Case Reports in Infectious Diseases最新文献

{"title":"Osteomyelitis of the Hip due to <i>Granulicatella adiacens</i>: A Case Report of an Extremely Rare Cause of Bone Infection.","authors":"Niccolò Garofalo, Lorenzo Onorato, Margherita Macera, Ilaria De Luca, Gabriele Martin, Gianluca Conza, Annalisa Itro, Nicola Coppola, Giuseppe Toro","doi":"10.1155/crdi/7967434","DOIUrl":"10.1155/crdi/7967434","url":null,"abstract":"<p><strong>Background: </strong><i>Granulicatella adiacens (G. adiacens)</i> is a nutritionally variant <i>Streptococcus</i> generally observed in the human mouth microbiota. Although <i>G</i>. <i>adiacens</i> is involved in bacterial endocarditis and bacteremia, bone and joint infections are extremely rare. In the present study, we reported the first known case of hip osteomyelitis related to <i>G. adiacens</i>. Moreover, a commentary on the available evidence was also performed.</p><p><strong>Case presentation: </strong>A 59-year-old male with a former substance use disorder who initially complained of low back pain with a medical history negative for any other comorbidities, albeit absence seizures. After an accurate evaluation, hip osteomyelitis caused by <i>G. adiacens</i> was diagnosed. In our patient, neither bacteremia nor infectious endocarditis was reported, as well as previous oral surgery. The diagnosis of <i>G. adiacens</i> was performed through 16S rRNA gene sequencing. A three-stage surgery was performed based on surgical debridement and antibiotic-cemented spacer implant, antibiotic-cemented spacer renewal, spacer removal, and prosthesis implantation. Throughout the entire period, the patient received antibiotic therapy with doxycycline and cotrimoxazole. At the final follow-up, the patient was infection-free, but a poor hip function was reported.</p><p><strong>Conclusion: </strong><i>G. adiacens</i> is rarely associated with bone osteomyelitis, probably because of the difficulty in culture isolation that might lead to misdiagnosis, especially in cases of polymicrobial infection. In our experience, debridement, prolonged antibiotics, and two-stage/three- stage prosthesis implantation could be considered as a treatment strategy for hip osteomyelitis involving <i>G.</i> a<i>diacens</i>.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"7967434"},"PeriodicalIF":0.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking Tuberculosis Pericarditis: The Role of Xpert MTB/RIF in Early Diagnosis and Treatment-A Case Report.","authors":"Saumya Nanda, Tharun Shyam, Prabal K C, Oluchi Ndulue, Daniel Jacobs, Armando Seitllari, Shaurya Sharma, Yu Shia Lin, Vijay Shetty","doi":"10.1155/crdi/2518518","DOIUrl":"10.1155/crdi/2518518","url":null,"abstract":"<p><p>Tuberculous pericarditis (TBP) is an uncommon but serious form of extrapulmonary tuberculosis that remains diagnostically challenging due to its nonspecific clinical features and the limited sensitivity of conventional methods such as smear microscopy, culture, and histopathology. We describe an 80-year-old man presenting with recurrent fever and weakness, found to have a large pericardial effusion with tamponade physiology requiring emergent pericardial window drainage. Pericardial fluid analysis demonstrated an exudative, lymphocyte-predominant effusion with elevated lactate dehydrogenase and low glucose levels, but initial acid-fast bacillus smear, histopathology, and sputum studies were negative. Xpert MTB/RIF testing performed on pericardial fluid detected <i>Mycobacterium tuberculosis</i>, enabling early initiation of antitubercular therapy prior to culture confirmation. This case underscores the importance of considering TBP in patients with unexplained pericardial effusion, particularly in those with epidemiologic risk factors, and highlights the diagnostic value of Xpert MTB/RIF as a rapid and highly specific molecular assay that can expedite diagnosis and improve clinical outcomes.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2518518"},"PeriodicalIF":0.8,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptococcal Meningitis Beyond Immunosuppression: A Case Report in an Immunocompetent Individual.","authors":"Ariba Sultan, Huda Raja, Amna Abrar, Abdullah Nadeem, Shameem Behram Khan, Nahid Raufi","doi":"10.1155/crdi/8630525","DOIUrl":"10.1155/crdi/8630525","url":null,"abstract":"<p><strong>Background: </strong>Cryptococcal meningitis is a life-threatening opportunistic fungal infection predominantly seen in immunocompromised hosts, yet it is increasingly recognized in apparently immunocompetent individuals. In tuberculosis-endemic regions, its diagnosis is frequently delayed or missed due to overlapping clinical and cerebrospinal fluid findings with tuberculous meningitis.</p><p><strong>Case presentation: </strong>A 44-year-old immunocompetent woman presented with a two-month history of progressive diffuse headache and subjective bilateral lower limb weakness. Neurological examination was unremarkable, and initial cerebrospinal fluid analysis revealed marked hypoglycorrhachia (1 mg/dL), elevated protein (356 mg/dL), and lymphocytic pleocytosis. Brain imaging showed leptomeningeal enhancement without mass lesions. Despite negative microbiological testing for tuberculosis, empirical antituberculous therapy was initiated based on presumptive tuberculous meningitis. Pulmonary imaging demonstrated cavitary nodules and calcified lymph nodes. Lack of clinical improvement prompted further investigation; India ink staining and fungal culture of cerebrospinal fluid eventually confirmed <i>Cryptococcus neoformans</i> infection. The patient had no evidence of HIV, diabetes, or other immunosuppressive conditions. Induction therapy with liposomal amphotericin B and fluconazole was administered, followed by consolidation and maintenance fluconazole. She showed marked clinical and cerebrospinal fluid improvement and was discharged on oral fluconazole with sustained recovery.</p><p><strong>Discussion: </strong>This case illustrates the diagnostic challenge of cryptococcal meningitis in immunocompetent patients, particularly in settings where tuberculous meningitis is common. Early reliance on India ink staining and fungal culture is essential when initial tuberculosis workup is negative or when response to antituberculous therapy is poor. The incidental detection of HHV-6 DNA likely represented viral reactivation without clinical significance.</p><p><strong>Conclusion: </strong>Cryptococcal meningitis must be considered in immunocompetent patients presenting with chronic meningitis, even in the absence of classic risk factors. Prompt mycological investigation can prevent diagnostic delays and improve outcomes.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"8630525"},"PeriodicalIF":0.8,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Nocardiosis Diagnosed by Plasma Metagenomic Next-Generation Sequencing in a Patient With Recurrent Febrile Neutropenia.","authors":"Maria Vega Brizneda, Jessica Lum, Hannah Wang, Zachary A Yetmar","doi":"10.1155/crdi/2832247","DOIUrl":"10.1155/crdi/2832247","url":null,"abstract":"<p><strong>Background: </strong>Nocardiosis disproportionately affects immunocompromised hosts. Early identification of <i>Nocardia</i> infections is critical as delays can lead to worse outcomes. Species such as <i>N. farcinica</i> are associated with increased risk of dissemination and resistance. Diagnosis of opportunistic infections in immunocompromised populations relies on culture, antigen, or serologic methods that often have limited sensitivity or specificity. Plasma microbial cell-free DNA metagenomic next-generation sequencing (mNGS) offers a noninvasive approach for early diagnosis of opportunistic infections.</p><p><strong>Case presentation: </strong>We report a case of pulmonary nocardiosis in an 87-year-old man with myelodysplastic syndrome and prolonged neutropenia diagnosed by plasma mNGS. He had been hospitalized multiple times with recurrent febrile neutropenia and respiratory symptoms. Standard noninvasive microbiologic workup was unrevealing, but lower respiratory specimens could not be readily obtained. Due to elevated risk of complications from invasive testing, plasma mNGS was used as a complementary tool and identified <i>N. farcinica</i>. Anti-<i>Nocardia</i> therapy was initiated, and his fevers resolved.</p><p><strong>Conclusion: </strong>mNGS is an emerging diagnostic tool that may identify <i>Nocardia</i> species from clinical specimens with a faster turnaround time than culture and enables rapid species identification. Although culture is still recommended for susceptibility testing, mNGS may expedite diagnosis in particular situations. This case supports the role of plasma mNGS as a complementary tool in the evaluation of febrile neutropenia and highlights its diagnostic potential.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2832247"},"PeriodicalIF":0.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13373437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Acquired Pneumococcal Ventriculitis as a Complication of Otogenic Pneumococcal Meningitis: A Case Report.","authors":"Marco Seneghini, Jonas Deppe, Alexis P R Terrapon, Philipp Balcerak, Georg Kägi, Werner C Albrich","doi":"10.1155/crdi/8876814","DOIUrl":"10.1155/crdi/8876814","url":null,"abstract":"<p><p>Pyogenic ventriculitis is a rare and potentially fatal infection of the ventricular system. While most reported cases are nosocomial and catheter-associated, ventriculitis as a complication of community-acquired bacterial meningitis is uncommon, particularly in adults, and carries a poor prognosis. We report the case of an 82-year-old previously healthy and unvaccinated woman who presented with a one-day history of fever, confusion, and purulent left-sided otorrhea on a 2-week background of flu-like symptoms. Cranial computed tomography was consistent with otogenic meningitis complicated by pneumocephalus, and lumbar puncture confirmed purulent meningitis. Empirical therapy for meningitis with ceftriaxone, amoxicillin, metronidazole, and dexamethasone was initiated, and surgical source control of the otogenic focus was performed. Both blood and cerebrospinal fluid cultures grew <i>Streptococcus pneumoniae</i> with a penicillin minimum inhibitory concentration of < 0.03 mg/L. Serotyping by multiplex PCR with confirmatory Quellung reaction, performed at the Swiss National Reference Center for Invasive Pneumococci, identified Serotype 3. Despite penicillin G monotherapy, fever and impaired consciousness persisted, and repeat imaging revealed meningitis-associated pyogenic ventriculitis with intraventricular debris. Adjunctive rifampicin and a series of cerebrospinal fluid drainage interventions (lumbar drain followed by external ventricular drain) failed to substantially improve neurological outcome. Antibiotic therapy was continued for 9 weeks, after which the patient was transferred to long-term institutional care with severe residual neurological impairment. This case illustrates the diagnostic and therapeutic challenges of meningitis-associated pyogenic ventriculitis in adults and the disproportionate severity of disease caused by Serotype 3 <i>S. pneumoniae</i>, whose unusually thick mucoid capsule promotes immune evasion and the formation of viscous purulent debris that hampers source control. The case is consistent with Swiss surveillance data showing that Serotype 3 remains a leading cause of invasive pneumococcal disease in older adults and serves as a sentinel event highlighting persistent gaps in adult pneumococcal immunization.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"8876814"},"PeriodicalIF":0.8,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148444485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piperacillin/Tazobactam-Induced Bilateral Optic Disc Edema With Serous Retinal Fluid in a Young Female With Pelvic Abscess and Sepsis.","authors":"Georgios Papaetis, Ioannis Kazakos, Eleftheria Lazarou, Pantelis Kountourakis, Charis Antoniou, Konstantinos Mikellidis","doi":"10.1155/crdi/2925958","DOIUrl":"10.1155/crdi/2925958","url":null,"abstract":"<p><strong>Introduction: </strong>The typical visual symptoms of optic disc edema are transient visual obscurations due to fluctuations of the optic nerve head blood perfusion. If it remains untreated, it can cause damage and significant vision loss. Piperacillin/tazobactam (PIP/TAZ) exerts broad activity against most gram-positive and gram-negative aerobic and anaerobic bacteria, including many pathogens producing beta-lactamases. It is administered for the treatment of moderate-to-severe bacterial infections. Ocular adverse reactions after the administration of PIP/TAZ have been rarely reported.</p><p><strong>Case presentation: </strong>We report a case of a 32-year-old woman, who developed pelvic abscess and sepsis, as a complication of caesarean section. She experienced bilateral optic disc edema with associated intraretinal and subretinal fluid during PIP/TAZ therapy. PIP/TAZ was discontinued the fourth day of its administration and was substituted with ertapenem. Progressive resolution of optic disc edema in both eyes, with complete normalization of the fundus and retinal nerve fiber layer thickness, was observed 2 months after drug discontinuation. However, persistent bilateral discontinuity of the foveal ellipsoid zone remained.</p><p><strong>Conclusion: </strong>Bilateral optic disc edema with serous retinal fluid after PIP/TAZ therapy is very rare. Prompt discontinuation of the medication and ophthalmic evaluation should be immediately considered when visual symptoms arise. Further pharmacovigilance reporting is warranted to clarify the rarity of this adverse effect after PIP/TAZ administration.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2925958"},"PeriodicalIF":0.8,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13359116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosyphilis Presenting as Rapid Cognitive Decline With Demonstrated Improvement Posttreatment: A Case Report.","authors":"James Smith, Michael Angputra, Roger Ho","doi":"10.1155/crdi/1161141","DOIUrl":"10.1155/crdi/1161141","url":null,"abstract":"<p><p>Syphilis has become an increasing public health concern in recent times, with rising incidence globally. It is often referred to as the 'great imitator' due to its diverse clinical presentations across multiple stages. Neurosyphilis, a tertiary manifestation of <i>Treponema pallidum</i> infection, can present with neuropsychiatric features including rapid cognitive decline. It remains an important but potentially overlooked cause of cognitive impairment (CI). However, few cases document objective cognitive and functional improvement following treatment, especially within a short time frame. We describe the case of a 67-year-old man with rapid cognitive decline, displaying impairments in various cognitive domains: learning and memory, attention and executive functioning. The presence of Argyll-Robertson pupils combined with positive serological and cerebrospinal fluid testing confirmed a diagnosis of neurosyphilis. Following treatment with intravenous penicillin G, serial cognitive assessment demonstrated objective improvement in his cognition and functioning within 1 month of treatment. Our observation of such an improvement in neurosyphilis-driven CI in this time frame is a finding not commonly documented in associated literature. This case highlights the importance of thorough history taking, including a sexual history, alongside physical examination in diagnosing neurosyphilis. Additionally, it supports the importance of considering neurosyphilis when investigating patients with unexplained cognitive decline and suggests there is a degree of reversibility when treated promptly. Further research is needed to better characterise the treatability of neurosyphilis-related CI.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"1161141"},"PeriodicalIF":0.8,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13357987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Peritoneal Dialysis-Associated Peritonitis Due to <i>Mycobacterium tuberculosis</i>: Case Report and Review of the Literature.","authors":"Jenna Maco Wick, Joseph David Cooper","doi":"10.1155/crdi/5448802","DOIUrl":"10.1155/crdi/5448802","url":null,"abstract":"<p><p>A 73-year-old man from the Philippines with Type 2 diabetes mellitus and end-stage renal disease on peritoneal dialysis developed peritonitis. The infection was refractory to empiric therapy, and the pathogen was identified as <i>Mycobacterium tuberculosis</i>, when 4 weeks after collection, a preliminary positive AFB culture underwent PCR testing. He did not initially tolerate a regimen of isoniazid, rifampin, pyrazinamide, and ethambutol but temporarily tolerated rifabutin, levofloxacin, and ethambutol and ultimately tolerated a regimen of levofloxacin, ethambutol, and pyrazinamide. This case highlights the diagnostic and treatment challenges of peritonitis due to tuberculosis, emphasizing the importance of including tuberculosis in the differential diagnosis. Given the severity and the limited current understanding, further research is needed to guide effective management and improve outcomes.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"5448802"},"PeriodicalIF":0.8,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13352137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-Associated <i>Burkholderia cenocepacia</i> Infective Endocarditis in a Patient Receiving Maintenance Hemodialysis.","authors":"Zhong Xhen Khor, Xin Yee Chong, Nor Zanariah Zainol Abidin, Kok Soon Lee","doi":"10.1155/crdi/6619649","DOIUrl":"10.1155/crdi/6619649","url":null,"abstract":"<p><p><i>Burkholderia cenocepacia</i>, a member of the <i>Burkholderia cepacia</i> complex (BCC), is an opportunistic, intrinsically multidrug-resistant Gram-negative bacillus most commonly associated with nosocomial outbreaks and chronic pulmonary infection in patients with cystic fibrosis. Endocarditis caused by <i>B. cenocepacia</i> is extremely rare and has been reported mainly in intravenous drug users or in association with prosthetic valves. We report a fatal case of native mitral valve infective endocarditis caused by <i>B. cenocepaci</i>a in a patient with end-stage renal disease (ESRD) receiving maintenance hemodialysis. A 50-year-old woman with diabetes mellitus, hypertension, and ESRD on hemodialysis had recently been treated for <i>B. cenocepacia</i> bacteremia, identified by MALDI-TOF MS, with a 2-week course of intravenous ceftazidime. During the same admission, thrombosis of her arteriovenous fistula necessitated placement of a central venous dialysis catheter. She represented shortly after discharge with altered mental status. Blood cultures obtained from both peripheral and central sites again yielded Gram-negative bacilli, with differential time to positivity suggesting a catheter-related source. The organism was identified as <i>B. cenocepacia</i> by MALDI-TOF mass spectrometry. Transthoracic echocardiography demonstrated a mobile mitral valve vegetation measuring 1.6 × 0.9 cm. Given extensive comorbidities and poor surgical candidacy, care was transitioned to palliation and the patient died during hospitalization. This case highlights the potential for <i>B. cenocepacia</i> to cause invasive endocardial infection in hemodialysis patients with indwelling central venous catheters.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"6619649"},"PeriodicalIF":0.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Headache and Visual Field Loss: Manifestations in a Patient With Chronic <i>Brucellosis</i> Meningitis: Case Report With Brief Literature Review.","authors":"Shiva Shabani","doi":"10.1155/crdi/8192652","DOIUrl":"10.1155/crdi/8192652","url":null,"abstract":"<p><p>Brucellosis is a zoonotic infection caused by <i>Brucella</i> species, often leading to serious complications and presenting diagnostic challenges. A 45-year-old female patient presented with a headache that had persisted for two months and was recently accompanied by visual disturbances. Notably, the patient's headache began 6 weeks postpartum, and she had no prior history of illness, medication use, or headaches. Imaging studies were normal, and cerebrospinal fluid (CSF) analysis revealed meningitis, with a positive Wright test. After excluding other potential causes and considering the patient's consumption of local dairy products, the diagnosis of <i>Brucella</i> meningitis was confirmed. The patient was treated with a standard three-drug regimen for 6 months and was followed throughout the treatment period. Initially, her headache resolved, followed by improvement in visual symptoms. Follow-up serologic tests showed a declining trend in <i>Brucella</i> titers, and perimetry results returned to normal by the fourth month of treatment. This case underscores the importance of including <i>Brucella</i> in the differential diagnosis of patients with chronic meningitis, especially in endemic regions, and highlights the favorable outcomes associated with prompt treatment.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"8192652"},"PeriodicalIF":0.8,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}