Case Reports in Dermatology最新文献_第7页

Treatment of Ectopic Hidradenitis Suppurativa of the Lower Leg with Setons: A Case Report. 塞通治疗下肢化脓性异位汗腺炎1例。

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Case Reports in Dermatology Pub Date : 2026-02-17 eCollection Date: 2026-01-01 DOI: 10.1159/000551053

Minna Möller, Anja Pahlow Mose, Meirav Holmdahl

引用次数: 0

Kaposi Sarcoma Associated with Pemphigus Vulgaris in the Setting of Immunosuppressive Therapy: Case Report and Review of Literature. 免疫抑制治疗下卡波济肉瘤合并寻常性天疱疮的病例报告及文献复习。

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Case Reports in Dermatology Pub Date : 2026-02-14 eCollection Date: 2026-01-01 DOI: 10.1159/000551054

Hanie Masouri, Sepehr Broumand Sani, Sama Heidari, Navid Namakizadeh Esfahani

{"title":"Kaposi Sarcoma Associated with Pemphigus Vulgaris in the Setting of Immunosuppressive Therapy: Case Report and Review of Literature.","authors":"Hanie Masouri, Sepehr Broumand Sani, Sama Heidari, Navid Namakizadeh Esfahani","doi":"10.1159/000551054","DOIUrl":"10.1159/000551054","url":null,"abstract":"Introduction: Pemphigus vulgaris (PV) is a chronic autoimmune blistering disorder characterized by intraepidermal blisters affecting the skin and mucous membranes. The primary treatment for PV is systemic corticosteroid therapy, which is often prolonged due to the disease's chronic and relapsing course. The interplay between autoimmunity and long-term immunosuppressive treatment can predispose patients to secondary complications, including Kaposi sarcoma (KS), an angioproliferative tumor primarily involving the skin and soft tissues. When KS develops in the context of immunosuppressive therapy, particularly in patients with autoimmune diseases such as PV, it is classified as iatrogenic KS.Case presentation: We report the case of a 74-year-old female diagnosed with PV who developed iatrogenic KS following treatment with high-dose intravenous immunoglobulin (150 g) and systemic corticosteroids. Despite tapering of immunosuppressive medications, the KS lesions did not regress. As a result, the patient was referred to an oncologist for further evaluation and management.Conclusion: This case highlights the potential role of both autoimmunity and immunosuppressive therapy in the development of iatrogenic KS. While tapering immunosuppressive drugs has been reported as an effective approach for KS resolution in some cases, it may not be sufficient in all instances. Close monitoring and timely oncologic referral are essential in managing such complications.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"199-209"},"PeriodicalIF":0.7,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-Induced Melasma in Patients on 5-Alpha Reductase Inhibitors: A Case Report. 5- α还原酶抑制剂治疗患者药物性黄褐斑1例。

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Case Reports in Dermatology Pub Date : 2026-02-14 eCollection Date: 2026-01-01 DOI: 10.1159/000551051

Hiba Elhaj, Kelsey A Orrell, Renée A Beach

{"title":"Drug-Induced Melasma in Patients on 5-Alpha Reductase Inhibitors: A Case Report.","authors":"Hiba Elhaj, Kelsey A Orrell, Renée A Beach","doi":"10.1159/000551051","DOIUrl":"10.1159/000551051","url":null,"abstract":"Introduction: Melasma is a chronic hyperpigmentation disorder with pathogenesis linked to hormonal mediation, ultraviolet and heat exposure, and genetic predisposition. Five-alpha reductase inhibitors (5-ARIs), including finasteride and dutasteride, are widely prescribed for treatment of benign prostatic hyperplasia (BPH) and off-label for androgen-mediated dermatologic conditions, yet pigmentary adverse effects are rarely reported. To date, only one case documenting melasma following 5-ARI use has been published. We report two additional cases of finasteride-induced melasma.Case summaries: A 53-year-old woman with Fitzpatrick Skin Type V developed progressive cheek hyperpigmentation approximately 1 year after initiating oral finasteride for frontal fibrosing alopecia. Clinical evaluation supported a diagnosis of melasma. Finasteride was discontinued, and treatment with cysteamine 5% cream led to partial improvement within 5 months. A 66-year-old man with FST VI presented with 1 year history of melasma on his forehead and temples, unresponsive to multiple topical therapies. It was revealed he had been taking oral finasteride for approximately 10 years for treatment of BPH. He was diagnosed with 5-ARI-induced melasma. Therapy was modified to include cysteamine cream, glutathione cream, azelaic acid, and a retinoid, and he was referred to his urologist for evaluation of finasteride discontinuation.Conclusion: These cases expand the limited literature on finasteride-associated melasma and highlight that improvement may require both discontinuation of the drug and targeted melasma therapy. Clinicians should consider 5-ARI exposure when evaluating new-onset or refractory facial hyperpigmentation, particularly in individuals with darker skin types, as early recognition and medication review may help mitigate persistent pigmentation.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"170-176"},"PeriodicalIF":0.7,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13030906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Erratum. 勘误表。

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Case Reports in Dermatology Pub Date : 2026-02-11 eCollection Date: 2026-01-01 DOI: 10.1159/000550557

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Dupilumab for Chronic Spontaneous Urticaria with Comorbid Type 2 Inflammatory Conditions: Case Report and Systematic Review of the Literature. Dupilumab治疗慢性自发性荨麻疹合并2型炎症：病例报告和文献系统回顾

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Case Reports in Dermatology Pub Date : 2026-02-09 eCollection Date: 2026-01-01 DOI: 10.1159/000550758

Somaia Naassan, Marianne Baastrup Søndergaard, Celeste Porsbjerg, Ruben Due Lorentsen, Simon Francis Thomsen

{"title":"Dupilumab for Chronic Spontaneous Urticaria with Comorbid Type 2 Inflammatory Conditions: Case Report and Systematic Review of the Literature.","authors":"Somaia Naassan, Marianne Baastrup Søndergaard, Celeste Porsbjerg, Ruben Due Lorentsen, Simon Francis Thomsen","doi":"10.1159/000550758","DOIUrl":"10.1159/000550758","url":null,"abstract":"Introduction: Chronic spontaneous urticaria (CSU) is a heterogeneous, Th2-driven condition where standard therapies, including antihistamines and omalizumab, are often insufficient. Dupilumab, an IL-4Rα antagonist approved for several Th2-mediated diseases, has shown efficacy in CSU. We present a rare case of CSU coexisting with both asthma and eosinophilic gastroenteritis, successfully treated with dupilumab, highlighting the potential effectiveness and appropriateness of dupilumab in patients with multiple, simultaneous Th2-mediated comorbidities, and provide a systematic review of the literature.Case presentation: A 32-year-old man with refractory CSU, asthma, and eosinophilic gastroenteritis was treated with dupilumab. The patient achieved complete remission of CSU, asthma, and eosinophilic gastroenteritis with dupilumab, with no reported side effects. A systematic literature search of PubMed and Embase identified eight studies comprising 25 CSU patients, most with coexisting atopic dermatitis or asthma. The majority achieved symptom control of urticaria as well as of the coexisting Th2 diseases, with only one report of mild side effects.Conclusions: Dupilumab is a suitable therapeutic option in patients with CSU and coexisting Th2-mediated conditions.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"160-169"},"PeriodicalIF":0.7,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Co-Presentation of Two Skin Patterns in a Case of Granulomatosis with Polyangiitis: A Case Report and Literature Review. 肉芽肿病合并多血管炎不寻常的两种皮肤类型的共同表现：1例报告和文献复习。

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Case Reports in Dermatology Pub Date : 2026-02-05 eCollection Date: 2026-01-01 DOI: 10.1159/000550882

Supakit Krailert, Suchaya Pajareeyaphan, Nuntouchaporn Amonchaisakda

{"title":"Unusual Co-Presentation of Two Skin Patterns in a Case of Granulomatosis with Polyangiitis: A Case Report and Literature Review.","authors":"Supakit Krailert, Suchaya Pajareeyaphan, Nuntouchaporn Amonchaisakda","doi":"10.1159/000550882","DOIUrl":"10.1159/000550882","url":null,"abstract":"Introduction: Granulomatosis with polyangiitis (GPA) is a rare necrotizing granulomatous vasculitis that affects small-to-medium-sized vessels. Cutaneous involvement is common, but highly variable in morphology, complicating diagnosis. Herein, we present a case of GPA co-presenting with two skin patterns.Case presentation: A 61-year-old Thai woman presented with chronic cough, constitutional symptoms, and weight loss. Chest computed tomography revealed multiple pulmonary nodules, and lung biopsy showed chronic granulomatous inflammation. Subsequently, the patient developed rapidly progressive glomerulonephritis with crescent features. During hospitalization, she exhibited two distinct cutaneous morphologies: erythematous hyperkeratotic umbilicated papules with crusting on both elbows and erythematous-to-violaceous vesiculopapules on both auricles. Histopathological examination of the elbow lesions revealed features consistent with early palisaded neutrophilic granulomatous dermatitis (PNGD), whereas the auricular lesions demonstrated bullous vasculitis. Although the 2022 ACR/EULAR GPA classification score was below the diagnostic threshold, the multidisciplinary team concluded that clinical, histopathological, and radiological findings supported the diagnosis of GPA. The patient responded well to immunosuppressive therapy, including intravenous methylprednisolone, cyclophosphamide, and plasma exchange therapy.Conclusions: This case shows an unusual combination of bullous vasculitis and PNGD in a patient with GPA, highlighting the importance of recognizing uncommon skin lesions as possible clues to underlying systemic vasculitis.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"153-159"},"PeriodicalIF":0.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatofibrosarcoma Protuberans at the Presumed Injection Site following CoronaVac COVID-19 Vaccination: A Case Report. 冠状病毒COVID-19疫苗接种后推定注射部位的皮肤纤维肉瘤隆突：1例报告

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Case Reports in Dermatology Pub Date : 2026-02-02 eCollection Date: 2026-01-01 DOI: 10.1159/000550437

Xiaoling Cao, Rong Yin, Dongming Lv, Zhongye Xu, Zhicheng Hu, Bing Tang

{"title":"Dermatofibrosarcoma Protuberans at the Presumed Injection Site following CoronaVac COVID-19 Vaccination: A Case Report.","authors":"Xiaoling Cao, Rong Yin, Dongming Lv, Zhongye Xu, Zhicheng Hu, Bing Tang","doi":"10.1159/000550437","DOIUrl":"10.1159/000550437","url":null,"abstract":"Introduction: Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing, locally aggressive cutaneous sarcoma. Trauma and scars have been proposed as potential triggers in a subset of cases.Case presentation: We report a 30-year-old man who developed a progressively enlarging mass in the left deltoid region within several months after receiving two doses of the CoronaVac COVID-19 vaccine administered to the same arm. The lesion was diagnosed as DFSP approximately 19 months after vaccination. Histopathology showed a storiform spindle-cell neoplasm with diffuse CD34 positivity, and fluorescence in situ hybridization demonstrated the COL1A1-PDGFB fusion, consistent with DFSP. The tumor was managed with wide local excision with 2-cm clinical margins; final margins were negative. At 24 months of follow-up after surgery, there was no evidence of local recurrence or metastasis.Conclusions: This case illustrates a temporal association between a new mass at a presumed injection site and DFSP. While causality cannot be inferred from a single case, persistent post-injection nodules should prompt evaluation. The overall benefits of COVID-19 vaccination remain substantial.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"142-147"},"PeriodicalIF":0.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relapse of Juvenile Dermatomyositis following Eight Years in Remission: A Case Report. 青少年皮肌炎缓解8年后复发1例报告。

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Case Reports in Dermatology Pub Date : 2026-01-30 eCollection Date: 2026-01-01 DOI: 10.1159/000549462

Jordan Book, Ty Theriot, Jonathan Joseph, Christopher Haas

{"title":"Relapse of Juvenile Dermatomyositis following Eight Years in Remission: A Case Report.","authors":"Jordan Book, Ty Theriot, Jonathan Joseph, Christopher Haas","doi":"10.1159/000549462","DOIUrl":"10.1159/000549462","url":null,"abstract":"Introduction: Dermatomyositis is an autoimmune inflammatory condition that is characterized by proximal muscle weakness and a variety of cutaneous manifestations.Case presentation: In this report, we discuss the case of a 27-year-old white female who developed a relapse of juvenile dermatomyositis (JDM) 8 years after remission. The patient presented with a 4-month history of progressive proximal muscle weakness and rash, as well as a more recent onset of dysphagia. Severe cutaneous involvement was apparent on examination with ulcerated, pruritic plaques, violaceous papules, and diffuse erythema. Laboratories revealed elevated CK, aldolase, and CRP, with positive anti-NXP2, anti-U1 RNP, and anti-U2 RNP antibodies. Based on the clinical picture and diagnostic results, a relapse of JDM was diagnosed and various medication trials were initiated. Since initial presentation, the patient has improved and is currently stable on a regimen of hydroxychloroquine, IVIG, low-dose corticosteroids, tofacitinib, and gabapentin. Her myositis is in remission; however, she continues to experience burdensome cutaneous symptoms and overall significant disease impact.Conclusion: This case highlights the possibility of JDM relapse even after prolonged remission, underscoring the importance of maintaining a high index of suspicion for symptom recurrence. It also offers a thorough example of multimodal therapy use for refractory JDM.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"148-152"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Refractory Erythroderma with Abrocitinib: A Case Report. 阿布替尼成功治疗难治性红皮病1例。

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Case Reports in Dermatology Pub Date : 2026-01-29 eCollection Date: 2026-01-01 DOI: 10.1159/000550416

Yuping Zhang, Chen Li, Chuanjian Lu, Jingjie Yu

{"title":"Successful Treatment of Refractory Erythroderma with Abrocitinib: A Case Report.","authors":"Yuping Zhang, Chen Li, Chuanjian Lu, Jingjie Yu","doi":"10.1159/000550416","DOIUrl":"10.1159/000550416","url":null,"abstract":"Introduction: Erythroderma represents a severe dermatological condition often challenging to treat, especially in cases unresponsive to standard therapies. Currently, evidence for the use of abrocitinib in this setting is limited, leaving a gap in available treatment options.Case presentation: We report the case of an adult patient with refractory erythroderma who failed to respond to conventional treatments, including glucocorticoids, immunosuppressants, and biologics. To manage the acute flare, abrocitinib was initiated alongside a tapering course of glucocorticoids. Over the treatment course, the patient demonstrated significant clinical improvement, including reduction in erythema, associated symptoms, and hair regrowth. Importantly, the glucocorticoids were successfully discontinued, and no recurrence or serious adverse events were observed during a 6-month follow-up.Conclusion: This case indicates that abrocitinib may be a promising therapeutic option for patients with erythroderma resistant to existing treatments. Further research with larger patient cohorts is necessary to establish its efficacy and safety in this context.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"130-135"},"PeriodicalIF":0.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Holistic Treatment Incorporating Moist Wound Healing for Postoperative Radiation-Induced Perineal Ulcer in Rectal Malignancy: A Case Report. 直肠恶性肿瘤术后放射性会阴溃疡综合湿创面愈合1例。

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Case Reports in Dermatology Pub Date : 2026-01-29 eCollection Date: 2026-01-01 DOI: 10.1159/000550713

Guikuan Nie, Yahong Zhang, Xichuan Wu, Yan Luo, Huiyong Song, Hao Li, Qiyang He, Qinping Wu, Rongmeng Chen

{"title":"Holistic Treatment Incorporating Moist Wound Healing for Postoperative Radiation-Induced Perineal Ulcer in Rectal Malignancy: A Case Report.","authors":"Guikuan Nie, Yahong Zhang, Xichuan Wu, Yan Luo, Huiyong Song, Hao Li, Qiyang He, Qinping Wu, Rongmeng Chen","doi":"10.1159/000550713","DOIUrl":"10.1159/000550713","url":null,"abstract":"Introduction: Radiation-induced perineal ulcers are often refractory to conventional dry exposure therapies. This article reports a case of extensive radiation-induced ulceration successfully managed using a moist wound healing protocol.Case presentation: A 67-year-old male developed progressive perianal, scrotal, and penile ulceration following radiotherapy for rectal carcinoma. Four weeks of conventional dry exposure therapy proved ineffective. Upon admission, the patient was transitioned to a holistic treatment incorporating moist wound healing. This approach resulted in complete reepithelialization of the lesions within 1 week.Conclusion: This case demonstrates the limitations of dry healing protocols for radiation-induced cutaneous injuries. The application of moist wound healing principles provided rapid efficacy. This offers a valuable clinical strategy for managing refractory perineal radiation ulcers.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"18 1","pages":"115-122"},"PeriodicalIF":0.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0