Revista medica del Instituto Mexicano del Seguro Social最新文献_第3页

[CAR-T cells in Dermatology: Mechanisms of action and applications in autoimmune diseases]. CAR-T细胞在皮肤病学中的作用机制及其在自身免疫性疾病中的应用

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617135

Osmara Morales-Hernández, Silvia Méndez-Flores

{"title":"[CAR-T cells in Dermatology: Mechanisms of action and applications in autoimmune diseases].","authors":"Osmara Morales-Hernández, Silvia Méndez-Flores","doi":"10.5281/zenodo.14617135","DOIUrl":"https://doi.org/10.5281/zenodo.14617135","url":null,"abstract":"Background: Chimeric Antigen Receptor T (CAR-T) cells have revolutionized the treatment of hematological malignancies and are expanding into autoimmune rheumatological diseases. In dermatology, they open a new therapeutic field for autoimmune disorders.Objective: To evaluate the mechanisms of action and therapeutic applications of CAR-T cells in autoimmune dermatological diseases, exploring the challenges and future perspectives for their clinical application.Material and methods: A thorough review was conducted in PubMed of preclinical and clinical studies on the application of CAR-T in dermatological diseases, selecting articles from the last 5 years with a focus on autoimmune diseases.Results: The potential of CAR-T cells in autoimmune dermatological diseases is highlighted, such as in pemphigus vulgaris, where CAR-T cells targeting pathogenic anti-Dsg3 B cells have shown efficacy. In cutaneous lupus erythematosus, CAR-T cells directed at CD19 have achieved significant clinical remissions. Additionally, applications in psoriasis and melanoma are explored, although efficacy is limited by adverse factors.Conclusions: CAR-T therapy represents a promising option for the management of refractory dermatological diseases, with favorable results in preclinical and clinical models. However, its clinical implementation faces challenges such as optimizing safety and reducing off-target effects. Future research should focus on next-generation CARs and clinical trials that validate their efficacy and safety profile in dermatology.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6626"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cesarean section risk assessment for pregnant women at term]. [足月孕妇剖宫产风险评估]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14616915

Carlos José Molina-Pérez, María Guadalupe Berumen-Lechuga, Alfredo Leaños-Miranda

{"title":"[Cesarean section risk assessment for pregnant women at term].","authors":"Carlos José Molina-Pérez, María Guadalupe Berumen-Lechuga, Alfredo Leaños-Miranda","doi":"10.5281/zenodo.14616915","DOIUrl":"10.5281/zenodo.14616915","url":null,"abstract":"Background: Every year, approximately 140 million births occur, with the majority being spontaneous deliveries in women without risk factors, resulting in vaginal births of healthy newborns.Objective: To develop a prognostic score to predict the probability of cesarean section in pregnant women at term with a single live fetus presenting with initial labor at hospital admission.Material and methods: Through a case-control study, pregnant women at term with initial labor at hospital admission were included. Cases were women with labor that culminated in an emergency cesarean section and controls were women who had a normal vaginal delivery. Clinical history was questioned, and a complete physical examination was performed. The odds ratio (OR) and 95% confidence intervals were calculated.Results: Seventy women were included, 27 cases and 43 controls. There were differences between groups in maternal weight, obesity, primiparity, uterine activity, history of premature rupture of membranes (PROM), cervical dilatation and effacement (p < 0.05). Factors associated with the risk of cesarean delivery were maternal obesity, primiparity, PROM, dilatation < 6 cm, and effacement < 50% (OR ≥ 3.3). Score ≥ 3.5 on the proposed scale is associated with the risk of cesarean delivery with a sensitivity of 81.5% and a specificity of 79%.Conclusion: Factors associated with the risk of cesarean delivery are maternal obesity, primiparity, and PROM. Score >4 points on the proposed scale is associated with the risk of cesarean delivery.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6357"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Laparoscopic management of gastric schwannoma]. 胃神经鞘瘤的腹腔镜治疗。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617155

Andric Pérez-Ortiz, Ana Yolanda Sandoval-Mussi, Anallely Luna-Hernández, Antonio Giovanni Spaventa-Ibarrola, Antonio Herrera-González, César Manuel Vargas-Sahagun, Carlos Zerrweck

{"title":"[Laparoscopic management of gastric schwannoma].","authors":"Andric Pérez-Ortiz, Ana Yolanda Sandoval-Mussi, Anallely Luna-Hernández, Antonio Giovanni Spaventa-Ibarrola, Antonio Herrera-González, César Manuel Vargas-Sahagun, Carlos Zerrweck","doi":"10.5281/zenodo.14617155","DOIUrl":"https://doi.org/10.5281/zenodo.14617155","url":null,"abstract":"Background: Gastric schwannoma is a rare GI tract tumor. Commonly, cases are asymptomatic and often misdiagnosed as gastrointestinal stromal tumors (GIST) or gastric leiomyomas.Clinical case: A 34-year-old female presented to the clinic for a gastric sleeve for obesity. Preoperatively, there was a GIST misdiagnosis. A CT scan showed a 16 mm gastric tumor in the lesser curvature adjacent to segment III of the liver. Endoscopic ultrasound showed a lesion arising from the muscularis mucosa. The biopsy was positive for spindle cells. The patient underwent a laparoscopic resection and Roux-en-Y gastric bypass. The pathology report showed S100-positive spindle cells compatible with gastric schwannoma.Conclusions: Like our case, gastric schwannomas are usually asymptomatic and arise in middle-aged women. However, their submucosal location in imaging studies, even endoscopic ultrasound, often leads to misdiagnosis. Postoperative pathology and immunohistochemical examinations are critical for final diagnosis and distinguishing features of other malignant stromal cell tumors. Care must be taken in cases with prominent lymph nodes on diagnostic laparoscopy.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6338"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cryptococcus albidus, Naganishia albida, primary skin infection, first case reported in Mexico]. [嗜性隐球菌，嗜性隐球菌，原发皮肤感染，墨西哥报告首例]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617216

María Fernanda Corona-Rosas, Aurora Paola Cruz Alcalá-Alegría, Salma Triana-González, Jesús Gaitán-Martínez, Jorge Procopio-Velázquez

{"title":"[Cryptococcus albidus, Naganishia albida, primary skin infection, first case reported in Mexico].","authors":"María Fernanda Corona-Rosas, Aurora Paola Cruz Alcalá-Alegría, Salma Triana-González, Jesús Gaitán-Martínez, Jorge Procopio-Velázquez","doi":"10.5281/zenodo.14617216","DOIUrl":"10.5281/zenodo.14617216","url":null,"abstract":"Background: The increase in immunosuppressive treatments and diseases that affect cellular immunity, such as diabetes, renal disease, and oncological or rheumatological conditions, has led to a rise in infections caused by opportunistic microorganisms. The aim of this work is to identify Naganishia albida as an infectious pathogen in immunocompromised patients, highlighting its importance and clinical evolution.Clinical case: One of the first identified cases of Naganishia albida is reported in a patient with immunosuppression secondary to oncological treatment, with domestic activity exposure being the main risk factor. The patient had a good clinical outcome due to timely diagnosis, guided by biopsy culture and reverse stains.Conclusion: Given the increase in conditions that affect the immune system, it is crucial for physicians of any specialty to pay special attention to secondary infections caused by immunosuppression. Without appropriate treatment, these infections can become invasive, negatively impacting the prognosis and evolution of the patient.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6543"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comment on the article "Asthma control and quality of life of asthmatic children and their caregivers"]. [评论文章“哮喘控制与哮喘儿童及其照护者的生活质量”]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14616863

José Miguel Fuentes-Pérez

引用次数: 0

[Child development in children with exclusive breastfeeding]. [纯母乳喂养儿童的发育]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617105

Néstor Isaí Domínguez-Delgado, Jacqueline Lezama-González, Elisa Sánchez-Cabrera, Socorro Méndez-Martínez, Carolina Sánchez-Pérez, Israel Bello-Guerrero, José Víctor Retama-Xochicale

{"title":"[Child development in children with exclusive breastfeeding].","authors":"Néstor Isaí Domínguez-Delgado, Jacqueline Lezama-González, Elisa Sánchez-Cabrera, Socorro Méndez-Martínez, Carolina Sánchez-Pérez, Israel Bello-Guerrero, José Víctor Retama-Xochicale","doi":"10.5281/zenodo.14617105","DOIUrl":"https://doi.org/10.5281/zenodo.14617105","url":null,"abstract":"Background: Exclusive breastfeeding (EBF) is essential for child development, offering cognitive, motor and emotional benefits.Objective: To determine child development in children with exclusive breastfeeding.Material and methods: A longitudinal and retrospective study was conducted on children aged 1 to 24 months, with and without exclusive breastfeeding (EBF). Development was assessed at three time points (baseline, three months, and six months) using the Infant Development Assessment Test, which measures gross motor skills, fine motor skills, language, and social aspects. Child-related variables (age, sex, and gestational age) and maternal variables (age, socioeconomic status, and education level) were analyzed using descriptive and inferential statistics with SPSS v24.Results: In a sample of 359 children, with a median age of 9 months (1-24), 52.4% were girls, with a median gestational age of 39 weeks (37-42). The median maternal age was 24 years (16-38), with a predominance of middle-high socioeconomic status (70.8) and secondary or higher education (55.4%). 52.9% of children received EBF. Initially, 83.1% of children with EBF obtained a green score in development, increasing to 97.8% at three months and 99.4% at six months. In contrast, in children without EBF, only 28.9% obtained a green score initially, increasing to 34.9% at three months and 48.5% at six months (p < 0.001).Conclusion: Children with EBF showed superior development compared to those without EBF, underlining the importance of breastfeeding in psychomotor, cognitive and social development.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6598"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Jejunal diverticular disease: a rare cause of gastrointestinal bleeding]. [空肠憩室病：一种罕见的消化道出血原因]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617208

Víctor Jesús Ávalos-Herrera, Gerardo Enrique Borunda-Escudero, Jesús Eduardo Núñez-Cabrera, Leonardo Rizo-Guzmán, Karen Denis Gómez-Arciniega

{"title":"[Jejunal diverticular disease: a rare cause of gastrointestinal bleeding].","authors":"Víctor Jesús Ávalos-Herrera, Gerardo Enrique Borunda-Escudero, Jesús Eduardo Núñez-Cabrera, Leonardo Rizo-Guzmán, Karen Denis Gómez-Arciniega","doi":"10.5281/zenodo.14617208","DOIUrl":"https://doi.org/10.5281/zenodo.14617208","url":null,"abstract":"Background: Digestive bleeding is an important cause of hospital admission; however, the mortality rate in these patients has not been reduced. Digestive bleeding has a multiple etiology; specifically, bleeding from the small intestine accounts for 5 to 10% of gastrointestinal hemorrhages, of which between 0.06% and 5% of cases are caused by diverticula of the small intestine. Most cases are asymptomatic; however, the symptomatic form is highly variable and can present with multiple complications, such as massive bleeding. Therefore, the objective of this study was to explore the approach to jejunal diverticular disease (JDD) with gastrointestinal bleeding.Clinical case: A 48-year-old male patient presented with massive digestive bleeding of unknown origin, initially treated with angiography and embolization, with a satisfactory outcome. However, six days after discharge, the patient experienced new massive bleeding that required an urgent exploratory laparotomy, during which jejunal diverticular disease (JDD) of the small intestine was identified.Conclusions: Diverticula of the small intestine are usually asymptomatic, and complications are rare; however, they can affect the patient's survival. Therefore, an appropriate approach, accurate and timely diagnosis, and a multidisciplinary management strategy are required to offer the best therapeutic options for the patient.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6421"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Multiple sclerosis and the Epstein-Barr Virus: Current perspectives on their pathogenic mechanisms]. [多发性硬化症和爱泼斯坦-巴尔病毒：目前对其致病机制的看法]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617124

Luis Felipe Hernández-Salomón

{"title":"[Multiple sclerosis and the Epstein-Barr Virus: Current perspectives on their pathogenic mechanisms].","authors":"Luis Felipe Hernández-Salomón","doi":"10.5281/zenodo.14617124","DOIUrl":"https://doi.org/10.5281/zenodo.14617124","url":null,"abstract":"The Epstein-Barr virus (EBV) is a herpesvirus that infects more than 90% of the world's population and is implicated in various diseases, including lymphoproliferative and neoplastic disorders. Recently, evidence has suggested a strong association between EBV and multiple sclerosis (MS). Although EBV infection is common, only a minority of carriers develop MS, indicating the influence of genetic and environmental factors in the pathogenesis. This article reviews the molecular mechanisms through which EBV might influence the development of MS. One mechanism discussed is molecular mimicry, where the similarity between EBV viral antigens and central nervous system proteins could induce a cross-reactive autoimmune response. Additionally, the mechanisms by which EBV evades the immune response are reviewed, including the expression of proteins such as EBNA1 and EBNA2, which interfere with the function of T and NK cells. Genetic factors, such as the HLA-DRB1*15:01 allele, a principal risk factor for MS, are also reviewed. This allele acts as a co-receptor facilitating the infection of B cells by EBV, which could explain the increased susceptibility to MS in individuals with this allele. Furthermore, EBV may alter the epigenetic regulation of genes associated with MS, affecting the expression of key genes in immune response and inflammation. Finally, immunotherapies targeting EBV, such as those based on cytotoxic T lymphocytes, are discussed.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6391"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comment on the article "Severe coronavirus-2 infection background for cardiovascular complications"]. [对《严重冠状病毒2型感染背景导致心血管并发症》一文的评论]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14616788

Dulce Naara Flores-Carmona

引用次数: 0

[Innate immune response to interferon gamma in severe Covid-19 positive patients]. [Covid-19严重阳性患者对干扰素γ的先天免疫应答]。

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-03-03 DOI: 10.5281/zenodo.14617070

Fabiola Del Rocío Villalobos-Gómez, Anastacio Palacios-Marmolejo, Rogelio Salinas-Gutiérrez, Hugo Enrique Lagunes-Servín

{"title":"[Innate immune response to interferon gamma in severe Covid-19 positive patients].","authors":"Fabiola Del Rocío Villalobos-Gómez, Anastacio Palacios-Marmolejo, Rogelio Salinas-Gutiérrez, Hugo Enrique Lagunes-Servín","doi":"10.5281/zenodo.14617070","DOIUrl":"10.5281/zenodo.14617070","url":null,"abstract":"Background: SARS-CoV-2 is associated with the activation of innate immunity, with an observed increase in neutrophils, mononuclear phagocytes, and natural killer cells, as well as a decrease in T cells. Interferon plays important roles in restricting viruses and is crucial because it participates in both innate and adaptive immunity. Gamma interferon (IFN-γ) is a cytokine that plays a fundamental role in maintaining homeostasis in the body, both in vitro and in vivo.Objective: An immunological study was conducted to measure the concentrations of IFN-γ in severe SARS-CoV-2-positive patients.Material and methods: Around 500 sera from patients with similar respiratory comorbidities at the onset of the disease were analyzed, using healthy patients as controls. The sera from SARS-CoV-2-positive individuals were processed using the ELISA technique, and the statistical treatment of the data involved creating a database with the absorbance readings, which were then converted into concentrations in pg/ml.Results: We can infer that the amount of IFN-γ expression depends on the patient's condition; the more severe the patient's condition, the higher the expression of this cytokine compared to their baseline levels, ranging from 0 to 0.5 μg/ml.Conclusion: It is suggested that the IFN-γ response plays an important role in controlling the disease, and effective therapies are recommended for the treatment of Covid-19, which will lead to the implementation of therapeutic approaches aimed at counteracting the immune system, especially in the more severe forms of the disease.","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 2","pages":"e6353"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0