Case Reports in Infectious Diseases最新文献

{"title":"Retinal Detachment Complicating Endogenous Endophthalmitis in a COVID-19 Patient With Superimposed <i>Streptococcus pneumoniae</i> Bacteremia.","authors":"Madiha Hijazi, Jana Kotaich, Alaa Fares, Safaa Ghanem, Ghinwa Dakdouki","doi":"10.1155/crdi/8875730","DOIUrl":"10.1155/crdi/8875730","url":null,"abstract":"<p><p>Endophthalmitis is a rare, vision-threatening ocular infection. During the COVID-19 pandemic, the widespread use of immunosuppressive agents-particularly corticosteroids-and prolonged hospital stays have been associated with an increased risk of secondary bacterial infections, including ocular involvement. One such opportunistic pathogen is <i>Streptococcus pneumoniae</i>. Among the rare but severe complications of endogenous endophthalmitis is retinal detachment (RD), which often results in a poor visual prognosis. We present a unique case of RD secondary to endogenous endophthalmitis in a COVID-19 patient with <i>S. pneumoniae</i> bacteremia. This case highlights the importance of early ophthalmologic evaluation in patients with ocular symptoms during or after COVID-19 infection to ensure timely intervention and improve clinical outcomes.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"8875730"},"PeriodicalIF":1.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Presentation of <i>Mycobacteroides abscessus</i> Thigh Mass: A Case Report.","authors":"Ryan J Blake, Grant R McChesney, H James Williams, Steven M Holland, Allison M Lastinger","doi":"10.1155/crdi/6970929","DOIUrl":"10.1155/crdi/6970929","url":null,"abstract":"<p><p><i>Mycobacterium abscessus</i> is a rapidly growing non-<i>tuberculous Mycobacterium</i> (NTM) primarily associated with pulmonary infections, particularly in individuals with underlying lung conditions. While soft tissue infections are less common, their incidence has been increasing. These infections are challenging to treat due to inherent resistance to many antibiotics obtained through spontaneous mutation as well as physical characteristics of the microbes. The case presented here describes a 61-year-old female without obvious risk factors for mycobacterial infection who developed an intramuscular abscess over a 2-year period following a mechanical fall. Surgical resection with a complex antibiotic regimen was required based on macrolide resistance and a lack of established treatment plans for such a rare presentation. This case highlights the increasing incidence of NTM and the variable clinical presentation. Early identification with a combination of surgery and antibiotics is usually indicated to successfully manage these infections. Even without obvious risk factors, NTM infection should be considered in the presence of soft tissue and intramuscular abscesses.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6970929"},"PeriodicalIF":0.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miltefosine Failure and Amphotericin B Success in the Treatment of a Case of Cutaneous <i>Leishmania Braziliensis</i> in a Recent Traveler in Belize and Guatemala.","authors":"Michelle Y Ko, Emilie Fowler, Amanda Scott, Daniel Z Uslan","doi":"10.1155/crdi/6644758","DOIUrl":"10.1155/crdi/6644758","url":null,"abstract":"<p><p>We report the case of a 53-year-old male with recent travel to Guatemala and Belize who was diagnosed with cutaneous leishmaniasis (CL). He was treated empirically with miltefosine with no improvement and switched to amphotericin B upon species identification of <i>L. braziliensis</i>, resulting in the resolution of his lesions. This case demonstrates that clinicians should recognize the importance of systemic therapy for treating complex CL, as well as the importance of identification of species type for tailoring treatments. Furthermore, while miltefosine has proven efficacious for CL in many New World locales, it has demonstrated lower cure rates for CL in Guatemala, and thus identification of the region of origin of the CL infection is imperative for further guiding treatment, which may vary according to the differences in drug potency or region-specific resistance rates.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6644758"},"PeriodicalIF":1.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Mpox and HSV-1 Proctitis in a Young Male With AIDS: A Case Report of Treatment Failure.","authors":"Mikhail Sukhoroslov, Fouad Kaddour-Hocine, Muhammad Hammad Ashraf, Navya Mandalapu, Shivani Bansal, Matthew Peachey","doi":"10.1155/crdi/6338218","DOIUrl":"10.1155/crdi/6338218","url":null,"abstract":"<p><p>Managing the mpox in patients with advanced HIV infection and coinfections poses significant challenges. This report discusses a young male with advanced HIV (CD4 count 28) and severe concurrent mpox and HSV-1 proctitis. Despite initial treatment with oral tecovirimat, acyclovir, and antiretrovirals, the patient's condition worsened, requiring readmission. The patient received intravenous tecovirimat, vaccinia immune globulin, and brincidofovir. Sigmoidoscopy revealed extensive rectal and sigmoid lesions that necessitated prolonged hospitalization and pain management. This case emphasizes the complexity of treating severe coinfections in immunocompromised patients, highlighting the need for a multidisciplinary approach and consideration of alternative therapies when standard treatment fails.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6338218"},"PeriodicalIF":1.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perianesthetic Management in a Patient With Alzheimer's Disease Complicated With Pulmonary Infection Who Underwent Emergency Right Artificial Femoral Head Replacement Surgery: A Case Report and Review of the Literature.","authors":"Wenying Song, Jing Huang, Ying Li, Jiajia Liu, Hui Ding","doi":"10.1155/crdi/4053129","DOIUrl":"10.1155/crdi/4053129","url":null,"abstract":"<p><p><b>Background:</b> Choosing the appropriate timing for surgery is a common clinical problem when hip fracture occurs in elderly patients with a variety of complications. <b>Case Presentation:</b> We present a fatal case involving an 84-year-old male patient with bradycardia who underwent cardiac pacemaker implantation and presented with cognitive impairment, Alzheimer's disease, and pulmonary infection and had an American Society of Anesthesiologists (ASA) IV status; this patient underwent emergency right artificial femoral head replacement surgery. We strengthened our perioperative evaluation and monitoring, but the patient's condition did not improve after the operation. <b>Conclusion:</b> We utilized multidisciplinary consultation before the operation, attempted to improve the state of the patient before the operation, chose an appropriate anesthetic scheme during the operation, strengthened cardiopulmonary protections, and returned the patient to the ward safely after the operation; however, the patient did not recover well post operation.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"4053129"},"PeriodicalIF":1.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shoulder Tuberculosis: Management of a Posteriori Diagnosis After a Reverse Prosthesis Implantation.","authors":"Giordano G, Lourtet-Hascoët J, Martin Blondel G, Bonnet E","doi":"10.1155/crdi/8378621","DOIUrl":"10.1155/crdi/8378621","url":null,"abstract":"<p><p>We report a rare case of reverse shoulder prosthesis implantation in a patient retrospectively showing a chronic tuberculous osteoarthritis and meningitis. In this atypical presentation, the patient presented only a chronic shoulder pain, with no clinical or imaging sign of tuberculosis. After the implantation of a reverse shoulder prosthesis, the patient presented a reactivation of a tuberculosis causing a meningitis. The diagnosis of shoulder osteoarthritis caused by <i>M. tuberculosis</i> was confirmed retrospectively on deep perioperative samples by standard culture, PCR, and positive pathology. The management of the patient consisted in 12 months of a medical antituberculosis therapy and showed a favorable outcome.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"8378621"},"PeriodicalIF":1.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Cases of Dengue Fever Confirmed in the National Hospitals of Zinder and Niamey.","authors":"Doutchi Mahamadou, Adamou Lagare, Moussa Sahada, Adamou Bara Abdoul-Aziz, Mahaman Moustapha Lamine, Souleymane Adoum Fils, Bagnou Hamsatou, Hamidou Issa Hama, George Thomas, Ramatou Hamidou Lazoumar, Garba Abdoul Aziz, Adehossi Eric","doi":"10.1155/crdi/6694128","DOIUrl":"10.1155/crdi/6694128","url":null,"abstract":"<p><p>Dengue is an emerging arbovirus infection caused by any of the four serotypes of dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4) and transmitted via the bite of a mosquito from the genus Aedes. We hereby report seven cases of dengue hospitalized at the infectious and tropical disease departments of the National Hospitals of Zinder and Niamey from October 22, 2023, to December 05, 2023. All the cases presented fever, vomiting, algic, and hemorrhagic syndrome. Results from the complete blood count analysis revealed that all the patients had thrombocytopenia, six cases have leukopenia and two cases have anemia. Furthermore, one case of kidney failure was recorded. The case confirmation was conducted at the National Reference Laboratory for Arbovirus on blood samples using qualitative Real-Time Polymerase Chain Reaction (qRT-PCR). The technic is based on the amplification of any of the four serotypes of dengue virus nucleic acid using specific primers and probes as described by Wagner et al. All the cases recovered after hospitalization.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6694128"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient.","authors":"Jeffrey Valencia Uribe, Ann-Katrin Valencia, Brian Nudelman, Nicole Nudelman, Dante P Melendez Lecca","doi":"10.1155/crdi/9917703","DOIUrl":"10.1155/crdi/9917703","url":null,"abstract":"<p><p><b>Background:</b> Co-infection with disseminated cryptococcosis and toxoplasma encephalitis is rare but presents significant diagnostic and therapeutic challenges, particularly in severely immunocompromised patients. This case study highlights the complexities involved in managing such dual infections. <b>Case Presentation:</b> We describe a 43-year-old Hispanic male with Stage IV EBV-positive diffuse large B-cell lymphoma and hemophagocytic lymphohistiocytosis who presented with progressive weakness and altered mental status. Initial brain MRI revealed multiple enhancing lesions. Diagnostic tests for cryptococcosis and toxoplasma were inconclusive; however, a positive cryptococcal antigen test, new lung nodules, and potential central nervous system involvement suggested possible disseminated cryptococcosis. Diagnosis of cryptococcal meningoencephalitis could not be confirmed due to negative CSF cultures. <b>Management and Outcome:</b> Despite initiating treatment with amphotericin B and flucytosine for suspected cryptococcosis, the patient's condition did not improve. Initial Karius and CSF PCR tests for Toxoplasma were negative. A subsequent brain biopsy, however, confirmed toxoplasmic encephalitis. Treatment was adjusted to intravenous Trimethoprim/Sulfamethoxazole for toxoplasmosis, with continued fluconazole for cryptococcosis. The patient exhibited significant clinical improvement with this revised therapy. <b>Conclusion:</b> Diagnosing concurrent cryptococcal and toxoplasma infections is challenging due to overlapping clinical symptoms and variability in test sensitivities. This case underscores the need for a comprehensive diagnostic approach and the critical role of brain biopsy when other diagnostic methods, such as Karius testing and CSF PCR, are inconclusive. Prompt empirical treatment based on clinical suspicion, with subsequent treatment adjustments guided by clinical response and follow-up assessments, is essential for effective management.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"9917703"},"PeriodicalIF":1.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergent Meningoencephalitis Following Spinal Anesthesia: A Case Report.","authors":"Yara Mouawad, Mahmoud El-Hussein, Joelle Kalaji, Patrick Nasrallah, Cima Hamieh, Eric Revue","doi":"10.1155/crdi/9468161","DOIUrl":"10.1155/crdi/9468161","url":null,"abstract":"<p><p><b>Background:</b> Iatrogenic meningitis is a rare but increasingly reported condition, particularly following invasive spinal procedures. The incidence is uncertain, ranging from none to two cases per 10,000 operations. Most cases involve infections with viridans streptococci. Septic meningitis presents with neurologic symptoms and elevated white blood cell counts in the cerebrospinal fluid (CSF), potentially leading to significant long-term neurologic damage or death if not promptly treated. <b>Case Presentation:</b> A 32-year-old previously healthy male presented with severe headache, phonophobia, photophobia, nuchal rigidity, and fever, one day after undergoing anterior cruciate ligament (ACL) reconstructive surgery under spinal anesthesia. Initial evaluation revealed a Glasgow Coma Scale (GCS) score of 11, leukocytosis with neutrophilia, and turbid CSF with 3200 WBC/mm², 100% neutrophils, and Gram-positive diplococci identified <i>as Streptococcus salivarius.</i> Blood cultures confirmed the same pathogen. The patient was diagnosed with meningoencephalitis, likely contracted via the spinal anesthesia procedure. Despite initial deterioration requiring intubation and intensive care, the patient responded well to targeted antibiotic therapy and was discharged in stable condition. <b>Discussion:</b> The clinical outcome of iatrogenic bacterial meningitis significantly depends on the virulence of the infecting organism. High-virulence pathogens have been associated with higher mortality rates, whereas infections caused by low-virulence bacteria like viridans streptococci generally have a more favorable prognosis. The infection likely occurred due to contamination during the spinal anesthesia procedure, despite the use of standard aseptic precautions. This underscores the importance of stringent infection control measures, including the use of face masks, thorough handwashing, sterile gloves, and appropriate skin antisepsis. <b>Conclusion:</b> This case highlights the potential for meningoencephalitis following spinal anesthesia, a rare but serious complication. Adhering to stringent aseptic guidelines and protocols is critical to prevent such infections. Prompt diagnosis and treatment are essential to mitigate the risks of severe neurologic damage and improve patient outcomes. Further research is needed to better understand the infection control measures that can prevent iatrogenic meningitis in spinal procedures.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"9468161"},"PeriodicalIF":1.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encased by Infection: A Rare Case of Retroperitoneal Fibrosis Induced by Disseminated Cysticercosis.","authors":"Lufeng Zhang, Shaoyang Zhan","doi":"10.1155/crdi/6221398","DOIUrl":"10.1155/crdi/6221398","url":null,"abstract":"<p><p>Cysticercosis refers to a disease caused by the larvae of <i>Taenia solium</i> parasitizing various tissues and organs of the human body. It is reported that cysticercosis is most commonly caused by the central nervous system, and retroperitoneal fibrosis is rare. We report a case of retroperitoneal fibrosis caused by cysticercosis and a urinary tract obstruction caused by retroperitoneal fibrosis, which was successfully relieved by transurethral stenting. The complex pathophysiological mechanism of cysticercosis-induced retroperitoneal fibrosis requires further study. In the diagnosis and treatment of the disease, it is very important to consider the patient's epidemiological history and the presence of parasite infection.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6221398"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}