Case Reports in Infectious Diseases最新文献

{"title":"Cefepime-Induced Encephalopathy in a Patient With Uncompromised Renal Function: A Case Report.","authors":"Aayusha Dhakal, Ozone Gautam","doi":"10.1155/crdi/6650287","DOIUrl":"10.1155/crdi/6650287","url":null,"abstract":"<p><p>Cefepime, a fourth-generation cephalosporin, is widely used in the treatment of infections caused by resistant Gram-negative bacteria especially <i>Pseudomonas aeruginosa</i>, or in severe infections, septic shock, and infections in immunocompromised patients. As it crosses the blood-brain barrier, it can cause neurotoxicity which has mostly been reported in patients with impaired renal function. Patients can present with drowsiness, confusion, delirium, agitation, stupor, or coma, and sometimes with generalized myoclonus and seizures within two to six days after starting the antibiotic. This is a rare case report where a patient with intact kidney function presented with confusion and incoherence. After excluding the possible causes for encephalopathy, cefepime-induced encephalopathy was diagnosed and the patient gradually improved after discontinuing the medication. This case is an unusual presentation of symptoms in a patient with normal kidney function, which necessitates further studies to establish other potential risk factors of cefepime-induced neurotoxicity.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6650287"},"PeriodicalIF":1.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-Resistant <i>Shigella sonnei</i> Bacteremia in an Immunocompetent Postgastric Bypass Patient Without Typical Risk Factors.","authors":"Alejandra Gutierrez, Shovendra Gautam","doi":"10.1155/crdi/9910105","DOIUrl":"10.1155/crdi/9910105","url":null,"abstract":"<p><p><i>Shigella</i> bacteremia, though rare, is a serious condition that highlights the importance of recognizing potential complications in patients with <i>Shigella</i> infections. In this paper, we present a case of <i>Shigella</i> bacteremia in a 53-year-old female s/p a Roux-en-Y gastric bypass revision four months prior, presenting with acute onset of nausea, vomiting, and persistent, explosive, watery diarrhea which started one day after she consumed pork chops and ground beef. Initial laboratory tests indicated leukocytosis and hypokalemia. Human immunodeficiency virus (HIV), rapid plasma regain (RPR), and Hepatitis C were nonreactive. A computed tomography (CT) scan of the abdomen and pelvis showed no intestinal wall thickening or any other acute abnormalities. Blood cultures identified a <i>Shigella sonnei</i> infection that was resistant to multiple antibiotics. She was treated with intravenous meropenem. <i>Shigella</i> bacteremia is a rare complication of <i>Shigella</i> infection and requires thorough investigation to identify potential underlying factors. Antibiotic susceptibilities should also be assessed, given the increasing resistance of <i>Shigella</i> strains to previously effective treatments.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"9910105"},"PeriodicalIF":1.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Imported Case of Gigantic Amoebic Liver Abscess in a 24-Year-Old Woman in Singapore.","authors":"Edwin Chong Yu Sng, Jean-Marc Chavatte","doi":"10.1155/crdi/6230349","DOIUrl":"10.1155/crdi/6230349","url":null,"abstract":"<p><p>A liver abscess can be due to several different microbiological aetiologies. While pyogenic liver abscess is most frequently encountered, amoebic liver abscess and hydatid cyst caused by the parasites, <i>Entamoeba histolytica</i> and <i>Echinococcus granulosus,</i> respectively, should be considered whenever there is epidemiological exposure. As parasitic infections are now rarely seen in clinical practice in developed countries with improvement in sanitation, lack of clinical experience in managing amoebic liver abscesses and overlapping clinical and imaging features between amoebic and pyogenic liver abscesses may lead to delay in diagnosis. In particular, although amoebic liver abscesses respond well to treatment if diagnosed early, they can progress and rupture with high mortality if treatment is delayed. Hence, early diagnosis and prompt initiation of antimicrobials are crucial to prevent complications and death. This case report highlights a case of a very large 21 cm ALA in a young lady to illustrate the challenges faced during diagnostic evaluation.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6230349"},"PeriodicalIF":1.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Man Living in the Wilderness Presents With a Unique Case of <i>Erysipelothrix rhusiopathiae</i> Causing Primary CNS Infection.","authors":"Kevin Andrew Smith, Alejandra Méndez, Lindsey J Reese","doi":"10.1155/crdi/6625621","DOIUrl":"10.1155/crdi/6625621","url":null,"abstract":"<p><p>We report the first published case of <i>Erysipelothrix rhusiopathiae</i> causing subdural empyema. This 66-year-old male patient had relevant exposure history including living in a tent in the woods and having direct contact with wildlife. His main symptom which triggered his presentation was diplopia with exam findings consistent with a left partial oculomotor nerve palsy. Initial attempts at less invasive source control via burr holes alone failed. He was treated successfully with craniectomy and aqueous penicillin G with a duration of 6 weeks following surgery. CNS infection as the primary manifestation of <i>Erysipelothrix rhusiopathiae</i> has been reported in only one other case based on our review of the literature. This pathogen demonstrates an ability to manifest infection in many ways and remains susceptible to narrow spectrum beta-lactams.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6625621"},"PeriodicalIF":1.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Survival Following Spontaneous Maternal Recovery From Ebola Virus Disease in a Resource-Limited Setting in Western Democratic Republic of the Congo.","authors":"Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka, Rigo Fraterne-Muhayangabo, Richard Kitenge-Omasumbu, Placide Mbala-Kingebeni, Zacharie Tsongo-Kibendelwa, Olivier Nyakio-Ngeleza, Ines Claris-Mwatsi, Juakali Sihali-Kyolov, Théophile Barhwamire-Kabesha, Celine Kavira-Malengera, Micheline Feza-Malira, Richard Bitwe-Mihanda, Dieudonné Sengeyi-Mushengezi-Amani, Mija Ververs","doi":"10.1155/crdi/2987569","DOIUrl":"10.1155/crdi/2987569","url":null,"abstract":"<p><p><b>Background:</b> Pregnancy induces physiological decline in maternal immunity. Ebola virus disease (EVD) in pregnancy is associated with obstetrical complications, and vaccination in early pregnancy is recommended, but may not be without risk. <b>Case Presentation:</b> We described neonatal survival after spontaneous maternal EVD recovery. This neonate was born to a 25-year-old mother admitted to an Ebola Treatment Unit (ETU) in July, 2020, after 11 days of symptoms. She was vaccinated with rVSV-ZEBOV three days before symptom onset and her real-time polymerase chain of reaction (RT-PCR) results confirmed EVD and malarial infection two days after, but she refused hospitalization. She was treated at home with PO ASAQ, amoxicillin, paracetamol, albendazole, omeprazole, and papaverine. Eleven days later, due to clinical deterioration and onset of vaginal hemorrhage, she finally accepted to be transferred in ETU. She was Parity 2, fetal age at admission was 5 weeks and 3 days. Upon admission, her EVD PCR measured NP 26.3 and GP 32.9. She did not receive monoclonal therapy against Ebola infection due to stock shortage. She received intravenous, artesunate, ceftriaxone, and papaverine. She experienced spontaneous resolution of EVD 18 days after symptom onset and was discharged. At 40 weeks gestation, seven and a half months after EVD recovery, she delivered a healthy female infant, APGAR 10/10/10, weighing 3450 g. Maternal blood, adnexal, and newborn blood samples were RT-PCR negative, and the mother and the baby were discharged after 14 days. At our last follow-up, in June 2023 (2 years, 3 months after delivery), the mother and the baby were in good health. <b>Conclusion:</b> Neonatal survival following spontaneous maternal recovery from EVD in the first trimester of gestation is rare but possible, even in the context of limited clinical resources for treatment.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"2987569"},"PeriodicalIF":1.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Management of Dengue Fever in a Nonendemic Country: Lessons From an Acute Febrile Illness in Iran During the COVID-19 Outbreak.","authors":"Kimia Mozahheb Yousefi, Solaleh Aminian, Masoud Ebrahimi, Sara Minaeian, Azadeh Laali","doi":"10.1155/crdi/5742576","DOIUrl":"10.1155/crdi/5742576","url":null,"abstract":"<p><p>Dengue fever is a tropical arboviral disease that presents with a broad spectrum of clinical manifestations and can occasionally emerge in nonendemic regions due to factors such as international travel. This case report details a 47-year-old Iranian man who had recently returned from Jakarta, Indonesia, presenting with fever, diarrhea, vomiting, and myalgia during the COVID-19 outbreak. Despite initial misdiagnoses, dengue fever was confirmed through polymerase chain reaction (PCR) testing. Moreover, the serological analysis using enzyme-linked immunosorbent assay (ELISA) further demonstrated the presence of both IgM and IgG antibodies against the dengue virus. Initially, the patient's symptoms overlapped with COVID-19 and gastrointestinal infections, complicating the diagnosis. The management included supportive care, precautions against bleeding, fluid therapy, and empirical antibiotics due to suspected coinfections. This case highlights the importance of considering travel history and the possibility of nonendemic diseases in the differential diagnosis of febrile illnesses of unknown origin (FUO), particularly during concurrent outbreaks. Comprehensive history-taking and rigorous diagnostic evaluation are essential in such cases.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"5742576"},"PeriodicalIF":1.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tick-Borne Encephalitis Presenting as Brachial Plexus Injury: A Case Report.","authors":"Angelika Maksimiuk, Dominik Wawrzuta, Joanna Zajkowska","doi":"10.1155/crdi/7003058","DOIUrl":"https://doi.org/10.1155/crdi/7003058","url":null,"abstract":"<p><p>Tick-borne encephalitis (TBE) is a viral infection with variable clinical presentations, including neurological complications. We report a case of TBE in a 34-year-old farmer from an endemic region in Poland. The patient initially presented with paresis of the right brachial plexus. The diagnosis was challenging due to the absence of previous flu-like symptoms, often related to TBE infection. Neurological evaluations revealed paresis and muscle atrophy in the right upper limb, and serological tests confirmed TBE infection. Despite treatment efforts, neurological deficits persisted. This case highlights the need to consider TBE in the differential diagnosis of sudden-onset neurological disorders, especially in TBE-endemic regions, to ensure prompt intervention and prevent long-term complications.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"7003058"},"PeriodicalIF":1.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of <i>Nocardia kroppenstedtii</i> Infection Successfully Treated With a Multidisciplinary Approach.","authors":"Francesco Foglia, Annalisa Ambrosino, Giuseppe Greco, Annalisa Chianese, Carla Zannella, Francesca Cinone, Alfonso Reginelli, Diego Sandro Giordano, Giovanni Tortorella, Maria Teresa Laieta, Anna De Filippis, Massimiliano Galdiero, Rita Greco, Emiliana Finamore","doi":"10.1155/crdi/6452173","DOIUrl":"10.1155/crdi/6452173","url":null,"abstract":"<p><p><i>Nocardia</i> species constitute a diverse group of microorganisms classified as aerobic actinomyces. Among these species, many have been implicated as causative agents of severe human infections, particularly in immunocompromised patients, affecting lungs, skin, and nervous system. Here, we described a rare species, identified as <i>Nocardia kroppenstedtii,</i> isolated at the Complex Operative Unit of Virology and Microbiology from the subxiphoid formation and pseudonodular formation in the left leg of a 69-year-old immunocompetent patient, who was hospitalized and treated at the Complex Operative Unit of Internal Medicine and Geriatrics of the University Hospital of Campania \"Luigi Vanvitelli\" in an antimicrobial diagnostic stewardship context. This rare pathogen was first isolated in 2014 from a bronchoalveolar lavage sample obtained from a lung transplant recipient. Since then, only five cases of clinical interest have been described in literature.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6452173"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolated From a Patient in a Midwestern U.S. Hospital With a History of Indian Travel: Therapeutic Strategies and Clinical Outcomes.","authors":"Christopher Phan, Kristen Tsai, Christian M Gill, Robin Chamberland, Christian Hendrix, Rong Hou","doi":"10.1155/crdi/8155592","DOIUrl":"10.1155/crdi/8155592","url":null,"abstract":"<p><p>Carbapenemases have had increasing prevalence within the United States and worldwide. Here, we present a case of carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) which is unique due to the rarity of multiple mechanisms of resistance within the <i>Klebsiella pneumoniae</i> harboring New Delhi metallo-<i>β</i>-lactamases (NDM), oxacillinase-48 (OXA-48)-like, and cefotaximase (CTX-M) resistance genes, detected in a patient following an international travel. This case demonstrates the need for a multidisciplinary approach to optimize the treatment of multidrug-resistant Gram-negative organisms.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"8155592"},"PeriodicalIF":1.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymicrobial Osteomyelitis in a Patient With Isolation of <i>Trueperella bernardiae</i>: A Case Report and Literature Review.","authors":"Marco Antonio Delaye-Martínez, Edgar Samuel Vanegas-Rodríguez, Braulio Mendez-Sotelo, María de Lourdes García-Hernández, Claudia Adriana Colín-Castro, Rafael Franco-Cendejas, Luis Esaú López-Jácome","doi":"10.1155/crdi/6010539","DOIUrl":"10.1155/crdi/6010539","url":null,"abstract":"<p><p><b>Background:</b> <i>Trueperella bernardiae</i> is a Gram-positive rod that has been described as an opportunistic pathogen in immunocompromised patients. In a significant number of documented cases, infections with <i>Trueperella bernardiae</i> have been associated with polymicrobial infections, which highlight the fact that important bacteria-bacteria relations might be involved in the natural course of these infections, especially in patients with chronic disease courses and a history of multiple antibiotic treatments. <b>Case Presentation:</b> We present a case of a 24-year-old woman with a 3-year history of a chronic pressure ulcer on the right foot associated with varus and cavus deformity. As per relevant medical history, she was positive for multiple wound healing sessions with wound debridement and a large number of antibiotic treatments with minimal improvement. Microbiological cultures were taken from the wound, and a soft tissue infection diagnosis was initially made. Empirical treatment was initiated with levofloxacin. At 48 h, cultures were positive for <i>Providencia stuartii, Pseudomonas aeruginosa, Proteus penneri, Streptococcus agalactiae</i>, and <i>Trueperella bernardiae</i>, and the susceptibility test was performed. Three weeks later, the symptoms progressed to purulent exudate of the wound and foul-smelling with the positive probe-to-bone test. Diagnosis was changed to polymicrobial osteomyelitis, and antibiotic therapy with ciprofloxacin and trimethoprim-sulfamethoxazole was prescribed for a 4-week course of treatment, achieving the complete remission of symptoms. <b>Conclusions:</b> <i>Trueperella bernardiae</i> represents an emerging bacterium that can be isolated in various clinical presentations. On osteoarticular infections, the presence of comorbidities, mobility limitations, and a history of multiple antibiotic treatments may be determinant. Their isolation as part of polymicrobial infections highlights relevant interspecies interactions. Research is still lacking in determining standardized methodologies for susceptibility testing and specific clinical breakpoints to guide clinical decisions.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2025 ","pages":"6010539"},"PeriodicalIF":1.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}