María Nayeli Acosta-Gutiérrez, Julia Del Carmen Rodríguez-García, David Manuel Miranda-Canteros, Célida Duque-Molina, Ernesto Krug-Llamas, Alma Belen Membrila-Torres, Beatriz Nohemi Aguirre-Mendoza, Itzel Valtierra-Martinez, Joel Bailon-Brito, Diego Salomón Balcón-Caro
{"title":"[The Pierde Kilos, Gana Vida strategy, scope and prospects].","authors":"María Nayeli Acosta-Gutiérrez, Julia Del Carmen Rodríguez-García, David Manuel Miranda-Canteros, Célida Duque-Molina, Ernesto Krug-Llamas, Alma Belen Membrila-Torres, Beatriz Nohemi Aguirre-Mendoza, Itzel Valtierra-Martinez, Joel Bailon-Brito, Diego Salomón Balcón-Caro","doi":"10.5281/zenodo.13306787","DOIUrl":"https://doi.org/10.5281/zenodo.13306787","url":null,"abstract":"<p><strong>Background: </strong>The Pierde Peso, Gana Vida (Lose Weight, Gain Life) strategy is granted to patients with overweight or obesity, it started in 2022 with the purpose of ordering, integrating and making efficient actions in the care of overweight and obesity, however, its effectiveness is unknown.</p><p><strong>Objective: </strong>To analyze the changes in the following parameters: body weight, waist circumference, glucose, cholesterol and triglycerides in patients who received the strategy in the 35 IMSS state offices during the two semesters of 2022.</p><p><strong>Material and methods: </strong>A retrospective cohort study was conducted including 76,760 patients incorporated into the strategy in the two semesters of 2022. Trend analysis was performed before and after each semester of intervention. Analytical statistics were used for related samples with Student's t-test. SPPSS v25 software was used for data analysis.</p><p><strong>Results: </strong>Patients who received this strategy in each semester presented significant decrease in the parameters: body weight, waist circumference, glucose, cholesterol and triglycerides.</p><p><strong>Conclusions: </strong>The Pierde Peso, Gana Vida strategy makes the actions in obesity care efficient and allows achieving good results in the beneficiaries.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 6","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Administrative work program of de Educational Research and Teacher Training Center in Puebla].","authors":"Blanca Estela Ruiz-Barrón, Sarahi Guerrero-Barrios, Luz Karina Ramírez-Dueñas, Socorro Méndez-Martínez, Jorge Ayón-Aguilar, Máximo Alejandro García-Flores","doi":"10.5281/zenodo.13306718","DOIUrl":"https://doi.org/10.5281/zenodo.13306718","url":null,"abstract":"<p><strong>Background: </strong>The Administrative Work Program at the Center for Educational Research and Teacher Training (CIEFD) was based on the approach of the administrative area to publicize the aspects covered by the environment and the daily operation of the Unit, since all of this is an essential part In order for the CIEFD to function correctly, it must also be verified that the work within the organization is carried out correctly and that each element fulfills its functions.</p><p><strong>Objetive: </strong>Describe the different aspects of the administrative work program of the Center for Educational Research and Teacher Training in Puebla.</p><p><strong>Material and methods: </strong>Qualitative narrative study that describes each of the important administrative areas in the CIEFD: Financial Resources, Material Resources, Human Resources, Conservation and Maintenance, Civil Protection, Competitiveness Model and IT Coordination.</p><p><strong>Results: </strong>Each administrative area of the CIEFD converges into an administrative program that is governed by its own regulations and it is the administrator's task to converge all these areas by coordinating all aspects of the workforce, directing and managing, as well as allocating the necessary resources (materials economic and human) to ensure that work flows can be effective and that the Center's goals and objectives are met.</p><p><strong>Conclusion: </strong>The administrative areas of the CIEFD are essential for the training of human resources, teaching and managerial professionalization.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 6","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Alejandro Aguilar-Vázquez, Nallely Denisse Ruvalcaba-Sánchez, Julián Alberto Hernández-Domínguez, Sergio De Jesús Aguilar Castillo
{"title":"[Electroencephalographic patterns and their association with functional prognosis in anti-NMDA autoimmune encephalitis].","authors":"Christian Alejandro Aguilar-Vázquez, Nallely Denisse Ruvalcaba-Sánchez, Julián Alberto Hernández-Domínguez, Sergio De Jesús Aguilar Castillo","doi":"10.5281/zenodo.13306743","DOIUrl":"10.5281/zenodo.13306743","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune encephalitis is a rare disease with low incidence and prevalence but carries high rates of disability and potential fatality.</p><p><strong>Objective: </strong>To determine whether the presence of abnormal electroencephalographic patterns in patients with anti-NMDAR autoimmune encephalitis affects functional prognosis at 3 months.</p><p><strong>Material and methods: </strong>A retrospective, observational, analytical, longitudinal-cross-sectional study was conducted with a retrospective cohort.</p><p><strong>Results: </strong>Out of a total of 44 patients with anti-NMDAR autoimmune encephalitis, concerning electroencephalographic findings, 19 patients had a normal EEG result (43.2%), 18 had cortical dysfunction (40.9%), 7 had epileptiform reports (15.9%), and only 1 had a Delta Brush report (2.3%). The functional outcome of patients at 3 months measured by the modified Rankin Scale (mRS) was as follows: 3 patients without disability (6.8%), 6 patients with mild disability (13.6%), 17 patients with mild to moderate disability (38.6%), 9 patients with moderate to severe disability (20.5%), 1 patient bedridden (2.3%), and 2 deceased (5.6%).</p><p><strong>Conclusion: </strong>In our study, no association was found between an abnormal electroencephalographic pattern and a worse functional prognosis at 3 months in patients with autoimmune encephalitis. Although the electroencephalogram analyzed is the initial one, it would be necessary to assess later whether the persistence of abnormalities in the electroencephalogram is related to a greater number of sequelae and disabilities.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 6","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yolanda Monserrath Jacobo-Delgado, Luis Adrián De Jesús-González, Bruno Rivas-Santiago
{"title":"[Tuberculosis: Analysis of the history and development of multiple antibiotic resistance].","authors":"Yolanda Monserrath Jacobo-Delgado, Luis Adrián De Jesús-González, Bruno Rivas-Santiago","doi":"10.5281/zenodo.13306769","DOIUrl":"https://doi.org/10.5281/zenodo.13306769","url":null,"abstract":"<p><p>Tuberculosis is an ancient disease that has accompanied humanity for the last three thousand years and is considered the oldest infectious disease that still exists. The Mycobacterium tuberculosis bacillus was spread worldwide due to human migrations, and there is archaeological evidence of spinal tuberculosis cases in Egyptian and Andean mummies, as well as texts that attributed the disease to social factors before suspecting its infectious nature. Throughout its history, humans have dealt with this pathology by developing unusual and ineffective therapies, leading to a significant increase in the disease's mortality. In the past century, the first antibiotics were introduced, bringing hope to eradicate this disease. However, evolutionary pressure has led to the emergence of multi-drug-resistant strains. Today, the development of computational techniques, such as artificial intelligence, has given us new hope for generating drugs and potential immunomodulatory therapies. However, it is essential to remember that those who do not know their history are doomed to repeat it. In this review, we summarize the history of tuberculosis, analyzing theories of its possible origin, its discovery, the creation of the first empirical treatments, vaccines, the emergence of new antibiotics, and how the mycobacterium quickly develops resistance.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 6","pages":"137"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandra Martínez-Vázquez, Ricardo Jorge García-Bermúdez, Julián Alberto Hernández-Domínguez, José Alfredo Sierra-Ramírez
{"title":"[Radiological clinical profile of multiple cranial neuropathy and recurrence risk factors].","authors":"Alejandra Martínez-Vázquez, Ricardo Jorge García-Bermúdez, Julián Alberto Hernández-Domínguez, José Alfredo Sierra-Ramírez","doi":"10.5281/zenodo.10814313","DOIUrl":"10.5281/zenodo.10814313","url":null,"abstract":"<p><strong>Background: </strong>Multiple cranial neuropathies (MCN) are the dysfunction of 2 or more cranial nerves, simultaneously or sequentially. The most common causes are tumors, followed by vascular and traumatic causes, central nervous system infections and Guillain-Barré syndrome and its variants.</p><p><strong>Objective: </strong>To identify the radiological clinical profile of MCN in patients of a tertiary-care hospital.</p><p><strong>Material and methods: </strong>Observational, cross-sectional, retrospective and analytical study in patients of 18 years of age or older, with a diagnosis of MCN. It was used descriptive statistics, and normality curves were determined. To establish differences, it was used chi-squared or Student's t test with the statistical package SPSS, version 29.</p><p><strong>Results: </strong>46 patients with a mean age 49 years (± 16) were studied. 29 (63%) were male. Findings in the magnetic resonance of the skull were normal in 34%; the reinforcement of the cavernous sinus in 26%. Non-infectious inflammatory was the most frequent etiology (43%). 83% of the inflammatory etiology presented improvement at discharge while those of non-inflammatory etiology were discharged without improvement (odds ratio [OR] 8, p 0.001). 87% had pain in their clinical picture unlike subjects with non-inflammatory etiology (OR 4, p < 0.01). 73% of the population with inflammatory etiology presented recurrence, and none of the subjects with a non- inflammatory cause (OR 0.5, p 0.022).</p><p><strong>Conclusions: </strong>The most common presentation of MCN in our study was cavernous sinus syndrome or sphenoidal cleft, with a non-acute course. The possibility of documenting an inflammatory etiology impacts the risk of recurrence and improvement upon hospital discharge.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 suppl 2","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth Michel Ortega-Rocha, Brenda Hernández-Rico, Laura Cecilia Bonifaz-Alfonzo, Alicia Lemini-López
{"title":"[Translational medicine in dermatology: experience in the Specialties Hospital of the 21st Century National Medical Center].","authors":"Elizabeth Michel Ortega-Rocha, Brenda Hernández-Rico, Laura Cecilia Bonifaz-Alfonzo, Alicia Lemini-López","doi":"10.5281/zenodo.10814393","DOIUrl":"https://doi.org/10.5281/zenodo.10814393","url":null,"abstract":"<p><p>Through multidisciplinary research, translational medicine allows a comprehensive approach to diseases in order to provide patients with adequate treatment, whose aim is personalized and precision medicine. In this context, the Cellular Immunology Laboratory of the Immunochemistry Research Unit, and the Dermatology Service of the 21st Century National Medical Center's Specialties Hospital (Hospital de Especialidades del Centro Médico Nacional Siglo XXI) have achieved a partnership that aspires to provide better quality patient care. This objective is achieved by evaluating the inflammatory skin infiltrates in different pathologies to observe changes in local immunity related to the response to treatment, and with the disease progression distinguish between dermatological diseases, highlight the importance of comprehensive skin care, and make decisions about treatment choice. This article will describe the results obtained from different research protocols (derived from this collaboration) in patients with different dermatoses such as warts, squamous cell carcinoma, mycosis fungoides and psoriasis. The evidence presented highlights the importance of collaborative work between clinical services and research laboratories so that scientific knowledge can be translated towards the comprehensive management of patients and towards personalized and precision medicine.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 suppl 2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Crhistian Alejandro Aguilar-Vázquez, Carlos César Reyes-Hernández, Julián Alberto Hernández-Domínguez, Alejandra Diana Raymundo-Carrillo, Elizabeth Damaris Flores-Vivaldo
{"title":"[Report of 3 cases of acute hemorrhagic leukoencephalitis in Mexico].","authors":"Crhistian Alejandro Aguilar-Vázquez, Carlos César Reyes-Hernández, Julián Alberto Hernández-Domínguez, Alejandra Diana Raymundo-Carrillo, Elizabeth Damaris Flores-Vivaldo","doi":"10.5281/zenodo.10814411","DOIUrl":"10.5281/zenodo.10814411","url":null,"abstract":"<p><strong>Background: </strong>Acute hemorrhagic leukoencephalitis (AHLE) or Weston-Hurst syndrome is a rare and severe variant of acute disseminated encephalomyelitis (ADEM). It causes fulminant hemorrhagic demyelination of the central nervous system, and has high mortality and morbidity. Due to the increase in cases and to its high rate of mortality, we decided to make a series of cases and a review of the disease.</p><p><strong>Clinical cases: </strong>We present 3 cases of Mexican patients, with clinical, radiological, and cerebrospinal fluid presentation compatible with the disease, with little response to treatment and high short-term morbidity. In 2 of the cases, there was positive evidence of aquaporin 4 antibodies (ac-AQP4), without any other apparent trigger.</p><p><strong>Conclusions: </strong>There is little evidence on the clinical evolution and medical management of the disease. With the arrival of the COVID-19 pandemic, there was an increase in cases of these diseases of autoimmune etiology. Although these cases did not present previous infection by COVID 19, there was an increase in the immunogenicity of ab- AQP4. Because of this, we believe it is important to distinguish it, describe as many cases as possible, and provide more information about its diagnosis, treatment, and prognosis. Likewise, we carried out a brief systematic review of the bibliography.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 suppl 2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Alejandro Jiménez-Ochoa, María Margarita Contreras-Serratos, Martha Leticia González-Bautista, Constantino López-Macías, Lourdes Andrea Arriaga-Pizano, Miriam Elizabeth Aguilar-Marquez
{"title":"[Survival after hematopoietic stem cell transplantation with identical and haploidentical donors].","authors":"Marco Alejandro Jiménez-Ochoa, María Margarita Contreras-Serratos, Martha Leticia González-Bautista, Constantino López-Macías, Lourdes Andrea Arriaga-Pizano, Miriam Elizabeth Aguilar-Marquez","doi":"10.5281/zenodo.10814305","DOIUrl":"10.5281/zenodo.10814305","url":null,"abstract":"<p><strong>Background: </strong>Allogeneic hematopoietic stem cell transplantation (HSCT) is a therapy that offers the potential to cure hematological malignancies. One limitation is that only 25% of patients will have an identical donor. The use of haploidentical donors allows 95% of patients to have a donor. Experience in Mexico with haploidentical HSCT is limited. In 2018, the Haploidentical Transplantation Program began at the Hospital de Especialidades (Specialties Hospital) from the Centro Médico Nacional Siglo XXI (21st Century National Medical Center).</p><p><strong>Objective: </strong>To compare the overall survival of patients undergoing HSCT with an identical or haploidentical donor at the Hospital de Especialidades.</p><p><strong>Material and methods: </strong>A retrospective, observational study was carried out in patients undergoing HSCT at the Hospital de Especialidades, from January 2018 to December 2022. All patients who received HSCT were included. Overall survival analysis was performed using Kaplan-Meier curves. A significance level of p < 0.05 was considered.</p><p><strong>Results: </strong>109 patients who underwent to allogeneic HSCT were analyzed, 34% of them had a haploidentical donor. There were no differences in overall survival. The haploidentical group presented greater cytomegalovirus reactivation and less chronic graft-versus-host disease (GVHD).</p><p><strong>Conclusions: </strong>No differences in survival were found in both groups, which is why haploidentical transplantation could be a good treatment option in patients who do not have an identical donor at our institution.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 suppl 2","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The Specialties Hospital of the 21st Century National Medical Center: 60 trailblazing years in Mexican medicine].","authors":"Francisco José Avelar-Garnica","doi":"10.5281/zenodo.10814287","DOIUrl":"https://doi.org/10.5281/zenodo.10814287","url":null,"abstract":"<p><p>The objective of this letter to the editor is to make a reflection about the past, present and future of the Specialties Hospital \"Dr. Bernardo Sepúlveda Gutiérrez\" from the 21st Century National Medical Center, on the occasion of its 60th anniversary.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 suppl 2","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayeli Ortiz-Olvera, Araceli Muñoz-Bautista, Mario Molina-Ayala, Rita A Gómez-Díaz, Segundo Morán-Villota
{"title":"[Occult thyroid dysfunction in outpatients with liver cirrhosis].","authors":"Nayeli Ortiz-Olvera, Araceli Muñoz-Bautista, Mario Molina-Ayala, Rita A Gómez-Díaz, Segundo Morán-Villota","doi":"10.5281/zenodo.10814357","DOIUrl":"https://doi.org/10.5281/zenodo.10814357","url":null,"abstract":"<p><strong>Background: </strong>Several alterations in thyroid function have been identified in patients with liver cirrhosis (LC).</p><p><strong>Objective: </strong>To carry out a thyroid disease screening in adult patients with LC.</p><p><strong>Material and methods: </strong>A cross-sectional study. Serum levels of thyroid-stimulating hormone (TSH) and free-tetraiodothyronine (T4) were measured, and compared according to etiology of the cirrhosis, sex, model of end-stage liver disease (MELD) score, and Child-Pugh (C-P) class.</p><p><strong>Results: </strong>The most frequent etiology was hepatitis C virus (45%), followed by non- alcoholic fatty liver-disease (17%). We found thyroid dysfunction in 36% of the patients. The most frequent alteration was subclinical hypothyroidism (34%). Patients with alcohol-induced cirrhosis had the highest frequency of subclinical hypothyroidism (45%) and TSH levels were higher in patients with cirrhosis due to autoimmune disease and in those with alcohol-induced cirrhosis.</p><p><strong>Conclusion: </strong>We found no correlation between thyroid hormone levels, age, MELD score, or C-P. Our results showed that occult primary thyroid dysfunction is frequent in outpatients with LC, regardless of age, etiology, or liver reserve. Subclinical hypothyroidism was the main alteration and presented more frequently in patients with alcohol-induced cirrhosis. Longitudinal studies are needed to know the impact of subclinical hypothyroidism on the clinical progression of patients with cirrhosis.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"62 suppl 2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}