Recalcitrant Basal Cell Carcinoma after Grenz Ray Therapy: Introduction of High-Intensity Focused Ultrasound for Minimally Invasive Management.

IF 0.9 Q4 DERMATOLOGY
Case Reports in Dermatology Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI:10.1159/000539722
Jørgen Serup, Tomasz Zawada, Torsten Bove
{"title":"Recalcitrant Basal Cell Carcinoma after Grenz Ray Therapy: Introduction of High-Intensity Focused Ultrasound for Minimally Invasive Management.","authors":"Jørgen Serup, Tomasz Zawada, Torsten Bove","doi":"10.1159/000539722","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Grenz ray therapy popular in dermatology decades ago causes multiple and recalcitrant skin cancer in the treated field many years later. The treatment of choice is surgical excision, but limitations especially disfiguring scarring are a major challenge. We introduce 20 MHz high-intensity focused ultrasound (HIFU) as a new therapy overcoming the limitations of excisional surgery.</p><p><strong>Case presentation: </strong>A 66-year-old female, who in the 1980s had received several grenz ray treatments of the scalp, developed multiple basal cell carcinomas in the field. She had over 30 excisional surgeries including Mohs surgery in the past with many local complications but, nevertheless, recurrent cancers. HIFU treatments applied to eight basal cell carcinomas and two precancerous lesions resulted in complete clearing at 12-month control, but one recurrence after 15 months.</p><p><strong>Conclusion: </strong>The HIFU treatment is convenient, with very few complications, and applicable to field eradication of skin premalignancies and malignancies. HIFU may fill out a hitherto unmet need of both preventive and curative treatment with better long-term control of patients with recalcitrant skin cancer after grenz ray given in the past. HIFU is a new potentially important therapeutic modality in skin oncology, combining curative treatment, field eradication, and prevention in one procedure through treatment of lesions in different states of progression.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250693/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000539722","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Grenz ray therapy popular in dermatology decades ago causes multiple and recalcitrant skin cancer in the treated field many years later. The treatment of choice is surgical excision, but limitations especially disfiguring scarring are a major challenge. We introduce 20 MHz high-intensity focused ultrasound (HIFU) as a new therapy overcoming the limitations of excisional surgery.

Case presentation: A 66-year-old female, who in the 1980s had received several grenz ray treatments of the scalp, developed multiple basal cell carcinomas in the field. She had over 30 excisional surgeries including Mohs surgery in the past with many local complications but, nevertheless, recurrent cancers. HIFU treatments applied to eight basal cell carcinomas and two precancerous lesions resulted in complete clearing at 12-month control, but one recurrence after 15 months.

Conclusion: The HIFU treatment is convenient, with very few complications, and applicable to field eradication of skin premalignancies and malignancies. HIFU may fill out a hitherto unmet need of both preventive and curative treatment with better long-term control of patients with recalcitrant skin cancer after grenz ray given in the past. HIFU is a new potentially important therapeutic modality in skin oncology, combining curative treatment, field eradication, and prevention in one procedure through treatment of lesions in different states of progression.

格林兹射线治疗后复发的基底细胞癌:引入高强度聚焦超声进行微创治疗。
导言:几十年前流行于皮肤科的格列茨射线疗法会在多年后导致治疗部位出现多发性和顽固性皮肤癌。首选的治疗方法是手术切除,但手术的局限性,尤其是毁容性疤痕是一大挑战。我们引入了 20 兆赫高强度聚焦超声(HIFU)作为一种新疗法,克服了切除手术的局限性:病例介绍:一位 66 岁的女性,在 20 世纪 80 年代曾接受过多次头皮格列兹射线治疗,后来在头皮部位出现了多发性基底细胞癌。她过去曾接受过包括莫氏手术在内的 30 多次切除手术,虽然出现了许多局部并发症,但仍有癌症复发。对 8 个基底细胞癌和 2 个癌前病变进行 HIFU 治疗后,在 12 个月的控制期后,基底细胞癌完全消失,但在 15 个月后有一个复发:结论:HIFU 治疗方便、并发症少,适用于现场根除皮肤癌前病变和恶性肿瘤。HIFU 可以满足迄今为止尚未得到满足的预防性和治疗性治疗需求,它可以更好地长期控制过去接受过克伦茨射线治疗后顽固不化的皮肤癌患者。HIFU 是皮肤肿瘤学中一种新的潜在重要治疗方式,它通过治疗处于不同进展状态的病变,将治疗、野外根除和预防结合在一次手术中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
1.60
自引率
0.00%
发文量
57
审稿时长
9 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信