Case Reports in Infectious Diseases最新文献

{"title":"Rapidly Progressive Mucormycosis Presenting as Giant Cell Arteritis as a First Presentation of Diabetes in a Woman With Diabetic Ketoacidosis: A Case Report and Review of the Literature.","authors":"Suha Nori, Dua Nori, Hala O Abdallah, Ansam Nafah, Muath N M Salman, Haitham Hamadneh, Reem Shihab","doi":"10.1155/crdi/4066148","DOIUrl":"10.1155/crdi/4066148","url":null,"abstract":"<p><strong>Background: </strong>Disseminated mucormycosis is a rare, angioinvasive fungal infection predominantly affecting immunocompromised individuals, especially those with poorly controlled diabetes.</p><p><strong>Case presentation: </strong>A 57-year-old Palestinian woman presented with sudden unilateral blindness, ophthalmoplegia, facial numbness, and ptosis, with hyperglycemia. Early brain MRI/MRA/MRV findings were normal, suggesting that giant cell arteritis, or other autoimmune vasculitis, was suspected; thus, IV steroids were administered. Subsequently, her condition progressed to bilateral fixed pupils, complete ophthalmoplegia, and palatal black necrosis. Subsequent imaging and sinus biopsy confirmed disseminated mucormycosis. Treatment included intravenous Amphotericin B, anticoagulation, functional endoscopic sinus surgery, and later left eye enucleation. Despite maximal therapy, she developed a large hemorrhagic venous infarction and ultimately died.</p><p><strong>Conclusions: </strong>Mucormycosis can initially mimic autoimmune or vascular neuro-ophthalmic disease and may present with normal imaging. In acute vision loss with hyperglycemia, maintaining early suspicion and avoiding corticosteroids until fungal infection is excluded are essential to prevent rapid, fatal progression.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"4066148"},"PeriodicalIF":0.8,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13172605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147961825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptococcal Lung Infection Simulating Metastasis in a Myxoid Liposarcoma Patient: A Case Report.","authors":"Mariko M Kawamura, Masatake Matsuoka, Hideki Ujiie, Shin Ariga, Shinichi Nakazato, Kenjiro Kato, Takayuki Hashimoto, Yoshihiro Matsuno, Tatsuya Kato, Norimasa Iwasaki","doi":"10.1155/crdi/5538208","DOIUrl":"10.1155/crdi/5538208","url":null,"abstract":"<p><strong>Introduction: </strong>Myxoid liposarcoma is a soft tissue sarcoma with a high tendency for lung metastasis. Its aggressive nature necessitates accurate diagnosis and treatment planning to improve outcomes.</p><p><strong>Case report: </strong>A 31-year-old man presented with a three-year history of an asymptomatic, progressively enlarging mass in his right thigh. Magnetic resonance imaging indicated a soft tissue tumor within the sartorius muscle, and an incisional biopsy suggested myxoid liposarcoma. Staging computed tomography scans revealed two nodules in the right lung, leading to an initial diagnosis of Stage IV myxoid liposarcoma. Given his overall health and the presumed resectability of the lesions, the patient underwent three courses of preoperative chemotherapy with doxorubicin and ifosfamide. Follow-up imaging showed no change in the size of the tumor or lung nodules. A wide resection of the thigh tumor was performed, including part of the vastus medialis, sartorius, and gracilis muscles. Postoperatively, 65 gray (relative biological effectiveness) of proton radiation therapy was administered. Subsequently, a robot-assisted thoracoscopic right lower lobectomy and lymph node dissection were performed to resect the lung nodules. Histological examination of the lung lesions revealed necrotizing granulomas with numerous round-shaped yeasts. The special stains confirmed pulmonary cryptococcosis, ruling out metastasis and revising the tumor staging to Stage Ib. Consequently, postoperative chemotherapy was canceled, and the patient showed no recurrence over 3 years of follow-up.</p><p><strong>Discussion: </strong>This case emphasizes the need for histopathological evaluation of lung lesions in sarcoma patients, as not only cryptococcosis but also various fungal infections can mimic metastasis, potentially altering the treatment plan and prognosis.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"5538208"},"PeriodicalIF":0.8,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Role of ACE Polymorphisms in Severe Malaria: A Case Report.","authors":"Raffaella Pisapia, Andrea Pomicino, Giuseppina Minei, Isabella Iadevito, Alessandro Perrella","doi":"10.1155/crdi/9821533","DOIUrl":"10.1155/crdi/9821533","url":null,"abstract":"<p><p>Malaria, primarily caused by <i>Plasmodium falciparum</i>, remains a critical global health challenge, particularly in sub-Saharan Africa. Genetic factors such as angiotensin-converting enzyme (ACE) I/D polymorphism have been implicated in influencing malaria severity and outcomes. We report the case of a 40-year-old woman from Seychelles, residing in Ivory Coast, who developed severe <i>P. falciparum</i> malaria complicated by thrombosis. Laboratory findings revealed hyperparasitemia, acute kidney injury, and metabolic acidosis. Genetic testing through real time PCR identified the ACE I/D polymorphism, along with other thrombophilic variants such as MTHFR C677T and A1298C, suggesting a potential role in clinical course. This case aims to contribute to the debate about the role of ACE polymorphisms in malaria severity. Comprehensive studies are warranted to explore the genetic landscape in malaria-endemic regions and its implications for personalized treatment strategies.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"9821533"},"PeriodicalIF":0.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Pleural Tuberculosis Presenting With Noncaseating Granulomas: A Diagnostic Challenge.","authors":"Maria Akiki, Chebly Dagher, Jessica Abrantes-Figueiredo","doi":"10.1155/crdi/6448395","DOIUrl":"10.1155/crdi/6448395","url":null,"abstract":"<p><p>Tuberculous pleural effusion is the second most common form of extrapulmonary tuberculosis after tuberculous lymphadenitis. Despite its frequency, diagnosis remains challenging due to its paucibacillary nature, and confirmation often requires invasive procedures. We report a 26-year-old male with no significant medical history who presented with persistent dyspnea, cough, and left-sided chest pain after recent travel to Pakistan. He denied known tuberculosis exposure. Imaging demonstrated a left pleural effusion, and thoracentesis revealed a lymphocytic exudate with elevated adenosine deaminase. Pleural fluid acid-fast bacilli smear and tuberculosis polymerase chain reaction were negative. Given the high clinical suspicion for tuberculosis, the patient underwent thoracoscopy with pleural biopsy, which demonstrated noncaseating granulomas. Although the histopathological findings were atypical, empiric antituberculous therapy was initiated. One month later, pleural biopsy cultures grew <i>Mycobacterium tuberculosis</i>, confirming the diagnosis. Pleural tuberculosis remains difficult to diagnose, as conventional microbiological tests are highly specific but have limited sensitivity. This case highlights the critical role of pleural biopsy in guiding early management and underscores that empiric therapy should be strongly considered when clinical suspicion and epidemiologic risk factors are high, even if initial diagnostic studies are negative.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"6448395"},"PeriodicalIF":0.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title: Abdominal Wall Necrotizing Fasciitis in a Preemie: A Case Report of a Fulminant Course.","authors":"Hari Narayan Rai, Sagar Kafle, Smriti Basnet, Prabineshwor Prasad Lekhak, Aakash Mishra, Saukat Ali, Sunil Raja Manandhar, Ashish Lal Shrestha","doi":"10.1155/crdi/5555074","DOIUrl":"10.1155/crdi/5555074","url":null,"abstract":"<p><p>Necrotizing fasciitis (NF), a rapidly progressive soft-tissue infection characterized by extensive tissue necrosis, is a fulminant condition that, if not treated promptly, can become fatal. Predominantly a disease of adulthood, its occurrence in the pediatric and neonatal populations is rare. We report a case of a preterm newborn who developed NF of the abdominal wall due to the rare etiology of invasive <i>Klebsiella pneumoniae</i> in the setting of culture-proven sepsis secondary to ventilator-associated pneumonia. This case highlights the challenges of early recognition and management in unstable preterm neonates with rapidly progressive infections, in whom a fatal outcome could not be avoided despite timely and intensive management efforts.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"5555074"},"PeriodicalIF":0.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Miliary Tuberculosis Complicated by Knee Joint Tuberculosis.","authors":"Saiki Yoshimura, Kentaro Satomi, Kohei Fujita, Hiromasa Tachibana, Yuta Okada, Naoki Fujimoto, Shogo Toyama, Takanori Ito, Takuma Imakita, Issei Oi, Osamu Kanai, Kiminobu Tanizawa","doi":"10.1155/crdi/9328618","DOIUrl":"10.1155/crdi/9328618","url":null,"abstract":"<p><p>This case report details a 75-year-old male diagnosed with miliary tuberculosis (TB) who subsequently developed tuberculous arthritis in his left knee. The patient was initially admitted for a hemorrhagic gastric ulcer, where chest imaging and positive cultures from multiple sites confirmed miliary TB. Standard antitubercular therapy was started, but 6 weeks later, he presented with worsening pain and swelling in his left knee. A joint aspiration and MRI confirmed tuberculous arthritis with an abscess, which necessitated surgical debridement in addition to the drug regimen. We emphasize that orthopaedic TB often requires surgical intervention alongside medication for successful treatment. While total knee arthroplasty can be an effective treatment for joint destruction, the previous report suggests that it should be delayed until after a prolonged course of antitubercular therapy (e.g., 12 months or more) to prevent recurrence.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"9328618"},"PeriodicalIF":0.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chagasic Esophagopathy With Achalasia and Megaesophagus: A Case Report.","authors":"Gabriel Xerez de Oliveira, Beatriz Lacerda Bezerra, José Antonio da Silva Júnior, Ellany Gurgel Cosme do Nascimento, Cléber de Mesquita Andrade","doi":"10.1155/crdi/9930462","DOIUrl":"10.1155/crdi/9930462","url":null,"abstract":"<p><p>Chagasic esophagopathy, resulting from Trypanosoma cruzi-induced myenteric plexus denervation, leads to lower esophageal sphincter hypertonia, esophageal body hypertrophy, and dilation (megaesophagus), manifesting as progressive dysphagia and regurgitation that impair nutritional status and quality of life. This case report aims to describe chronic esophageal dysphagia in a patient from an endemic area in northeastern Brazil, highlighting diagnostic and therapeutic challenges within the public health system, including delays due to COVID-19 restrictions and resource limitations. A 67-year-old female from Rio Grande do Norte, with prior Chagas disease diagnosis (2004, etiologically treated), hypertension, and dyslipidemia, presented in 2019 with solid-food dysphagia and nocturnal regurgitation. Initial tests (chest X-ray, ECG, and echocardiography) were normal, but contrast studies (barium esophagogram, and colon) were delayed until 2022, revealing 7 cm esophageal dilation (Rezende Group III), cardia narrowing, and retained contrast/food residues. Symptoms worsened, with a 5 kg weight loss and liquid-only diet. Videolaparoscopic Heller-Pinotti cardiomyotomy was performed in September 2023 after clinical optimization (isosorbide dinitrate and domperidone). The 2 h procedure was uneventful; discharge occurred within 24 h on zero diet, progressing to normal intake by 5 weeks. By February 2024, she was asymptomatic, with a 2 kg weight gain (from 66 kg). This case confirms laparoscopic cardiomyotomy's efficacy (90% success in Rezende I-III) for symptom resolution in nonadvanced chagasic megaesophagus. Public health insights underscore Chagas underreporting, late diagnosis, and public health system barriers in vulnerable populations, advocating early serological screening and etiological treatment in acute phases to prevent chronic digestive forms in endemic regions.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"9930462"},"PeriodicalIF":0.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Postneurosurgical Central Nervous System Infection Caused by <i>Acinetobacter baumannii</i> in a Critically Ill Patient Treated With Cefiderocol. A Case Report.","authors":"Giuseppe Accurso, Angelica Ancona, Giovanni Marco Costa, Filippo Vitale, Domenico Petronaci, Giorgia Corpora, Luigi Profera, Antonino Giarratano, Santi Maurizio Raineri","doi":"10.1155/crdi/7327571","DOIUrl":"10.1155/crdi/7327571","url":null,"abstract":"<p><strong>Introduction: </strong><i>Acinetobacter baumannii</i> (<i>A. baumannii</i>), a gram-negative bacterium, has become a significant hospital pathogen and the cause of severe nosocomial infections, especially in the intensive care unit (ICU). Bacterial meningitis is a recognized complication that can occur after neurosurgery, and the number of cases of multidrug-resistant (MDR) meningitis caused by <i>A. baumannii</i> is increasing. Critically ill patients in the ICU are at high risk, and the consequences are potentially fatal. Cefiderocol is a novel cephalosporin that can treat carbapenem-resistant infections in patients with limited treatment options. No clinical trials have investigated its capability to penetrate cerebrospinal fluid.</p><p><strong>Case presentation: </strong>We describe the case of a 66-year-old man who was admitted to our neurointensive care unit after head trauma. On the CT scan performed on admission to the hospital, there was evidence of a subdural hematoma and subarachnoid and intraparenchymal hemorrhages in the frontotemporal region bilaterally. The patient then underwent a decompressive craniectomy. During hospitalization and following cranioplasty, the patient experienced a central nervous recurrence of carbapenem-resistant <i>A. baumannii</i> (CRAB) meningitis, which was treated with cefiderocol, resulting in a resolution of signs and symptoms of infection within a few days.</p><p><strong>Conclusion: </strong>We present the first case of CRAB meningitis treated with this cefiderocol dosing regimen. In our case of postneurosurgical MDR meningitis reinfection caused by <i>A. baumannii</i>, cefiderocol as monotherapy brought about a clinical and microbiological cure in both blood and cerebrospinal fluid without the occurrence of adverse effects such as seizure.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"7327571"},"PeriodicalIF":0.8,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Case of Lemierre's Syndrome: <i>Porphyromonas asaccharolytica</i>-Induced Monoplegia, Epiduritis, and Meningitis in a 50-Year-Old Woman-A Case Report.","authors":"Alexis Krin, E Aldige, F Birot-Jaulin, F Labaste, S Buys","doi":"10.1155/crdi/5537970","DOIUrl":"10.1155/crdi/5537970","url":null,"abstract":"<p><strong>Introduction: </strong>Lemierre's syndrome, characterized by internal jugular vein thrombosis and secondary septic emboli following an oropharyngeal infection, is mainly caused by <i>Fusobacterium necrophorum</i>. We report a case of Lemierre's syndrome caused by <i>Porphyromonas asaccharolytica</i>, resulting in pulmonary septic embolism, acute respiratory failure, meningitis, epiduritis, and monoplegia-a complication not previously reported.</p><p><strong>Case report: </strong>A 50-year-old woman initially presented with tonsillitis and subsequently developed severe sepsis. Clinical examination revealed meningeal stiffness, acute renal failure, elevated inflammatory markers, and severe thrombocytopenia. Cerebrospinal fluid analysis was consistent with meningitis, although cultures remained negative. Following admission, the patient developed acute respiratory failure, requiring transfer to intensive care unit for noninvasive ventilatory support. Computed tomography revealed tonsillar edema, thrombosis of the left internal jugular vein, and bilateral pulmonary consolidations. Empirical treatment was initiated with broad-spectrum antibiotics (ceftriaxone, metronidazole, piperacillin-tazobactam), platelet transfusions, and intravenous heparin. Blood cultures identified <i>P. asaccharolytica</i>, leading to de-escalation of antibiotic therapy to amoxicillin. Two days later, the patient developed left upper limb palsy. Magnetic resonance imaging showed cervical epiduritis extending from C3 to C7. Corticosteroid therapy was initiated on Day three. The patient was transferred to the medical ward on Day fifteen and discharged from hospital on Day 30. Treatment comprised 4 weeks of corticosteroids therapy and 6 weeks of antibiotic therapy. At follow-up, partial neurological recovery was observed; however, residual left upper limb paresis persisted. Anticoagulation therapy was maintained for 3 months. Electroneuromyography revealed axonal injury involving the C6-C7-C8-T1 nerve root distribution.</p><p><strong>Conclusion: </strong><i>P. asaccharolytica</i> is a rare etiological agent of Lemierre's syndrome. Neurological complications are uncommon but may include meningitis, cerebral abscess, or cranial nerve palsies, the latter being more commonly associated with <i>F. necrophorum</i>. We report the case of a 50-year-old woman with Lemierre's syndrome caused by <i>P. asaccharolytica</i>, who presented with monoplegia, epiduritis, and meningitis.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"5537970"},"PeriodicalIF":0.8,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond 'One Size Fits All': Abatement of Linezolid-Induced Thrombocytopenia Through Therapeutic Drug Monitoring and Precision Dosing-A Case Study.","authors":"Kennedy C Concannon, Taylor Gullickson, Daniel C DeSimone, Omar Abu Saleh, Tanner M Johnson, Ryan W Stevens, Josh Clement","doi":"10.1155/crdi/3214119","DOIUrl":"10.1155/crdi/3214119","url":null,"abstract":"<p><strong>Background: </strong>Linezolid is an oxazolidinone antibiotic used in the treatment of Gram-positive bacterial infections. However, its prolonged use is often limited by adverse effects, including thrombocytopenia. Therapeutic drug monitoring (TDM) has been proposed to individualize linezolid dosing to mitigate such adverse effects. This study presents a case of linezolid-induced thrombocytopenia successfully managed with TDM and dose individualization in a patient receiving linezolid as chronic suppressive therapy for cardiac implantable electronic device (CIED) infection.</p><p><strong>Methods: </strong>A 92-year-old female with a history of recurrent <i>Corynebacterium striatum</i> bacteremia and complex cardiovascular conditions who completed a six-week course of intravenous therapy and were placed on chronic suppressive therapy with oral linezolid. Given the risk of thrombocytopenia, TDM was utilized to guide linezolid dosing. Platelet counts and linezolid trough levels were regularly monitored, and dose adjustments were made accordingly.</p><p><strong>Results: </strong>Upon initiation of linezolid (600 mg daily), the patient's baseline platelet count was 150 × 10⁹/L. On day 19, platelet counts declined to 73 × 10⁹/L. Linezolid was temporarily withheld, and TDM revealed a supratherapeutic trough level of 10.26 mcg/mL. The dosage was adjusted to 300 mg once daily, leading to the stabilization of platelet counts at 140 × 10⁹/L. Subsequent monitoring showed a trough level within the target range (7.62 mcg/mL) with no further episodes of thrombocytopenia or additional adverse effects out to day 172.</p><p><strong>Conclusion: </strong>This case highlights the utility of TDM in managing linezolid-induced thrombocytopenia, particularly in patients requiring prolonged therapy. TDM enabled precise dose adjustments, ensuring therapeutic efficacy while minimizing toxicity. The findings support the broader implementation of TDM in linezolid therapy to enhance patient safety and treatment outcomes, particularly in long-term therapy or deep-seated infections.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"3214119"},"PeriodicalIF":0.8,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}