头孢吡肟致未受损肾功能患者脑病1例报告。

IF 1 Q4 INFECTIOUS DISEASES
Case Reports in Infectious Diseases Pub Date : 2025-03-29 eCollection Date: 2025-01-01 DOI:10.1155/crdi/6650287
Aayusha Dhakal, Ozone Gautam
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引用次数: 0

摘要

头孢吡肟是第四代头孢菌素,广泛用于治疗耐药革兰氏阴性菌(特别是铜绿假单胞菌)引起的感染,或严重感染、感染性休克和免疫功能低下患者的感染。当它穿过血脑屏障时,可引起神经毒性,这主要发生在肾功能受损的患者身上。患者在开始使用抗生素后2至6天内可出现嗜睡、精神错乱、躁动、麻木或昏迷,有时出现全身肌阵挛和癫痫发作。这是一个罕见的病例报告,患者完整的肾功能表现为混乱和不连贯。排除可能的脑病原因后,诊断为头孢吡肟所致脑病,停药后病情逐渐好转。本病例在肾功能正常的患者中表现出不寻常的症状,需要进一步研究以确定头孢吡肟引起神经毒性的其他潜在危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cefepime-Induced Encephalopathy in a Patient With Uncompromised Renal Function: A Case Report.

Cefepime, a fourth-generation cephalosporin, is widely used in the treatment of infections caused by resistant Gram-negative bacteria especially Pseudomonas aeruginosa, or in severe infections, septic shock, and infections in immunocompromised patients. As it crosses the blood-brain barrier, it can cause neurotoxicity which has mostly been reported in patients with impaired renal function. Patients can present with drowsiness, confusion, delirium, agitation, stupor, or coma, and sometimes with generalized myoclonus and seizures within two to six days after starting the antibiotic. This is a rare case report where a patient with intact kidney function presented with confusion and incoherence. After excluding the possible causes for encephalopathy, cefepime-induced encephalopathy was diagnosed and the patient gradually improved after discontinuing the medication. This case is an unusual presentation of symptoms in a patient with normal kidney function, which necessitates further studies to establish other potential risk factors of cefepime-induced neurotoxicity.

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