Julia Holzgruber, Jacqueline Oberneder-Popper, Emmanuella Guenova, Wolfram Hötzenecker
{"title":"Acrokeratosis Paraneoplastica (Bazex Syndrome): A Case Report.","authors":"Julia Holzgruber, Jacqueline Oberneder-Popper, Emmanuella Guenova, Wolfram Hötzenecker","doi":"10.1159/000525381","DOIUrl":"https://doi.org/10.1159/000525381","url":null,"abstract":"<p><p>Acrokeratosis paraneoplastica Bazex is a rare paraneoplastic skin manifestation, typically causing acral psoriasiform lesions. Patients usually show erythematous hyperkeratosis with yellowish, adherent scales on the hands and feet or other acral locations such as ears or nose. We herein report a case of Bazex syndrome in a male patient, who was previously diagnosed with hepatocellular carcinoma. Our case report highlights this rare condition as early diagnosis may impact the patient's course of tumor disease and prognosis.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":" ","pages":"307-312"},"PeriodicalIF":0.9,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/f5/cde-0014-0307.PMC9710447.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35344574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of Condylomata Acuminata Using a New Non-Vapor-Generating Focused Ultrasound Method following Imiquimod 5% Cream.","authors":"Jacek Calik, Tomasz Zawada, Torsten Bove","doi":"10.1159/000525896","DOIUrl":"https://doi.org/10.1159/000525896","url":null,"abstract":"<p><p>Condylomata acuminata is the most common sexually transmitted disease in the world. Physical treatments include excision, cryotherapy, electrocautery and ablative CO<sub>2</sub>, and Nd:YAG laser ablation, while topical treatments include imiquimod immunotherapy and antimitotic podophyllotoxin or sinecatechins. Efficacies of all methods are low, and recurrences are very common. A new combined method is presented as a single case in a 25-year-old male patient diagnosed with numerous condylomas on the penis, scrotum, and lower abdomen. The treatment consisted of a 7-week topical monotherapy using 5% imiquimod cream followed by local treatment with 20 MHz high-intensity focused ultrasound on remaining recalcitrant lesions. Results showed resolution of approximately 70% of the condylomas after imiquimod treatment, and full resolution of all recalcitrant condylomas treated subsequently with high-intensity focused ultrasound. The method is concluded to be safe and effective and, furthermore, presents a new physical method that does not generate airborne infectious human papillomavirus particles that pose a health risk for the medical team performing therapy. Further studies in larger populations are recommended to confirm the combined efficacy of the proposed method.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"275-282"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/d6/cde-0014-0275.PMC9941760.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Report of Unusual Case of Acquired Dermal Melanocytosis on the Scalp of a Caucasian Man with a Literature Review.","authors":"Fatemeh Mohaghegh, Parvin Rajabi, Samin Nabavinejad, Elham Tavousi Tabatabaei","doi":"10.1159/000528353","DOIUrl":"https://doi.org/10.1159/000528353","url":null,"abstract":"<p><p>Dermal melanocytosis includes several benign pigmented lesions which present as blue-gray color which is a result of the color transmission of melanin pigment through the dermis. While some types are present at birth, there is an acquired variant, acquired dermal melanocytosis (ADM), which usually involves faces of middle-aged Asian women. To the best of our knowledge, there are limited reports of extra facial ADM which all are on the trunk and extremities. Herein, we report a unique case of extra facial ADM affecting the scalp of a middle-aged man and provide a review of all extra facial ADM cases that have been reported.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"368-376"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/7e/cde-0014-0368.PMC9841790.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Novel Treatment of Nonuremic Calciphylaxis with Sodium Thiosulfate and Iloprost: A Case Report.","authors":"Lisa Wiltfang, Nina Booken, Stefan W Schneider","doi":"10.1159/000525712","DOIUrl":"https://doi.org/10.1159/000525712","url":null,"abstract":"<p><p>Calciphylaxis is a rare and potentially life-threatening disease which occurs most frequently in end-stage renal disease. Here, we describe a 69-year-old male patient who presented to the clinic with extremely painful necrotic ulcers of the right lower extremity. His risk factors included hypertension, diabetes mellitus type II, steatosis hepatis, and chronic hepatitis B. Laboratory studies revealed no signs for uremia, hyperparathyroidism, and normal phosphorus as well as calcium levels. A diagnosis of nonuremic calciphylaxis was made in correlation with clinical and histological features. A novel therapeutic approach combining sodium thiosulfate and iloprost showed remarkable improvement of the wound-associated pain and healing of the ulcers within 3 months. Due to its high mortality rate, an early diagnosis and initiation of treatment are crucial to be beneficial for patient outcomes.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"269-274"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/6d/cde-0014-0269.PMC9941758.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
António Guilherme Murinello, Helena Sá Damásio, Pedro Guedes, António Manuel de Figueiredo, Adriana Santos, Ana Serrano
{"title":"Acute Disseminated Panniculitis Associated with Alpha-1 Antitrypsin Deficiency.","authors":"António Guilherme Murinello, Helena Sá Damásio, Pedro Guedes, António Manuel de Figueiredo, Adriana Santos, Ana Serrano","doi":"10.1159/000526156","DOIUrl":"https://doi.org/10.1159/000526156","url":null,"abstract":"<p><p>Alpha-1 antitrypsin deficiency, although one of the most common genetic diseases, is a very rare and often undiagnosed cause of panniculitis. The authors present a case characterized by an acute involvement of several areas in the thorax, abdomen, and limbs, occurring after repetitive trauma of the perineal area caused by a long period of cycling. After performing the differential diagnosis and establishing etiology, the patient was started on augmentation therapy with plasma-derived synthetic human alpha-1 proteinase inhibitor and the disease has been under control since then. We recommend lifelong treatment with this medication. At the end of a 10-year follow-up, there has been no evidence of pulmonary emphysema or liver disease. The authors perform a concise review of the genetic and pathogenic mechanisms behind this disease, with a special focus on panniculitis and its treatment.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"283-290"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/14/cde-0014-0283.PMC9941762.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renni Yuniati, Rakhma Yanti Hellmi, Gema Citra Dwijayanti, Meira Dewi Kusuma Astuti, Gerard Pals, Dimitra Micha, Sultana Mh Faradz
{"title":"Epidermolysis Bullosa and Rickets in a 21-Year-Old Female: A Case Report.","authors":"Renni Yuniati, Rakhma Yanti Hellmi, Gema Citra Dwijayanti, Meira Dewi Kusuma Astuti, Gerard Pals, Dimitra Micha, Sultana Mh Faradz","doi":"10.1159/000525068","DOIUrl":"https://doi.org/10.1159/000525068","url":null,"abstract":"<p><p>Epidermolysis bullosa (EB) is a group of rare genetic diseases that exhibit mechanical fragility of the skin. This condition will result in the occurrence of skin blisters, skin erosions, and skin ulcerations when the skin is subjected to trauma. In this case report, we present a case of EB and multiple skeletal deformities in a 21-year-old female. She came to our clinic with recurrent skin exfoliations and blisters that occurred since she was 4 years old and multiple bones bowing since she was 9 years old. On physical examinations, we found generalized hypopigmentation macule with erythematous skin. There were numerous bullae and crusted lesions, with erosion and excoriations on the lesions. Laboratory examinations identified low vitamin D 25-OH (8.6 ng/mL). Bone densitometry measurement found low bone density, and X-ray examination found osteopenia and bone bowing. Using whole-exome sequencing, no causative pathogenic sequence or copy number variants in the genes associated with Mendelian inherited disorders were detected. The low levels of vitamin D 25-OH may most likely be the main reason for the occurrence of rickets in this patient aside from the genetic disorder.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"291-301"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/96/cde-0014-0291.PMC9941763.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Špela Šuler Baglama, Anja Trajber Horvat, Irena Peteln, Gregor Borut Ernst Jemec
{"title":"Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports.","authors":"Špela Šuler Baglama, Anja Trajber Horvat, Irena Peteln, Gregor Borut Ernst Jemec","doi":"10.1159/000528128","DOIUrl":"https://doi.org/10.1159/000528128","url":null,"abstract":"<p><p>The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"362-367"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/82/cde-0014-0362.PMC9841798.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Kern, Luisa Kleinheinrich, Robert Feldmann, Paul Sator, Alexander Stella, Friedrich Breier
{"title":"Dupilumab-Induced Lichen Planus: A Case with Oral and Cutaneous Eruptions.","authors":"Laura Kern, Luisa Kleinheinrich, Robert Feldmann, Paul Sator, Alexander Stella, Friedrich Breier","doi":"10.1159/000527918","DOIUrl":"https://doi.org/10.1159/000527918","url":null,"abstract":"Lichen planus is a chronic, inflammatory, immune-mediated dermatosis affecting the patient’s skin, scalp, mucous membranes, and nails. Drug-induced lichen planus is described after the administration of antimalarials, ß-blockers, methyldopa, NSAIDs, penicillamines, and sodium aurothiomalate. The use of biologicals such as adalimumab, etanercept, and infliximab has also been linked with the appearance of lichenoid eruptions in the recent past. In this case, we report on a patient developing oral and cutaneous lichen planus after the administration of dupilumab. The lichenoid lesions occurred after 11 months of the drug’s administration and involved the buccal walls, trunk, and extremities. Dupilumab had been administered in an effort to counter severe atopic dermatitis exacerbations. Dupilumab is associated with a downregulation of T-helper 2 cell activation by blocking the Interleukin-4/Interleukin-13 pathway, so leading to a TH1/TH2 imbalance. This imbalance may cause a shift toward a TH1-mediated immune response and be an explanation for the drug-induced lichen planus. Dupilumab was discontinued, and the patient was treated with oral corticosteroids and UVB phototherapy, leading to a significant improvement in the lichen planus lesions.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"356-361"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d9/00/cde-0014-0356.PMC9841792.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acoustic Wave Therapy for the Treatment of Extensive Scar Fields: A Case Report.","authors":"C Bettina Rümmelein, Ikonija Koceva","doi":"10.1159/000525070","DOIUrl":"https://doi.org/10.1159/000525070","url":null,"abstract":"<p><p>We report a severe scalding case with an affected skin area of 30-40% of the body surface. The patient suffered from severe itching and pain in the hypertrophic scar parts even 1.5 years after the accident. Treatment with acoustic wave therapy almost daily during the first treatment cycle was able to significantly reduce the discomfort. On representation after 1 year, the skin condition showed significant improvement. The second treatment cycle brought further improvement. At the last check-up 2 years later, the patient was free of complaints.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"264-268"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/2d/cde-0014-0264.PMC9947520.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10782839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Luísa João, Tomás Pessoa E Costa, Paulo Barreto, André Lencastre
{"title":"Tocilizumab-Induced Erythema Annulare Centrifugum.","authors":"Ana Luísa João, Tomás Pessoa E Costa, Paulo Barreto, André Lencastre","doi":"10.1159/000526938","DOIUrl":"https://doi.org/10.1159/000526938","url":null,"abstract":"<p><p>We report the case of a 42-year-old woman with rheumatoid arthritis undergoing treatment with subcutaneous tocilizumab for the past 6 months. Three days after the administration, an asymptomatic inflammatory annular plaque of 4 cm with discrete whitish scales at the inner border margin developed at the injection site in the left iliac fossa. A smaller plaque in the left groin appeared soon after. The mycological exam was negative. Histology showed a lymphoplasmacytic superficial and deep perivascular, and periadnexal, dermal infiltrate, without epidermal changes. Lesions spontaneously regressed in 4 months. The diagnosis was clinically and histologically consistent with erythema annulare centrifugum, following the exclusion of other differential diagnoses. Erythema annulare centrifugum represents a delayed-type hypersensitivity reaction generally considered idiopathic or otherwise related to numerous triggers, including drugs such as biologics. We describe the first reported case of tocilizumab-induced erythema annulare centrifugum. This case should alert dermatologists to this relatively rare and complex entity and should raise awareness to cutaneous biologic drug reactions.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"14 3","pages":"302-306"},"PeriodicalIF":0.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/eb/cde-0014-0302.PMC9941759.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}