Stefano Veraldi, Rossana Schianchi, Italo Francesco Aromolo, Gianluca Nazzaro
{"title":"Treatment of Chronic-Relapsing Pitted Keratolysis with Glycopyrronium Bromide Cream: Case Report.","authors":"Stefano Veraldi, Rossana Schianchi, Italo Francesco Aromolo, Gianluca Nazzaro","doi":"10.1159/000542484","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Pitted keratolysis (PK) is a superficial bacterial infection located almost exclusively on the soles. The most important predisposing factor is hyperhidrosis. PK is characterized by small, isolated or confluent, crateriform, noninflammatory pits. Maceration and malodor are the two most important signs and symptoms. The therapy of PK is very often unsatisfactory.</p><p><strong>Case presentation: </strong>Two patients with chronic-relapsing PK were successfully treated with a cream containing 1% glycopyrronium bromide, a new topical anticholinergic with anti-hyperhidrosis action.</p><p><strong>Conclusions: </strong>Although our experience is currently based on only 2 patients, glycopyrronium bromide cream can be taken into consideration for prevention of chronic-relapsing PK.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"17 1","pages":"9-13"},"PeriodicalIF":0.9000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666262/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000542484","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Pitted keratolysis (PK) is a superficial bacterial infection located almost exclusively on the soles. The most important predisposing factor is hyperhidrosis. PK is characterized by small, isolated or confluent, crateriform, noninflammatory pits. Maceration and malodor are the two most important signs and symptoms. The therapy of PK is very often unsatisfactory.
Case presentation: Two patients with chronic-relapsing PK were successfully treated with a cream containing 1% glycopyrronium bromide, a new topical anticholinergic with anti-hyperhidrosis action.
Conclusions: Although our experience is currently based on only 2 patients, glycopyrronium bromide cream can be taken into consideration for prevention of chronic-relapsing PK.