[激素免疫组化阳性垂体腺瘤侵袭性生长模式]。

Victor Hugo Bello-Lemus, Fernando Torres-Zapiain, Blanca Olivia Murillo-Ortiz
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引用次数: 0

摘要

背景:垂体腺瘤是鞍区最常见的肿瘤,它通常是良性的,然而,向鞍旁和/或鞍上的侵袭性生长可影响重要结构,导致高死亡率。目的:探讨垂体腺瘤侵袭性生长模式及其与免疫组化激素标志物阳性的关系。材料与方法:纳入2020年3月至2022年3月期间,年龄在18岁以上,经组织病理学诊断为垂体腺瘤,并有免疫组织化学报告和磁共振造影的患者,性别不限。MRI按Knosp和Hardy分类,按激素免疫组化阳性和阴性分为有创和无创。结果:50例符合纳入标准。激素免疫组化阳性腺瘤28例(56%),激素免疫组化阴性腺瘤22例(46%)。侵袭性生长模式为:Knosp分类50%为鞍旁生长,Hardy分类74%为鞍上生长。我们没有观察到侵袭行为与激素免疫组化阳性之间的任何关系。结论:我国垂体腺瘤的性别、年龄分布与国际文献非常相似,以女性多见,年龄分布在30 ~ 60岁以上。根据Hardy分类,最常见的侵袭性生长类型为鞍上。我们没有观察到鞍上或鞍旁浸润性生长模式与激素免疫组化阳性之间的显著关系。有趣的是,海绵窦的不侵犯与复发的减少有显著的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Pattern of invasive growth of pituitary adenomas with positive hormonal immunohistochemistry].

Background: Pituitary adenoma is the most frequent tumor of the selar region, it is generally benign, however, invasive growth towards parasellar and/or suprasellar can affect important structures causing high morbimortality.

Objective: To determine the invasive growth pattern of pituitary adenomas and its relationship with positive immunohistochemistry hormonal markers.

Material and methods: In the period from March 2020 to March 2022, patients of both sexes, older than 18 years, with histopathological diagnosis of pituitary adenoma, with immunohistochemistry report and contrasted magnetic resonance imaging were included. They were classified into invasive and non-invasive according to Knosp and Hardy classifications by MRI and according to hormonal immunohistochemistry as positive or negative.

Results: 50 cases fulfilled the inclusion criteria. 28 adenomas (56%) with positive hormonal immunohistochemistry and 22 adenomas (46%) with negative hormonal immunohistochemistry. The invasive growth pattern was as follows 50% parasellar according to Knosp classification and 74% suprasellar according to Hardy classification. We did not observe any relationship between invasive behavior and positive hormonal immunohistochemistry.

Conclusions: The incidence of pituitary adenoma by sex and age was very similar to the international literature, being more frequent in females and by age between 30 and over 60 years. The most frequent invasive growth pattern was suprasellar by Hardy classification. We did not observe a significant relationship between supra or parasellar invasive growth pattern and positive hormonal immunohistochemistry. Interestingly, there is a significant relationship between non-invasion of the cavernous sinus and less recurrence.

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