Case Reports in Dermatology最新文献_第7页

A Novel Case of Multicentric Reticulohistiocytosis Associated with Renal Cell Carcinoma Successfully Treated with Infliximab and Methotrexate. 用英夫利西单抗和甲氨蝶呤成功治疗肾细胞癌相关多中心网状组织胞增多症的新病例

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Case Reports in Dermatology Pub Date : 2023-01-09 eCollection Date: 2023-01-01 DOI: 10.1159/000528254

Suraj Patel, Mandy Alhajj, Conrad Brimhall

{"title":"A Novel Case of Multicentric Reticulohistiocytosis Associated with Renal Cell Carcinoma Successfully Treated with Infliximab and Methotrexate.","authors":"Suraj Patel, Mandy Alhajj, Conrad Brimhall","doi":"10.1159/000528254","DOIUrl":"10.1159/000528254","url":null,"abstract":"Multicentric reticulohistiocytosis (MRH) is categorized as a rare non-Langerhans cell histiocytosis most commonly seen in women in the fourth to fifth decade of life. This systemic inflammatory condition affects multiple organ systems and can result in severe joint destruction which can progress to arthritis mutilans. To date, various underlying malignancies have been discovered in patients with MRH including breast, gastric, thymic, hepatic, and melanoma. There has been 1 case of underlying renal cell carcinoma reported in a patient diagnosed with MRH. Additionally, there is no consistently recognized treatment for MRH described in the literature. The rarity of the disease contributes to the difficulty in defining a standardized treatment. We present the case of a patient with extensive joint and skin involvement who was successfully treated with infliximab and methotrexate, experienced clinical improvement, and was later diagnosed with clear cell renal cell carcinoma. The synergistic effects of infliximab and methotrexate, in combination with the low side-effect profile, appear to be promising in the setting of MRH and in our patient resulted in the resolution of symptoms and cutaneous manifestations. We suggest this regimen as an effective combination therapy. We emphasize thorough and continuous screening for underlying malignancy associated with MRH, despite clinical improvement or negative malignancy work-up upon initial diagnosis.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/f7/cde-2023-0015-0001-528254.PMC9827444.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Rare Case of Prurigo Pigmentosa in a Danish Sibling Couple. 丹麦一对兄弟姐妹患罕见色斑疹1例。

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000528422

Maria Danielsen, Kristine Pallesen, Rikke Riber-Hansen, Anne Bregnhøj

引用次数: 0

Localized Bullous Pemphigoid in a Patient with Acquired Reactive Perforating Collagenosis. 获得性反应性穿孔性胶原沉积患者的局限性大疱性类天疱疮。

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000528140

Masahiro Oka

{"title":"Localized Bullous Pemphigoid in a Patient with Acquired Reactive Perforating Collagenosis.","authors":"Masahiro Oka","doi":"10.1159/000528140","DOIUrl":"https://doi.org/10.1159/000528140","url":null,"abstract":"A 61-year-old man presented with 6-month and 5-day histories of multiple, pruritic nodular eruptions on the trunk and extremities and bullous eruptions on the left foot, respectively. The nodular eruptions had been treated with topical corticosteroids without improvement. He had been diagnosed with diabetes mellitus at the age of 42 years and had been suffering from end-stage renal disease for 1 year. Physical examination revealed scattered violet-brown papules and nodules on the trunk and extremities, many of which had central umbilicated necrosis or keratin plugs. Additionally, two tense bullae and five erosions were noted on the dorsal aspect of the left foot. Laboratory tests showed elevated levels of serum anti-bullous pemphigoid (BP)180 antibody. Histopathological findings of a nodule and a bulla were compatible with those of acquired reactive perforating collagenosis (ARPC) and BP, respectively. The papular and nodular lesions were diagnosed as ARPC, while bullous and erosive lesions were diagnosed as localized BP. The present case, together with previously reported cases of coexisting generalized BP and ARPC, suggests that coexistence of BP, regardless of whether generalized or localized, is significantly associated with ARPC.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/28/cde-2023-0015-0001-528140.PMC9818675.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10513397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Possible Efficacy of Vedolizumab, an Anti-α4β7 Integrin Antibody, in Palmoplantar Pustulosis. 抗-α4β7整合素抗体Vedolizumab治疗掌跖脓疱病的可能疗效

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000529080

Hitoshi Terui, Rintaro Moroi, Atsushi Masamune, Setsuya Aiba, Kenshi Yamasaki

引用次数: 2

Generalized Pustular Psoriasis Flare-Up after Both Doses of BBIBP-CorV Vaccination in a Patient under Adalimumab Treatment: A Case Report. 在阿达木单抗治疗的患者中，两剂BBIBP-CorV疫苗接种后全身性脓疱性银屑病发作:一例报告

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000530074

Dorsa Dayani, Hatam Rokhafrouz, Kamran Balighi

引用次数: 1

Use of Talimogene Laherparepvec to Treat Cutaneous Squamous Cell Carcinoma in a Renal Transplant Patient. 利莫gene Laherparepvec治疗肾移植患者皮肤鳞状细胞癌。

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000530851

Max Miller, Nancy H Kim, Maya K Thosani, Justin C Moser

{"title":"Use of Talimogene Laherparepvec to Treat Cutaneous Squamous Cell Carcinoma in a Renal Transplant Patient.","authors":"Max Miller, Nancy H Kim, Maya K Thosani, Justin C Moser","doi":"10.1159/000530851","DOIUrl":"https://doi.org/10.1159/000530851","url":null,"abstract":"A 66-year-old female with a history of two renal transplants due to recurrent thrombotic thrombocytopenic purpura presented to clinic with multiple lesions identified to be non-metastatic cutaneous squamous cell carcinoma (CSCC). The patient previously underwent multiple Mohs procedures and radiation therapy treatment but continued to develop CSCC lesions with increasing frequency. After discussing multiple treatment options, it was elected to pursue treatment with Talimogene laherparepvec (T-VEC) given the systemic immune responses it can cause, with low theoretical risk of graft rejection. After starting intratumoral T-VEC injections, treated lesions began to decrease in size, and a reduction in the rate of new CSCC lesions was observed. Treatment was held due to unrelated renal complications during which time new CSCCs developed. Patient was restarted on T-VEC therapy with no recurrent renal issues. Upon reinitiating treatment, injected and non-injected lesions showed reduction in size, and the development of new lesions again ceased. One injected lesion was resected via Mohs micrographic surgery due to its size and discomfort. On sectioning, this demonstrated an exuberant lymphocytic perivascular infiltrate which was consistent with treatment response to T-VEC, with little active tumor. With high rates of non-melanoma skin cancer in renal transplant patients, their transplant status significantly limits treatment options, specifically with regards to anti-PD-1 therapy. This case suggests T-VEC can generate local and systemic immune responses in the setting of immunosuppression and that T-VEC may be a beneficial therapeutic option for transplant patients with CSCC.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9719350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflectance Confocal Microscopy of Skin after the Sting of the Jellyfish Pelagia noctiluca. 夜光水母蜇伤后皮肤的反射共聚焦显微镜观察。

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000529049

Giovanni Paolino, Matteo Riccardo Di Nicola, Riccardo Pampena, Vittoria Giulia Bianchi, Santo Raffaele Mercuri

{"title":"Reflectance Confocal Microscopy of Skin after the Sting of the Jellyfish Pelagia noctiluca.","authors":"Giovanni Paolino, Matteo Riccardo Di Nicola, Riccardo Pampena, Vittoria Giulia Bianchi, Santo Raffaele Mercuri","doi":"10.1159/000529049","DOIUrl":"https://doi.org/10.1159/000529049","url":null,"abstract":"Jellyfish are aquatic animals of the phylum Cnidaria found in seas all over the world. They are characterized by the presence of cnidocytes, cells that contain a secretory organelle, the cnidocyst, mainly used for predation and defense purposes. An adult female patient presented to our Unit of Dermatology, for a 10 days-old history of macular-erythematous lesions in her right upper limb, due to a sting by a mauve stinger Pelagia noctiluca. Dermoscopy showed a general pinkish background surmounted by numerous brown dots and lines, distributed along the surface of the skin. Reflectance confocal microscopy (RCM) showed the presence of multiple partially hyperreflective, highly coiled, hollow, and harpoonlike structures through the epidermis but without the barbed tubes found in a previous RCM report, likely due to a greater time elapsed between the sting and the dermatological visit. This case highlights how dermoscopy and RCM may help clinicians for the diagnosis of jellyfish stings.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/4d/cde-2023-0015-0001-529049.PMC10368086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Eosinophilic Fasciitis Presenting as an Ichthyosiform Eruption of the Bilateral Ankles. 嗜酸性筋膜炎表现为双侧踝关节鱼鳞状喷发。

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000529477

Nedyalko N Ivanov, Ashley Garvin, Michael J Mahon, Sean Stephenson

引用次数: 0

Adalimumab for the Treatment of Periodontitis in a 35-Year-Old Woman with Hidradenitis Suppurativa. 阿达木单抗治疗35岁女性化脓性汗腺炎牙周炎

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000528139

Yiqiu Yao, Misbah Noshela Ghazanfar, Astrid-Helene Ravn Jørgensen, Hans Christian Ring, Simon Francis Thomsen

引用次数: 0

Multiple Dermatomyofibromas in a Patient with Ehlers-Danlos Syndrome. ehers - danlos综合征患者多发性皮肌瘤。

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Case Reports in Dermatology Pub Date : 2023-01-01 DOI: 10.1159/000530423

Mark Lewis Derbyshire, Amy Leigh Brady, Ramsay Sami Farah

引用次数: 0