Case Reports in Infectious Diseases最新文献

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Emphysematous Pyelonephritis due to Candida glabrata and Candida tropicalis Bezoar: A Case Report. 光秃念珠菌与热带念珠菌牛黄致肺气性肾盂肾炎1例。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-08-05 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/2502643
John Corbyn Cravero, Hunter Martin, Lauren Sisco
{"title":"Emphysematous Pyelonephritis due to <i>Candida glabrata</i> and <i>Candida tropicalis</i> Bezoar: A Case Report.","authors":"John Corbyn Cravero, Hunter Martin, Lauren Sisco","doi":"10.1155/crdi/2502643","DOIUrl":"10.1155/crdi/2502643","url":null,"abstract":"<p><p>Emphysematous pyelonephritis (EPN) is a severe, necrotizing infection that can affect the renal parenchyma, collecting system, or perinephric tissue. Although typically caused by enteric Gram-negative bacteria, infections secondary to <i>Candida</i> occur rarely. We present the case of a 72-year-old female who was transferred from an outside hospital with a chief complaint of abdominal pain in the setting of dislodged percutaneous nephrostomy tube for chronic hydronephrosis. Clinically, she presented without evidence of septic shock but was found to have elevated creatinine (6.04), concerning for acute renal failure. Urology was consulted and performed cystoscopy that showed a large bilateral mass consistent with fungal ball formation. Subsequent urine cultures speciated <i>Candida tropicalis</i> and <i>Candida glabrata</i>. Per infectious disease recommendations, the patient was initially started on treatment with fluconazole and flucytosine; however, fluconazole was switched to amphotericin B deoxycholate after sensitivities reported resistance to fluconazole for <i>Candida tropicalis</i>. Additionally, urology performed a bilateral percutaneous nephroscopy with ultrasonic lithotripsy for removal of her fungal bezoar on Day 22 of her hospitalization with subsequent nephrostograms that showed a patent genitourinary system. This case demonstrates successful treatment of EPN secondary to azole-resistant <i>Candida</i> species using combined systemic antifungal therapy and an endourologic approach. This avoided the use of percutaneous nephrostomy irrigation with amphotericin deoxycholate as recommended in current guidelines and prevented potential complications this procedure carries.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2502643"},"PeriodicalIF":0.8,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced HIV Presenting With Pancytopenia and HLH-Like Hyperinflammation Secondary to Disseminated Talaromycosis: A Case Report. 晚期HIV表现为全血细胞减少症和继发于弥散性塔氏霉病的hlh样高炎症:1例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/9257582
Zhong Xhen Khor
{"title":"Advanced HIV Presenting With Pancytopenia and HLH-Like Hyperinflammation Secondary to Disseminated Talaromycosis: A Case Report.","authors":"Zhong Xhen Khor","doi":"10.1155/crdi/9257582","DOIUrl":"10.1155/crdi/9257582","url":null,"abstract":"<p><p>Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that may complicate advanced HIV infection, most commonly triggered by opportunistic infections. We report a man with advanced HIV who presented with prolonged fever and pancytopenia without an identifiable source despite extensive investigation. Bone marrow examination demonstrated haemophagocytosis, while blood mycobacterial culture yielded <i>Penicillium marneffei</i>, now classified as <i>Talaromyces marneffei</i>. Together with prolonged fever, pancytopenia, marked hyperferritinaemia and a retrospective HScore of 189, these findings supported disseminated talaromycosis with an HLH-like hyperinflammatory syndrome; complete HLH-2004 testing was not available. The patient demonstrated rapid clinical and haematological recovery following antifungal therapy with amphotericin B, without the need for HLH-directed immunosuppressive treatment. Antiretroviral therapy was subsequently initiated, followed by successful treatment of chronic hepatitis C infection. This case highlights the importance of early consideration of fungal infections and HLH-like syndromes in advanced HIV, as well as the diagnostic value of bone marrow examination in identifying treatable causes of prolonged febrile illness.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"9257582"},"PeriodicalIF":0.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13417486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wohlfahrtiimonas chitiniclastica Bacteremia Associated With Maggot-Infested Ulcers and Tumor Lysis Syndrome in Ohio, USA: A Case Report. 美国俄亥俄州与蛆感染溃疡和肿瘤溶解综合征相关的几丁质裂殖虫虫菌血症一例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/6760136
Adil Menon, Morgan K Morelli, Heather Hulec
{"title":"<i>Wohlfahrtiimonas chitiniclastica</i> Bacteremia Associated With Maggot-Infested Ulcers and Tumor Lysis Syndrome in Ohio, USA: A Case Report.","authors":"Adil Menon, Morgan K Morelli, Heather Hulec","doi":"10.1155/crdi/6760136","DOIUrl":"10.1155/crdi/6760136","url":null,"abstract":"<p><strong>Background: </strong><i>Wohlfahrtiimonas chitiniclastica</i> is an emerging Gram-negative bacillus historically linked to larvae of the parasitic fly <i>Wohlfahrtia magnifica</i>. Although most human infections have been reported in Europe and Asia, cases are increasingly recognized in North America.</p><p><strong>Case summary: </strong>A 74-year-old man from Ohio presented with sepsis and maggot-infested decubitus ulcers. Blood cultures grew Gram-negative, oxidase-positive rods that could not be identified at the home institution. The isolate was referred to an outside hospital, where it was initially misidentified as <i>Edwardsiella</i> species before definitive identification as <i>W. chitiniclastica</i> by MALDI-TOF MS (Bruker MALDI Biotyper), confirmed by supplementary biochemical testing, 6 days after the initial culture draw. Additional testing identified the rare anaerobe <i>Tissierella praeacuta</i>. Blood cultures at the home institution also identified <i>Proteus mirabilis</i> and <i>Staphylococcus aureus</i>. The clinical course was complicated by metastatic cancer and spontaneous tumor lysis syndrome (uric acid 14.6 mg/dL, LDH 2157 U/L) that improved following rasburicase therapy. The patient received empiric intravenous piperacillin-tazobactam for approximately 24 days, followed by de-escalation to ceftriaxone. Follow-up blood cultures were sterile. Goals of care were transitioned to palliation, and the patient died on hospital day 30.</p><p><strong>Conclusion: </strong>This case illustrates <i>W. chitiniclastica</i> bacteremia in Ohio, USA, and highlights diagnostic challenges including initial misidentification by conventional methods, the importance of MALDI-TOF MS for definitive identification, and possible vector adaptation to regional muscid fly species. The coisolation of <i>T. praeacuta</i> underscores the complex wound microbiome associated with chronic neglected ulcers.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"6760136"},"PeriodicalIF":0.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis, Management, and Outcome of Antituberculous Drug-Induced Liver Injury in a Low-Resource Setting: A Case Report. 低资源环境中抗结核药物引起的肝损伤的诊断、管理和结果:一个病例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/1056322
Samuel Alomatu, Mirabel Kah-Keh Nanjoh, Salimatu Asam Moro, John Gerald A Adiiboka, Pascal Deeshini Aliu Alhassan, Odalys Rivera Hernandez
{"title":"Diagnosis, Management, and Outcome of Antituberculous Drug-Induced Liver Injury in a Low-Resource Setting: A Case Report.","authors":"Samuel Alomatu, Mirabel Kah-Keh Nanjoh, Salimatu Asam Moro, John Gerald A Adiiboka, Pascal Deeshini Aliu Alhassan, Odalys Rivera Hernandez","doi":"10.1155/crdi/1056322","DOIUrl":"10.1155/crdi/1056322","url":null,"abstract":"<p><strong>Background: </strong>Antituberculous drugs carry substantial hepatotoxic risk, most commonly manifesting as idiosyncratic drug-induced liver injury. Although cases of antituberculosis drug-induced liver injury (AT-DILI) have been reported in Ghana, significant challenges remain in its diagnosis, monitoring, and management in low-resource settings.</p><p><strong>Main symptoms and clinical findings: </strong>We report the case of a 50-year-old woman who developed severe AT-DILI, initially misdiagnosed as cholecystitis, on a background of chronic hepatitis C infection with established liver cirrhosis. She was referred to the Tamale Teaching Hospital during the continuation phase of first-line antituberculosis therapy, presenting with nausea, anorexia, and right upper quadrant abdominal pain. A clinical examination revealed mild pallor, jaundice, Grade 1 bilateral pitting pedal edema, and moderate ascites.</p><p><strong>Diagnosis therapeutic intervention and outcome: </strong>At the referral facility, diagnostic and monitoring constraints were encountered, including the unavailability of liver biopsy, the lack of routine baseline liver function testing, and out-of-pocket costs for serial laboratory monitoring. In addition, the absence of single-drug formulations of isoniazid and rifampicin precluded sequential rechallenges, necessitating rechallenges with a fixed-dose combination during the continuation phase. The patient failed rechallenge and was transitioned to an all-oral second-line antituberculous regimen consisting of bedaquiline, pretomanid, linezolid, and moxifloxacin, alongside direct-acting antiviral therapy for chronic hepatitis C. This resulted in the resolution of liver injury and the successful completion of tuberculosis treatment without complications.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic and management challenges of AT-DILI in low-resource settings, particularly where baseline liver function testing, serial monitoring, and access to single-drug formulations for rechallenge are limited.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"1056322"},"PeriodicalIF":0.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Radiological Features of a Large Intracranial Hydatid Cyst: A New Case Report. 颅内大包虫囊肿的临床和影像学特征:新报告1例。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/4791747
Kazem Ghaemi, Mahmoodreza Behravan, Soudabe Eshaghi, Omid Shafaee, Amir Tavakoli Kareshk
{"title":"Clinical and Radiological Features of a Large Intracranial Hydatid Cyst: A New Case Report.","authors":"Kazem Ghaemi, Mahmoodreza Behravan, Soudabe Eshaghi, Omid Shafaee, Amir Tavakoli Kareshk","doi":"10.1155/crdi/4791747","DOIUrl":"10.1155/crdi/4791747","url":null,"abstract":"<p><p>Intracranial hydatid cyst is a rare but potentially fatal parasitic infection caused by the larval stage of <i>Echinococcus granulosus</i>. This report details a case of an intracranial hydatid cyst in an 11-year-old boy who presented with progressive headaches, nausea, vomiting, urinary incontinence, and tachycardia. Physical examination and initial laboratory studies were unremarkable, with no eosinophilia noted. Neuroimaging revealed a large cystic lesion in the left temporal lobe with significant mass effect. While initial differential diagnoses included various cystic lesions, the imaging characteristics were most consistent with a hydatid cyst. Surgical management involved a standard craniotomy and the Dowling technique for cyst removal, emphasizing meticulous technique to avoid rupture. The patient recovered well postoperatively with no neurological deficits and was discharged on albendazole therapy. This case underscores the importance of considering hydatid cyst in the differential diagnosis of intracranial cystic lesions, particularly in endemic areas with relevant exposure history.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"4791747"},"PeriodicalIF":0.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal Myiasis Associated With E. coli Bacteremia, Spinal Osteomyelitis, and Epidural Abscess: A Case Report. 鼻蝇病合并大肠杆菌血症、脊柱骨髓炎和硬膜外脓肿1例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-27 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/4888769
Faith Miller, Jesse McLean, Giulio DiDiodato
{"title":"Nasal Myiasis Associated With <i>E. coli</i> Bacteremia, Spinal Osteomyelitis, and Epidural Abscess: A Case Report.","authors":"Faith Miller, Jesse McLean, Giulio DiDiodato","doi":"10.1155/crdi/4888769","DOIUrl":"10.1155/crdi/4888769","url":null,"abstract":"<p><strong>Introduction: </strong>Nasal myiasis is a rare parasitic infestation that can predispose to secondary bacterial infection, though progression to systemic complications is uncommon. Cases in nonendemic regions are rare and may present diagnostic challenges.</p><p><strong>Case presentation: </strong>We report a case of community-acquired nasal myiasis in a 65-year-old woman presenting with an altered level of consciousness, found to have <i>E. coli</i> bacteremia and subsequent spinal osteomyelitis complicated by an epidural phlegmon requiring surgical decompression. Larvae were directly visualized within the anterior nasal cavity, with no evidence of deeper airway involvement or additional sites of infestation. Despite extensive investigation, including abdominal and pelvic imaging, no alternative infectious source was identified. Intraoperative cultures were negative following approximately 16 days of antimicrobial therapy.</p><p><strong>Discussion: </strong>Although a direct microbiological link between the nasal infestation and bacteremia could not be established, the clinical findings support a plausible secondary bacterial invasion facilitated by mucosal disruption.</p><p><strong>Conclusion: </strong>This case highlights the potential for severe systemic complications arising from nasal myiasis and underscores the importance of early recognition and thorough evaluation of atypical sources of bacteremia.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"4888769"},"PeriodicalIF":0.8,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Nonsurgical Resolution of Descending Necrotizing Mediastinitis: A Case-Based Illustration of Clinical Management. 降下性坏死性纵隔炎的成功非手术治疗:临床管理的案例说明。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-27 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/7360270
Feras Al Lami, Abdulfattah Bengheshir, Mohamed Hadi Mohamed Abdelhamid
{"title":"Successful Nonsurgical Resolution of Descending Necrotizing Mediastinitis: A Case-Based Illustration of Clinical Management.","authors":"Feras Al Lami, Abdulfattah Bengheshir, Mohamed Hadi Mohamed Abdelhamid","doi":"10.1155/crdi/7360270","DOIUrl":"10.1155/crdi/7360270","url":null,"abstract":"<p><strong>Background: </strong>Descending necrotizing mediastinitis (DNM) is a relatively uncommon complication of deep neck infections. However, with inappropriate use of antibiotics, steroids, or underlying medical problems such as immunocompromised conditions, this type of infection can become life-threatening.</p><p><strong>Methods: </strong>We report a case of Ludwig Angina with DNM, diagnosed at the end of December 2019. The subject was a 17-year-old female admitted to the pediatric intensive care unit after two weeks of clinically significant distress and swelling in her neck, tongue, and lips. The predominant underlying oropharyngeal infection originated from the mandibular 3rd molar.</p><p><strong>Results: </strong>The patient was successfully treated due to early diagnosis and adequate medical intervention. Supportive medications were highly effective, including bronchodilators to assist in breathing and improve lung air entry, intravenous glucocorticoids like dexamethasone for their anti-inflammatory effect, and a regimen of antibiotics. No surgical intervention was necessary; the only procedures performed were percutaneous drainage of an abscess in the submandibular area and chest tube insertion for pleural effusion.</p><p><strong>Conclusions: </strong>Early diagnosis and appropriate medical treatment are critical in managing DNM. Supportive medications and minimally invasive procedures can effectively manage the condition, avoiding the need for extensive surgical intervention. This case highlights the importance of vigilant diagnosis and comprehensive medical management in improving patient outcomes.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"7360270"},"PeriodicalIF":0.8,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Tuberculosis and Sarcoidosis Presented With Pleuropericardial Effusion: A Challenging Case Report. 肺结核和结节病表现为胸膜心包积液:一个具有挑战性的病例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-26 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/5770992
Atousa Hakamifard, Sara Abolghasemi, Mitra Heidarpour, Mahnaz Momenzadeh
{"title":"Pulmonary Tuberculosis and Sarcoidosis Presented With Pleuropericardial Effusion: A Challenging Case Report.","authors":"Atousa Hakamifard, Sara Abolghasemi, Mitra Heidarpour, Mahnaz Momenzadeh","doi":"10.1155/crdi/5770992","DOIUrl":"10.1155/crdi/5770992","url":null,"abstract":"<p><p>Differentiating tuberculosis (TB) from sarcoidosis, especially in TB endemic regions, is one of the major clinical challenges because these two diseases may show considerable similarity in terms of clinical manifestations, imaging findings, and granulomatous pattern. In addition, the presence of noncaseating granuloma alone is not sufficient for the definitive diagnosis of sarcoidosis because in some cases, TB may also show granulomas without necrosis. In this report, a 83-year-old man is presented with fever, productive cough, chest pain, weakness, and mild dyspnea, who had a history of pleural and pericardial effusion, with elevated pericardial adenosine deaminase (ADA), a positive tuberculin skin test, and pleural granuloma. The patient was initially treated with anti-TB therapy for probable diagnosis of TB pleurisy and also corticosteroid for probable sarcoidosis, but because of the development of drug-induced hepatitis, treatment was interrupted and modified several times. On subsequent presentation, chest high-resolution computed tomography (HRCT) showed pericardial thickening, pericardial effusion, pulmonary nodules with a perilymphatic distribution, right hilar lymphadenopathy, and a cavitary lesion in the right upper lobe. Sputum smear was 3+ positive for acid-fast bacilli, and anti-TB treatment was reinitiated. Nevertheless, because of the imaging pattern, relative response to corticosteroid, and pathologic findings including non-necrotizing granulomas, the possibility of concurrent sarcoidosis was also raised. After evaluating the possibility of TB progression and the effect of interruptions in anti-TB therapy caused by drug-induced hepatitis, the patient was treated with anti-TB regimen together with prednisolone and later azathioprine. Hence, the clinical case of pulmonary TB and probable sarcoidosis has been described in this study. The patient underwent anti-TB and immunosuppression therapy and experienced significant improvement.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"5770992"},"PeriodicalIF":0.8,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13402884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Usutu Virus Encephalitis Treated With Corticosteroids: A Case Report. 糖皮质激素治疗重症乌苏图病毒脑炎1例
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-24 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/2284329
Stefania Casolari, Deborah Lusetti, Elena Martini, Licia Gozzi, Gabriella Orlando, Erica Franceschini, Cristina Mussini
{"title":"Severe Usutu Virus Encephalitis Treated With Corticosteroids: A Case Report.","authors":"Stefania Casolari, Deborah Lusetti, Elena Martini, Licia Gozzi, Gabriella Orlando, Erica Franceschini, Cristina Mussini","doi":"10.1155/crdi/2284329","DOIUrl":"10.1155/crdi/2284329","url":null,"abstract":"<p><p>Usutu virus (USUV) is a neurotropic flavivirus, phylogenetically related to West Nile virus (WNV), maintained in the environment through a bird-to-mosquito transmission cycle, with humans and other animals occasionally becoming infected. In recent years, different cases of human infections have been reported concomitantly with increased viral circulation in several European countries. Most USUV infections in humans remain asymptomatic; however, neuroinvasive disease has been reported, mainly in the elderly and the immunocompromised but also in healthy individuals. Herein, we report a case of severe USUV meningoencephalitis in an elderly patient treated with a short course of dexamethasone and discuss the potential role of steroids in light of the most recent literature on the pathogenetic mechanisms of arboviral encephalitis.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2284329"},"PeriodicalIF":0.8,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13397092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteomyelitis of the Hip due to Granulicatella adiacens: A Case Report of an Extremely Rare Cause of Bone Infection. 髋部骨髓炎由棘芽肉芽菌引起:一例极为罕见的骨感染。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-07-22 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/7967434
Niccolò Garofalo, Lorenzo Onorato, Margherita Macera, Ilaria De Luca, Gabriele Martin, Gianluca Conza, Annalisa Itro, Nicola Coppola, Giuseppe Toro
{"title":"Osteomyelitis of the Hip due to <i>Granulicatella adiacens</i>: A Case Report of an Extremely Rare Cause of Bone Infection.","authors":"Niccolò Garofalo, Lorenzo Onorato, Margherita Macera, Ilaria De Luca, Gabriele Martin, Gianluca Conza, Annalisa Itro, Nicola Coppola, Giuseppe Toro","doi":"10.1155/crdi/7967434","DOIUrl":"10.1155/crdi/7967434","url":null,"abstract":"<p><strong>Background: </strong><i>Granulicatella adiacens (G. adiacens)</i> is a nutritionally variant <i>Streptococcus</i> generally observed in the human mouth microbiota. Although <i>G</i>. <i>adiacens</i> is involved in bacterial endocarditis and bacteremia, bone and joint infections are extremely rare. In the present study, we reported the first known case of hip osteomyelitis related to <i>G. adiacens</i>. Moreover, a commentary on the available evidence was also performed.</p><p><strong>Case presentation: </strong>A 59-year-old male with a former substance use disorder who initially complained of low back pain with a medical history negative for any other comorbidities, albeit absence seizures. After an accurate evaluation, hip osteomyelitis caused by <i>G. adiacens</i> was diagnosed. In our patient, neither bacteremia nor infectious endocarditis was reported, as well as previous oral surgery. The diagnosis of <i>G. adiacens</i> was performed through 16S rRNA gene sequencing. A three-stage surgery was performed based on surgical debridement and antibiotic-cemented spacer implant, antibiotic-cemented spacer renewal, spacer removal, and prosthesis implantation. Throughout the entire period, the patient received antibiotic therapy with doxycycline and cotrimoxazole. At the final follow-up, the patient was infection-free, but a poor hip function was reported.</p><p><strong>Conclusion: </strong><i>G. adiacens</i> is rarely associated with bone osteomyelitis, probably because of the difficulty in culture isolation that might lead to misdiagnosis, especially in cases of polymicrobial infection. In our experience, debridement, prolonged antibiotics, and two-stage/three- stage prosthesis implantation could be considered as a treatment strategy for hip osteomyelitis involving <i>G.</i> a<i>diacens</i>.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"7967434"},"PeriodicalIF":0.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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