Case Reports in Dermatology最新文献_第4页

Pityriasis Lichenoides et Varioliformis Acuta Developing during Pembrolizumab Treatment for Bladder Cancer. 彭博利珠单抗（Pembrolizumab）治疗膀胱癌期间出现的脓疱疮和苔藓样变。

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Case Reports in Dermatology Pub Date : 2024-05-17 eCollection Date: 2024-01-01 DOI: 10.1159/000538767

Yuki Mizutani, Ena Noda, Makoto Kondo, Akinobu Hayashi, Keiichi Yamanaka

{"title":"Pityriasis Lichenoides et Varioliformis Acuta Developing during Pembrolizumab Treatment for Bladder Cancer.","authors":"Yuki Mizutani, Ena Noda, Makoto Kondo, Akinobu Hayashi, Keiichi Yamanaka","doi":"10.1159/000538767","DOIUrl":"10.1159/000538767","url":null,"abstract":"Introduction: Anti-PD-1 immunotherapies enhance T-cell responses against tumor cells by blocking the interaction between PD-1 and its ligand, PD-L1. While these therapies offer significant benefits in treating various malignancies, they can also lead to several immune-related adverse events (irAEs), most notably manifesting in the skin. Lichenoid reactions, eczema, and vitiligo are the three most prevalent forms of cutaneous irAE.Case presentation: Here, we report a rare case of a pityriasis lichenoides et varioliformis acuta (PLEVA) that developed during pembrolizumab treatment for invasive bladder cancer. A 53-year-old man, receiving pembrolizumab for invasive bladder cancer, developed erythematous papules on his legs after his 11th infusion. The skin lesions gradually spread to his entire trunk and extremities. A punch biopsy revealed several apoptotic keratinocytes and spongiosis, along with perivascular and lichenoid lymphocytic infiltration with vacuolar alteration. Immunohistochemistry showed infiltration of CD4+ and CD8+ T cells in both the epidermis and dermis. Granzyme B-positive inflammatory cells were also slightly present. From these results, he was diagnosed with PLEVA, which might be classified as a lichenoid eruption, especially based on the histological findings.Conclusion: We hypothesize that the anti-PD-1 antibody might lead to epidermal necrosis by amplifying the expression of cytolytic molecules such as granzyme B in CD8+ T cells.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"16 1","pages":"116-122"},"PeriodicalIF":0.9,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Removal of 17 Tattoos Self-Administered Using Black Eyeliner Ink with Quality-Switched Neodymium-Doped Yttrium Aluminum Garnet 1,064-nm Laser: A Case Report 使用质量开关掺钕钇铝石榴石 1,064 nm 激光成功去除 17 个使用黑色眼线墨水自制的纹身：病例报告

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Case Reports in Dermatology Pub Date : 2024-04-22 DOI: 10.1159/000538555

S. M. S. Jafari, Simon Bossart, Maurice A. Adatto, Laurence Feldmeyer, Nikhil Yawalkar, K. Heidemeyer

{"title":"Successful Removal of 17 Tattoos Self-Administered Using Black Eyeliner Ink with Quality-Switched Neodymium-Doped Yttrium Aluminum Garnet 1,064-nm Laser: A Case Report","authors":"S. M. S. Jafari, Simon Bossart, Maurice A. Adatto, Laurence Feldmeyer, Nikhil Yawalkar, K. Heidemeyer","doi":"10.1159/000538555","DOIUrl":"https://doi.org/10.1159/000538555","url":null,"abstract":"Abstract Introduction Tattooing has a rich historical presence in various human civilizations, with the earliest physical evidence dating back to around 3258 BC. While acceptance of tattoos is increasing in the Western world, negative associations remain. Short-pulsed lasers, such as Q-Switched (QS) or picosecond lasers, are the gold standard for tattoo removal. Case Presentation This case report discusses the successful removal of 17 amateur tattoos, which were self-administered by a 19-year-old female patient using black eyeliner ink and sewing needles. The tattoos, distributed across her body, including the face and hands, were partially or completely removed over 10 sessions using the QS Neodymium-doped Yttrium Aluminum Garnet 1,064-nm laser. Conclusion The factors that influence the efficacy of tattoo removal are highlighted, including tattoo type, location, and coexisting fibrosis. The psychological and social importance of effective tattoo removal is emphasized, particularly for young people seeking to disassociate from past experiences or affiliations.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"29 10","pages":"108 - 115"},"PeriodicalIF":0.9,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140676045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thoracocervicofacial Purpura as a Presenting Symptom of Seizure Disorder: A Case Report 胸颈面部紫癜是癫痫发作的先兆症状：病例报告

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Case Reports in Dermatology Pub Date : 2024-04-10 DOI: 10.1159/000537901

Waseem K. Alhawsawi, K. A. Hawsawi, Alhusain Alshareef, Rama Halabi, Ammar Baksh, Basant A Alzubaidy

{"title":"Thoracocervicofacial Purpura as a Presenting Symptom of Seizure Disorder: A Case Report","authors":"Waseem K. Alhawsawi, K. A. Hawsawi, Alhusain Alshareef, Rama Halabi, Ammar Baksh, Basant A Alzubaidy","doi":"10.1159/000537901","DOIUrl":"https://doi.org/10.1159/000537901","url":null,"abstract":"Abstract Introduction Postictal thoracocervicofacial purpura (PTP) is a rare clinical sign after a seizure episode and may be the only objective sign seen in patients who are unaware of their own seizure disorder. Moreover, it can be the only reason a patient seeks medical care after a seizure activity. Case Presentation Herein, we report a 23-year-old, living alone and not known to have any medical illnesses, who presented to our emergency department complaining of asymptomatic purpuric facial rash extending to his neck and upper chest that started suddenly when he woke up that morning. Tongue and distal lateral thigh erosions were also noticed during physical examination, as well as conjunctival hemorrhage. In addition, the patient stated that he experienced similar prior episode of purpuric rash over the face, and disappeared uneventfully within 2 weeks. Blood work was remarkable for elevated urine creatinine (21,692 mg/L) and creatine kinase (1,207 mg/L). Given his clinical features and initial laboratory results, a diagnosis of PTP was made. Conclusion Patients who present with petechial rash over the chest, neck, malar area along with conjunctival hemorrhage as an only complaint should be suspected to have or evaluated for seizure disorder.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"29 1","pages":"102 - 107"},"PeriodicalIF":0.9,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140717109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Siltuximab and 1,927 nm Fractional Laser for the Treatment of Cutaneous Manifestations in Castleman’s Disease: The Role of Dermoscopy and Reflectance Confocal Microscopy for Lesion Evaluation 西妥昔单抗和1,927 nm点阵激光治疗卡斯特曼病皮肤症状的疗效：皮肤镜和反射共聚焦显微镜在病变评估中的作用

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Case Reports in Dermatology Pub Date : 2024-04-08 DOI: 10.1159/000536483

G. Paolino, Marco Ardigò, E. Della-Torre, Luca Moroni, N. Rizzo, Matteo Riccardo Di Nicola, V. G. Bianchi, Lorenzo Dagna, Giuseppe Alvise Ramirez, S. Mercuri

{"title":"Efficacy of Siltuximab and 1,927 nm Fractional Laser for the Treatment of Cutaneous Manifestations in Castleman’s Disease: The Role of Dermoscopy and Reflectance Confocal Microscopy for Lesion Evaluation","authors":"G. Paolino, Marco Ardigò, E. Della-Torre, Luca Moroni, N. Rizzo, Matteo Riccardo Di Nicola, V. G. Bianchi, Lorenzo Dagna, Giuseppe Alvise Ramirez, S. Mercuri","doi":"10.1159/000536483","DOIUrl":"https://doi.org/10.1159/000536483","url":null,"abstract":"Abstract Introduction Multicentric Castleman’s disease (MCD) with cutaneous involvement has rarely been discussed in dermatologic literature, with few reports. Cutaneous lesions in MCD may induce deep scars, causing a significant impact in the daily life of the patients. The treatment of Castleman’s disease (CD) is usually a challenge, especially in case of cutaneous involvement. Case Presentation We report the case of a 35-year-old Caucasian man with a 3-year-old history of MCD with cutaneous involvement that we treated with a combined therapy characterized by siltuximab and 1,927 nm fractional laser. The patient showed a therapeutic response, characterized by a reduction of systemic symptoms and cutaneous manifestations. Conclusion We believe that the combination of siltuximab and 1,927 nm fractional laser might have a synergistic beneficial role in patients with cutaneous iMCD and maximize esthetic outcomes. Anyway, additional evidence is needed to validate our findings.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"166 1","pages":"97 - 101"},"PeriodicalIF":0.9,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140731265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cystic Sponge Anus 海绵囊肿肛门

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Case Reports in Dermatology Pub Date : 2024-04-02 DOI: 10.1159/000536085

H. H. van der Zee, P. Aarts

引用次数: 0

Expanding the Differential Diagnosis of the Painful Nail: A Case of an Onychopapilloma with Neuroma. 扩展疼痛性指甲的鉴别诊断：一例伴有神经瘤的趾甲瘤

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Case Reports in Dermatology Pub Date : 2024-03-28 eCollection Date: 2024-01-01 DOI: 10.1159/000538087

Jade Conway, Cynthia M Magro, Shari R Lipner

{"title":"Expanding the Differential Diagnosis of the Painful Nail: A Case of an Onychopapilloma with Neuroma.","authors":"Jade Conway, Cynthia M Magro, Shari R Lipner","doi":"10.1159/000538087","DOIUrl":"10.1159/000538087","url":null,"abstract":"Introduction: Onychopapilloma most commonly presents as longitudinal erythronychia, but diagnosis may be challenging in some cases due to varied clinical presentations. Most patients with onychopapillomas do not report associated pain but instead more commonly report functional interference.Case report: We present a case of a 74-year-old female with a 5-year history of splitting and lifting of the right thumbnail, accompanied by nail sensitivity and intermittent painful throbbing. Clinical examination was significant for a less than 1 mm red line with distal onycholysis. Love's test and a cold test performed with ice pack were negative. X-ray of the right thumb was negative for erosion or exostosis. Nail biopsy was performed, and dermatopathology was consistent with onychopapilloma with a concomitant traumatic neuroma.Conclusion: We report a case of onychopapilloma with a concomitant traumatic neuroma. Subungual neuromas are extremely rare and have not previously been associated with onychopapilloma. Our case supports the expansion of the differential diagnosis for a painful nail and demonstrates the importance of diagnostic confirmation with biopsy and histopathology.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"16 1","pages":"88-93"},"PeriodicalIF":0.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffuse Lichen Planopilaris Masquerading as Diffuse Alopecia Areata. 伪装成弥漫性脱发的弥漫性扁平苔癣

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Case Reports in Dermatology Pub Date : 2024-03-25 eCollection Date: 2024-01-01 DOI: 10.1159/000538064

Li Jie Helena Yoo, Nekma Meah, Dmitri Wall, Ian McDonald

引用次数: 0

Management of Locally Advanced Basal Cell Carcinoma with Sonic Hedgehog Pathway Targeted Therapy: A Case Report and Discussion. 用音速刺猬蛋白通路靶向疗法治疗局部晚期基底细胞癌：病例报告与讨论

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Case Reports in Dermatology Pub Date : 2024-03-13 eCollection Date: 2024-01-01 DOI: 10.1159/000537817

Neal Ferrin, Darwin Edmond, Ryan Jones, Laurence E McCahill

{"title":"Management of Locally Advanced Basal Cell Carcinoma with Sonic Hedgehog Pathway Targeted Therapy: A Case Report and Discussion.","authors":"Neal Ferrin, Darwin Edmond, Ryan Jones, Laurence E McCahill","doi":"10.1159/000537817","DOIUrl":"10.1159/000537817","url":null,"abstract":"Introduction: Basal cell carcinoma (BCC) is the most common skin malignancy in the world. While most lesions are treated using surgical methods, others may present as locally advanced or metastatic disease and are not amenable to surgical therapy alone. Treatment with sonic hedgehog pathway inhibitors (vismodegib, sonidegib) is designed to inhibit key signaling proteins and gene pathways involved with BCC to reduce the uncontrolled proliferation of basal cells in complicated disease and can be invaluable in treating patients with advanced disease.Case presentation: We describe the course of a 68-year-old man who presented with a 7.2 × 6 cm exophytic and ulcerated locally invasive BCC of his upper back. The patient was started on daily vismodegib treatment with the goal of eventual surgical resection. After 11 weeks of therapy, he had significant improvement in both wound size and appearance. After 18 weeks of therapy, he had achieved a near complete clinical response of the central aspect of lesion with three remaining small peripheral lesions. These lesions were biopsied, and two were found to be negative for malignancy, while a small inferior nodule was positive for squamous cell carcinoma (SCC). Vismodegib therapy was discontinued after a total of 26 weeks of therapy. Excision of the SCC was performed, and the patient remains disease free at 2 years.Conclusion: This case report shows the efficacy of hedgehog pathway inhibitor therapy in the treatment of a locally advanced BCC with complete pathologic response, not requiring surgical intervention.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"16 1","pages":"75-82"},"PeriodicalIF":0.9,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repair of a Large Nasal Ala and Medial Cheek Defect: Case Report. 修复大鼻孔阿拉和面颊内侧缺损：病例报告

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Case Reports in Dermatology Pub Date : 2024-03-13 eCollection Date: 2024-01-01 DOI: 10.1159/000535976

Hannah E Myers, Ashley A Kessler, Michael Roberts, Christopher Buckley

引用次数: 0

Comprehensive Treatment of a Rare Case of Complete Primary Pachydermoperiostosis with Large Facial Keloid Scars: A Case Report and Literature Review. 对一例罕见的伴有面部大面积瘢痕的完全性原发性厚皮病的综合治疗：病例报告与文献综述

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Case Reports in Dermatology Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI: 10.1159/000536550

Haibo Zhao, Jianglin Zhang, Renliang He, Linlin Bao

{"title":"Comprehensive Treatment of a Rare Case of Complete Primary Pachydermoperiostosis with Large Facial Keloid Scars: A Case Report and Literature Review.","authors":"Haibo Zhao, Jianglin Zhang, Renliang He, Linlin Bao","doi":"10.1159/000536550","DOIUrl":"10.1159/000536550","url":null,"abstract":"Introduction: Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy, is a rare autosomal dominant disease with primary clinical features of pachydermia (thickening of skin) and periostosis (new bone formation). Keloid scar formation is also rather obscure, and some scientists have claimed that keloid scars contain an excessive amount of fibroblasts compared with normal skin as well as a dense mass of irregularly deposited connective tissues.Case presentation: A 25-year-old man exhibited extensive skin folding on his face, a gyrus-like scalp, depressed nasolabial folds, and keloids. Symptoms began at 18 years of age, progressing insidiously. Additionally, he experienced clubbing of fingers and toes, joint pain, muscle soreness, and hyperhidrosis. Radiographic examinations revealed thickened bone and cystic regions. Diagnosed with complete primary PDP and facial keloid scars, he underwent skin dermabrasion, biopsies, and a comprehensive treatment involving, botulinum toxin injections, 5-fluorouracil, and a carbon dioxide lattice laser.Conclusion: PDP presents challenges due to its unclear etiology but stabilizes over time in most cases. Comprehensive treatment strategies, including dermabrasion and a combination of intralesional therapies, are effective in managing keloids in PDP patients. This case contributes to the understanding of managing rare diseases and underscores the importance of personalized approaches to improve therapeutic outcomes in patients with complete primary PDP and concurrent keloids.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"16 1","pages":"63-69"},"PeriodicalIF":0.9,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0