Case Reports in Dermatology最新文献

{"title":"Multiple Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Report.","authors":"Aljoharah Al Saud, Reem Alsergani, Ahmed Alhumidi, Abdullah Aleisa","doi":"10.1159/000543349","DOIUrl":"10.1159/000543349","url":null,"abstract":"<p><strong>Introduction: </strong>Anaplastic large cell lymphomas (ALCL) are a subtype of non-Hodgkin lymphoma categorized into systemic and cutaneous (cALCL) subtypes. cALCL are frequently characterized by their lack of ALK receptor expression, which differentiates them from their systemic counterparts. cALCLs present as solitary or grouped skin lesions. Due to their rarity, cALCLs are frequently misdiagnosed as other skin conditions.</p><p><strong>Case presentation: </strong>We report the case of a female with a 30-year history of expanding skin lesions on the upper and lower limbs, abdomen, and back. During her initial presentation, the lesions were thought to be due to an arthropod bite. However, lesion biopsy revealed ALK-negative cALCL and methicillin-resistant <i>Staphylococcus aureus.</i> A full workup excluded systemic ALCL and, therefore, confirmed the diagnosis of primary cALCL. The patient was placed on methotrexate to treat the lesions and sulfamethoxazole/trimethoprim to treat the infection.</p><p><strong>Conclusion: </strong>Our case highlights the need to consider cALCL in the differential diagnosis of patients with persistent skin lesions.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"68-73"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented Superficial Basal Cell Carcinoma of the Nipple-Areola Complex: A Case Report.","authors":"Xinru Chen, Na Zhang, Hongping Ge, Xiaoli Zhai, Meiyan Wang, Min Zhang","doi":"10.1159/000542168","DOIUrl":"10.1159/000542168","url":null,"abstract":"<p><strong>Introduction: </strong>Basal cell carcinoma (BCC) is the most common type of skin malignancy, accounting for approximately 80% of all non-melanoma skin cancers (NMSCs). Ultraviolet (UV) exposure is a significant risk factor for BCC development, which typically occurs in sun-exposed areas. BCC arising in non-sun-exposed regions, such as the nipple-areola complex (NAC), is exceedingly rare, with fewer than 100 cases reported globally. This report describes a case of pigmented superficial BCC in the NAC of a 76-year-old Asian woman.</p><p><strong>Case presentation: </strong>A 76-year-old Asian female presented with a 5-year history of a slowly enlarging lesion on her left breast, with recent rapid growth. Physical examination revealed a 10 mm × 8 mm blue-gray, pearl-like plaque on the NAC. Histopathology confirmed pigmented superficial BCC. Preoperative imaging, including breast ultrasound, chest computed tomography (CT), SPECT-CT, and axillary lymph node ultrasound, showed no evidence of metastasis. The patient underwent standard surgical excision with a 10 mm margin, followed by pathologic evaluation, confirming clear margins. The patient was discharged on the second postoperative day and remained asymptomatic at a 3-month follow-up.</p><p><strong>Conclusion: </strong>Pigmented superficial BCC of the NAC is an uncommon presentation due to the area's minimal sun exposure and lack of pilosebaceous units. This case underscores the importance of considering BCC in non-sun-exposed areas, particularly in elderly patients. While nonsurgical options such as photodynamic therapy may offer superior esthetic outcomes, the patient's financial constraints led to the selection of a cost-effective surgical excision, which successfully eliminated the tumor.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"19-25"},"PeriodicalIF":0.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verrucous Eccrine Angiomatous Hamartoma: A Case Report.","authors":"Ali Sadeghinia, Yasaman Sadeghi, Alireza Ghanadan, Elham Mazaherpour","doi":"10.1159/000533667","DOIUrl":"10.1159/000533667","url":null,"abstract":"<p><p>Eccrine angiomatous hamartoma (EAH) is a rare malformation presenting with the proliferation of eccrine glands and other dermal structures. It typically presents as a solitary lesion on extremities that appears at birth or during childhood. It is generally asymptomatic but may be associated with hyperhidrosis or pain. Here we report a case of verrucous EAH located on the heel of a 27-year-old man, which is an uncommon presentation of this tumor, and review the clinical characteristics, histologic findings, and prognosis of this rare condition.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"38-41"},"PeriodicalIF":0.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frieden's Group-V Aplasia Cutis Congenita with in utero Scarring in a Dichorionic Twin: A Case Report and Comprehensive Literature Review.","authors":"Anvar Paraparambil Vellamgot, Rajesh Pattu Valappil, Ahmed Hosny Tomerak, Hakam Khatib, Khalil Salameh","doi":"10.1159/000541676","DOIUrl":"10.1159/000541676","url":null,"abstract":"<p><strong>Introduction: </strong>Aplasia cutis congenita (ACC) is a rare congenital disorder characterized by the localized absence of skin at birth, primarily affecting the scalp but also affecting the trunk and limbs. Nine different presentations have been reported. Group V-ACC (G-V ACC) is a rare type associated with fetus papyraceus. The pathogenesis is speculated to involve ischemia from acute hypovolemia or disseminated intravascular coagulation due to thrombotic tissue affecting the surviving twin. Management of ACC depends on lesion severity, focusing on preventing infection and promoting healing, with conservative measures in most cases and surgical intervention in some cases. The long-term prognosis for isolated G-V ACC is generally favorable unless associated with systemic complications.</p><p><strong>Case presentation: </strong>We report a neonate diagnosed with Group G-V ACC associated with fetus papyraceus from a dichorionic diamniotic twin pregnancy. Born to a 28-year-old Asian mother, this female infant presented with extensive, healed, scar-like lesions on her flanks and upper thighs. These lesions were consistent with the \"H\"-shaped distribution commonly described in ACC linked to fetus papyraceus. Despite significant dermatological manifestations, the infant showed no other external abnormalities or systemic involvement, and comprehensive screenings, including ultrasounds and chromosomal microarray, were normal.</p><p><strong>Conclusion: </strong>This discussion highlights the rarity of ACC associated with fetus papyraceus, with only a few over 100 cases reported globally. This case underscores the importance of recognizing the patterns and potential complications of ACC in twins, contributing to better diagnostic acumen and management strategies for neonatal care.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Imaging of Primary Cutaneous Osteoma of the Forehead.","authors":"Soma Nakaso, Nobuaki Ishii, Masataka Akimoto, Rei Ogawa","doi":"10.1159/000543125","DOIUrl":"10.1159/000543125","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoma cutis is a rare benign cutaneous nodule characterized by ectopic bone formation in the dermis or subcutaneous tissue. While most cases of osteoma cutes are secondary to inflammation, tumors, or scars, there are rare primary cases with no apparent preceding lesion. Primary osteoma cutis can be broadly classified into two categories: those associated with metabolic abnormalities, such as pseudohypoparathyroidism and Albright's hereditary osteodystrophy, and those without such underlying conditions in a more specific sense.</p><p><strong>Case presentation: </strong>We present a case of primary osteoma cutis specifically located on the forehead in a young woman. Histopathological findings revealed a nodule of bone tissue within the dermis, along with some contiguous cartilage tissue. The patient underwent preoperative ultrasonography, computed tomography, and magnetic resonance imaging.</p><p><strong>Conclusion: </strong>We report this case because there have been no reports of primary osteoma cutis with complete preoperative imaging findings to the best of our knowledge.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"26-32"},"PeriodicalIF":0.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Bilateral Hyperpigmented Macules on the Lower Legs Possibly due to Cyclophosphamide.","authors":"Jun Yamamoto, Taku Fujimura, Yoshihide Asano","doi":"10.1159/000543124","DOIUrl":"10.1159/000543124","url":null,"abstract":"<p><strong>Introduction: </strong>Chemotherapeutic agents occasionally induce various cutaneous adverse events, but hyperpigmentation due to cyclophosphamide is extremely rare.</p><p><strong>Case presentation: </strong>A case of atypical bilateral hyperpigmented macules on the lower legs possibly due to cyclophosphamide was presented. A physical examination on his initial visit revealed xerotic skin exhibiting brownish discoloration with black scales on both lower legs. In addition, diffuse pigmented macules were distributed on the nail beds and tongues. Dermoscopic findings revealed brownish unstructured areas and black dots consistent with follicles. A biopsy specimen from his lower leg showed an increased melanin in the basal and stratum corneum. We diagnosed him as having bilateral hyperpigmented macules on the lower legs possibly due to cyclophosphamide.</p><p><strong>Conclusion: </strong>Although the mechanism of hyperpigmentation caused by cyclophosphamide is still unknown, our present case suggests that cutaneous hyperpigmentation is likely due to direct stimulation of hair follicles by cyclophosphamide.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"14-18"},"PeriodicalIF":0.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Hereditary Leukonychia with Intramatricial Triamcinolone: A Case Report.","authors":"Eden Axler, Shari R Lipner","doi":"10.1159/000543032","DOIUrl":"10.1159/000543032","url":null,"abstract":"<p><strong>Introduction: </strong>Hereditary leukonychia is a rare genetic nail disorder characterized by whitening of the nail plate, which is sometimes due to mutations in the <i>phospholipase C delta-1</i> (<i>PLCδ1</i>) gene. While leukonychia is typically asymptomatic, it carries significant psychosocial burden, and patients often report that others comment that they look like they are wearing nail polish. There are no known treatment options.</p><p><strong>Case presentation: </strong>A 39-year-old Kuwaiti male with autosomal recessive variant of PLCδ1-related non-syndromic leukonychia affecting nine fingernails presented for treatment because he was socially stigmatized. Treatment with 30% glycolic acid chemical peel was ineffective. Because there is evidence suggesting a link between PLCδ1-related hereditary leukonychia and abnormal keratinization, we hypothesized that injection of steroids into the nail matrix, which could inhibit keratinocyte activity and reduce nail matrix inflammation, may be an effective treatment. Following treatment with intramatricial triamcinolone, the patient experienced complete resolution of leukonychia in five fingernails and partial improvement in the remaining four.</p><p><strong>Conclusion: </strong>We present a case of successful treatment of hereditary leukonychia due to a phospholipase C δ-1 gene mutation with intramatricial triamcinolone. This case highlights the potential of this treatment approach for leukonychia and warrants further investigation in larger cohort studies.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"33-37"},"PeriodicalIF":0.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Chronic-Relapsing Pitted Keratolysis with Glycopyrronium Bromide Cream: Case Report.","authors":"Stefano Veraldi, Rossana Schianchi, Italo Francesco Aromolo, Gianluca Nazzaro","doi":"10.1159/000542484","DOIUrl":"10.1159/000542484","url":null,"abstract":"<p><strong>Introduction: </strong>Pitted keratolysis (PK) is a superficial bacterial infection located almost exclusively on the soles. The most important predisposing factor is hyperhidrosis. PK is characterized by small, isolated or confluent, crateriform, noninflammatory pits. Maceration and malodor are the two most important signs and symptoms. The therapy of PK is very often unsatisfactory.</p><p><strong>Case presentation: </strong>Two patients with chronic-relapsing PK were successfully treated with a cream containing 1% glycopyrronium bromide, a new topical anticholinergic with anti-hyperhidrosis action.</p><p><strong>Conclusions: </strong>Although our experience is currently based on only 2 patients, glycopyrronium bromide cream can be taken into consideration for prevention of chronic-relapsing PK.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"9-13"},"PeriodicalIF":0.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecthyma Gangrenosum of Fungal Origin: A Case Report.","authors":"Germán Andrés León-Sánchez, Heiler Lozada-Ramos, Jorge Enrique Daza-Arana, Andrés Darío Restrepo-Becerra, Ruben Varela-Miranda","doi":"10.1159/000542105","DOIUrl":"10.1159/000542105","url":null,"abstract":"<p><strong>Introduction: </strong>Ecthyma gangrenosum (EG) is usually a dermatologic manifestation of a <i>Pseudomonas aeruginosa</i> infection in an immunocompromised individual but may sometimes be caused by other bacteria or fungi in an immunocompromised or non-immunocompromised individual.</p><p><strong>Case presentation: </strong>A 75-year-old woman with a history of high blood pressure and sequels of ischemic cerebral infarction presented with a 5-day history of general malaise, cough with yellow sputum, and respiratory distress. The patient had pale mucous membranes, temperature of 38.5°C, tachycardia, normal blood pressure, SaO₂ of 85%, intercostal retractions, and severe bronchospasm upon hospital admission. No skin lesions were seen. The patient was admitted to the intensive care unit (ICU) because of her critical condition and was supported with invasive mechanical ventilation. Her blood count showed 8,100 leukocytes/mm³, neutrophils 79%, hemoglobin 10.1 g/dL, creatinine 1.1 mg/dL, and C-reactive protein 328 mg/dL. Arterial blood gases showed metabolic acidosis and moderate hypoxemia. The initial report of blood and urine cultures was negative for bacteria, and positive for influenza A H1N1. The patient was treated with oseltamivir and intravenous methylprednisolone for acute respiratory distress syndrome associated with the viral infection that occurred. Subsequently, violaceus macular and papular lesions appeared, which evolved into ulcerated lesions with erythematous border and necrotic center were seen in the anterior region of the chest and abdomen, from where <i>Candida metapsilosis</i> was isolated. EG was reported in this patient, who was also immunocompromised because of steroid use, had a prolonged stay in the ICU and received broad-spectrum antibiotics. Fungemia and urinary infection due to different fungi were also found.</p><p><strong>Conclusion: </strong>It is worth mentioning that EG can be caused by germs other than <i>P. aeruginosa</i> and fungal infections should not be ruled out.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"16 1","pages":"240-247"},"PeriodicalIF":0.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Aleukemic Leukemia Cutis with Testicular Involvement: A Case Report.","authors":"Sophie Bailleux, Sandrine Cao, Bita Dezfoulian, Patrick Collins, Joan Somja, Sophie Gatineau, Julie Longton, Arjen F Nikkels","doi":"10.1159/000542377","DOIUrl":"10.1159/000542377","url":null,"abstract":"<p><strong>Introduction: </strong>Aleukemic leukemia cutis (ALC) is a rare condition and concerns less than 10% of leukemia cutis (LC) cases. LC is defined as a cutaneous infiltration of neoplastic myeloid or lymphoid blasts, which occurs in the absence of any prior bone marrow or peripheral blood involvement.</p><p><strong>Case presentation: </strong>A pediatric case of B-cell ALL presenting as ALC is presented because of an exceptional testicular localization.</p><p><strong>Conclusion: </strong>B-cell acute lymphoblastic leukemia presenting as ALC is rarely described in the literature, and this case could be the first of childhood ALC with testicular involvement.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"16 1","pages":"248-253"},"PeriodicalIF":0.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}