[Cryptococcus albidus, Naganishia albida, primary skin infection, first case reported in Mexico].

Background: The increase in immunosuppressive treatments and diseases that affect cellular immunity, such as diabetes, renal disease, and oncological or rheumatological conditions, has led to a rise in infections caused by opportunistic microorganisms. The aim of this work is to identify Naganishia albida as an infectious pathogen in immunocompromised patients, highlighting its importance and clinical evolution.

Clinical case: One of the first identified cases of Naganishia albida is reported in a patient with immunosuppression secondary to oncological treatment, with domestic activity exposure being the main risk factor. The patient had a good clinical outcome due to timely diagnosis, guided by biopsy culture and reverse stains.

Conclusion: Given the increase in conditions that affect the immune system, it is crucial for physicians of any specialty to pay special attention to secondary infections caused by immunosuppression. Without appropriate treatment, these infections can become invasive, negatively impacting the prognosis and evolution of the patient.