Acta cirurgica brasileira最新文献

{"title":"Cardioprotective effects of the ranolazine in myocardial infarction mediated by stimulation of the endogenous mediators involved in ischemic preconditioning.","authors":"Junaid Tantray, Francisco Sandro Menezes-Rodrigues, José Mario Podanosque, Fernando Sabia Tallo, Afonso Caricati-Neto, Ashish Kumar Sharma, Akhilesh Patel, Rajesh Kumar Sharma, Shivam Singh, Bolatkan Arlan Beibituly","doi":"10.1590/acb410926","DOIUrl":"10.1590/acb410926","url":null,"abstract":"<p><strong>Purpose: </strong>Hypothesis centered on the idea that ranolazine could induce responses similar to ischemic preconditioning, involving nitric oxide, adenosine, bradykinin, and adenosine triphosphate (ATP)-dependent potassium channels.</p><p><strong>Methods: </strong>Ischemia-reperfusion injury was established using Langendroff technique. Thirty-minute ischemia and 120-minute reperfusion to coronary artery to isolated heart were model of myocardial infarction. There were studied the following groups: control (ischemia-reperfusion), ischemic preconditioning, ranolazine (10 µmol/L), ranolazine + L-NAME (30 µmol/L) and ranolazine + aminoguanidine (30 µmol/L), ranolazine + theophylline (50 µmol/L), ranolazine + aminophylline (50 µmol/L), ranolazine + icatibantl (100 µmol/L), ranolazine + bromelain (250 µmol/L), ranolazine + 5-hydroxydecanoate (30 µmol/L), and ranolazine + glimepiride (50 µmol/L) in perfusate.</p><p><strong>Results: </strong>Ranolazine and ischemic preconditioning groups demonstrated cardioprotective effects by reducing infarct size, as well as levels of lactate dehydrogenase (LDH), creatine phosphokinase myoglobin (CK-MB), and troponin I and cardiac parameters like left ventricular developed pressure (LVDP) and left ventricular maximum rate of contraction (dP/dTmax). Maximum rate of relaxation (dP/dTmin) was improved. Conversely, treatments with L-NAME, aminoguanidine, theophylline, aminophylline, icatibant, bromelain, 5-hydroxydecanoate, and glimepiride increased infarct size, LDH, CK-MB, and troponin I levels, and cardiac parameters like LVDP, dP/dTmax, and dP/dTmin were depressed. This data provides evidence that ranolazine employs nitric oxide, adenosine, bradykinin, and ATP-dependent potassium channels as secondary messengers in cardioprotection.</p><p><strong>Conclusion: </strong>ranolazine can be a pharmacological alternative to surgical ischemic preconditioning utilized prior to interventional procedures like coronary artery bypass graft surgery and heart transplantation, offering improved patient compliance.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e410926"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yellow wave: impact of a structured educational initiative on trauma education development.","authors":"Vitor Favali Kruger, João Victor Franqueira, Andrea de Melo Alexandre Fraga, Thiago Rodrigues Araujo Calderan, José Vitor Coimbra Trindade, Gustavo Pereira Fraga","doi":"10.1590/acb411126","DOIUrl":"10.1590/acb411126","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of the Yellow Wave Initiative on trauma surgery education, academic skills, career choices, and educational equity among medical students from three Brazilian medical schools.</p><p><strong>Methods: </strong>This prospective longitudinal study enrolled 58 medical students from three institutions in Campinas, SP, Brazil. The intervention consisted of scientific mentorship, research methodology training, manuscript development for the 23rd European Congress of Trauma, and presentation skills workshops. Academic development, research capabilities, career intentions, and program satisfaction were assessed through post-congress electronic questionnaires using McNemar tests for paired comparisons and χ2 tests for associations.</p><p><strong>Results: </strong>Trauma league members showed higher interest in general surgery compared to non-members (61.5 vs. 22.7%, odds ratio = 10.88, p = 0.002). Significant improvements were observed across key academic skills post-intervention (all p < 0.001), including presentation abilities (from 20.8% good/very good pre to 85.4% post), research capabilities (25 to 79.2%), and academic writing (20.8 to 83.3%). Additionally, 62% of participants reported positive impact on their academic career aspirations (p = 0.006).</p><p><strong>Conclusion: </strong>The initiative enhanced academic skills and career development among Brazilian medical students, increasing engagement in trauma surgery and prevention activities while addressing educational gaps through hands-on learning.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e411126"},"PeriodicalIF":1.3,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of dutasteride and tamsulosin, alone or in association, in the kidney morphology: experimental study in rats.","authors":"Marcello Henrique Araujo da Silva, Simone Gomes Ferreira, Bianca Martins Gregório, Francisco José Sampaio, Diogo Benchimol de Souza","doi":"10.1590/acb410826","DOIUrl":"10.1590/acb410826","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the renal morphology after isolated and combined administration of dutasteride and tamsulosin in rats.</p><p><strong>Methods: </strong>Forty male rats were divided in groups: control group; D, receiving 0.5 mg/kg/day of dutasteride; T, receiving 0.4 mg/kg/day of tamsulosin; and D+T, receiving both dutasteride and tamsulosin. The drugs were given by gavage for 40 days. The animals were killed, and kidneys were collected for stereological analyses of kidney volume, cortical volume, volumetric density of glomeruli, mean glomerular volume, and number of glomeruli per kidney. Data was compared by analysis of variance followed by Bonferroni's post-hoc test.</p><p><strong>Results: </strong>Kidney weight, kidney volume, cortical volume, and glomerular volumetric density were reduced in all treated groups, in comparison to control group. The mean glomerular volume was reduced in groups D and D+T, in comparison to control rats, but in group T this parameter was not altered. Finally, the number of glomeruli per kidney was reduced by 37.9% in the group D, by 25.7% in group T, and by 33.07% in group D+T, in comparison to control group.</p><p><strong>Conclusion: </strong>The use of dutasteride and tamsulosin (isolated or in combination) promoted kidney damage with nephron losses in the rodent model. Animals that received dutasteride showed more severe renal modifications than those that received tamsulosin and combined therapy.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e410826"},"PeriodicalIF":1.3,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone health up to five years after Roux-en-Y gastric bypass: a cross-sectional study during the COVID-19 pandemic.","authors":"Alexandre Naegele de Oliveira, Taís Daiene Russo Hortencio, Daniela Vicinansa Monaco Ferreira, Karina Schiavoni Scandelai Cardoso Dos Reis, Roberto José Negrão Nogueira","doi":"10.1590/acb411426","DOIUrl":"10.1590/acb411426","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate bone health in obese patients undergoing surgery using the Roux-en-Y gastric bypass (RYGB) technique.</p><p><strong>Methods: </strong>In a sample of 22 obese patients undergoing RYGB surgery, evaluation of bone densitometry (BD) and plasma levels of calcium, phosphorus, magnesium, vitamin D (VITD), parathyroid hormone (PTH), alkaline phosphatase, and albumin was performed.</p><p><strong>Results: </strong>Signs of potential changes in calcification were detected in plasma tests, expressed as a decrease in VITD (46.4%) and an increase in PTH (50%). Three patients presented with bone framework damage. BD was unequivocally altered in three patients. A decrease in bone density was observed in 14 and 15 patients in the lumbar and femoral regions, respectively.</p><p><strong>Conclusion: </strong>Although PTH and VITD dosages did not show a direct correlation with BD, it was observed that approximately half of the patients had altered dosages of these hormones up to five years after surgery, and there was damage to the bone health expressed by BD. Loss to follow-up may have contributed to the increased risk of developing metabolic bone disease.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e411426"},"PeriodicalIF":1.3,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12918775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone health up to five years after Roux-en-Y gastric bypass: a cross-sectional study during the COVID-19 pandemic.","authors":"Alexandre Naegele de Oliveira, Taís Daiene Russo Hortencio, Daniela Vicinansa Monaco Ferreira, Karina Schiavoni Scandelai Cardoso Dos Reis, Roberto José Negrão Nogueira","doi":"10.1590/acb411426","DOIUrl":"https://doi.org/10.1590/acb411426","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate bone health in obese patients undergoing surgery using the Roux-en-Y gastric bypass (RYGB) technique.</p><p><strong>Methods: </strong>In a sample of 22 obese patients undergoing RYGB surgery, evaluation of bone densitometry (BD) and plasma levels of calcium, phosphorus, magnesium, vitamin D (VITD), parathyroid hormone (PTH), alkaline phosphatase, and albumin was performed.</p><p><strong>Results: </strong>Signs of potential changes in calcification were detected in plasma tests, expressed as a decrease in VITD (46.4%) and an increase in PTH (50%). Three patients presented with bone framework damage. BD was unequivocally altered in three patients. A decrease in bone density was observed in 14 and 15 patients in the lumbar and femoral regions, respectively.</p><p><strong>Conclusion: </strong>Although PTH and VITD dosages did not show a direct correlation with BD, it was observed that approximately half of the patients had altered dosages of these hormones up to five years after surgery, and there was damage to the bone health expressed by BD. Loss to follow-up may have contributed to the increased risk of developing metabolic bone disease.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e411426"},"PeriodicalIF":1.3,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Atractylenolide III alleviates sepsis-mediated lung injury via inhibition of FoxO1 and VNN1 protein.","authors":"","doi":"10.1590/acb360802.retraction","DOIUrl":"https://doi.org/10.1590/acb360802.retraction","url":null,"abstract":"<p><p>[This retracts the article doi: 10.1590/ACB360802].</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e000001"},"PeriodicalIF":1.3,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of direct and remote ischemic post and preconditioning in the kidney of young rats: histological and laboratory evaluation.","authors":"Arthur Henrique de Almeida Oliveira, Daniel Meirelles de Paula, Suellen Serafini, Uenis Tannuri, Ana Cristina Aoun Tannuri","doi":"10.1590/acb410726","DOIUrl":"10.1590/acb410726","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of direct and remote ischemic preconditioning and postconditioning on kidney ischemia-reperfusion injury in young rats.</p><p><strong>Methods: </strong>This study was divided into two experimental phases: preconditioning and postconditioning. In each phase, 78 rats were randomly assigned to four groups: control (CG), ischemia-reperfusion (IRG), direct ischemic pre/postconditioning (DIPG), and remote ischemic pre/postconditioning (RIPG). Animals were euthanized at 0- or 24-hours post-procedure, and samples were collected for histological and biochemical analyses.</p><p><strong>Results: </strong>The sum of the histological findings revealed no significant differences among the pre/postconditioning groups. However, serum calcium levels were significantly higher in preconditioning, DIPG compared to the control group (p = 0.002), and in postconditioning, DIPG and RIPG compared to the control group (p = 0.028 and p = 0.005, respectively). In postconditioning, the chlorine levels were higher in IRG compared to the DIPG group (p = 0.029).</p><p><strong>Conclusion: </strong>In our findings, ischemic preconditioning and ischemic postconditioning no provided significant protection of renal tissue.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e410726"},"PeriodicalIF":1.3,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of complementary therapies in controlling inflammatory signs, symptoms, and complications after lower third molar extraction: a bibliometric analysis of the top 100 most-cited articles.","authors":"Vinícius Lima de Almeida, Danilo Cassiano Ferraz, Giovanna Miranda Cabral, Arthur Henrique Gobbi, Walbert de Andrade Vieira, Lívia Bonjardim Lima, Rafael Rodrigues Lima, Sigmar de Mello Rode, Luiz Renato Paranhos","doi":"10.1590/acb410626","DOIUrl":"10.1590/acb410626","url":null,"abstract":"<p><strong>Purpose: </strong>To conduct a bibliometric analysis of the 100 most-cited articles on the use of complementary therapies for controlling inflammatory signs, symptoms, and complications after lower third molar extraction.</p><p><strong>Methods: </strong>An electronic search was performed on the Web of Science Core Collection database. A graphical bibliometric network was created in Power BI software (Microsoft, Redmond, WA, United States of America). Spearman's correlation test was used to assess the correlation among the number of citations, journal impact factor, and the year of publication.</p><p><strong>Results: </strong>The selected articles received 4,199 citations, covering the years 1983 to 2023. Most publications occurred in 2016. Article citations averaged 41.99. The most frequent Keywords Plus terms, considering more than five occurrences, were \"removal,\" \"pain,\" \"surgery,\" and \"trismus.\" The main keywords defined by the authors, considering more than five occurrences, were \"pain,\" \"swelling,\" and \"trismus.\" The Asian and European continents presented the highest number of publications and citations. Randomized clinical trial was the most prevalent study type. Regarding authors' affiliations, the University of Turin stood out in the number of publications.</p><p><strong>Conclusion: </strong>The article with the highest number of citations was published in Serbia. Turkey and Italy accounted for the highest number of publications and citation density. Although most included studies were randomized clinical trials, improving comparison and decision-making requires methodological standardization.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e410626"},"PeriodicalIF":1.3,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academic bedside rounding in 10 As: the decalogue technique.","authors":"Diego Adão, Gabriela Caetano Lopes Martins, Leonardo Yuri Kasputis Zanini, Mateus de Almeida Oliveira, Parisina Fraga Carvalho, Leonardo de Mello Del Grande, Fernando Augusto Mardiros Herbella","doi":"10.1590/acb410526","DOIUrl":"10.1590/acb410526","url":null,"abstract":"<p><strong>Purpose: </strong>To propose the 10 As decalogue technique, a structured framework for surgical bedside rounding.</p><p><strong>Methods: </strong>This narrative review and perspective piece presents a descriptive model for bedside rounding, designed for implementation in university hospitals. Literature review was done in MEDLINE via PubMed up to May 2025, using both free terms and Medical Subject Headings related to medical education, clinical rounds, and surgical training. The technique was developed based on clinical and educational principles, addressing both surgical and academic needs.</p><p><strong>Results: </strong>The decalogue consists of the following steps: anticipation, assistant team presentation, authorization, (self)appraisal, assessment, alerts, advice, agreement, annotation, and afterwards. It facilitates comprehensive case discussion, improves trainee clinical skills, and fosters empathy and trust in patient interactions. It addresses time constraints by prioritizing critical cases and enhances learning through debriefing and feedback. Challenges include managing time for multiple patients and ensuring patient comfort during public discussions, mitigated by clear authorization and sensitive communication.</p><p><strong>Conclusion: </strong>The 10 As decalogue is an effective tool for surgical bedside rounding, promoting resident education, reducing errors, and enhancing patient involvement. Its structured approach is particularly suited for academic settings, with adaptability to balance educational and clinical demands.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e410526"},"PeriodicalIF":1.3,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health resource mobilization: state or government policies?","authors":"Everson Artifon, Marcio Roberto Facanali, José Pinhata Otoch","doi":"10.1590/acb409025","DOIUrl":"10.1590/acb409025","url":null,"abstract":"","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e409025"},"PeriodicalIF":1.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}