Case Reports in Infectious Diseases最新文献

{"title":"Neonatal Survival Following Spontaneous Maternal Recovery From Ebola Virus Disease in a Resource-Limited Setting in Western Democratic Republic of the Congo.","authors":"Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka, Rigo Fraterne-Muhayangabo, Richard Kitenge-Omasumbu, Placide Mbala-Kingebeni, Zacharie Tsongo-Kibendelwa, Olivier Nyakio-Ngeleza, Ines Claris-Mwatsi, Juakali Sihali-Kyolov, Théophile Barhwamire-Kabesha, Celine Kavira-Malengera, Micheline Feza-Malira, Richard Bitwe-Mihanda, Dieudonné Sengeyi-Mushengezi-Amani, Mija Ververs","doi":"10.1155/crdi/2987569","DOIUrl":"10.1155/crdi/2987569","url":null,"abstract":"<p><p><b>Background:</b> Pregnancy induces physiological decline in maternal immunity. Ebola virus disease (EVD) in pregnancy is associated with obstetrical complications, and vaccination in early pregnancy is recommended, but may not be without risk. <b>Case Presentation:</b> We described neonatal survival after spontaneous maternal EVD recovery. This neonate was born to a 25-year-old mother admitted to an Ebola Treatment Unit (ETU) in July, 2020, after 11 days of symptoms. She was vaccinated with rVSV-ZEBOV three days before symptom onset and her real-time polymerase chain of reaction (RT-PCR) results confirmed EVD and malarial infection two days after, but she refused hospitalization. She was treated at home with PO ASAQ, amoxicillin, paracetamol, albendazole, omeprazole, and papaverine. Eleven days later, due to clinical deterioration and onset of vaginal hemorrhage, she finally accepted to be transferred in ETU. She was Parity 2, fetal age at admission was 5 weeks and 3 days. Upon admission, her EVD PCR measured NP 26.3 and GP 32.9. She did not receive monoclonal therapy against Ebola infection due to stock shortage. She received intravenous, artesunate, ceftriaxone, and papaverine. She experienced spontaneous resolution of EVD 18 days after symptom onset and was discharged. At 40 weeks gestation, seven and a half months after EVD recovery, she delivered a healthy female infant, APGAR 10/10/10, weighing 3450 g. Maternal blood, adnexal, and newborn blood samples were RT-PCR negative, and the mother and the baby were discharged after 14 days. At our last follow-up, in June 2023 (2 years, 3 months after delivery), the mother and the baby were in good health. <b>Conclusion:</b> Neonatal survival following spontaneous maternal recovery from EVD in the first trimester of gestation is rare but possible, even in the context of limited clinical resources for treatment.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"2987569"},"PeriodicalIF":1.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scrub Typhus Combined With Septic Shock Disseminated Intravascular Coagulation and Significant Hyperfibrinolysis: A Case Report and Review of the Literature.","authors":"Dewen Ma, Xiaohong Wan, Haihui Yang, Liying Yang, Ankang Peng, Quping Yuan, You Li, Shunhang Xu","doi":"10.1155/crdi/1931423","DOIUrl":"https://doi.org/10.1155/crdi/1931423","url":null,"abstract":"<p><p><b>Introduction:</b> Scrub typhus is an acute infectious disease caused by <i>Orientia tsutsugamushi</i>, whose pathophysiology is characterized by systemic small-vessel vasculitis. Its high misdiagnosis rate stems from its nonspecific clinical features. If not diagnosed and treated in time, patients may rapidly progress to multiorgan dysfunction syndrome (MODS) or even disseminated intravascular coagulation (DIC), posing a severe threat to life. <b>Case Presentation:</b> The patient was a 68-year-old male with \"recurrent fever and dry cough for six days.\" He was admitted to the hospital with a diagnosis of scrub typhus. After admission, he developed severe acute respiratory distress syndrome (ARDS), MODS, septic shock, DIC with thrombocytopenia, hypofibrinogenemia, significant hyperfibrinolysis, and myocardial depression. The patient improved following treatment with doxycycline, moxifloxacin, renal replacement therapy, blood transfusion, antifibrinolysis, invasive mechanical ventilation, and other supportive therapies. The patient's coagulation profile in DIC caused by scrub typhus demonstrated significant hyperfibrinolysis, differing from that of garden-variety sepsis, and no similar cases were identified in a search of medical literature/databases. <b>Conclusion:</b> The fibrinolytic system in DIC caused by scrub typhus is excessively active, and antifibrinolytic therapy may benefit such patients. Further research on the distinct coagulation abnormalities in scrub typhus-associated DIC would be highly valuable compared to sepsis-associated DIC.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"1931423"},"PeriodicalIF":1.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic Knee Joint Infection Secondary to <i>Granulicatella adiacens</i>: A Case Report.","authors":"Edward Lovering, Farhang Alaee, Michelle Bahrain","doi":"10.1155/crdi/5407160","DOIUrl":"https://doi.org/10.1155/crdi/5407160","url":null,"abstract":"<p><p><i>Granulicatella adiacens</i> is an uncommon cause of prosthetic joint infection (PJI). Here, we report a case of <i>Granulicatella adiacens</i> prosthetic knee joint infection in a patient who was previously managed for <i>Granulicatella</i> bacteremia 10 months earlier. The infection was managed with a planned two-stage surgical revision and prolonged IV antibiotics. This case underscores the rare pathogenic potential of a typically benign commensal organism, highlighting the importance of considering atypical pathogens in common clinical presentations.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"5407160"},"PeriodicalIF":1.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Management of Dengue Fever in a Nonendemic Country: Lessons From an Acute Febrile Illness in Iran During the COVID-19 Outbreak.","authors":"Kimia Mozahheb Yousefi, Solaleh Aminian, Masoud Ebrahimi, Sara Minaeian, Azadeh Laali","doi":"10.1155/crdi/5742576","DOIUrl":"10.1155/crdi/5742576","url":null,"abstract":"<p><p>Dengue fever is a tropical arboviral disease that presents with a broad spectrum of clinical manifestations and can occasionally emerge in nonendemic regions due to factors such as international travel. This case report details a 47-year-old Iranian man who had recently returned from Jakarta, Indonesia, presenting with fever, diarrhea, vomiting, and myalgia during the COVID-19 outbreak. Despite initial misdiagnoses, dengue fever was confirmed through polymerase chain reaction (PCR) testing. Moreover, the serological analysis using enzyme-linked immunosorbent assay (ELISA) further demonstrated the presence of both IgM and IgG antibodies against the dengue virus. Initially, the patient's symptoms overlapped with COVID-19 and gastrointestinal infections, complicating the diagnosis. The management included supportive care, precautions against bleeding, fluid therapy, and empirical antibiotics due to suspected coinfections. This case highlights the importance of considering travel history and the possibility of nonendemic diseases in the differential diagnosis of febrile illnesses of unknown origin (FUO), particularly during concurrent outbreaks. Comprehensive history-taking and rigorous diagnostic evaluation are essential in such cases.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"5742576"},"PeriodicalIF":1.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tick-Borne Encephalitis Presenting as Brachial Plexus Injury: A Case Report.","authors":"Angelika Maksimiuk, Dominik Wawrzuta, Joanna Zajkowska","doi":"10.1155/crdi/7003058","DOIUrl":"https://doi.org/10.1155/crdi/7003058","url":null,"abstract":"<p><p>Tick-borne encephalitis (TBE) is a viral infection with variable clinical presentations, including neurological complications. We report a case of TBE in a 34-year-old farmer from an endemic region in Poland. The patient initially presented with paresis of the right brachial plexus. The diagnosis was challenging due to the absence of previous flu-like symptoms, often related to TBE infection. Neurological evaluations revealed paresis and muscle atrophy in the right upper limb, and serological tests confirmed TBE infection. Despite treatment efforts, neurological deficits persisted. This case highlights the need to consider TBE in the differential diagnosis of sudden-onset neurological disorders, especially in TBE-endemic regions, to ensure prompt intervention and prevent long-term complications.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"7003058"},"PeriodicalIF":1.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of <i>Nocardia kroppenstedtii</i> Infection Successfully Treated With a Multidisciplinary Approach.","authors":"Francesco Foglia, Annalisa Ambrosino, Giuseppe Greco, Annalisa Chianese, Carla Zannella, Francesca Cinone, Alfonso Reginelli, Diego Sandro Giordano, Giovanni Tortorella, Maria Teresa Laieta, Anna De Filippis, Massimiliano Galdiero, Rita Greco, Emiliana Finamore","doi":"10.1155/crdi/6452173","DOIUrl":"10.1155/crdi/6452173","url":null,"abstract":"<p><p><i>Nocardia</i> species constitute a diverse group of microorganisms classified as aerobic actinomyces. Among these species, many have been implicated as causative agents of severe human infections, particularly in immunocompromised patients, affecting lungs, skin, and nervous system. Here, we described a rare species, identified as <i>Nocardia kroppenstedtii,</i> isolated at the Complex Operative Unit of Virology and Microbiology from the subxiphoid formation and pseudonodular formation in the left leg of a 69-year-old immunocompetent patient, who was hospitalized and treated at the Complex Operative Unit of Internal Medicine and Geriatrics of the University Hospital of Campania \"Luigi Vanvitelli\" in an antimicrobial diagnostic stewardship context. This rare pathogen was first isolated in 2014 from a bronchoalveolar lavage sample obtained from a lung transplant recipient. Since then, only five cases of clinical interest have been described in literature.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6452173"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolated From a Patient in a Midwestern U.S. Hospital With a History of Indian Travel: Therapeutic Strategies and Clinical Outcomes.","authors":"Christopher Phan, Kristen Tsai, Christian M Gill, Robin Chamberland, Christian Hendrix, Rong Hou","doi":"10.1155/crdi/8155592","DOIUrl":"10.1155/crdi/8155592","url":null,"abstract":"<p><p>Carbapenemases have had increasing prevalence within the United States and worldwide. Here, we present a case of carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) which is unique due to the rarity of multiple mechanisms of resistance within the <i>Klebsiella pneumoniae</i> harboring New Delhi metallo-<i>β</i>-lactamases (NDM), oxacillinase-48 (OXA-48)-like, and cefotaximase (CTX-M) resistance genes, detected in a patient following an international travel. This case demonstrates the need for a multidisciplinary approach to optimize the treatment of multidrug-resistant Gram-negative organisms.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"8155592"},"PeriodicalIF":1.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymicrobial Osteomyelitis in a Patient With Isolation of <i>Trueperella bernardiae</i>: A Case Report and Literature Review.","authors":"Marco Antonio Delaye-Martínez, Edgar Samuel Vanegas-Rodríguez, Braulio Mendez-Sotelo, María de Lourdes García-Hernández, Claudia Adriana Colín-Castro, Rafael Franco-Cendejas, Luis Esaú López-Jácome","doi":"10.1155/crdi/6010539","DOIUrl":"10.1155/crdi/6010539","url":null,"abstract":"<p><p><b>Background:</b> <i>Trueperella bernardiae</i> is a Gram-positive rod that has been described as an opportunistic pathogen in immunocompromised patients. In a significant number of documented cases, infections with <i>Trueperella bernardiae</i> have been associated with polymicrobial infections, which highlight the fact that important bacteria-bacteria relations might be involved in the natural course of these infections, especially in patients with chronic disease courses and a history of multiple antibiotic treatments. <b>Case Presentation:</b> We present a case of a 24-year-old woman with a 3-year history of a chronic pressure ulcer on the right foot associated with varus and cavus deformity. As per relevant medical history, she was positive for multiple wound healing sessions with wound debridement and a large number of antibiotic treatments with minimal improvement. Microbiological cultures were taken from the wound, and a soft tissue infection diagnosis was initially made. Empirical treatment was initiated with levofloxacin. At 48 h, cultures were positive for <i>Providencia stuartii, Pseudomonas aeruginosa, Proteus penneri, Streptococcus agalactiae</i>, and <i>Trueperella bernardiae</i>, and the susceptibility test was performed. Three weeks later, the symptoms progressed to purulent exudate of the wound and foul-smelling with the positive probe-to-bone test. Diagnosis was changed to polymicrobial osteomyelitis, and antibiotic therapy with ciprofloxacin and trimethoprim-sulfamethoxazole was prescribed for a 4-week course of treatment, achieving the complete remission of symptoms. <b>Conclusions:</b> <i>Trueperella bernardiae</i> represents an emerging bacterium that can be isolated in various clinical presentations. On osteoarticular infections, the presence of comorbidities, mobility limitations, and a history of multiple antibiotic treatments may be determinant. Their isolation as part of polymicrobial infections highlights relevant interspecies interactions. Research is still lacking in determining standardized methodologies for susceptibility testing and specific clinical breakpoints to guide clinical decisions.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6010539"},"PeriodicalIF":1.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De Quervain's Tenosynovitis Virally Exacerbated by SARS-CoV-2 and Influenza Infections: A Case Report.","authors":"Maria Gergoudis, Logan Laubach, Glenn E Lee, Jeffrey R Donowitz","doi":"10.1155/crdi/5117572","DOIUrl":"10.1155/crdi/5117572","url":null,"abstract":"<p><p>We present the case of a fully vaccinated 39-year-old male with no pertinent past medical history who initially presented with De Quervain's tenosynovitis which was successfully treated with a corticosteroid injection. His symptoms recurred during a COVID-19 infection, which was treated with a repeat corticosteroid injection. Symptoms recurred during an influenza infection and were subsequently treated with a first dorsal compartment release. The etiology of De Quervain's tenosynovitis remains unclear. It has classically been categorized as a noninflammatory degenerative process, but recent evidence suggests a possible inflammatory connection. Here, we present a case of recurrent De Quervain's tenosynovitis exacerbated by two distinct viral infections. We hypothesize that viral-induced systemic inflammation led to localized recurrence of inflammation within the tendon sheath. Further studies including cytokine analysis and inflammatory markers are needed to advance this hypothesis.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"5117572"},"PeriodicalIF":1.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manifestation of Cytomegalovirus-Associated Gastritis and Colitis With Immunosuppression and Review of Literature.","authors":"Ahmad Mirza, John Erikson Yap, Rajan Kapoor, Imran Gani","doi":"10.1155/crdi/1143576","DOIUrl":"10.1155/crdi/1143576","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) infection in immunocompromised patients can cause significant morbidity and mortality. Early recognition and treatment helps to improve outcome. We present a case of postrenal transplant CMV infection causing both upper and lower gastrointestinal infection and symptoms. Patient developed significant co-morbidity which required multiple hospital admissions and therapeutic interventions.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"1143576"},"PeriodicalIF":1.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}