Multiple Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Report.

IF 0.9 Q4 DERMATOLOGY

Case Reports in Dermatology Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI:10.1159/000543349

Aljoharah Al Saud, Reem Alsergani, Ahmed Alhumidi, Abdullah Aleisa

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Abstract

Introduction: Anaplastic large cell lymphomas (ALCL) are a subtype of non-Hodgkin lymphoma categorized into systemic and cutaneous (cALCL) subtypes. cALCL are frequently characterized by their lack of ALK receptor expression, which differentiates them from their systemic counterparts. cALCLs present as solitary or grouped skin lesions. Due to their rarity, cALCLs are frequently misdiagnosed as other skin conditions.

Case presentation: We report the case of a female with a 30-year history of expanding skin lesions on the upper and lower limbs, abdomen, and back. During her initial presentation, the lesions were thought to be due to an arthropod bite. However, lesion biopsy revealed ALK-negative cALCL and methicillin-resistant Staphylococcus aureus. A full workup excluded systemic ALCL and, therefore, confirmed the diagnosis of primary cALCL. The patient was placed on methotrexate to treat the lesions and sulfamethoxazole/trimethoprim to treat the infection.

Conclusion: Our case highlights the need to consider cALCL in the differential diagnosis of patients with persistent skin lesions.

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多发性原发性皮肤间变性大细胞淋巴瘤1例报告。

间变性大细胞淋巴瘤（ALCL）是一种非霍奇金淋巴瘤亚型，分为全身和皮肤（cALCL）亚型。cALCL通常以缺乏ALK受体表达为特征，这将其与系统性同行区分开来。calcl表现为孤立或成组的皮肤病变。由于罕见，calcl经常被误诊为其他皮肤病。病例介绍：我们报告的情况下，女性与30年的历史扩大皮肤病变的上肢和下肢，腹部和背部。在她最初的表现，病变被认为是由于节肢动物咬伤。然而，病变活检显示alk阴性cALCL和耐甲氧西林金黄色葡萄球菌。全面检查排除了全身性ALCL，因此确认了原发性cALCL的诊断。患者给予甲氨蝶呤治疗病变，磺胺甲恶唑/甲氧苄啶治疗感染。结论：我们的病例强调了在持续皮肤病变患者的鉴别诊断中考虑cALCL的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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