Case Reports in Dermatology最新文献_第5页

A Case of Lip Psoriasis in a 14-Year-Old Boy Successfully Treated with Adalimumab. 阿达木单抗成功治疗一例14岁男孩唇银屑病。

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Case Reports in Dermatology Pub Date : 2023-09-04 eCollection Date: 2023-01-01 DOI: 10.1159/000532103

Francesca Caroppo, Laura Gnesotto, Maria Ludovica Deotto, Roberto Salmaso, Anna Belloni Fortina

引用次数: 0

A Case of Lamina Lucida-Type Linear IgA Disease Complicated by Colon Polyposis and Rectal Adenocarcinoma. 椎板Lucida型线性IgA病并发结肠息肉病和直肠腺癌1例。

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Case Reports in Dermatology Pub Date : 2023-09-01 eCollection Date: 2023-01-01 DOI: 10.1159/000532104

Akiko Miyazaki, Saori Itoi-Ochi, Mami Hayashi, Asako Ota, Kengo Nagai, Shinya Inoue, Naohiro Tomita, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida, Takashi Hashimoto

{"title":"A Case of Lamina Lucida-Type Linear IgA Disease Complicated by Colon Polyposis and Rectal Adenocarcinoma.","authors":"Akiko Miyazaki, Saori Itoi-Ochi, Mami Hayashi, Asako Ota, Kengo Nagai, Shinya Inoue, Naohiro Tomita, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida, Takashi Hashimoto","doi":"10.1159/000532104","DOIUrl":"10.1159/000532104","url":null,"abstract":"Linear IgA disease (LAD) is a rare autoimmune bullous disease characterized by IgA deposition in the basement membrane zone (BMZ). A 66-year-old male was treated for myelodysplastic syndrome at our hospital for 5 years, during which his condition remained stable. He visited our department because of erythema with itching, which appeared 1 year ago and gradually exacerbated with the development of blisters and erosions. During the first visit, multiple erythemas with erosions and crusts on their periphery were observed on the trunk and lower limbs. Histopathological examination revealed subepidermal blisters with inflammatory cell infiltration, mainly constituting of neutrophils, eosinophils, and lymphocytes. Direct and indirect immunofluorescence showed linear IgA deposits in the BMZ and IgA anti-BMZ antibodies, respectively, while immunoblotting using a concentrated culture supernatant of HaCaT cells detected IgA antibodies reactive to 120-kDa LAD-1. Accordingly, the patient was diagnosed with lamina lucida-type LAD. Subsequent colonoscopy revealed multiple colorectal polyps and rectal adenocarcinoma (Tis, N0, and M0). Multigene panel test showed an ATM variant of unknown significance but did not detect any pathogenic variants associated with intestinal polyposis syndrome. The skin lesions quickly resolved with oral diaphenylsulfone 50 mg/day and resection of the colorectal polyps and adenocarcinoma. To our knowledge, this is the first reported case of LAD associated with multiple colorectal polyps and rectal adenocarcinoma. Additionally, we also analyzed reported cases of LAD associated with malignancy from the literature.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reticular Erythematous Mucinosis in an African Woman with HIV Infection: Case Report and Literature Review. 一名非洲女性艾滋病毒感染者的网状红斑粘液病：病例报告和文献综述。

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Case Reports in Dermatology Pub Date : 2023-07-17 eCollection Date: 2023-01-01 DOI: 10.1159/000531464

Daniela Tenea, Cinzia Campaini

{"title":"Reticular Erythematous Mucinosis in an African Woman with HIV Infection: Case Report and Literature Review.","authors":"Daniela Tenea, Cinzia Campaini","doi":"10.1159/000531464","DOIUrl":"10.1159/000531464","url":null,"abstract":"Reticular erythematous mucinosis is a rare and persistent form of primary idiopathic mucinosis, often referred to as plaque-like cutaneous mucinosis or midline mucinosis. It presents with reticulate patches or erythematous plaques with predilection for the anterior and posterior trunk. Affected patients are frequently asymptomatic. Pruritus or burning sensations were reported after exposure to the sun. The aetiology remains obscure; its pathogenesis is poorly understood, particularly in immunocompromised patients such as HIV-infected patients. The disease associations are not uniformly documented. Antimalarial agents significantly improve and shorten the course of the disease. We report a case of a 31-year-old African woman with underlying HIV infection who displayed the classical clinical and histological features of reticular erythematous mucinosis. This condition is rare among the HIV-infected patients, particularly in those of African descent, in whom lichen myxoedematosus/scleromyxoedema variants and acral persistent papular mucinoses were most frequently reported. The higher incidence of photosensitivity in HIV-infected individuals including the patients with skin of colour may play a potential role in reticular erythematous mucinosis. Its relationship with lupus erythematosus and photosensitivity in the context of HIV infection is discussed. To the best of our knowledge, this is the first reported case of reticular erythematous mucinosis in an African HIV-infected patient. This case highlights the need for diagnostic awareness in cases presenting with erythematous plaques and patches in a net-like pattern developing on the midline and sun-exposed areas of the trunk.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/2d/cde-2023-0015-0001-531464.PMC10360453.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate Response to Brentuximab Vedotin in a Patient with Localized MF-LCT. 局部 MF-LCT 患者对 Brentuximab Vedotin 的即时反应

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Case Reports in Dermatology Pub Date : 2023-07-14 eCollection Date: 2023-01-01 DOI: 10.1159/000529576

Agnieszka Giza, Karol Miklusiak, Przemysław Hałubiec, Andrzej Jaworek, Dagmara Zimowska-Curyło, Grzegorz Dyduch, Tomasz Sacha

{"title":"Immediate Response to Brentuximab Vedotin in a Patient with Localized MF-LCT.","authors":"Agnieszka Giza, Karol Miklusiak, Przemysław Hałubiec, Andrzej Jaworek, Dagmara Zimowska-Curyło, Grzegorz Dyduch, Tomasz Sacha","doi":"10.1159/000529576","DOIUrl":"10.1159/000529576","url":null,"abstract":"The large cell transformation of mycosis fungoides (MF-LCT) is a phenomenon observed in the advanced stages of mycosis fungoides (MF), which is the most common primary cutaneous lymphoma. The diagnostic criteria of MF-LCT are a minimum of 25% of large cells or a formation of microscopic nodules of them in the histological examination of skin samples. The clinical outcomes for MF-LCT are poor, as less than 20% of patients survive 5 years after diagnosis, but the expression of the CD30 antigen is generally considered to be associated with a better prognosis. We present a case of a patient with the diagnosis of MF with LCT, with an ulcerated tumor lesion approximately 30 × 20 cm in size on the right lateral abdominal wall. Brentuximab vedotin (BV) treatment was started due to the presence of the CD30 antigen, with a quick and impressive regression of the cutaneous lesion and tumor mass and good treatment tolerance. After follow-up of 20 months, patient remains in complete remission. A schedule of treatment for MF-LCT is directed mainly by the clinical stage of the disease and the comorbidities; the more severe clinical course of the disease requires systemic treatment. If at least 5% of the cells found in the skin lesions biopsy sample express the CD30 antigen, a beneficial effect of BV treatment could be expected. It may seem that the use of BV is one of the optimal therapeutic options in patients with advanced MF-LCT showing expression of CD30.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/60/cde-2023-0015-0001-529576.PMC10368084.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature. 口腔蕈样真菌病2例报告并文献复习。

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Case Reports in Dermatology Pub Date : 2023-07-12 eCollection Date: 2023-01-01 DOI: 10.1159/000530935

Carolina Alexander-Savino, Alexandra Boye-Doe, Edith Bowers, Anne Beaven

{"title":"Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature.","authors":"Carolina Alexander-Savino, Alexandra Boye-Doe, Edith Bowers, Anne Beaven","doi":"10.1159/000530935","DOIUrl":"10.1159/000530935","url":null,"abstract":"Oral and laryngeal cutaneous T-cell lymphoma (CTCL) is rare and usually associated with poor prognosis. Here, we discuss 2 cases of oral CTCL that developed in heavily pretreated patients and provide a review of the literature. The first case is of a 46-year-old African American male with rapidly progressive disease, presenting with a lesion on his hard palate 6 months after being diagnosed with a CD4+CD8+ CTCL. His cutaneous disease was widespread with tumors on >80% of his body surface area. Unfortunately, the patient died 2 ½ years after his CTCL diagnosis and 7 months after developing the oral CTCL lesion. The second case is of a 38-year-old African American male with stage IIb CD3+CD4+CD30+ mycosis fungoides (MF), who developed a tumor on the hard palate 6 months after diagnosis. He received palliative radiation to the oral lesion and multiple lines of systemic therapy for pulmonary, laryngeal, esophageal, and gastric involvement. Biopsy of the gastric lesions showed a CD30+ T-cell lymphoma with the same clonal peak as in his skin but with large cell transformation. Brentuximab vendoin was started, and the patient is now in complete remission, 30 months later. From the 76 cases of oral CTCL that have been reported in the English language, six were of transformed MF. The most common sites affected were the tongue and palate, and the most common presentation were erythematous or ulcerated tumors, plaques, or nodules associated with dysphagia and pain. Oral CTCL typically occurs years after the initial diagnosis of CTCL and portend a poor prognosis with an average survival of just over 1 year after development of oral lesions.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/2c/cde-2023-0015-0001-530935.PMC10368101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Uncommon Presentation of Neonatal Lupus Erythematosus: A Case Report. 新生儿红斑狼疮的罕见表现：病例报告。

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Case Reports in Dermatology Pub Date : 2023-06-06 eCollection Date: 2023-01-01 DOI: 10.1159/000530465

Sara Al Janahi, Raghda Al Maashari

引用次数: 0

Granulomatous Pigmented Purpuric Dermatosis in a Patient with (Inactive) Myasthenia Gravis: A Case Report and Review of the Literature. 肉芽肿性色素紫癜性皮肤病合并(非活动性)重症肌无力1例报告及文献复习。

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Case Reports in Dermatology Pub Date : 2023-05-25 eCollection Date: 2023-01-01 DOI: 10.1159/000530034

Apirada Dhekariyapak, Penpun Wattanakrai

{"title":"Granulomatous Pigmented Purpuric Dermatosis in a Patient with (Inactive) Myasthenia Gravis: A Case Report and Review of the Literature.","authors":"Apirada Dhekariyapak, Penpun Wattanakrai","doi":"10.1159/000530034","DOIUrl":"10.1159/000530034","url":null,"abstract":"Granulomatous pigmented purpuric dermatosis (GPPD) is a rare histologic variant of pigmented purpuric dermatosis (PPD) characterized by dermal histiocyte-rich interstitial infiltration with or without granuloma formation in addition to the other typical features of PPD. GPPD was previously observed more frequently to affect Asians and was reported to be associated with dyslipidemia. However, our literature search of 45 documented GPPD cases revealed an increasing prevalence in Caucasians in addition to dyslipidemia and associated autoimmune diseases. To date, etiopathogenesis of GPPD is unknown but may involve dyslipidemia, genetic and immunological factors such as autoimmune dysregulation or a sarcoidal reaction associated with C. acnes. GPPD is usually persistent and recalcitrant to treatments. We report a case of GPPD in a 57-year-old Thai woman with underlying myasthenia gravis who presented with a pruritic eruption on both lower legs. After treatment with 0.05% clobetasol propionate cream and oral colchicine, the lesion improved with marked flattening and disappeared with residual postinflammatory hyperpigmentation. We provide a literature review of the epidemiology, etiopathogenesis, concomitant comorbidities, clinical symptoms, dermatoscopic features, and treatments of GPPD.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9719351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI-Induced Neurosensory Events in Decorative Black Tattoos: Study by Advanced Experimental Methods. MRI诱发黑纹身神经感觉事件的实验研究

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Case Reports in Dermatology Pub Date : 2023-05-25 eCollection Date: 2023-01-01 DOI: 10.1159/000530220

Kasper Køhler Alsing, Ole Olsen, Christian Bender Koch, Rasmus Hvass Hansen, Daniel Pergament Persson, Klaus Qvortrup, Jørgen Serup

{"title":"MRI-Induced Neurosensory Events in Decorative Black Tattoos: Study by Advanced Experimental Methods.","authors":"Kasper Køhler Alsing, Ole Olsen, Christian Bender Koch, Rasmus Hvass Hansen, Daniel Pergament Persson, Klaus Qvortrup, Jørgen Serup","doi":"10.1159/000530220","DOIUrl":"10.1159/000530220","url":null,"abstract":"Adverse reactions in tattooed skin during magnetic resonance imaging (MRI) are rare but well known. Previous reports describe sudden burning pain in tattooed skin, sometimes accompanied by mild erythema and oedema when entering MRI scanners. The pathophysiology remains unclear, but simple direct thermal heating can be excluded. It has been hypothesized that MRI-triggered torque and traction create neural sensations from magnetic pigment particles. However, this case enlightens yet another possible mechanism. We present a 35-year-old woman experiencing reoccurring stinging sensations in three decorative black tattoos just seconds after the initiation of the MRI. Single-blind tests with handheld power magnets or a dummy could reproduce painful subjective feelings in her tattooed skin. Similar events were provoked during re-evaluation with MRI. Surprisingly, chemical analyses and electron microscopy of skin samples revealed carbon black as the colouring agent - no iron-based solids were detected. Our case demonstrates that MRI tattoo reactions are not limited to magnetic contaminants alone. More distinct subgroups of MRI-induced reactions may occur. We hypothesize that radiofrequency induction of surface currents in black carbon particles adjacent to sensory axons in the dermis may lead to neurosensations.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48126684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Unilateral Lichen Planus Pigmentosus with Blaschko's Line Distribution: A Case Report. 伴有布拉氏线分布的单侧扁平苔藓色素沉着症：病例报告

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Case Reports in Dermatology Pub Date : 2023-04-27 eCollection Date: 2023-01-01 DOI: 10.1159/000529632

Almuntsrbellah Almudimeegh, Mohammed Habib, Omar Alsuhaibani, Nawaf Alkhudhayri

引用次数: 1

Acral Fibrochondromyxoid Tumor Presenting as Enlarging Nodule Involving the Distal Fingertip and Hyponychium: A Case Report. 肢端纤维软骨粘液样瘤表现为扩大结节累及远端指尖及颏下:1例报告。

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Case Reports in Dermatology Pub Date : 2023-03-16 eCollection Date: 2023-01-01 DOI: 10.1159/000529568

Rhiannon C Miller, Cynthia M Magro, Laura E Melnick, Shari R Lipner

引用次数: 0