Cutaneous Rosai-Dorfman Disease: A Report of 2 Cases and a Review of Recent Literature (2018-2023).

IF 0.9 Q4 DERMATOLOGY

Case Reports in Dermatology Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI:10.1159/000546382

Fatemeh Mohaghegh, Mina Saber, Parvin Rajabi, Haniyeh Sohrabi

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Abstract

Introduction: Rosai-Dorfman disease (RDD) is a rare, benign histiocytic disorder that can present as isolated cutaneous RDD (CRDD), often mimicking other dermatologic conditions and complicating diagnosis.

Case presentation: We report two cases of CRDD: one with palms and soles involvement, and another as an exophytic facial mass, initially misdiagnosed and unsuccessfully treated. Dermoscopy revealed distinctive features, including yellow ovoid structures, linear vessels, and cotton-like white globules. Histopathological and immunohistochemical analyses confirmed CRDD with histiocytic infiltration and emperipolesis, key histological markers of CRDD.

Conclusion: A review of 53 cases (2018-2023) highlights CRDD's clinical variability, common anatomical sites, and diverse treatment responses, emphasizing the need for individualized management and early recognition for optimal treatment. These findings contribute to a broader understanding of CRDD and support a multidisciplinary approach to optimizing patient care.

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皮肤Rosai-Dorfman病2例报告及近期文献回顾（2018-2023）

Rosai-Dorfman病（RDD）是一种罕见的良性组织细胞疾病，可以表现为孤立的皮肤RDD (CRDD)，通常模仿其他皮肤疾病并使诊断复杂化。病例介绍：我们报告2例CRDD: 1例累及手掌和脚底，另1例为外生性面部肿块，最初误诊，未成功治疗。皮肤镜检查显示明显的特征，包括黄色卵形结构，线性血管和棉花样的白色球体。组织病理学和免疫组织化学分析证实CRDD伴有组织细胞浸润和表皮增生，这是CRDD的关键组织学标志。结论：通过对53例CRDD病例（2018-2023）的回顾性分析，我们发现CRDD的临床变异性、常见的解剖部位和不同的治疗反应，强调需要个体化治疗和早期识别以获得最佳治疗。这些发现有助于更广泛地了解CRDD，并支持多学科方法来优化患者护理。

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