Case Reports in Infectious Diseases最新文献_第4页

Late Relapse of Previous Pulmonary Cryptococcosis With Symptoms Resembling Cerebral Infarction: A Case Report. 症状类似脑梗塞的肺隐球菌病晚期复发：病例报告。

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Case Reports in Infectious Diseases Pub Date : 2024-10-04 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3905985

Anatoli Pinchuk, Gernot Geginat, Volker Rickerts, Belal Neyazi, Klaus Peter Stein, Christian Mawrin, I Erol Sandalcioglu, Ali Rashidi

{"title":"Late Relapse of Previous Pulmonary Cryptococcosis With Symptoms Resembling Cerebral Infarction: A Case Report.","authors":"Anatoli Pinchuk, Gernot Geginat, Volker Rickerts, Belal Neyazi, Klaus Peter Stein, Christian Mawrin, I Erol Sandalcioglu, Ali Rashidi","doi":"10.1155/2024/3905985","DOIUrl":"https://doi.org/10.1155/2024/3905985","url":null,"abstract":"Cryptococcosis, an infection caused by Cryptococcus neoformans and Cryptococcus gattii, predominantly targets the central nervous system (CNS) in patients with AIDS but is not limited to this group. The disease can also occur in individuals with various immunosuppressive conditions, frequently involving the brain or lungs. Cryptococcal meningitis (CM) is the most common form of fungal meningoencephalitis, leading to intracerebral infections, cerebral infarction, or hydrocephalus. The clinical presentation of CM is nonspecific, and imaging features can vary significantly. This case report presents a patient with cerebral infarction, who was HIV-negative but had been on long-term cortisone therapy. Notably, the patient had a history of pulmonary cryptococcosis 15 years prior to cerebral involvement. When initially at our clinic, histology and culture results from brain biopsies were negative and the earlier pulmonary cryptococcosis history was unknown. Subsequently, cryptococcal antigen was detected in both serum and cerebrospinal fluid (CSF), and C. neoformans was cultivated from CSF. This case highlights the critical importance of maintaining a high index of suspicion for CM, particularly in patients with a history of previous cryptococcal infections, and it also demonstrates the possibility of false-negative brain biopsy results due to secondary vascular events associated with CM.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"3905985"},"PeriodicalIF":1.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capnocytophaga canimorsus Septicemia With Sepsis-Induced Coagulopathy and Endocarditis. Capnocytophaga canimorsus 败血症伴有败血症引起的凝血功能障碍和心内膜炎。

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Case Reports in Infectious Diseases Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4010115

Jeannine L Kühnle, Maximilian Leitner, Vitalie Mazuru, Kai Borchardt, Sören L Becker, Franziska Roth, Robert Bals, Philipp M Lepper, Hans-Joachim Schäfers, Isabella T Jaumann

{"title":"Capnocytophaga canimorsus Septicemia With Sepsis-Induced Coagulopathy and Endocarditis.","authors":"Jeannine L Kühnle, Maximilian Leitner, Vitalie Mazuru, Kai Borchardt, Sören L Becker, Franziska Roth, Robert Bals, Philipp M Lepper, Hans-Joachim Schäfers, Isabella T Jaumann","doi":"10.1155/2024/4010115","DOIUrl":"https://doi.org/10.1155/2024/4010115","url":null,"abstract":"Capnocytophaga canimorsus is a rare cause of serious infections with a high mortality of 10% to 30%. It is usually found in the oral cavity of cats and dogs and can cause severe sepsis in immunocompromised patients. An 81-year-old female Caucasian patient presented with C. canimorsus sepsis after a dog bite in her finger three days before presentation to our emergency department. She initially was presented to us with sepsis, thrombopenia, and schistocytes in her laboratory findings, suggesting the differential diagnoses of the multiple subtypes of thrombotic microangiopathy. She was admitted to the medical intensive care unit of the University Hospital of Saarland because of septic shock with circulatory insufficiency. The patient received plasmapheresis, antibiotics, and dialysis, under which she improved significantly. The fingertip of the affected finger developed necrosis and had to be amputated. Furthermore, the patient was diagnosed with a mitral valve endocarditis, a very rare complication of C. canimorsus infection. It was treated conservatively with antibiotics and was no longer detectable 8 weeks after the diagnosis. Surgical intervention was not needed. The case describes well that it is still difficult to distinguish between thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC), and sepsis-induced coagulopathy (SIC), especially in the early phases of acute disease, especially in C. canimorsus-induced sepsis.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"4010115"},"PeriodicalIF":1.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocal Osteomyelitis in an Adolescent Patient With Cat Scratch Disease. 一名青少年猫抓病患者的多灶性骨髓炎

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Case Reports in Infectious Diseases Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9562634

Burcu Topçu, Hale Usluer Gönüllü, Osman Yeşilbaş, Pınar Polat Suma, Ahmet Soysal

{"title":"Multifocal Osteomyelitis in an Adolescent Patient With Cat Scratch Disease.","authors":"Burcu Topçu, Hale Usluer Gönüllü, Osman Yeşilbaş, Pınar Polat Suma, Ahmet Soysal","doi":"10.1155/2024/9562634","DOIUrl":"https://doi.org/10.1155/2024/9562634","url":null,"abstract":"Cat scratch disease (CSD) typically presents as a self-limiting lymphadenopathy associated with a cat bite or scratch and commonly affects children and young adults. Atypical manifestations, involving the eyes, nervous system, heart, liver, spleen, skin, and musculoskeletal system, could be severe and difficult to diagnose, and they could occur in 5%-20% of the cases. Herein, we report an unusual case of CSD with multifocal osteomyelitis. A 15-year-old girl presented with right axillary lymphadenopathy. Since she had a history of cat scratch, azithromycin was started for CSD. Two days later, she was readmitted to our hospital with severe back pain which required differential diagnosis. Lumbar spinal magnetic resonance imaging (MRI) revealed multifocal vertebral osteomyelitis. The patient was hospitalized, and then teicoplanin and cefotaxime were added to the azithromycin therapy. After excluding the possible other causes, the definitive diagnosis of osteomyelitis secondary to CSD was made upon the combination of the MRI scan findings of the vertebrae, histopathological investigation of excisional right axillary biopsy, positron-emission tomography/computed tomography (PET/CT), and Bartonella henselae serologies. Atypical manifestations of CSD are widely variable; therefore, it should be kept in mind in the differential diagnosis of severe musculoskeletal pain and osteomyelitis.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"9562634"},"PeriodicalIF":1.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Neutralizing Capacity of Tixagevimab plus Cilgavimab (AZD7442) against Different SARS-CoV-2 Variants: A Case Report Study with Comparison to a Vaccinated Population. 评估 Tixagevimab 加 Cilgavimab (AZD7442) 对不同 SARS-CoV-2 变体的中和能力：与接种疫苗人群进行比较的病例报告研究。

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Case Reports in Infectious Diseases Pub Date : 2024-08-31 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9163490

Constant Gillot, Jean-Louis Bayart, Vincent Maloteau, Jean-Michel Dogné, Jonathan Douxfils, Julien Favresse

{"title":"Evaluation of Neutralizing Capacity of Tixagevimab plus Cilgavimab (AZD7442) against Different SARS-CoV-2 Variants: A Case Report Study with Comparison to a Vaccinated Population.","authors":"Constant Gillot, Jean-Louis Bayart, Vincent Maloteau, Jean-Michel Dogné, Jonathan Douxfils, Julien Favresse","doi":"10.1155/2024/9163490","DOIUrl":"10.1155/2024/9163490","url":null,"abstract":"AZD7442 (150 mg of tixagevimab plus 150 mg of cilgavimab) has been approved for the preexposure prophylaxis of COVID-19 and for the treatment of adults and adolescents with COVID-19 who do not require supplemental oxygen and who are at increased risk of severe COVID-19. Thus, the aim of the present study is to evaluate the neutralizing capacity of tixagevimab and cilgavimab across different SARS-CoV-2 variants in two patients who received AZD7442 for immunoprophylaxis. A cohort of subjects (n = 45) who had received the BNT162b2 mRNA COVID-19 vaccine has been included to compare these two preventive strategies. Neutralizing antibody (NAb) titers against several variants were assessed against the wild-type, alpha, beta, gamma, delta, omicron BA.5, and XBB.1.5 variants. Binding antibodies have also been measured. NAbs T 1/2 for AZD7442 was 8.1 days (95% CI: 5.1-19.5 days) and was 11.8 days (95% CI: 7.9-23.7 days) for the primo-vaccination cohort. The time to reach neutralization negativity was 108.3 days (95% CI: 66.9-130.7) for AZD7442 compared to 95.4 days (95% CI: 31.0-119.7 days) for the primo-vaccination cohort. The time to reach NAbs' negativity differs between variants with the maximum value obtained for alpha (i.e., 101.1 days (95% CI: 30.0-135.4 days)) and the minimum obtained for beta (i.e., 61.2 days (95% CI: 37.8-77.1 days)). Our results reinforce the need of reviewing the use of AZD7442 in relation to variants of concern and potentially adapting its administration schedule. AZD7442 could be indicated for short-term prophylaxis in frail patients who may be acutely exposed to SARS-CoV-2.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"9163490"},"PeriodicalIF":1.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of a Rare Rickettsia felis Infection Complicated with Unusual Pericardial Effusion and Cardiac Tamponade Using an mNGS Test. 使用 mNGS 检测诊断并发异常心包积液和心脏填塞的罕见立克次体感染。

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Case Reports in Infectious Diseases Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8877876

Tien-Lung Po, Chien-Hsien Huang, Chia-Hsun Lin, Huei-Fong Hung

{"title":"Diagnosis of a Rare Rickettsia felis Infection Complicated with Unusual Pericardial Effusion and Cardiac Tamponade Using an mNGS Test.","authors":"Tien-Lung Po, Chien-Hsien Huang, Chia-Hsun Lin, Huei-Fong Hung","doi":"10.1155/2024/8877876","DOIUrl":"10.1155/2024/8877876","url":null,"abstract":"The occurrence of sporadic rickettsial infections has been consistently undervalued and overlooked, primarily owing to a limited emphasis on routine examinations for rickettsioses in clinical practice. At present, the immunofluorescence assay is the prevailing diagnostic method for suspected rickettsioses that enables the detection of specific antibodies against rickettsia in human serum. Herein, we present an exceptional instance of rickettsial infection that was characterized by a rare manifestation of extensive pericardial effusion leading to dyspnea and cardiac tamponade. A diagnosis of chronic fibrosing pericarditis was established based on pericardium tissue obtained through pericardiotomy, and a conclusive metagenomic next-generation sequencing test confirmed the presence of Rickettsia felis infection. The cat flea, scientifically known as Ctenocephalides felis, is the predominant carrier of R. felis. An escalating incidence of human R. felis infections has raised concerns, particularly in light of the burgeoning population of domesticated animals in many contemporary societies.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"8877876"},"PeriodicalIF":1.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Swift Onset, Swift Recovery: Unusual Nonrheumatic Myocarditis in a Young Adult Post Group A Streptococcal Pharyngitis. 迅速发病，迅速恢复：A 组链球菌咽炎后一名年轻成人的非风湿性心肌炎。

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Case Reports in Infectious Diseases Pub Date : 2024-08-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4942739

Andres Rios, Colby Wood, Ricardo Isaiah Garcia, Emily C Mitchell, Jacob Nichols

{"title":"Swift Onset, Swift Recovery: Unusual Nonrheumatic Myocarditis in a Young Adult Post Group A Streptococcal Pharyngitis.","authors":"Andres Rios, Colby Wood, Ricardo Isaiah Garcia, Emily C Mitchell, Jacob Nichols","doi":"10.1155/2024/4942739","DOIUrl":"10.1155/2024/4942739","url":null,"abstract":"This case report highlights the unusual presentation and management of nonrheumatic myocarditis in a 24-year-old male, an age demographic not commonly associated with myocardial complications following Group A streptococcal pharyngitis. The patient, devoid of any prior medical history, manifested symptoms one day after being diagnosed with Group A streptococcal pharyngitis, a stark contrast to the typical progression of myocardial complications. The swift onset of symptoms and the patient's subsequent clinical presentation necessitated a comprehensive diagnostic approach. The patient's symptoms were successfully alleviated with amoxicillin and anti-inflammatory therapy, underscoring its potential efficacy in managing nonrheumatic myocarditis. This case serves as a poignant reminder of the importance of maintaining a broad differential diagnosis, especially in atypical presentations, and the pivotal role of timely clinical intervention. The insights from this report contribute to the broader understanding of nonrheumatic myocarditis, emphasizing the significance of tailored diagnostic and therapeutic strategies to ensure optimal patient outcomes.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"4942739"},"PeriodicalIF":1.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bartonella henselae Hepatic Abscesses and Associated Osteomyelitis in a Pediatric Patient. 一名小儿患者的肝脓肿和相关骨髓炎（Bartonella henselae Hepatic Abscess and Associated Osteomyelitis）。

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Case Reports in Infectious Diseases Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7810497

Molly Antonson, Lauren Klingemann, Kari Neemann

{"title":"Bartonella henselae Hepatic Abscesses and Associated Osteomyelitis in a Pediatric Patient.","authors":"Molly Antonson, Lauren Klingemann, Kari Neemann","doi":"10.1155/2024/7810497","DOIUrl":"10.1155/2024/7810497","url":null,"abstract":"Bartonella henselae is a Gram-negative bacillus transmitted to humans via cat saliva or scratch. Cat scratch disease, the typical clinical manifestation of B. henselae infection, presents as localized cutaneous or regional lymphadenopathy. Rare, atypical presentations, generally reflecting bloodborne disseminated disease, can include hepatosplenic, cardiac, ocular, neurologic, or musculoskeletal involvement. Here, we present a case of disseminated B. henselae with hepatic abscesses and associated ischial osteomyelitis in an immunocompetent 2-year-old male patient. Although osteomyelitis is a rare manifestation of B. henselae infection, it should be included in the differential diagnosis in pediatric patients presenting with fever of unknown origin and musculoskeletal pain, especially in the setting of cat exposure. Hepatic involvement of B. henselae infection is associated with significant morbidity; therefore, abdominal imaging is critical in the diagnostic workup. This patient was successfully treated after a 6-week course of azithromycin and rifampin, as evidenced by symptom resolution and improved fluid collections on repeat imaging. While most cases of B. henselae resolve without treatment, in severe or disseminated infection such as this case, antibiotics such as azithromycin and rifampin should be considered for treatment.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"7810497"},"PeriodicalIF":1.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Bacterial Meningitis Caused by Hematogenous Spread of Vancomycin-Resistant Enterococcus faecium in an Immunocompromised Patient. 免疫力低下患者因耐药万古霉素肠球菌血源性传播引发细菌性脑膜炎的罕见病例。

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Case Reports in Infectious Diseases Pub Date : 2024-07-25 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2193650

Myeongji Kim, Christopher Graham, Ryan W Stevens, Aditya Shah

引用次数: 0

Diagnosis and Treatment Challenges of Candida guilliermondii in Immunocompromised Patients: A Case Study in a Neutropenic AML Patient. 免疫力低下患者中吉利蒙地念珠菌的诊断和治疗难题：中性粒细胞减少性急性髓细胞白血病患者的病例研究。

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Case Reports in Infectious Diseases Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7806235

Dhruvi Modi, Sophie Dessureault, John Greene

{"title":"Diagnosis and Treatment Challenges of Candida guilliermondii in Immunocompromised Patients: A Case Study in a Neutropenic AML Patient.","authors":"Dhruvi Modi, Sophie Dessureault, John Greene","doi":"10.1155/2024/7806235","DOIUrl":"10.1155/2024/7806235","url":null,"abstract":"Although fungal infections causing intestinal perforation and necrosis are rare, they can be particularly dangerous in immunosuppressed patients, often leading to increased mortality rates and poor prognoses. Candida species are typically surface fungi, but in patients with compromised immune systems, they can invade the small intestine and cause angioinvasive infections. A case study involving a 30-year-old female with acute myeloid leukemia (AML) illustrates this phenomenon. The patient was presented with symptoms of abdominal pain, fever, diarrhea, recurrent episodes of intestinal necrosis, hematomas due to thrombocytopenia, and subsequent postoperative enterocutaneous fistulas. Extensive testing ruled out other possible causes of intestinal necrosis and enteritis, including Crohn's and CMV diseases. Candida guilliermondi was ultimately identified in blood cultures from the periphery, peritoneal fluid, and intestinal biopsy of respected sections, indicating that it was responsible for intestinal invasion and necrosis. The patient was then treated with amphotericin B, cefepime, and metronidazole. This case highlights the potential severity of fungal infections in immunosuppressed patients, particularly Candida species, and the importance of prompt diagnosis and appropriate treatment.","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"7806235"},"PeriodicalIF":1.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clostridium paraputrificum Bacteremia and Ectopic Ileal Varices in Underlying Chronic Portal and Superior Mesenteric Vein Thrombosis: Report of a Rare Case. 伴有慢性门静脉和肠系膜上静脉血栓的副猪梭状芽孢杆菌菌血症和异位回肠静脉曲张：罕见病例报告。

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Case Reports in Infectious Diseases Pub Date : 2024-07-18 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9443664

Grigorios Smanis, Eirini Avgoustou, Ioannis Papadopoulos, Antonios Papadopoulos, Athanasios Athanasakos, Elias Athanasiadis, Foula Vassilara

引用次数: 0