Case Reports in Infectious Diseases最新文献

{"title":"A Case Report of COVID-19 With Tracheobronchial Aspergillosis.","authors":"Haolei Liu, Hailu Jiao, Jun Feng, Hui Gao, Shikui Wu","doi":"10.1155/crdi/4627040","DOIUrl":"https://doi.org/10.1155/crdi/4627040","url":null,"abstract":"<p><p>The concurrence of COVID-19 and tracheobronchial aspergillosis (TBA) is rarely documented in clinical practice. This report presents a case of TBA in a patient diagnosed with COVID-19 prior to the administration of immunosuppressive agents. This case underscores the necessity of considering fungal infections in patients with COVID-19, even during the early stages of the disease. The combination of timely bronchoscopy, antiviral therapy, and antifungal treatment resulted in favorable therapeutic outcomes for the patient.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"4627040"},"PeriodicalIF":1.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Dengue With Hyperinflammatory State and Associated Acute Pancreatitis.","authors":"Susan Alessandra Rodriguez Gonzalez, Linda Banegas, Edwin Mauricio Cantillano Quintero, Jesús Domínguez-Rojas","doi":"10.1155/crdi/8029446","DOIUrl":"https://doi.org/10.1155/crdi/8029446","url":null,"abstract":"<p><p>The increase in the incidence of dengue cases in the region has led to the identification of multiple complications associated with the disease. The present study presents the case of an adolescent girl with severe dengue in a hyperinflammatory state, who presented mild acute pancreatitis. This complication, although infrequent, can be harmful. In the clinical case presented, the patient presented severe dengue, according to the clinical diagnosis. In addition, polyserositis was observed, with positive NS1, IgG, and IgM, elevated transaminases above 1000 U/L and elevated levels of inflammatory markers such as ferritin, LDH, procalcitonin, and decreased fibrinogen. The diagnosis of acute pancreatitis was established based on two main criteria: elevated serum lipase/amylase and imaging studies. The patient did not experience significant abdominal pain; however, she manifested intense and persistent nausea for a period of 3 days. Despite presenting no other risk factors for acute pancreatitis, the patient was suffering from an infectious process. Treatment consisted of a complete 24-h fast and adequate hydration, which resulted in a progressive improvement in the patient's condition.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"8029446"},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Myelopathy as Initial Presentation of Disseminated Histoplasmosis: A Case Report.","authors":"Lisle Blackbourn, Elisa Yoo, Michael D Lunt, Umair Hamid","doi":"10.1155/crdi/1124517","DOIUrl":"https://doi.org/10.1155/crdi/1124517","url":null,"abstract":"<p><p>Histoplasmosis is a fungal infection caused by the fungus <i>Histoplasma capsulatum</i> that can rarely present with central nervous system (CNS) manifestations that include meningitis, encephalitis, focal brain or spinal cord lesions, and stroke syndromes. Because of this variation from patient to patient, CNS histoplasmosis is a difficult clinical diagnosis to make, which can be further hindered by no highly sensitive diagnostic testing available. Here, we present a unique case of a 46-year-old male immunocompromised due to type 1 diabetes mellitus with disseminated histoplasmosis as an acute presentation of myelopathy. Patient had left leg weakness for a few days prior to presentation and a neurological exam remarkable for signs of acute thoracic myelopathy, specifically concerning for Brown-Séquard syndrome. MRI imaging demonstrated an enhancing thoracic spinal cord lesion along with multiple cerebral enhancing lesions, bilateral adrenal masses, and innumerable pulmonary nodules. Biopsy results demonstrated yeast forms consistent with Histoplasma species.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"1124517"},"PeriodicalIF":1.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cefepime-Induced Encephalopathy in a Patient With Uncompromised Renal Function: A Case Report.","authors":"Aayusha Dhakal, Ozone Gautam","doi":"10.1155/crdi/6650287","DOIUrl":"10.1155/crdi/6650287","url":null,"abstract":"<p><p>Cefepime, a fourth-generation cephalosporin, is widely used in the treatment of infections caused by resistant Gram-negative bacteria especially <i>Pseudomonas aeruginosa</i>, or in severe infections, septic shock, and infections in immunocompromised patients. As it crosses the blood-brain barrier, it can cause neurotoxicity which has mostly been reported in patients with impaired renal function. Patients can present with drowsiness, confusion, delirium, agitation, stupor, or coma, and sometimes with generalized myoclonus and seizures within two to six days after starting the antibiotic. This is a rare case report where a patient with intact kidney function presented with confusion and incoherence. After excluding the possible causes for encephalopathy, cefepime-induced encephalopathy was diagnosed and the patient gradually improved after discontinuing the medication. This case is an unusual presentation of symptoms in a patient with normal kidney function, which necessitates further studies to establish other potential risk factors of cefepime-induced neurotoxicity.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6650287"},"PeriodicalIF":1.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-Resistant <i>Shigella sonnei</i> Bacteremia in an Immunocompetent Postgastric Bypass Patient Without Typical Risk Factors.","authors":"Alejandra Gutierrez, Shovendra Gautam","doi":"10.1155/crdi/9910105","DOIUrl":"10.1155/crdi/9910105","url":null,"abstract":"<p><p><i>Shigella</i> bacteremia, though rare, is a serious condition that highlights the importance of recognizing potential complications in patients with <i>Shigella</i> infections. In this paper, we present a case of <i>Shigella</i> bacteremia in a 53-year-old female s/p a Roux-en-Y gastric bypass revision four months prior, presenting with acute onset of nausea, vomiting, and persistent, explosive, watery diarrhea which started one day after she consumed pork chops and ground beef. Initial laboratory tests indicated leukocytosis and hypokalemia. Human immunodeficiency virus (HIV), rapid plasma regain (RPR), and Hepatitis C were nonreactive. A computed tomography (CT) scan of the abdomen and pelvis showed no intestinal wall thickening or any other acute abnormalities. Blood cultures identified a <i>Shigella sonnei</i> infection that was resistant to multiple antibiotics. She was treated with intravenous meropenem. <i>Shigella</i> bacteremia is a rare complication of <i>Shigella</i> infection and requires thorough investigation to identify potential underlying factors. Antibiotic susceptibilities should also be assessed, given the increasing resistance of <i>Shigella</i> strains to previously effective treatments.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"9910105"},"PeriodicalIF":1.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Imported Case of Gigantic Amoebic Liver Abscess in a 24-Year-Old Woman in Singapore.","authors":"Edwin Chong Yu Sng, Jean-Marc Chavatte","doi":"10.1155/crdi/6230349","DOIUrl":"10.1155/crdi/6230349","url":null,"abstract":"<p><p>A liver abscess can be due to several different microbiological aetiologies. While pyogenic liver abscess is most frequently encountered, amoebic liver abscess and hydatid cyst caused by the parasites, <i>Entamoeba histolytica</i> and <i>Echinococcus granulosus,</i> respectively, should be considered whenever there is epidemiological exposure. As parasitic infections are now rarely seen in clinical practice in developed countries with improvement in sanitation, lack of clinical experience in managing amoebic liver abscesses and overlapping clinical and imaging features between amoebic and pyogenic liver abscesses may lead to delay in diagnosis. In particular, although amoebic liver abscesses respond well to treatment if diagnosed early, they can progress and rupture with high mortality if treatment is delayed. Hence, early diagnosis and prompt initiation of antimicrobials are crucial to prevent complications and death. This case report highlights a case of a very large 21 cm ALA in a young lady to illustrate the challenges faced during diagnostic evaluation.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6230349"},"PeriodicalIF":1.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Man Living in the Wilderness Presents With a Unique Case of <i>Erysipelothrix rhusiopathiae</i> Causing Primary CNS Infection.","authors":"Kevin Andrew Smith, Alejandra Méndez, Lindsey J Reese","doi":"10.1155/crdi/6625621","DOIUrl":"10.1155/crdi/6625621","url":null,"abstract":"<p><p>We report the first published case of <i>Erysipelothrix rhusiopathiae</i> causing subdural empyema. This 66-year-old male patient had relevant exposure history including living in a tent in the woods and having direct contact with wildlife. His main symptom which triggered his presentation was diplopia with exam findings consistent with a left partial oculomotor nerve palsy. Initial attempts at less invasive source control via burr holes alone failed. He was treated successfully with craniectomy and aqueous penicillin G with a duration of 6 weeks following surgery. CNS infection as the primary manifestation of <i>Erysipelothrix rhusiopathiae</i> has been reported in only one other case based on our review of the literature. This pathogen demonstrates an ability to manifest infection in many ways and remains susceptible to narrow spectrum beta-lactams.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6625621"},"PeriodicalIF":1.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Survival Following Spontaneous Maternal Recovery From Ebola Virus Disease in a Resource-Limited Setting in Western Democratic Republic of the Congo.","authors":"Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka, Rigo Fraterne-Muhayangabo, Richard Kitenge-Omasumbu, Placide Mbala-Kingebeni, Zacharie Tsongo-Kibendelwa, Olivier Nyakio-Ngeleza, Ines Claris-Mwatsi, Juakali Sihali-Kyolov, Théophile Barhwamire-Kabesha, Celine Kavira-Malengera, Micheline Feza-Malira, Richard Bitwe-Mihanda, Dieudonné Sengeyi-Mushengezi-Amani, Mija Ververs","doi":"10.1155/crdi/2987569","DOIUrl":"10.1155/crdi/2987569","url":null,"abstract":"<p><p><b>Background:</b> Pregnancy induces physiological decline in maternal immunity. Ebola virus disease (EVD) in pregnancy is associated with obstetrical complications, and vaccination in early pregnancy is recommended, but may not be without risk. <b>Case Presentation:</b> We described neonatal survival after spontaneous maternal EVD recovery. This neonate was born to a 25-year-old mother admitted to an Ebola Treatment Unit (ETU) in July, 2020, after 11 days of symptoms. She was vaccinated with rVSV-ZEBOV three days before symptom onset and her real-time polymerase chain of reaction (RT-PCR) results confirmed EVD and malarial infection two days after, but she refused hospitalization. She was treated at home with PO ASAQ, amoxicillin, paracetamol, albendazole, omeprazole, and papaverine. Eleven days later, due to clinical deterioration and onset of vaginal hemorrhage, she finally accepted to be transferred in ETU. She was Parity 2, fetal age at admission was 5 weeks and 3 days. Upon admission, her EVD PCR measured NP 26.3 and GP 32.9. She did not receive monoclonal therapy against Ebola infection due to stock shortage. She received intravenous, artesunate, ceftriaxone, and papaverine. She experienced spontaneous resolution of EVD 18 days after symptom onset and was discharged. At 40 weeks gestation, seven and a half months after EVD recovery, she delivered a healthy female infant, APGAR 10/10/10, weighing 3450 g. Maternal blood, adnexal, and newborn blood samples were RT-PCR negative, and the mother and the baby were discharged after 14 days. At our last follow-up, in June 2023 (2 years, 3 months after delivery), the mother and the baby were in good health. <b>Conclusion:</b> Neonatal survival following spontaneous maternal recovery from EVD in the first trimester of gestation is rare but possible, even in the context of limited clinical resources for treatment.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"2987569"},"PeriodicalIF":1.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scrub Typhus Combined With Septic Shock Disseminated Intravascular Coagulation and Significant Hyperfibrinolysis: A Case Report and Review of the Literature.","authors":"Dewen Ma, Xiaohong Wan, Haihui Yang, Liying Yang, Ankang Peng, Quping Yuan, You Li, Shunhang Xu","doi":"10.1155/crdi/1931423","DOIUrl":"https://doi.org/10.1155/crdi/1931423","url":null,"abstract":"<p><p><b>Introduction:</b> Scrub typhus is an acute infectious disease caused by <i>Orientia tsutsugamushi</i>, whose pathophysiology is characterized by systemic small-vessel vasculitis. Its high misdiagnosis rate stems from its nonspecific clinical features. If not diagnosed and treated in time, patients may rapidly progress to multiorgan dysfunction syndrome (MODS) or even disseminated intravascular coagulation (DIC), posing a severe threat to life. <b>Case Presentation:</b> The patient was a 68-year-old male with \"recurrent fever and dry cough for six days.\" He was admitted to the hospital with a diagnosis of scrub typhus. After admission, he developed severe acute respiratory distress syndrome (ARDS), MODS, septic shock, DIC with thrombocytopenia, hypofibrinogenemia, significant hyperfibrinolysis, and myocardial depression. The patient improved following treatment with doxycycline, moxifloxacin, renal replacement therapy, blood transfusion, antifibrinolysis, invasive mechanical ventilation, and other supportive therapies. The patient's coagulation profile in DIC caused by scrub typhus demonstrated significant hyperfibrinolysis, differing from that of garden-variety sepsis, and no similar cases were identified in a search of medical literature/databases. <b>Conclusion:</b> The fibrinolytic system in DIC caused by scrub typhus is excessively active, and antifibrinolytic therapy may benefit such patients. Further research on the distinct coagulation abnormalities in scrub typhus-associated DIC would be highly valuable compared to sepsis-associated DIC.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"1931423"},"PeriodicalIF":1.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic Knee Joint Infection Secondary to <i>Granulicatella adiacens</i>: A Case Report.","authors":"Edward Lovering, Farhang Alaee, Michelle Bahrain","doi":"10.1155/crdi/5407160","DOIUrl":"https://doi.org/10.1155/crdi/5407160","url":null,"abstract":"<p><p><i>Granulicatella adiacens</i> is an uncommon cause of prosthetic joint infection (PJI). Here, we report a case of <i>Granulicatella adiacens</i> prosthetic knee joint infection in a patient who was previously managed for <i>Granulicatella</i> bacteremia 10 months earlier. The infection was managed with a planned two-stage surgical revision and prolonged IV antibiotics. This case underscores the rare pathogenic potential of a typically benign commensal organism, highlighting the importance of considering atypical pathogens in common clinical presentations.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"5407160"},"PeriodicalIF":1.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}