Acta cirurgica brasileira最新文献_第5页

Use of industrial liquid silicone: a scoping review. 工业液体硅酮的使用：范围审查。

Acta cirurgica brasileira Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/acb395624

Ayla Gerk, Luiza Telles, Madeleine Carroll, Maria Eduarda de Freitas Mesquita do Nascimento, Rafaela Góes Bispo, Bruno Felipe Santos de Oliveira, Saulo Mendes, Sophie Nouveau Fonseca Guerreiro, Abbie Naus, Cristina Pires Camargo

{"title":"Use of industrial liquid silicone: a scoping review.","authors":"Ayla Gerk, Luiza Telles, Madeleine Carroll, Maria Eduarda de Freitas Mesquita do Nascimento, Rafaela Góes Bispo, Bruno Felipe Santos de Oliveira, Saulo Mendes, Sophie Nouveau Fonseca Guerreiro, Abbie Naus, Cristina Pires Camargo","doi":"10.1590/acb395624","DOIUrl":"10.1590/acb395624","url":null,"abstract":"Purpose: Illicit cosmetic injections remain highly prevalent and can cause serious complications, including death. We aimed to explore existing literature regarding the use of illicit cosmetic injections globally.Methods: We searched six databases with no language restriction from inception to 2022. We included all articles focused on adult patients of any gender who received any illicit cosmetic injection. Screening and data extraction followed standards from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews guidelines.Results: After screening 629 abstracts and 193 full texts, 142 citations were included. We identified articles from 28 countries and three multi-country studies. Most were from high-income (75.3%) and upper-middle-income countries (21.8%). Of all patients whose gender identity was described, 49.9% were transgender women, and 40.8% were cisgender women. The anatomic regions most frequently injected were the buttocks (35%) and the breast (13.3%). The most frequently described complications were granuloma (41.5%), dermatological problems (41.5%), infection (35.9%), and pulmonary complications (34.5%).Conclusions: We observed the impact of illicit silicone injections, particularly on cisgender women and transgender individuals. Existing barriers must be addressed, including healthcare prejudice and inadequate knowledge about care for gender minorities. This will require educating at-risk groups and enhancing policies to regulate these procedures.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e395624"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Segmental histomorphometry of the porcine ureter for use as a vascular xenograft. 用作血管异种移植的猪输尿管节段组织形态学。

Acta cirurgica brasileira Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/acb397524

Júlia Galian Ribeiro Táboas, Vivian Alves Pereira da Silva, Marco Aurélio Pereira Sampaio, Aline D'Avila Pereira, Maurício Alves Chagas, Marcelo Abidu Figueiredo

{"title":"Segmental histomorphometry of the porcine ureter for use as a vascular xenograft.","authors":"Júlia Galian Ribeiro Táboas, Vivian Alves Pereira da Silva, Marco Aurélio Pereira Sampaio, Aline D'Avila Pereira, Maurício Alves Chagas, Marcelo Abidu Figueiredo","doi":"10.1590/acb397524","DOIUrl":"10.1590/acb397524","url":null,"abstract":"Purpose: To histologically quantify the different tissues that make up the porcine ureter, (epithelial, connective, and muscular tissue) in the three segments labelled: cranial, middle and caudal, in order to identify the segment most compatible for use as a vascular graft.Methods: Fifteen porcine ureters were collected, divided into the three segments, and the samples were stained with hematoxylin and eosin, picrosirius red and Weigert's resorcin-fuchsin. The immunohistochemistry technique was applied for alpha-smooth muscle actin. Collagen fibers, muscle, epithelium, and elastic fibers tissue were quantified, in the entire ureter, and divided into hemispheres, comparing the different segments.Results: When comparing hemisphere segments, significant differences were observed (p < 0.01) for collagen and muscle tissue, with the cranial segment presenting the greatest amount of these components when compared to the middle and caudal. No significant difference was observed between the segments when comparing the entire ureters.Conclusions: After comparing the segments by hemisphere, the cranial segment presented a slight advantage for use as a vascular graft due to presenting greater collagen fiber content.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e397524"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ozone therapy applied topically, by bagging, or both on the healing of clean wounds induced in rat's skin. 臭氧疗法的局部应用、袋装应用或两者兼用对大鼠皮肤清洁伤口愈合的影响。

Acta cirurgica brasileira Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/acb397024

Bárbara Di Martino Frezza, Sheila Canevese Rahal, Ivan Felismino Charas Dos Santos, Bruna Martins da Silva, José Ivaldo de Siqueira Silva Junior, Gustavo Manea Ferreira, Michel de Campos Vettorato, Jéssica Leite Fogaça, Miriam Harumi Tsunemi, Carlos Eduardo Fonseca-Alves, Claudia Helena Pellizzon, Vinicius Dos Santos Rosa

{"title":"Effects of ozone therapy applied topically, by bagging, or both on the healing of clean wounds induced in rat's skin.","authors":"Bárbara Di Martino Frezza, Sheila Canevese Rahal, Ivan Felismino Charas Dos Santos, Bruna Martins da Silva, José Ivaldo de Siqueira Silva Junior, Gustavo Manea Ferreira, Michel de Campos Vettorato, Jéssica Leite Fogaça, Miriam Harumi Tsunemi, Carlos Eduardo Fonseca-Alves, Claudia Helena Pellizzon, Vinicius Dos Santos Rosa","doi":"10.1590/acb397024","DOIUrl":"10.1590/acb397024","url":null,"abstract":"Purpose: This study aimed to evaluate the effects of ozone therapy applied topically and/or by bagging on the healing of clean wounds induced in rat's skin.Methods: One hundred and twenty male rats of about 16 weeks old was divided into five groups: G1) saline solution (0.9%); G2) sunflower oil; G3) ozonated sunflower oil; G4) ozone bagging; G5) association of ozonated sunflower oil and ozone bagging. The wounds were evaluated through macroscopic, morphometric, histopathologic, and tensile strength analyses.Results: Analysis among groups showed a lower percentage of wound contraction in G1 compared to G4 only in M7D. The tensile strength of the wounds showed differences among groups in the seventh (M7D) and the 14th (M14D) postoperative day, and among time points in G1 (M14D > M7D). The elongation of the wounds showed differences in G3 (M7D > M14D). Histological evaluation of the wounds showed significant change in bleeding, mixed to mononuclear infiltrate, congestion, and tissue disorganization for tissue organization between groups and time points.Conclusions: Ozone therapy applied topically and/or by bagging was not deleterious to the healing of clean wounds induced in rat's skin, but ozone bagging showed the best contribution to the healing process.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e397024"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological insights into thoracic and lumbar sympathectomies in Brazil: a comparative analysis of open versus video-assisted procedures. 巴西胸椎和腰椎交感神经切除术的流行病学研究：开放手术与视频辅助手术的比较分析。

Acta cirurgica brasileira Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/acb397124

Beatriz de Holanda Name, Christiane Nazareth Silva, Marcelo Henrique Ribeiro Amoroso, Eduardo Mujica Pedrosa, Daniel Amaro Sousa

{"title":"Epidemiological insights into thoracic and lumbar sympathectomies in Brazil: a comparative analysis of open versus video-assisted procedures.","authors":"Beatriz de Holanda Name, Christiane Nazareth Silva, Marcelo Henrique Ribeiro Amoroso, Eduardo Mujica Pedrosa, Daniel Amaro Sousa","doi":"10.1590/acb397124","DOIUrl":"10.1590/acb397124","url":null,"abstract":"Purpose: To investigate the profile of hospital admissions for sympathectomies performed in the Brazilian Unified Health System (SUS), comparing open and video-assisted techniques.Methods: Data on sympathectomies were collected from the SUS Department of Informatics (DATASUS), recorded between 2014 and 2023. The data were tabulated, and descriptive statistics and correlation analyses were performed.Results: There was reduction in the number of admissions for all sympathectomies during the analyzed period. The use of video-assisted surgeries was higher than that of open surgeries for thoracic procedures, but lower for lumbar procedures. The costs of hospital admission for the procedures were similar, although the length of stay and mortality associated with open surgeries were higher, both in thoracic and lumbar sympathectomies.Conclusions: The collected data were not individualized, preventing follow-up. Additionally, the study did not account for procedures performed in the private healthcare system. Despite its limitations, this study provides an overview of sympathectomies in Brazil, indicating that, although open sympathectomies are potentially more disadvantageous, they are still widely performed, especially for lumbar procedures.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e397124"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of vitamin D on muscle strength and botulinum toxin dosage through surface electromyography. 通过表面肌电图观察维生素 D 对肌肉力量和肉毒杆菌毒素剂量的影响。

Acta cirurgica brasileira Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/acb396824

Marcelle Simões Coelho, Gabriel Cirone Lopes, Luigi Giovanni Bernardo Sichi, Sigmar de Mello Rode, Rodrigo Máximo de Araújo

{"title":"Influence of vitamin D on muscle strength and botulinum toxin dosage through surface electromyography.","authors":"Marcelle Simões Coelho, Gabriel Cirone Lopes, Luigi Giovanni Bernardo Sichi, Sigmar de Mello Rode, Rodrigo Máximo de Araújo","doi":"10.1590/acb396824","DOIUrl":"10.1590/acb396824","url":null,"abstract":"Purpose: To evaluate the influence of patients' serum vitamin D levels on muscle strength characteristics and whether it impacts the durability of botulinum toxin (BT) treatment.Methods: The muscle strength of the frontal and corrugator muscles was evaluated before and after the application of TB with pre- and post-application control measurements, and at weeks 2, 5 and 12. The effect of vitamin D on muscle strength and its interaction with BT were investigated in 20 patients. The muscle contraction force was measured by surface electromyography.Results: The results revealed statistically significant differences between the frontal measurement groups at weeks 2 and 5, as well as for the corrugator in the same weeks and at week 12. Regarding vitamin D, significant differences were observed only in the initial group with vitamin D > 30 ng/mL compared to < 30 ng/mL for the frontal muscles. Patients with higher levels of vitamin D had higher average muscle strength compared to those with lower levels in all evaluations.Conclusions: It was observed that vitamin D influences muscle strength and the necessary dosage of BT.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e396824"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental protocol for evaluation of biomaterials in an in-vivo silicone implant coverage. 在体内硅胶植入物覆盖中评估生物材料的实验方案。

Acta cirurgica brasileira Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.1590/acb396724

Chenia Frutuoso Silva, Victor de Araújo Felzemburgh, Amanda Dourado Moreno, José Valber Lima Meneses, Aryon de Almeida Barbosa Júnior, Isabela Cerqueira Barreto, Fúlvio Borges Miguel

{"title":"Experimental protocol for evaluation of biomaterials in an in-vivo silicone implant coverage.","authors":"Chenia Frutuoso Silva, Victor de Araújo Felzemburgh, Amanda Dourado Moreno, José Valber Lima Meneses, Aryon de Almeida Barbosa Júnior, Isabela Cerqueira Barreto, Fúlvio Borges Miguel","doi":"10.1590/acb396724","DOIUrl":"10.1590/acb396724","url":null,"abstract":"Purpose: To describe an experimental surgical model in rats using a dual-plane technique for evaluation of biomaterials in an in-vivo silicone implant coverage.Methods: This study was developed following the ISO 10993-6 standard. In this study, 40 male Wistar rats weighing between 250 and 350 g were used, distributed into two groups: experimental, biomaterial superimposed on the minimammary prosthesis (MP); and control, MP without implantation of the biomaterial, with eight animals at each biological point: 1, 2, 4, 12, and 26 weeks. Thus, at the end of biological points (1, 2, 4, 12, and 26 weeks; n = 8 animals per week), the tissue specimens achieved were fixed in buffered formalin and stained with hematoxylin-eosin.Results: Macroscopically, throughout the study, no postoperative complications were apparent. In the histological analysis, it was possible to observe the evolution of the inflammatory response, tissue repair, and fibrous capsule during the biological points.Conclusions: The experimental model described in this study proved to be suitable for evaluating the biomaterial used in the coverage of breast silicone implants.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e396724"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats. 咖啡因可减轻他莫昔芬诱发的 Wistar 大鼠脂肪肝。

Acta cirurgica brasileira Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.1590/acb396924

Yasin Sezgin, Ejder Saylav Bora, Duygu Burcu Arda, Yiğit Uyanikgil, Oytun Erbaş

{"title":"Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats.","authors":"Yasin Sezgin, Ejder Saylav Bora, Duygu Burcu Arda, Yiğit Uyanikgil, Oytun Erbaş","doi":"10.1590/acb396924","DOIUrl":"10.1590/acb396924","url":null,"abstract":"Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with adverse effects on the liver, including the development of fatty liver. This study aimed to investigate the potential protective effect of caffeine against tamoxifen-induced fatty liver in Wistar rats.Methods: Rats were divided into normal control, tamoxifen + saline, and tamoxifen + caffeine. Plasma samples were assessed for biochemical markers related to oxidative stress, inflammation, liver function, and cell damage. Additionally, liver histopathology was examined to quantify the extent of fatty infiltration.Results: In the tamoxifen + saline group, elevated levels of plasma malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), alanine aminotransferase (ALT), cytokeratin 18, and soluble ST2 were observed compared to the normal control group, indicating increased oxidative stress, inflammation, and liver injury (p < 0.01). Moreover, histopathological examination revealed a significant increase in fatty infiltration (p < 0.001). However, in the tamoxifen + caffeine group, these markers were markedly reduced (p < 0.05, p < 0.01), and fatty infiltration was significantly mitigated (p < 0.001).Conclusions: The findings suggest that caffeine administration attenuates tamoxifen-induced fatty liver in rats by ameliorating oxidative stress, inflammation, liver injury, and cell damage. Histopathological evidence further supports the protective role of caffeine. This study highlights the potential of caffeine as a therapeutic intervention to counter tamoxifen-induced hepatic complications, contributing to the optimization of breast cancer treatment strategies.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e396924"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway. 异氟醚预处理通过激活Brg1/Nrf2/HO-1信号通路防止糖尿病肾缺血再灌注损伤

Acta cirurgica brasileira Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.1590/acb396124

Daojing Gong, Ziqiang Dong, Xiaobo Chen, Hao Chen, Huihuang Lin

{"title":"Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.","authors":"Daojing Gong, Ziqiang Dong, Xiaobo Chen, Hao Chen, Huihuang Lin","doi":"10.1590/acb396124","DOIUrl":"10.1590/acb396124","url":null,"abstract":"Purpose: To examine whether isoflurane preconditioning (IsoP) has a protective effect against renal ischemia/reperfusion injury (I/RI) in diabetic conditions and to further clarify the underlying mechanisms.Methods: Control and streptozotocin-induced diabetic rats were randomly assigned to five groups, as follows: normal sham, normal I/R, diabetic sham, diabetic I/R, and diabetic I/R + isoflurane. Renal I/RI was induced by clamping renal pedicle for 45 min followed by reperfusion for 24 h. IsoP was achieved by exposing the rats to 2% isoflurane for 30 min before vascular occlusion. Kidneys and blood were collected after reperfusion for further analysis. Renal histology, blood urea nitrogen, serum creatinine, oxidative stress, inflammatory cytokines, and renal cell apoptosis were assessed. Furthermore, the expression of brahma related gene 1 (Brg1), nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and nuclear factor-κB (NF-κB) were determined.Results: Compared with control, diabetic rats undergoing I/R presented more severe renal injury, oxidative stress, inflammatory reaction, and apoptosis with the impairment of Brg1/Nrf2/HO-1 signaling. All these alterations were significantly attenuated by pretreatment with isoflurane.Conclusions: These findings suggest that isoflurane could alleviate renal I/RI in diabetes, possibly through improving Brg1/Nrf2/HO-1 signaling.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e396124"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects and mechanisms of Salvia miltiorrhiza Bunge extract on myocardial cell apoptosis in rat heart failure model. 丹参提取物对大鼠心衰模型心肌细胞凋亡的影响及机制

Acta cirurgica brasileira Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.1590/acb396524

Xiaofang Yang, Xuebin Zheng, Xiangqian Xiao, Li Li

{"title":"Effects and mechanisms of Salvia miltiorrhiza Bunge extract on myocardial cell apoptosis in rat heart failure model.","authors":"Xiaofang Yang, Xuebin Zheng, Xiangqian Xiao, Li Li","doi":"10.1590/acb396524","DOIUrl":"10.1590/acb396524","url":null,"abstract":"Purpose: This work aimed to investigate the effects of Tanshinone IIA (Tan IIA) on myocardial cell (MC) apoptosis in a rat model of heart failure (HF).Methods: Tan IIA was extracted from Salvia miltiorrhiza Bunge (SMB) using an ethanol reflux method. Fifty rats were randomly divided into five groups: sham (no treatment), mod (HF model establishment), low dose (LD: 0.1 mL/kg Tan IIA), medium dose (MD: 0.3 mL/kg Tan IIA), and high dose (HD: 0.5 mL/kg Tan IIA), with 10 rats in each group. The effects of different doses of Tan IIA on cardiac function, MC apoptosis, and the levels of proteins associated with the PI3K/Akt/mTOR signaling pathway were compared.Results: Mod group showed a significant decrease in systolic arterial pressure, mean arterial pressure, heart rate, left ventricular systolic pressure, left ventricular ejection fraction, left ventricular fractional shortening, and the levels of p-PI3K, p-Akt, and p-mTOR proteins versus sham group (p < 0.05). Additionally, the left ventricular end-diastolic diameter (LVIDd), end-systolic diameter, diastolic pressure, and MC apoptosis were significantly increased (p < 0.05). LD, MD, and HD groups exhibited significant improvements across various indicators of cardiac function and MC apoptosis versus mod group (p < 0.05).Conclusions: Tan IIA may improve cardiac function and inhibit MC apoptosis in rats with HF by modulating the PI3K/Akt/mTOR signaling pathway.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e396524"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis between symptoms of the upper gastrointestinal tract and endoscopic findings of patients undergoing upper digestive endoscopy in a reference center in the interior of Maranhão, Brazil. 对巴西马拉尼昂州内陆地区一家参考中心接受上消化道内窥镜检查的患者的上消化道症状与内窥镜检查结果之间的关系进行分析。

Acta cirurgica brasileira Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.1590/acb395824

Luis Thadeu Rebouças Santos, Mariana Paiva Braga Martins, Caio Dos Santos Souza, Rodrigo Rodrigues Silva, Marcos Antonio Custódio Neto da Silva

{"title":"Analysis between symptoms of the upper gastrointestinal tract and endoscopic findings of patients undergoing upper digestive endoscopy in a reference center in the interior of Maranhão, Brazil.","authors":"Luis Thadeu Rebouças Santos, Mariana Paiva Braga Martins, Caio Dos Santos Souza, Rodrigo Rodrigues Silva, Marcos Antonio Custódio Neto da Silva","doi":"10.1590/acb395824","DOIUrl":"10.1590/acb395824","url":null,"abstract":"Purpose: To analyze clinical and endoscopic aspects of dyspeptic patients submitted to upper endoscopy in a reference center in the interior of Maranhão, Brazil.Methods: Observational, descriptive, and analytical research through interviews and endoscopic reports of 80 patients with dyspeptic complaints submitted to upper endoscopy.Results: Among the respondents, 66.25% were women, most were aged ≥ 40 years old and had epigastric pain as their main symptom, and 29.75% had no appropriate indication to perform upper endoscopy. Mild enanthematous gastritis of the antrum was the most frequent finding, and 92.5% had non-significant findings. Rapid urease test was positive in 25%. The following findings showed a statistically significant correlation (p < 0.05): age < 40 years old, female gender, and gastric lesion with positive urease test; smoking with gastric lesion and age less than 40 years old with normal examination. Patients with significant findings had appropriate indications for upper endoscopy.Conclusions: The correct indication of upper endoscopy is essential for satisfactory endoscopic yields and accurate diagnosis.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e395824"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0