[Comment on the article "Erythrocyte morphological alterations as predictors of kidney injury severity"].

After reviewing the article "Erythrocyte morphological alterations as predictors of kidney injury severity" published by Cruz-Balbuena et al., we can emphasize that erythrocytic changes have several pathophysiological mechanisms, such as iron deficiency, vitamin B12 deficiency, and the pro-inflammatory state of chronic kidney disease (CKD) itself. Furthermore, due to the accumulation of uremic toxins that result in a shortened lifespan of erythrocytes, a selection bias was found in their population and a positive but non-linear correlation. There are already several well-established progression markers with better correlation.