Case Reports in Infectious Diseases最新文献

{"title":"Drug-Induced Hyperprolactinemia and Granulomatous Mastitis: A Case Report and Literature Review.","authors":"Mohammed Alenazi, Sarah Howse, Syed Ali Imran","doi":"10.1155/crdi/9409072","DOIUrl":"10.1155/crdi/9409072","url":null,"abstract":"<p><p>Granulomatous mastitis (GM) is a rare inflammatory condition of the breast that can mimic inflammatory breast cancer. We report a case of a 54-year-old female who developed recurrent GM symptoms in the context of drug-induced hyperprolactinemia, which resolved with dopamine agonist therapy. Our report suggests that serum prolactin should be tested in patients with GM and appropriately managed if elevated.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"9409072"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone and Joint Tuberculosis: The Experience From a Tuberculosis Department in Northern Greece.","authors":"Anastasios Vogiatzoglou, Maria Hadji Mitrova, Eleni Papadaki, Maria Sionidou, Katerina Manika","doi":"10.1155/crdi/1632733","DOIUrl":"10.1155/crdi/1632733","url":null,"abstract":"<p><p><b>Introduction:</b> Tuberculosis (TB) of bones and joints is a relatively rare manifestation of the disease. Biopsy is the key to diagnosing it, while chemotherapy is the cornerstone of treatment. Some patients need surgery in addition to anti-TB drugs. We present a series of eight cases of bone and joint TB. <b>Method:</b> The files of the patients with TB diagnosed and treated at the Pulmonary Department of Aristotle University of Thessaloniki (A.U.Th.) between 2013 and 2022 were reviewed. Patients with a bone or joint infection due to <i>M. tuberculosis</i> were selected. <b>Cases Presentation:</b> During these ten years, 307 cases of TB were found. Eight of them were TB of bones and joints (2.6%). Six patients were men and two women, with a mean age of 53.5 years and a standard deviation of 18.2 years. Half of them were native Greeks. The spine was involved in 4 cases, while two of the patients also had pulmonary TB. In seven cases, <i>M. tuberculosis</i> DNA was detected by PCR. Chemotherapy with anti-TB drugs was administered to all eight patients, with three of them undergoing surgery in addition to anti-TB medication. The minimum treatment duration was twelve months. Six out of eight cases had a good outcome. <b>Conclusions:</b> TB is a rare cause of infection of bones and joints; however, it should be included in the differential diagnosis of bone lesions. PCR for <i>M. tuberculosis</i> seems to have significantly good results in microbiological confirmation of osteoarticular TB.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"1632733"},"PeriodicalIF":1.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cefiderocol-Resistant <i>Elizabethkingia anophelis</i> Bacteremia Following WATCHMAN Implantation: A Case Report and Review of the Literature.","authors":"Anna DeFrank, Michael Bosco, Sigridh Muñoz Gómez, Amit Dhaliwal","doi":"10.1155/crdi/5221364","DOIUrl":"10.1155/crdi/5221364","url":null,"abstract":"<p><p><i>Elizabethkingia anophelis</i> is an emerging pathogen associated with nosocomial and community outbreaks. Treatment of infection caused by <i>E. anophelis</i> is not well-defined given its extensive drug resistance profile, and infection carries a poor prognosis. <i>E. anophelis</i> is intrinsically resistant to many classes of antibiotics including carbapenems and polymyxins due to multiple resistance genes. Resistance to novel β-lactam/β-lactamase inhibitors has also been reported. The activity of cefiderocol (FDC) is unknown. Here, we describe a case of FDC-resistant <i>E. anophelis</i> bacteremia following WATCHMAN implantation. To our knowledge, this is the first reported case of FDC resistance amongst <i>Elizabethkingia</i> spp.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"5221364"},"PeriodicalIF":1.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Outcome of Membranoproliferative Glomerulonephritis in a Patient With Hidden Visceral Leishmaniasis.","authors":"Ali Mansoursamaei, Maryam Valikhani, Hoofar Rafiee","doi":"10.1155/crdi/3448351","DOIUrl":"10.1155/crdi/3448351","url":null,"abstract":"<p><p><b>Background:</b> Visceral leishmaniasis (VL) is a systemic parasitic disease with diverse clinical manifestations, primarily affecting the spleen, liver, and bone marrow. While renal involvement in VL is well documented, it is often mild and resolves with effective treatment. However, severe renal complications, such as membranoproliferative glomerulonephritis (MPGN), are rare and typically associated with immunocompromised individuals. <b>Case Report:</b> We report the case of a 30-year-old male from a nonendemic region who presented with unusual clinical features of generalized edema and abdominal pain, without the classic signs of VL such as fever or hepatosplenomegaly. Clinical examination, laboratory investigations, and other therapeutic interventions ruled out hepatic and cardiac causes of edema, focusing the diagnosis on nephrotic syndrome and acute kidney injury (AKI). A renal biopsy revealed MPGN, a rare but documented complication of VL. The presence of an autoimmune disease was suspected initially, and the patient was treated with steroids without improvement. The diagnosis of VL was confirmed only after bone marrow biopsy, which identified Leishmania amastigotes. Despite prompt initiation of antileishmanial therapy with liposomal amphotericin B, the patient's renal function continued to diminish, which finally resulted in end-stage renal disease (ESRD). The patient later developed pleural and pericardial effusion, pulmonary embolism, and tamponade, ultimately leading to a fatal outcome. <b>Conclusion:</b> This case underscores the importance of considering VL in the differential diagnosis of unexplained renal dysfunction, even in the absence of classic symptoms and in nonendemic regions. It highlights the potential for VL to present with atypical renal manifestations such as MPGN, leading to severe and irreversible renal damage if diagnosis and treatment are delayed. Early recognition and intervention are critical to improving outcomes in VL-associated renal disease.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"3448351"},"PeriodicalIF":1.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Chromobacterium haemolyticum</i> Infection Subsequent to Experiencing a Traumatic Event in a Rice Field: A Case Report and Literature Review.","authors":"Mikiro Kato, Hiroyuki Kobayashi, Takuro Uchida","doi":"10.1155/crdi/6547509","DOIUrl":"10.1155/crdi/6547509","url":null,"abstract":"<p><p>The incidence of infections caused by <i>Chromobacterium haemolyticum</i>, phylogenetically related however distinct from <i>Chromobacterium violaceum</i>, has increased since its identification in 2008. Differences in their unique microbiological features have been highlighted, particularly regarding their phenotypic distinctions in the colony pigmentation and hemolysis. This is largely due to <i>C. haemolyticum</i> being misidentified as <i>C. violaceum</i>, using the current automated microbial identification systems. However, clinical aspects and outcomes of <i>C. haemolyticum</i> infections remain unclear as few clinically relevant cases have been reported and considered similar to <i>C. violaceum</i> infections. Consequently, we reported an extremely rare case of <i>C. haemolyticum</i> bacteremia, which was initially diagnosed as a <i>C. violaceum</i> infection, however was later confirmed to be a <i>C. haemolyticum</i> infection, using 16S ribosomal ribonucleic acid (rRNA) sequence analysis. Abscess formation was not observed, and the patient was treated with a short course of antibiotics. Ultimately, his condition resolved, without recurrence during the 1-year follow-up. Clinicians should be aware that if the isolated organism is originally identified as <i>C. violaceum</i>, however is phenotypically mismatched with colony nonpigmentation and beta-hemolysis; the organism may be <i>C. haemolyticum</i>. Mortality, abscess formation, and recurrence rates are lower than those of <i>C. violaceum</i>, and chronic broad-spectrum antibiotic suppression may not be required, potentially avoiding unnecessary antibiotic use and preventing multidrug resistance.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6547509"},"PeriodicalIF":1.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Throat to Limb: A Novel Case of Compartment Syndrome Following Group A Streptococcal Pharyngitis.","authors":"Simar Goyal, Justin Choy, Kendall Wermine, Sidart Pradeep, Khazeema Hafeez, Rusty Milhoan, Lavanya Srinivasan","doi":"10.1155/crdi/5016797","DOIUrl":"10.1155/crdi/5016797","url":null,"abstract":"<p><p>Acute compartment syndrome is a medical emergency caused by increased pressure within a closed fascial space, leading to tissue ischemia and potential limb loss or death if untreated. While typically secondary to trauma, rare cases have been associated with streptococcal infections. However, no documented case exists of compartment syndrome originating from Group A Streptococcus (GAS) pharyngitis. We present a 35-year-old female, with prediabetes, who presented to the emergency department with worsening right lower extremity (RLE) pain and edema following a febrile illness with pharyngitis. Throat swab on admission and subsequent blood cultures tested positive for beta-hemolytic GAS. Despite initial management for sepsis and cellulitis with myositis, she developed compartment syndrome requiring urgent fasciotomy. Her postoperative course was complicated by hypotension, toxic shock-like syndrome, menorrhagia, and transaminitis, but she ultimately recovered with IV antibiotics and stepwise Jacob's Ladder surgical wound closure. This report serves as the first known case of nontraumatic acute lower extremity compartment syndrome derived from disseminated GAS pharyngitis and may point to the development of novel virulence factor(s) for emerging strains of GAS in the United States. The case underscores the importance of recognizing GAS pharyngitis as a potential source of severe systemic infections, as early identification and aggressive management of invasive GAS infections may help prevent life-threatening complications.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"5016797"},"PeriodicalIF":1.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Mycobacterium neoaurum</i> Bacteremia in an Immunocompetent Patient in MICU: The First Reported Case in Qatar.","authors":"Alanoud Alshmarri, Noor Jassim, Hisham Elhiday, Bara Alqudah","doi":"10.1155/crdi/3710417","DOIUrl":"10.1155/crdi/3710417","url":null,"abstract":"<p><p><b>Background:</b> <i>Mycobacterium neoaurum</i> is a rare, rapidly growing nontuberculous mycobacterium that typically affects immunocompromised patients and is often associated with catheter-related infections. <b>Case Presentation:</b> We describe a case of <i>Mycobacterium neoaurum</i> bacteremia in an immunocompetent male admitted to the MICU with severe intracerebral hemorrhage. Notably, the infection occurred in the absence of central venous access. The organism was identified using MALDI-TOF MS, and the patient responded microbiologically to a combination antibiotic regimen, although his neurological prognosis remained poor. <b>Conclusion:</b> This is the first documented case of <i>Mycobacterium neoaurum</i> bacteremia in Qatar and one of the few reported cases globally in an immunocompetent patient without conventional risk factors.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"3710417"},"PeriodicalIF":0.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Diagnosis and Novel Treatment of Eyelid Molluscum Contagiosum.","authors":"Bangtao Yao, Yinling Wu, Chang'an Hu, Bei Wang, Xiaoli Yue","doi":"10.1155/crdi/9730930","DOIUrl":"https://doi.org/10.1155/crdi/9730930","url":null,"abstract":"<p><p>Molluscum contagiosum is an infectious skin disease caused by the molluscum contagiosum virus that affects 6 million people in the United States annually. However, molluscum contagiosum on the eyelid is uncommon. The aim of this article is to describe the clinical diagnosis and effect of curettage using fine forceps under an operating microscope in a patient with eyelid molluscum contagiosum. We reported a patient who presented with a two-month long history of a dome-shaped skin-colored papule with a central umbilication containing white caseous material on the left upper eyelid margin. The patient underwent a complete curettage using fine forceps under an operating microscope. Postoperative histopathology revealed Henderson-Patterson bodies. A diagnosis of eyelid molluscum contagiosum was made. At the 1-week follow-up, his symptoms had resolved completely without scarring. No recurrence was observed at a nine-month follow-up. This novel surgical method may be beneficial and safe for patients with eyelid molluscum contagiosum. Slit-lamp examination is a noninvasive and valuable tool for evaluating this condition. Typical pathological features may help in the diagnosis. Early diagnosis and precise treatment can prevent reinfection and control transmission. This report is particularly relevant to dermatologists and ophthalmologists because it offers valuable insights into a rare localization of molluscum contagiosum and its treatment approach.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"9730930"},"PeriodicalIF":1.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Febrile Pancytopenia and Hemophagocytosis From Disseminated Histoplasmosis in HIV/AIDS Patients: Two Cases and a Review of Combined Antifungal and Steroid Therapy.","authors":"Chinelo Animalu, Nupur Singh, Kenneth Cory Guice, Kase Maner","doi":"10.1155/crdi/2623694","DOIUrl":"https://doi.org/10.1155/crdi/2623694","url":null,"abstract":"<p><p>Hemophagocytosis is a clinical condition characterized by the engulfment of bone marrow cellular elements, including erythrocytes, leukocytes, platelets, and their precursors, by activated macrophages. It has been associated with several infectious organisms, including the Epstein-Barr virus (EBV) and histoplasmosis. Human immunodeficiency virus (HIV) has been known to trigger hemophagocytosis in the presence or absence of other infections. Disseminated histoplasmosis is a common opportunistic infection in advanced patients with acquired immunodeficiency syndrome (AIDS) in endemic areas; however, the best treatment for histoplasmosis associated with hemophagocytosis is uncertain. This article presents two cases of patients with AIDS secondary to uncontrolled HIV who were admitted with fever, malaise, low CD4 + counts, and a history of noncompliance with antiretroviral therapy (ART). Both patients had pancytopenia, markedly elevated serum ferritin, and elevated liver transaminases. The diagnosis of histoplasmosis was confirmed by positive fungal blood cultures, buffy coat smears showing intracellular fungal organisms, and positive urine <i>Histoplasma</i> antigen. Bone marrow biopsies revealed <i>Histoplasma capsulatum</i> (<i>H. capsulatum</i>) in Grocott methenamine silver (GMS) stains and fungal cultures, histiocytes with intracellular red blood cells, and precursors of granulocytes, consistent with hemophagocytosis. Both patients received amphotericin B but remained febrile and pancytopenic, eventually requiring corticosteroid therapy. We present our experience with these patients and discuss the management of hemophagocytosis in patients with AIDS with disseminated histoplasmosis. We also completed a literature review and created a list of all known cases of disseminated histoplasmosis complicated by HIV/AIDS and hemophagocytosis and listed previous treatments.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"2623694"},"PeriodicalIF":1.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pathogenic Potential of <i>Slackia exigua</i>: A Case Study of Bacteremia in a Patient With Oral Infection.","authors":"Gang Zhou, Lisa Cornelius, Dhammika H Navarathna","doi":"10.1155/crdi/2079663","DOIUrl":"https://doi.org/10.1155/crdi/2079663","url":null,"abstract":"<p><p><i>Slackia exigua</i> is an anaerobic, Gram-positive, nonspore-forming bacterium that is typically part of the normal oral microbiota. It is generally considered biochemically inert and is often dismissed as a nonpathogenic contaminant in clinical cultures, particularly in respiratory samples. However, in this case study, we report a rare instance of <i>S</i>. <i>exigua</i> bacteremia in a patient with multiple medical comorbidities who was hospitalized after reporting to Emergency Department due to fatigue and right ear pain. The patient subsequently developed signs of persistent symptoms of septicemia, prompting an extensive investigation. Blood cultures identified <i>S</i>. <i>exigua</i> as the causative agent. This case underscores the importance of thorough culture workup and clinical correlation, especially in immunocompromised patients and patients with multiple medical comorbidities. Comprehensive dental care and the administration of targeted antibiotic therapy resulted in the patient's full recovery. This report highlights the potential pathogenic role of <i>S</i>. <i>exigua</i> in certain clinical scenarios and emphasizes the need for awareness of its possible implications in systemic infections.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"2079663"},"PeriodicalIF":1.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}