Israel Enrique Crisanto-López, Renato García-González, María Patricia Saldaña-Guerrero, Rosa María Hernández-Camacho, Dulce María Castro-Coyotl
{"title":"[20q11.2 microdeletion syndrome: a phenotypic spectrum expansion. Case report].","authors":"Israel Enrique Crisanto-López, Renato García-González, María Patricia Saldaña-Guerrero, Rosa María Hernández-Camacho, Dulce María Castro-Coyotl","doi":"10.5281/zenodo.10278185","DOIUrl":"https://doi.org/10.5281/zenodo.10278185","url":null,"abstract":"<p><strong>Background: </strong>20q11.2 microdeletion syndrome [ORPHA: 444051] is a rare disease, since 16 patients have been reported in literature worldwide. Prevalence ratio is < 1:1,000,000 individuals. Haploinsufficiency on GDF5, SAMHD1 and EPB41L1 genes is important due to phenotypic manifestations in patients. Clinical features can be grouped into craniofacial abnormalities, limb abnormalities, neurological and perinatal disorders. The aim of this report is to present a clinical case of 20q11.21-q11.23 microdeletion, to describe clinical manifestations found, to compare them with features reported in literature, and to contribute to the phenotypic spectrum expansion.</p><p><strong>Clinical case: </strong>5-year-old female patient who presented hypotonia, psychomotor retardation, microcephaly, facial dysmorphia, pectus excavatum, thoracolumbar scoliosis, right hip subluxation, camptodactyly and clinodactyly. Karyotype test was normal and SNP microarray test reported deletion of chromosomal region 20q11.21-q11.23.</p><p><strong>Conclusions: </strong>It was presented a 20q11.2 microdeletion syndrome confirmed case that shares the features reported in literature, in addition to previously unreported features, such as blepharoptosis, pectus excavatum, scoliosis and hip dysplasia. Interdisciplinary management is important to improve the patient's condition (in her 3 spheres), in order to achieve her best possible health status.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Ignacio Rafael-Pérez, Alexis Jared Paz-López, Neri Ruvalcaba-Contreras
{"title":"[Pseudocyst of adrenal gland. Case report].","authors":"Carlos Ignacio Rafael-Pérez, Alexis Jared Paz-López, Neri Ruvalcaba-Contreras","doi":"10.5281/zenodo.10278191","DOIUrl":"https://doi.org/10.5281/zenodo.10278191","url":null,"abstract":"<p><strong>Background: </strong>Adrenal gland cysts are a rare entity, with a reported incidence in post-mortem series of 0.06-0.18%. However, the incidence seems to be increasing in recent years. The presentation of adrenal gland cysts is usually asymptomatic, but those cases in which symptoms are present are usually non-specific, which makes adrenal cysts generally recognized as incidentalomas. The finding is mainly made by computed tomography. The main objective of this article was to describe the clinical course of a patient with an adrenal gland pseudocyst, which is accompanied by symptoms of compression and persistent pain of long evolution in the left flank.</p><p><strong>Clinical case: </strong>A 65-year-old female patient attended the emergency room of a second-level hospital due to an increase in volume of the abdominal region with a sensation of fullness, heartburn, vomiting and pain. Computed tomography was performed, which reported a cystic mass and, later, exploratory laparotomy plus adrenalectomy were carried out. The pathology analysis reported a diagnosis of a 10 x 15 x 14 cm solid, cystic, and adherent tumor, coinciding with a pseudocyst of the adrenal gland.</p><p><strong>Conclusions: </strong>Adrenal gland cysts are rare. Computed tomography is recommended for its diagnosis and the standard of treatment is surgical intervention in the presence of symptoms.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Karen Iturbe-Betancourt, Gabriel Gerardo Huitrón-Bravo, Rodolfo Rivas-Ruiz, Gerson Valencia-Martínez, Oscar Gabriel Vivanco-Dávila, Eneida Camarillo-Romero
{"title":"[Dietary inflammatory index related to knee osteoarthritis symptomatology].","authors":"Ana Karen Iturbe-Betancourt, Gabriel Gerardo Huitrón-Bravo, Rodolfo Rivas-Ruiz, Gerson Valencia-Martínez, Oscar Gabriel Vivanco-Dávila, Eneida Camarillo-Romero","doi":"10.5281/zenodo.10278136","DOIUrl":"10.5281/zenodo.10278136","url":null,"abstract":"<p><strong>Background: </strong>Proinflammatory diet contributes to greater symptomatology in patients with knee osteoarthritis (KOA); however, in Mexico there seems to be no evidence of the dietary inflammatory role, being a country with high prevalence of overweight and obesity with an inclination towards a Western diet.</p><p><strong>Objective: </strong>To analyze the relationship between dietary inflammatory index (DII) and KOA symptomatology in Mexican patients.</p><p><strong>Material and methods: </strong>Analytical cross-sectional study in 100 patients aged 40 to 70 years. Pain, stiffness, and functionality were evaluated with the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the DII was calculated from the semi-quantitative food consumption frequency questionnaire (QFCFQ). For its analysis, linear regression was calculated.</p><p><strong>Results: </strong>DII was significantly associated with pain (p = 0.001, R² = 0.118), functionality (p = 0.003, R² = 0.087) and WOMAC score (p = 0.001, R² = 0.099). In the second linear regression model with the dependent variable functionality, waist circumference (WC) was adjusted obtaining an R² = 0.144 and higher significance p = 0.001.</p><p><strong>Conclusions: </strong>Proinflammatory DII was related to greater pain, lower functionality and a high WOMAC score, which is why the anti-inflammatory diet could be considered as a support for the treatment of the patient with KOA.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
César Silva-Luna, Enrique Villarreal-Ríos, Liliana Galicia-Rodríguez, Laura Estefanía Rosas-Marín, Mireya Franco-Saldaña, Mariana Del Rayo Guerrero-Mancer, Juana Liliana Sandoval-Barajas, Arturo Silva-Nuñez
{"title":"[Cost-effectiveness of digital care and face-to-face care in the first-level of care].","authors":"César Silva-Luna, Enrique Villarreal-Ríos, Liliana Galicia-Rodríguez, Laura Estefanía Rosas-Marín, Mireya Franco-Saldaña, Mariana Del Rayo Guerrero-Mancer, Juana Liliana Sandoval-Barajas, Arturo Silva-Nuñez","doi":"10.5281/zenodo.10278140","DOIUrl":"https://doi.org/10.5281/zenodo.10278140","url":null,"abstract":"<p><strong>Background: </strong>The medical care paradigm is face-to-face; however, technological development has led to the digital modality.</p><p><strong>Objective: </strong>To determine cost-effectiveness of digital care and face-to-face care at the first level of care.</p><p><strong>Material and methods: </strong>Cost-effectiveness study. 2 groups were integrated: the digital service and the face-to-face service. The sample size was calculated with the percentage formula for 2 groups, and the result was 217 per group. The effectiveness was evaluated in 3 dimensions: the satisfaction of the patient, of the doctor and of the medical assistant. In all 3 cases the Visual analogue scale was used. The cost corresponded to the fixed unit cost estimated with the technique of times and movements adjusted for the duration of care. The statistical analysis included averages, percentages and cost-effectiveness ratio.</p><p><strong>Results: </strong>The cost of digital attention is $343.83 and face-to-face attention is $171.91 (all estimated in Mexican pesos). From the patient's perspective, the effectiveness in digital care is $9.47 and in face-to-face is $9.25. The cost to reach effectiveness of 10 in face-to-face care is $185.85 and in digital care $363.20. From the physician's perspective, the cost to achieve effectiveness of 10 is $419.13 in digital care and $184.52 in face-to-face care. From the perspective of the medical assistant, to achieve effectiveness of 10, the cost in digital care is $468.43 and in face-to-face $179.83.</p><p><strong>Conclusions: </strong>Currently, the best cost-effectiveness ratio corresponds to face-to-face care; however, digital care is an option that will have to evolve.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edgar Uriel Quintana-Ortiz, Germán Ramón Bautista-López, Enrique Alfredo Bernal-Ruiz, Marco Alejandro Solórzano-Vázquez, Martha Alicia Hernández-Gonzále, Sergio Eduardo Solorio-Meza
{"title":"[Clinical outcomes of percutaneous intervention on the unprotected left main coronary artery].","authors":"Edgar Uriel Quintana-Ortiz, Germán Ramón Bautista-López, Enrique Alfredo Bernal-Ruiz, Marco Alejandro Solórzano-Vázquez, Martha Alicia Hernández-Gonzále, Sergio Eduardo Solorio-Meza","doi":"10.5281/zenodo.10278143","DOIUrl":"https://doi.org/10.5281/zenodo.10278143","url":null,"abstract":"<p><strong>Background: </strong>The debate on percutaneous coronary intervention (PCI) of the unprotected left main coronary artery (LMCA) has been constant over time.</p><p><strong>Objective: </strong>To investigate the clinical and procedural characteristics and cardiovascular outcomes of PCI of unprotected LMCA.</p><p><strong>Material and methods: </strong>Observational study which included patients with unprotected LMCA disease undergoing PCI; patients with cardiogenic shock prior to the procedure were excluded. We describe the clinical and angiographic characteristics, as well as the major adverse cardiac and cerebrovascular events (MACCE) according to the year of the procedure.</p><p><strong>Results: </strong>We included 73 patients, with a SYNTAX I score of 31.2 ± 9.1, mostly with ST-elevation acute coronary syndrome (35%). There was a higher frequency of triple vessel coronary disease (63%) and distal LMCA lesions (35%). The provisional stent technique was the most used for distal lesions (58%) and the 2-stent technique for bifurcation lesions (78%), supported by intravascular ultrasound (IVUS) in 38%. During follow-up, 19 presented MACCE (26%), out of which cardiac death occurred in 13%, non-cardiovascular death in 5%, non-fatal acute myocardial infarction in 1%, cerebrovascular event in 2%, and revascularization of the treated vessel in 4%.</p><p><strong>Conclusions: </strong>It was observed a similar frequency to the one appearing in other studies of cardiovascular events, mainly in patients with intermediate risk, which supports the increasing use of percutaneous intervention in this population.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Neuroendocrine expression markers in triple-negative, luminal-A, luminal-B and HER2neu breast cancer].","authors":"Yesica Guadalupe Barboza-García, Lázaro Ramírez-Balderrama, Mario Murguía-Pérez, Martha Alicia Hernández-González, Isette Yunue Landeros-Navarro","doi":"10.5281/zenodo.10278131","DOIUrl":"https://doi.org/10.5281/zenodo.10278131","url":null,"abstract":"<p><strong>Background: </strong>Primary breast tumors with neuroendocrine (NE) differentiation are a heterogeneous tumor group with diversity of biological behavior, with poorly defined prevalence and prognosis.</p><p><strong>Objective: </strong>To evaluate the chromogranin, synaptophysin, CD56, INSM1 markers expression prevalence and the association between NE differentiation and tumor molecular type.</p><p><strong>Material and methods: </strong>Observational, cross-sectional study which included 110 breast tissue samples with primary invasive carcinoma. Immunohistochemistry was performed for chromogranin, synaptophysin, CD56 and INMS1 markers. NE differentiation was considered with 10-90% positive cells, and NE tumor with > 90% positive cells.</p><p><strong>Results: </strong>26.3% showed neuroendocrine differentiation. Out of these, 48.2% were luminal-A type, 24.1% luminal-B, 11.5% HER2neu, 17.2% triple-negative; 1.8% were NE tumors. Tumors were marker positive, and out of these to chromogranin in 24.5%, synaptophysin in 28.2%, CD56 in 2.7%, INSM1 in 16.4%. Synaptophysin was expressed in 17.3% luminal-A type, 6.4% luminal-B, 0.9% HER2neu, 3.6% triple-negative. NE differentiation showed association with synaptophysin expression (r = 0.586, p = 0.0001).</p><p><strong>Conclusion: </strong>The NE differentiation prevalence was 26.3% in primary invasive breast cancers, with luminal-A molecular type predominance.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alison Flores-Gonzale, Luis Enrique Herrera-Del Valle, Víctor Ramón Lara-Ramírez, Ixchel Marco-Valdez, Ariadna Judith Torres-Pedroza, Karla Jannet Briceño-Rodas
{"title":"[Juvenile Pompe disease: Undescribed genotype. First report in Quintana Roo].","authors":"Alison Flores-Gonzale, Luis Enrique Herrera-Del Valle, Víctor Ramón Lara-Ramírez, Ixchel Marco-Valdez, Ariadna Judith Torres-Pedroza, Karla Jannet Briceño-Rodas","doi":"10.5281/zenodo.10278165","DOIUrl":"https://doi.org/10.5281/zenodo.10278165","url":null,"abstract":"<p><strong>Background: </strong>Pompe disease (PD) is a rare autosomal recessive genetic disorder (1 in 14,000) which affects the synthesis of acid alpha-glucosidase (AGA), leading to intralysosomal glycogen accumulation in muscle tissue. The clinical presentation is heterogeneous, with variable degrees of involvement and progression, classifiable based on the age of onset into infantile (classic or non-classic) and late-onset forms (juvenile or adult). The diagnostic test of choice is the enzymatic analysis of AGA, and the only pharmacological treatment is enzyme replacement therapy (ERT). This document aims to report a clinical case of late-onset PD.</p><p><strong>Clinical case: </strong>14-year-old male who started at the age of 5 with postural alterations, gait changes, and decreased physical performance compared to his peers. A diagnostic evaluation was initiated in 2022 due to worsening neuromuscular symptoms, accompanied by dyspnea, tachycardia, and chest pain. A suspicion of a lysosomal storage myopathy was established, and through enzymatic determination of AGA the diagnosis of PD was confirmed. The study of the GAA gene revealed the association of 2 previously unreported genomic variants. ERT was initiated, resulting in clinical improvement.</p><p><strong>Conclusions: </strong>The age of symptom onset, severity of clinical presentation, and prognosis of the disease depend on the specific mutations involved. In this case, the identified genetic alterations are associated with different phenotypes. However, based on the clinical presentation, it is categorized as juvenile PD with an indeterminate prognosis.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesús Sebastián Rodríguez-Gutiérrez, Antonio Tirado-Motel, Jesús Leonel Sarabia-Esquerra, Atziry Sarahi Urtuzuástegui-Gastelum, Ángel Alfonso Germán-Rentería
{"title":"[Hailey-Hailey disease: A case report].","authors":"Jesús Sebastián Rodríguez-Gutiérrez, Antonio Tirado-Motel, Jesús Leonel Sarabia-Esquerra, Atziry Sarahi Urtuzuástegui-Gastelum, Ángel Alfonso Germán-Rentería","doi":"10.5281/zenodo.10278169","DOIUrl":"10.5281/zenodo.10278169","url":null,"abstract":"<p><strong>Background: </strong>Hailey-Hailey disease is a rare autosomal dominant genodermatosis whose cause is the ATP2C1 gene mutation. A prevalence of 1 in 50,000 cases is estimated and it manifests as grouped flaccid vesicles that break easily. The diagnosis is confirmed with the histopathological study creating an appearance called \"dilapidated brick wall\", identifying dyskeratosis in the form of round bodies and pimples. Treatment ranges from general measures to multiple pharmacological options, with topical corticosteroids being the most commonly used.</p><p><strong>Clinical case: </strong>Male patient diagnosed with Hailey-Hailey disease. On physical examination we observed a dermatosis disseminated to the neck, trunk, axillary and inguinal folds, and intergluteal region, unilateral, asymmetric with a polymorphous appearance, constitution due to exulceration, erythema, some pustules and flaccid vesicles that coalesced to form eczematous and hypertrophic plaques with the presence of fine scales on their surface, with a chronic evolution accompanied by pruritus. We also took the opportunity to review the most relevant information in the literature regarding Hailey-Hailey disease, especially focused on the therapeutic aspect.</p><p><strong>Conclusions: </strong>It is important to take into account that Hailey-Hailey disease is a rare pathology, in order to make a differential diagnosis in daily clinical practice.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Graciela Garza-Rugerio, Noe Muñoz-Ahuatzin, María de la Luz León-Vázquez, Paola Maycotte-González, Patricia Seefoó-Jarquín
{"title":"[BIRADS 0 patient reclassification in a first-level of care unit].","authors":"Graciela Garza-Rugerio, Noe Muñoz-Ahuatzin, María de la Luz León-Vázquez, Paola Maycotte-González, Patricia Seefoó-Jarquín","doi":"10.5281/zenodo.10278086","DOIUrl":"https://doi.org/10.5281/zenodo.10278086","url":null,"abstract":"<p><strong>Background: </strong>In Mexico and the world, breast cancer is the cancer type with the highest incidence and mortality for women. Its incidence has increased due to a higher life expectancy and a higher exposure to risk factors. Screening is done by mammography using the BIRADS (Breast Imaging Reporting and Data System) system, the standard for mammography screening report which classifies lesions assigning recommendations for patient follow-up. The system goes from 0 (not conclusive) to 6 (demonstrated malignancy), being of interest for this study the BIRADS 0 category.</p><p><strong>Objective: </strong>To describe patients classified as BIRADS 0 by mammography and their reclassification in a first-level hospital during 2021.</p><p><strong>Material and methods: </strong>Retrospective, descriptive, cross-sectional, observational study. Women over 40 years with a BIRADS 0 result were studied. The following databases were used: Institutional Cancer Registry, Family Medicine Information System, Electronic Clinical File, and the mammography and patient list from preventive medicine.</p><p><strong>Results: </strong>Reclassification by ultrasound (US) was achieved in 100% of patients, in all of the BIRADS US categories. In 3.8% of BIRADS 0 patients, ductal adenocarcinoma was found and confirmed by histological testing.</p><p><strong>Conclusion: </strong>All of the reassessed lesions with US were adequately reclassified.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel Alexander Vázquez-Moreno, Miguel Cruz-López
{"title":"[Childhood overweight and obesity: A biomedical challenge in Mexico].","authors":"Miguel Alexander Vázquez-Moreno, Miguel Cruz-López","doi":"10.5281/zenodo.10278077","DOIUrl":"https://doi.org/10.5281/zenodo.10278077","url":null,"abstract":"<p><p>In Mexico, 1 out of 3 schoolchildren aged 5 to 11 years is overweight or obese, which represents one of the main public health concerns, due to the fact that this condition in the child population is highly associated with the development of metabolic complications in adults. To date, dietary and physical activity interventions to prevent this problem have shown modest results worldwide. Biomedical studies in Mexico have shown that the pathophysiology of childhood overweight and obesity presents different molecular patterns, inflammation and oxidative stress, possibly associated with specific variants in the genome. However, the challenge is to achieve a secure characterization of this evidence so that it can be used in intervention studies aimed to improve the ability to predict and treat childhood overweight and obesity in Mexico. The biomedical challenge is to make knowledge a prevention strategy in families, in society and in the country, in order to fight the serious problem of obesity and its consequences.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}