10.1159/000546135","DOIUrl":"10.1159/000546135","url":null,"abstract":"Introduction: Genital erosions occur in many dermatological conditions and can sometimes be difficult to classify, especially in older patients with multiple morbidities.Case presentation: We report the case of an 81-year-old patient with therapy-resistant genital erythema. Under topical antifungal therapy for a suspected diagnosis of Candida intrigue, the scrotal findings continued to progress, accompanied by genital erosions and new erosions on the nose and right knee. With evidence of IgG and C3 deposition on the basement membrane on direct immunofluorescence and subepidermal cleft formation on histology, a diagnosis of bullous pemphigoid with predominant genital involvement was made.Conclusion: In conclusion, this case study illustrates that skin biopsies should be taken in cases of therapy-resistant erythema with erosions in order to clarify the dignity and ultimately to be able to adapt the treatment. In addition, it is important to examine the entire integument, including the mucous membranes close to the skin, to avoid overlooking groundbreaking findings. Bullous pemphigoid is the most common blistering autoimmune skin disease and occurs mainly in older people. However, the classic picture of bulging blisters is not always present. Bullous pemphigoid may masquerade clinically as pruritic eczema, erythroderma, or erosions. Predominant genital involvement has only been described in a few case reports.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"191-195"},"PeriodicalIF":0.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Necrobiosis Lipoidica with Abrocitinib: A Case Report. 阿布替尼成功治疗脂质坏死性坏死1例。

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Case Reports in Dermatology Pub Date : 2025-04-26 eCollection Date: 2025-01-01 DOI: 10.1159/000546134

Yuping Zhang, Yirong Li, Fengjiao Meng, Chen Li

引用次数: 0

Kasabach-Merritt Phenomenon: Diagnosis, Management, and Outcome on Two Cases in a Sub-Saharan Country (Senegal). Kasabach-Merritt现象：撒哈拉以南国家（塞内加尔）两例病例的诊断、管理和结果。

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Case Reports in Dermatology Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI: 10.1159/000546020

Khadim Diop, Mame Téné Ndiaye Diop, Ibrahima Diop, Ines Mejri, Lana Yassine, Fatou Diassé, Fatime Tall, Idrissa Demba Ba, Maodo Ndiaye, Ousmane Ndiaye

{"title":"Kasabach-Merritt Phenomenon: Diagnosis, Management, and Outcome on Two Cases in a Sub-Saharan Country (Senegal).","authors":"Khadim Diop, Mame Téné Ndiaye Diop, Ibrahima Diop, Ines Mejri, Lana Yassine, Fatou Diassé, Fatime Tall, Idrissa Demba Ba, Maodo Ndiaye, Ousmane Ndiaye","doi":"10.1159/000546020","DOIUrl":"10.1159/000546020","url":null,"abstract":"Introduction: Kasabach-Merritt phenomenon (KMP) is a rare and life-threatening disease, characterized by the profound thrombocytopenia and consumptive coagulopathy associated with vascular tumors. In sub-Saharan Africa, KMP-related data are scarce and it poses significant challenges in management, particularly due to limited availability of treatment resources. We report 2 cases of KMP observed in a sub-Saharan Africa country (Dakar, Senegal).Case presentation: Case 1: a 45-day-old male infant was admitted for a tumor lesion located in the axillary fold that has been evolving since birth. The lesion had rapidly become aggressive, inflammatory, and purpuric. Blood tests showed normocytic normochromic anemia with severe thrombocytopenia and high D-dimer levels. The diagnosis of a kaposiform hemangioendothelioma complicated by a KMP was retained. Treatment with betamethasone was initiated, but death occurred 6 days later secondary to cerebral hemorrhage. Case 2: a 2-month-old female infant was admitted for a rapidly aggressive, inflammatory, infiltrating tumor lesion on the face that had been progressing for 1 month. Blood tests showed normocytic normochromic anemia with severe thrombocytopenia and high D-dimer levels. The diagnosis of a KMP was retained. Treatment with corticosteroids, then combined with vincristine, was administered. The outcome was favorable with a considerable regression of the mass and improvement in biological parameters after 6 months.Conclusion: To our knowledge, we report the first case report on KMP in sub-Saharan Africa, particularly in pediatric dermatology in Dakar. Besides their rarity, these cases highlight the challenges in the management of KMP in a country with limited therapeutic resources.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"174-180"},"PeriodicalIF":0.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review. 广泛的指甲变化是儿童朗格汉斯细胞组织细胞增多症多系统参与的可能线索：一个病例报告和文献复习。

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Case Reports in Dermatology Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI: 10.1159/000545567

Xiaofei Gao, Bin Yu, Jiaotian Huang, Haixia Yang, Zhu Wei

{"title":"Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review.","authors":"Xiaofei Gao, Bin Yu, Jiaotian Huang, Haixia Yang, Zhu Wei","doi":"10.1159/000545567","DOIUrl":"10.1159/000545567","url":null,"abstract":"Introduction: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm that can involve nearly any organ, leading to multisystem damage. Nail involvement in LCH is particularly uncommon. Here we report a case of a young boy with multisystem LCH initially presenting with nail changes.Case presentation: We described a boy who presented with a 2-year history of asymptomatic changes characterized by onycholysis, subungual hyperkeratosis, and purpuric striae affecting most fingernails and toenails, initially attributed to onychomycosis. Two years later, he developed multisystem involvement affecting the pituitary gland, lungs, skin, liver, and spleen. The patient succumbed shortly after histopathological confirmation via skin biopsy due to massive gastrointestinal hemorrhage secondary to cirrhosis-induced portal hypertension.Discussion: Nail lesions may serve as the initial manifestation of LCH, often preceding other characteristic disease symptoms. This early presentation provides critical diagnostic opportunities for timely intervention. Consideration of LCH, biopsy, and comprehensive evaluation of organ involvement is essential to reduce the rate of misdiagnosis and the potential for unrecognized high-risk disease.Conclusion: Nail involvement in LCH, while rare, may serve as an early clinical indicator of multisystem disease.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"165-173"},"PeriodicalIF":0.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0