Revista medica del Instituto Mexicano del Seguro Social最新文献_第4页

[Retinal ischemia as an early marker of renal failure in non-proliferative retinopathy]. [视网膜缺血作为非增殖性视网膜病变肾功能衰竭的早期标志]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617022

Arturo Muñoz-Cornejo, Gloria Paulina Trujillo-Sánchez, Luis Miguel López-Montero, Martha Alicia Hernández-González

{"title":"[Retinal ischemia as an early marker of renal failure in non-proliferative retinopathy].","authors":"Arturo Muñoz-Cornejo, Gloria Paulina Trujillo-Sánchez, Luis Miguel López-Montero, Martha Alicia Hernández-González","doi":"10.5281/zenodo.14617022","DOIUrl":"10.5281/zenodo.14617022","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) presents complications such as diabetic retinopathy (DR) and nephropathy, both related to microvascular damage. DR is the leading cause of preventable blindness in T2DM. Retinal ischemia, detectable by fluorescein angiography (FA), is an early indicator, and its timely detection is crucial. Endothelial dysfunction affects vessels in organs such as the retina and kidneys. Microalbuminuria (MA) is an early sign of diabetic nephropathy (DN). Early detection, along with adequate metabolic control, can delay progression to end-stage renal disease.Objective: To investigate the relationship between retinal ischemia, detected by FA, and MA in patients with T2DM and non-proliferative DR at the No. 1 Specialty Hospital of Bajío.Material and methods: Cross-sectional study, with ethical approval. Diabetic patients without previous renal disease or proliferative DR were included. The sample of 66 patients was evaluated by FA and MA analysis (>30 mg/24 h). Chi-square and Student's t-tests were applied.Results: Patients with retinal ischemia were older (62.73 ± 8.93 vs. 57.50 ± 14.14 years; p = 0.05) and had a higher prevalence of MA (45% vs. 0%; p = 0.01). No significant differences were found in gender, DR severity, HbA1c, or creatinine levels.Conclusions: Retinal ischemia is associated with a higher prevalence of microalbuminuria in T2DM patients, supporting the study hypothesis.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6434"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Innate immune response to interferon gamma in severe Covid-19 positive patients]. [Covid-19严重阳性患者对干扰素γ的先天免疫应答]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617070

Fabiola Del Rocío Villalobos-Gómez, Anastacio Palacios-Marmolejo, Rogelio Salinas-Gutiérrez, Hugo Enrique Lagunes-Servín

{"title":"[Innate immune response to interferon gamma in severe Covid-19 positive patients].","authors":"Fabiola Del Rocío Villalobos-Gómez, Anastacio Palacios-Marmolejo, Rogelio Salinas-Gutiérrez, Hugo Enrique Lagunes-Servín","doi":"10.5281/zenodo.14617070","DOIUrl":"10.5281/zenodo.14617070","url":null,"abstract":"Background: SARS-CoV-2 is associated with the activation of innate immunity, with an observed increase in neutrophils, mononuclear phagocytes, and natural killer cells, as well as a decrease in T cells. Interferon plays important roles in restricting viruses and is crucial because it participates in both innate and adaptive immunity. Gamma interferon (IFN-γ) is a cytokine that plays a fundamental role in maintaining homeostasis in the body, both in vitro and in vivo.Objective: An immunological study was conducted to measure the concentrations of IFN-γ in severe SARS-CoV-2-positive patients.Material and methods: Around 500 sera from patients with similar respiratory comorbidities at the onset of the disease were analyzed, using healthy patients as controls. The sera from SARS-CoV-2-positive individuals were processed using the ELISA technique, and the statistical treatment of the data involved creating a database with the absorbance readings, which were then converted into concentrations in pg/ml.Results: We can infer that the amount of IFN-γ expression depends on the patient's condition; the more severe the patient's condition, the higher the expression of this cytokine compared to their baseline levels, ranging from 0 to 0.5 μg/ml.Conclusion: It is suggested that the IFN-γ response plays an important role in controlling the disease, and effective therapies are recommended for the treatment of Covid-19, which will lead to the implementation of therapeutic approaches aimed at counteracting the immune system, especially in the more severe forms of the disease.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6353"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comment on the article: "Diagnostic performance of the FINDRISC questionnaire to identify insulin resistance in adults"]. [对文章的评论：“FINDRISC问卷对成人胰岛素抵抗的诊断性能”]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14616808

Citlalli Valadez-Mayorga

引用次数: 0

[Elevated neutrophil-lymphocyte ratio and delayed graft function]. 中性粒细胞/淋巴细胞比例升高和移植物功能延迟。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617087

Itzy Maely Gaytán-Campos, Aurelio Chávez-Meza, José Oscar Juaréz-Sánchez, Yumar Alfredo Hurtado-Castillo, Rafael Luna-Montalbán, Martha Alicia Hernández-González

{"title":"[Elevated neutrophil-lymphocyte ratio and delayed graft function].","authors":"Itzy Maely Gaytán-Campos, Aurelio Chávez-Meza, José Oscar Juaréz-Sánchez, Yumar Alfredo Hurtado-Castillo, Rafael Luna-Montalbán, Martha Alicia Hernández-González","doi":"10.5281/zenodo.14617087","DOIUrl":"https://doi.org/10.5281/zenodo.14617087","url":null,"abstract":"Background: Delayed graft function (DGF) is a significant complication in kidney transplantation, adversely affecting graft and recipient survival. Therefore, it is important to establish tools that help predict this condition. The elevation of the neutrophil-to-lymphocyte ratio (NLR) has been studied as a predictor of DGF, with the premise that its increase is associated with systemic inflammation and, consequently, DGF.Objective: To analyze the association between an elevated NLR in the preoperative period and delayed graft function in kidney transplant recipients.Materials and methods: A prospective, observational, analytical, and longitudinal study. The sample included all patients admitted to the Nephrology Transplant Service at Hospital de Especialidades No. 1, Centro Médico Nacional Bajío, in 2023.Results: We found that an NLR greater than 3.5 in the preoperative period of patients undergoing kidney transplantation had 80% specificity and 28% sensitivity, compared to patients with an NLR of 3.5 or lower.Conclusions: There is no association between an elevated NLR in the preoperative period and delayed kidney graft function after transplantation. However, it may be associated with other risk factors, as demonstrated in the multivariate analysis, which revealed that donor acute kidney injury increased the likelihood of developing DGF by almost 200%.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6440"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Area strain as prognostic factor of functional recovering in myocardial infarction]. [面积应变作为心肌梗死功能恢复的预后因素]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617002

Joaquín Ahumada-Pérez, Luis Antonio Moreno-Ruíz, Carlos García-Cosío, Ivan Silvestre-Flores, Antonio Ruíz-Rivera, Noe Fernando Zamorano-Velázquez, Guadalupe Cleva Villanueva-López

{"title":"[Area strain as prognostic factor of functional recovering in myocardial infarction].","authors":"Joaquín Ahumada-Pérez, Luis Antonio Moreno-Ruíz, Carlos García-Cosío, Ivan Silvestre-Flores, Antonio Ruíz-Rivera, Noe Fernando Zamorano-Velázquez, Guadalupe Cleva Villanueva-López","doi":"10.5281/zenodo.14617002","DOIUrl":"10.5281/zenodo.14617002","url":null,"abstract":"Background: Area strain evaluates the longitudinal and circumferential deformation simultaneously. There are not estudies that support its benefit in predicting functional recovering in myocardial infarction.Objective: The aim was establish the prognostic value of the area strain measured within the first 7 days after succesful angioplasty to predicting functional recovering.Materail and methods: A prospective cohort study was performed during 3-month follow-up. Patients with myocardial infarction treated with succesful angioplasty were enrolled. The area strain was perfomed within the first 7 days. Functional recovering was defined as an improvement of the ejection fraction ≥ 10% at 3-months follow-up.Results: A total of 52 patients were enrolled. An area strain of ≤ -24.2 % appeared in the 45.5% of the patients with functional recovering, RR 16.25 (IC 95%: 2.55-103, p = 0.003). In the multivariate analyses the area strain of ≤ -24.2 % was the only variable with statistical significance with an OR of 13.15 (IC 95%: 1.83-94, p = 0.010) when was adjusted to hypertension, OR of 12.7 (IC 95%: 1.88-85.9, p = 0.009) adjusted to reperfusion time of ≤ 120 minutes and the OR was of 11.87 (IC 95%: 1.66-84.5, p = 0.013) adjusted to smoking.Conclusions: An area strain of ≤ - 24.2% is a prognostic factor of improvement of ejection fraction of ≥ 10% at 3-months follow-up in patients with myocardial infarction and succesful angioplasty.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6591"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ART adherence and its association with depression, anxiety and stress]. [抗逆转录病毒治疗依从性及其与抑郁、焦虑和压力的关系]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14616894

Carla Gabriela Guzmán-Mendoza, María Del Carmen Jiménez-González, Oscar Manuel Delgado-Cuellar, Iván de Jesús Ascencio-Montiel

{"title":"[ART adherence and its association with depression, anxiety and stress].","authors":"Carla Gabriela Guzmán-Mendoza, María Del Carmen Jiménez-González, Oscar Manuel Delgado-Cuellar, Iván de Jesús Ascencio-Montiel","doi":"10.5281/zenodo.14616894","DOIUrl":"10.5281/zenodo.14616894","url":null,"abstract":"Background: Stress, anxiety, and depression are associated with low adherence to antiretroviral therapy (ART) in HIV patients, but there are no reports of this association in southeastern Mexico.Objective: To describe the frequency of adherence to ART and its association with depression, anxiety, and stress.Material and methods: A cross-sectional study was conducted. 442 HIV-positive outpatients treated at General Hospital Number 1 in Tapachula, Chiapas, in the period August-December 2022 were analyzed. Adherence to ART was assessed with the Simplified Medication Adherence Questionnaire (SMAQ) and the Depression, Anxiety, and Stress Scale-21 (DASS-21) was applied. To assess the association between variables, adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated using a multivariate logistic regression model. Cases with ART adherence between 95% and 100% were compared with those with ART adherence below 95%.Results: Of the total 442 HIV-positive subjects, 344 had ART adherence between 95% and 100%, and 98 had ART adherence below 95%. The frequencies of depression, anxiety, and stress were 33%, 13.3%, and 8.8%, respectively. Associations were observed between ART adherence below 95% and anxiety, depression, and stress.Conclusions: Since low ART adherence was associated with depression, anxiety, and stress among HIV-positive patients, early mental health interventions may help improve therapeutic adherence.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6553"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Self-report of body silhouettes to discriminate high abdominal adiposity in adolescents]. [自我报告的身体轮廓，以区分高腹部肥胖的青少年]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14616936

Evelyn Yazmin Estrada-Nava, Marcela Veytia-López, Marcela Pérez-Rodríguez, Rosalinda Guadarrama-Guadarrama

{"title":"[Self-report of body silhouettes to discriminate high abdominal adiposity in adolescents].","authors":"Evelyn Yazmin Estrada-Nava, Marcela Veytia-López, Marcela Pérez-Rodríguez, Rosalinda Guadarrama-Guadarrama","doi":"10.5281/zenodo.14616936","DOIUrl":"10.5281/zenodo.14616936","url":null,"abstract":"Background: Obtaining abdominal adiposity through self-reporting of body silhouettes could be a tool in long-distance epidemiological studies.Objective: To determine the cut-off point of body silhouettes and evaluate their diagnostic certainty in the classification of abdominal adiposity in Mexican adolescents.Material and methods: An analytical cross-sectional study was carried out on adolescents aged 14 to 18, high school students in the State of Mexico. The participants signed the informed consent, a body silhouette (BS) scheme was applied and their waist circumference (WC) was measured at the abdominal midpoint. Descriptive analyzes were performed, the best cut-off point was determined using ROC curves and the Youden index, and the diagnostic performance of BS to identify abdominal adiposity was evaluated.Results: 513 students were included (57% female; median age 16 [IQR 15-17] years). BS 6 was found to be the best cut-off point for both women (Youden = 0.68) and men (Youden = 0.69). The sensitivity was 91% in women and 79% in men, the specificity was 77% in women and 89% in men, with a positive likelihood ratio of 3.92 (95%CI = 3.77, 4.08) for women and 7.08 ( 95%CI = 4.55, 11.0) for men.Conclusions: Self-reported BS are a tool with high certainty that can be used to discriminate abdominal adiposity in adolescents.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6426"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Peripheral ulcerative keratitis with necrotizing scleritis, manifestation of granulomatosis with polyangiitis]. [周围性溃疡性角膜炎伴坏死性巩膜炎，肉芽肿病伴多血管炎的表现]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617182

Alejandro Ulises Rebolloso-González, Dolores de Los Ángeles González-De la Mora

{"title":"[Peripheral ulcerative keratitis with necrotizing scleritis, manifestation of granulomatosis with polyangiitis].","authors":"Alejandro Ulises Rebolloso-González, Dolores de Los Ángeles González-De la Mora","doi":"10.5281/zenodo.14617182","DOIUrl":"https://doi.org/10.5281/zenodo.14617182","url":null,"abstract":"Background: Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune disorder that typically affects small and/or medium size vessels. A collaborative management form ophthalmologist and rheumatologist could led to long term remission of the disease despite being yet a life threatening pathology.Clinic case: A 61 years old masculine complied of recurrent cases of ocular discomfort managed as a bacterial conjunctivitis for 2 years, also patient with loss of visual acuity and weight loss mainly in the three previous months. After discard infectious diseases such as tuberculosis and syphilis being in a high incidence country GPA investigation were carried out and later diagnosed. He was to start proper treatment with rituximab but as systemic complications advance he could not managed to achieve disease control. Ocular involvement has been show to occur in around 30% percent of cases in several studies. It could cause scleritis as well as conjuntivitis, episcleritis, necrotizing keratitis, corneoscleral perforation, posterior uveitis, and optic neuritis. C-ANCA and high positive PR3 autoantibody have strong association and sensitivity with GPA. Rituximab has been prove to be the most accurate treatment for this disease.Conclusions: Necrotizing scleritis and peripheral ulcerative keratitis can be manifestation of GPA. An ophthalmic check up may be the key to reach a promptly diagnosis of a tough systemic case.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6015"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical characterization in patients with neurocutaneous syndrome]. 【神经皮肤综合征患者的临床特点】。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14616948

Yazmin Hernández-Castañeda, Daniela Juárez-Melchor, Aurea Vera-Loaiza, Alan Alberto Pérez-Arzola, Israel Enrique Crisanto-López, Pablo Omar Rodríguez-Hurtado

{"title":"[Clinical characterization in patients with neurocutaneous syndrome].","authors":"Yazmin Hernández-Castañeda, Daniela Juárez-Melchor, Aurea Vera-Loaiza, Alan Alberto Pérez-Arzola, Israel Enrique Crisanto-López, Pablo Omar Rodríguez-Hurtado","doi":"10.5281/zenodo.14616948","DOIUrl":"https://doi.org/10.5281/zenodo.14616948","url":null,"abstract":"Background: Neurocutaneous syndromes are a group of genetic diseases that affect the skin, eyes, central and peripheral nervous systems. They include Neurofibromatosis type 1 (NF1), Tuberous sclerosis (TS), Von-Hippel Lindau disease, Neurofibromatosis type 2 (NF2), Ataxia Telangiectasia (AT) and Hypomelanosis of Ito.Objective: To characterize the most frequent clinical manifestations in Neurocutaneous syndromes.Methods: A descriptive, observational, cross-sectional and ambivalent study was carried out in the Genetics service of the General Hospital of Zone No. 20. Patients diagnosed with any neurocutaneous syndrome of any age were included and agreed to participate in the study.Results: Thirty-nine patients were reviewed, 21 patients (53.8%) were women and 18 (46.2%) were men. The median age of the patients was 12 years, with an interquartile range (25th-75th percentiles) of 6 and 17 years, respectively. The most frequent neurocutaneous syndromes were NF1 (62%) and ET (18%). All patients presented cutaneous manifestations, and 16 patients (42.1%) presented at least one neurological manifestation.Conclusions: The timely interpretation of skin changes as primary lesions becomes a valuable instrument for the early identification of any neurological alteration; likewise, the search for skin changes should be carried out in all patients undergoing initial study for neurological manifestations.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6419"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Hidradenitis suppurativa, report with dual therapy: small molecules and biological therapy]. [化脓性汗腺炎，报道双重治疗：小分子和生物治疗]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617170

Paola Denise Elizalde-Hernández, Andres Jhojairo Solis-González, Fabiola Leonor Méndez-Flores, Lorena Estrada-Aguilar

{"title":"[Hidradenitis suppurativa, report with dual therapy: small molecules and biological therapy].","authors":"Paola Denise Elizalde-Hernández, Andres Jhojairo Solis-González, Fabiola Leonor Méndez-Flores, Lorena Estrada-Aguilar","doi":"10.5281/zenodo.14617170","DOIUrl":"https://doi.org/10.5281/zenodo.14617170","url":null,"abstract":"Background: Hidradenitis suppurativa is an immune-mediated disease characterized by abscesses, deep nodules and fistulas that connect them to each other or connect to the surface, creating infectious processes that are difficult to control, healing of fistulas, retractable tracts and painful ulcers of slow evolution that lead the patient to depression and anxiety. Treatment still shows unsatisfactory results for patient health.Clinic case: A 27-year-old woman with a 5-year history of this pathology in Hurley stage III is presented. Because of failure to treatment with first lines of management. Anti IL-17 biologic was started, with poor response, so JAK inhibitor was added with adequate response at 4 weeks in the modified Hurley scale, VAS of pain and DLQI.Conclusion: Combined therapy mediated by cytokines and cells of the humoral response of retractile and fistulous lesions in Hurley stages II and III is proposed as an adjuvant in the chronic response of the disease.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6596"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0