Goran Mirkovic, Markus Reinhold Mutke, Beda Muehleisen
{"title":"Characteristic Skin Eruptions with a Distinct Histological Pattern Allow Early Diagnosis of Vitamin C Deficiency.","authors":"Goran Mirkovic, Markus Reinhold Mutke, Beda Muehleisen","doi":"10.1159/000538916","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Scurvy has become a rare disease in western countries with potentially high morbidity. Early diagnosis is crucial and can be challenging.</p><p><strong>Case presentation: </strong>We present the case of a 56-year-old male patient who developed hemorrhagic diathesis after trivial impact trauma. Previously, the patient suffered from fatigue and loss of appetite. Characteristic skin eruptions and a distinct skin histology along with a decreased serum vitamin C level led to the diagnosis of scurvy. Following vitamin C supplementation, symptoms improved rapidly.</p><p><strong>Conclusion: </strong>In conclusion, vitamin C deficiency should be considered in cases with unclear hemorrhagic diathesis and a medical history of nutritional irregularities. Especially in cases of scurvy that do not yet show the full clinical spectrum of symptoms or have only moderately decreased serum vitamin C levels, thorough clinical dermatological examination and a skin biopsy are essential for early diagnosis and to prevent complications.</p>","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"16 1","pages":"123-127"},"PeriodicalIF":0.9000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249473/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000538916","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Scurvy has become a rare disease in western countries with potentially high morbidity. Early diagnosis is crucial and can be challenging.
Case presentation: We present the case of a 56-year-old male patient who developed hemorrhagic diathesis after trivial impact trauma. Previously, the patient suffered from fatigue and loss of appetite. Characteristic skin eruptions and a distinct skin histology along with a decreased serum vitamin C level led to the diagnosis of scurvy. Following vitamin C supplementation, symptoms improved rapidly.
Conclusion: In conclusion, vitamin C deficiency should be considered in cases with unclear hemorrhagic diathesis and a medical history of nutritional irregularities. Especially in cases of scurvy that do not yet show the full clinical spectrum of symptoms or have only moderately decreased serum vitamin C levels, thorough clinical dermatological examination and a skin biopsy are essential for early diagnosis and to prevent complications.
导言:坏血病在西方国家已成为一种罕见疾病,发病率可能很高。早期诊断至关重要,但也很有难度:本病例是一名 56 岁的男性患者,因轻微撞击外伤导致出血性休克。在此之前,患者经常感到疲倦和食欲不振。患者皮肤出现特征性糜烂,皮肤组织学特征明显,血清维生素 C 水平下降,因此被诊断为坏血病。补充维生素 C 后,症状迅速得到改善:总之,对于出血症状不明确、有营养失调病史的病例,应考虑维生素 C 缺乏症。特别是对于临床症状不明显或血清维生素 C 水平中度下降的坏血病病例,彻底的临床皮肤病检查和皮肤活检对于早期诊断和预防并发症至关重要。