Case Reports in Infectious Diseases最新文献_第2页

Febrile Pancytopenia and Hemophagocytosis From Disseminated Histoplasmosis in HIV/AIDS Patients: Two Cases and a Review of Combined Antifungal and Steroid Therapy. HIV/AIDS患者播散性组织胞浆菌病引起的发热性全血细胞减少和噬血症：2例及抗真菌和类固醇联合治疗的综述。

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Case Reports in Infectious Diseases Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/2623694

Chinelo Animalu, Nupur Singh, Kenneth Cory Guice, Kase Maner

{"title":"Febrile Pancytopenia and Hemophagocytosis From Disseminated Histoplasmosis in HIV/AIDS Patients: Two Cases and a Review of Combined Antifungal and Steroid Therapy.","authors":"Chinelo Animalu, Nupur Singh, Kenneth Cory Guice, Kase Maner","doi":"10.1155/crdi/2623694","DOIUrl":"https://doi.org/10.1155/crdi/2623694","url":null,"abstract":"Hemophagocytosis is a clinical condition characterized by the engulfment of bone marrow cellular elements, including erythrocytes, leukocytes, platelets, and their precursors, by activated macrophages. It has been associated with several infectious organisms, including the Epstein-Barr virus (EBV) and histoplasmosis. Human immunodeficiency virus (HIV) has been known to trigger hemophagocytosis in the presence or absence of other infections. Disseminated histoplasmosis is a common opportunistic infection in advanced patients with acquired immunodeficiency syndrome (AIDS) in endemic areas; however, the best treatment for histoplasmosis associated with hemophagocytosis is uncertain. This article presents two cases of patients with AIDS secondary to uncontrolled HIV who were admitted with fever, malaise, low CD4 + counts, and a history of noncompliance with antiretroviral therapy (ART). Both patients had pancytopenia, markedly elevated serum ferritin, and elevated liver transaminases. The diagnosis of histoplasmosis was confirmed by positive fungal blood cultures, buffy coat smears showing intracellular fungal organisms, and positive urine Histoplasma antigen. Bone marrow biopsies revealed Histoplasma capsulatum (H. capsulatum) in Grocott methenamine silver (GMS) stains and fungal cultures, histiocytes with intracellular red blood cells, and precursors of granulocytes, consistent with hemophagocytosis. Both patients received amphotericin B but remained febrile and pancytopenic, eventually requiring corticosteroid therapy. We present our experience with these patients and discuss the management of hemophagocytosis in patients with AIDS with disseminated histoplasmosis. We also completed a literature review and created a list of all known cases of disseminated histoplasmosis complicated by HIV/AIDS and hemophagocytosis and listed previous treatments.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"2623694"},"PeriodicalIF":1.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pathogenic Potential of Slackia exigua: A Case Study of Bacteremia in a Patient With Oral Infection. 露瓜Slackia的致病潜力：一个口腔感染患者菌血症的案例研究。

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Case Reports in Infectious Diseases Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/2079663

Gang Zhou, Lisa Cornelius, Dhammika H Navarathna

{"title":"The Pathogenic Potential of Slackia exigua: A Case Study of Bacteremia in a Patient With Oral Infection.","authors":"Gang Zhou, Lisa Cornelius, Dhammika H Navarathna","doi":"10.1155/crdi/2079663","DOIUrl":"https://doi.org/10.1155/crdi/2079663","url":null,"abstract":"Slackia exigua is an anaerobic, Gram-positive, nonspore-forming bacterium that is typically part of the normal oral microbiota. It is generally considered biochemically inert and is often dismissed as a nonpathogenic contaminant in clinical cultures, particularly in respiratory samples. However, in this case study, we report a rare instance of S. exigua bacteremia in a patient with multiple medical comorbidities who was hospitalized after reporting to Emergency Department due to fatigue and right ear pain. The patient subsequently developed signs of persistent symptoms of septicemia, prompting an extensive investigation. Blood cultures identified S. exigua as the causative agent. This case underscores the importance of thorough culture workup and clinical correlation, especially in immunocompromised patients and patients with multiple medical comorbidities. Comprehensive dental care and the administration of targeted antibiotic therapy resulted in the patient's full recovery. This report highlights the potential pathogenic role of S. exigua in certain clinical scenarios and emphasizes the need for awareness of its possible implications in systemic infections.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"2079663"},"PeriodicalIF":1.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salmonella Endocarditis: Rare Bacteremia Causing Mural Infective Endocarditis. 沙门氏菌心内膜炎：引起壁性感染性心内膜炎的罕见菌血症。

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Case Reports in Infectious Diseases Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/3830316

Seth Krueger, Michael Carcella, Caroline Dillon, Darrell McBride

{"title":"Salmonella Endocarditis: Rare Bacteremia Causing Mural Infective Endocarditis.","authors":"Seth Krueger, Michael Carcella, Caroline Dillon, Darrell McBride","doi":"10.1155/crdi/3830316","DOIUrl":"https://doi.org/10.1155/crdi/3830316","url":null,"abstract":"Current guidelines do not recommend routine cardiac imaging in patients with gram-negative bacteremia, as gram-negative infective endocarditis is rare. Nongastrointestinal Salmonella infections causing endocarditis are even more uncommon, especially in the developed world. We present the case of a 60-year-old female with Salmonella bacteremia, ultimately found to have a right atrial mural endocarditis involving an implantable cardioverter-defibrillator and an indwelling venous catheter. The vegetation and indwelling devices were removed from the operating room due to the high concern of embolization if performed percutaneously, and she completed 6 weeks of antibiotic therapy. Both indwelling devices were later replaced once treatment was completed, and there was no evidence of recurrence at the 8-month follow-up. This case proves that in those with cardiac implantable electronic devices and other indwelling devices which enter the heart, who are found to have atypical bacteremia, may benefit from cardiac imaging as a part of their workup.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"3830316"},"PeriodicalIF":1.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of COVID-19 With Tracheobronchial Aspergillosis. 新冠肺炎合并气管支气管曲霉病1例报告。

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Case Reports in Infectious Diseases Pub Date : 2025-04-13 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/4627040

Haolei Liu, Hailu Jiao, Jun Feng, Hui Gao, Shikui Wu

引用次数: 0

Severe Dengue With Hyperinflammatory State and Associated Acute Pancreatitis. 重症登革热伴高炎症状态及相关急性胰腺炎。

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Case Reports in Infectious Diseases Pub Date : 2025-04-12 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/8029446

Susan Alessandra Rodriguez Gonzalez, Linda Banegas, Edwin Mauricio Cantillano Quintero, Jesús Domínguez-Rojas

{"title":"Severe Dengue With Hyperinflammatory State and Associated Acute Pancreatitis.","authors":"Susan Alessandra Rodriguez Gonzalez, Linda Banegas, Edwin Mauricio Cantillano Quintero, Jesús Domínguez-Rojas","doi":"10.1155/crdi/8029446","DOIUrl":"https://doi.org/10.1155/crdi/8029446","url":null,"abstract":"The increase in the incidence of dengue cases in the region has led to the identification of multiple complications associated with the disease. The present study presents the case of an adolescent girl with severe dengue in a hyperinflammatory state, who presented mild acute pancreatitis. This complication, although infrequent, can be harmful. In the clinical case presented, the patient presented severe dengue, according to the clinical diagnosis. In addition, polyserositis was observed, with positive NS1, IgG, and IgM, elevated transaminases above 1000 U/L and elevated levels of inflammatory markers such as ferritin, LDH, procalcitonin, and decreased fibrinogen. The diagnosis of acute pancreatitis was established based on two main criteria: elevated serum lipase/amylase and imaging studies. The patient did not experience significant abdominal pain; however, she manifested intense and persistent nausea for a period of 3 days. Despite presenting no other risk factors for acute pancreatitis, the patient was suffering from an infectious process. Treatment consisted of a complete 24-h fast and adequate hydration, which resulted in a progressive improvement in the patient's condition.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"8029446"},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Myelopathy as Initial Presentation of Disseminated Histoplasmosis: A Case Report. 急性脊髓病作为弥散性组织胞浆菌病的初始表现：1例报告。

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Case Reports in Infectious Diseases Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/1124517

Lisle Blackbourn, Elisa Yoo, Michael D Lunt, Umair Hamid

{"title":"Acute Myelopathy as Initial Presentation of Disseminated Histoplasmosis: A Case Report.","authors":"Lisle Blackbourn, Elisa Yoo, Michael D Lunt, Umair Hamid","doi":"10.1155/crdi/1124517","DOIUrl":"https://doi.org/10.1155/crdi/1124517","url":null,"abstract":"Histoplasmosis is a fungal infection caused by the fungus Histoplasma capsulatum that can rarely present with central nervous system (CNS) manifestations that include meningitis, encephalitis, focal brain or spinal cord lesions, and stroke syndromes. Because of this variation from patient to patient, CNS histoplasmosis is a difficult clinical diagnosis to make, which can be further hindered by no highly sensitive diagnostic testing available. Here, we present a unique case of a 46-year-old male immunocompromised due to type 1 diabetes mellitus with disseminated histoplasmosis as an acute presentation of myelopathy. Patient had left leg weakness for a few days prior to presentation and a neurological exam remarkable for signs of acute thoracic myelopathy, specifically concerning for Brown-Séquard syndrome. MRI imaging demonstrated an enhancing thoracic spinal cord lesion along with multiple cerebral enhancing lesions, bilateral adrenal masses, and innumerable pulmonary nodules. Biopsy results demonstrated yeast forms consistent with Histoplasma species.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"1124517"},"PeriodicalIF":1.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cefepime-Induced Encephalopathy in a Patient With Uncompromised Renal Function: A Case Report. 头孢吡肟致未受损肾功能患者脑病1例报告。

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Case Reports in Infectious Diseases Pub Date : 2025-03-29 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/6650287

Aayusha Dhakal, Ozone Gautam

引用次数: 0

Antibiotic-Resistant Shigella sonnei Bacteremia in an Immunocompetent Postgastric Bypass Patient Without Typical Risk Factors. 无典型危险因素的胃旁路手术后免疫功能正常患者的耐抗生素sonnei志贺菌菌血症。

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Case Reports in Infectious Diseases Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/9910105

Alejandra Gutierrez, Shovendra Gautam

{"title":"Antibiotic-Resistant Shigella sonnei Bacteremia in an Immunocompetent Postgastric Bypass Patient Without Typical Risk Factors.","authors":"Alejandra Gutierrez, Shovendra Gautam","doi":"10.1155/crdi/9910105","DOIUrl":"10.1155/crdi/9910105","url":null,"abstract":"Shigella bacteremia, though rare, is a serious condition that highlights the importance of recognizing potential complications in patients with Shigella infections. In this paper, we present a case of Shigella bacteremia in a 53-year-old female s/p a Roux-en-Y gastric bypass revision four months prior, presenting with acute onset of nausea, vomiting, and persistent, explosive, watery diarrhea which started one day after she consumed pork chops and ground beef. Initial laboratory tests indicated leukocytosis and hypokalemia. Human immunodeficiency virus (HIV), rapid plasma regain (RPR), and Hepatitis C were nonreactive. A computed tomography (CT) scan of the abdomen and pelvis showed no intestinal wall thickening or any other acute abnormalities. Blood cultures identified a Shigella sonnei infection that was resistant to multiple antibiotics. She was treated with intravenous meropenem. Shigella bacteremia is a rare complication of Shigella infection and requires thorough investigation to identify potential underlying factors. Antibiotic susceptibilities should also be assessed, given the increasing resistance of Shigella strains to previously effective treatments.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"9910105"},"PeriodicalIF":1.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Imported Case of Gigantic Amoebic Liver Abscess in a 24-Year-Old Woman in Singapore. 新加坡1例24岁女性输入性巨大阿米巴肝脓肿。

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Case Reports in Infectious Diseases Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/6230349

Edwin Chong Yu Sng, Jean-Marc Chavatte

引用次数: 0

A Man Living in the Wilderness Presents With a Unique Case of Erysipelothrix rhusiopathiae Causing Primary CNS Infection. 一名生活在荒野的男子呈现了一个独特的病例丹毒弧菌引起原发性中枢神经系统感染。

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Case Reports in Infectious Diseases Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.1155/crdi/6625621

Kevin Andrew Smith, Alejandra Méndez, Lindsey J Reese

引用次数: 0