Acta cirurgica brasileira最新文献

Re-stricture after buccal mucosal graft urethroplasty: a systematic review and meta-analysis. 口腔粘膜移植尿道成形术后再狭窄：系统回顾和荟萃分析。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb403525

Gustavo Bono Yoshikawa, Gabriella Giandotti Gomar, Giovanna Ceccatto Gadens, Beatriz França Zanetti Saes, Maria Eduarda Andrade Galiciolli, Meire Ellen Pereira, Quelen Iane Garlet, Cláudia Sirlene Oliveira

{"title":"Re-stricture after buccal mucosal graft urethroplasty: a systematic review and meta-analysis.","authors":"Gustavo Bono Yoshikawa, Gabriella Giandotti Gomar, Giovanna Ceccatto Gadens, Beatriz França Zanetti Saes, Maria Eduarda Andrade Galiciolli, Meire Ellen Pereira, Quelen Iane Garlet, Cláudia Sirlene Oliveira","doi":"10.1590/acb403525","DOIUrl":"10.1590/acb403525","url":null,"abstract":"Purpose: To determine risk factors for re-stricture after buccal mucosal graft urethroplasty (BMGU) through a systematic review and meta-analysis.Methods: Following PRISMA guidelines, we collected data from PubMed, Scientific Electronic Library Online (SciELO), and Web of Science databases. The eligibility criteria included studies with male patients over 18 years old with urethral stricture recurrence after BMGU.Results: We retrieved 646 papers from three electronic databases. Records that did not meet the eligibility criteria and duplicates were excluded, resulting in 14 papers (3,240 patients) that underwent qualitative analysis, from which nine papers were suitable for meta-analysis. The meta-analysis identified diabetes mellitus (relative risk - RR: 1.58 [95% confidence interval - 95%CI 1.02-2.46];p = 0.04), penile/peno-bulbar site (RR: 1.57 [95%CI 1.04-2.37]; p = 0.03), and stricture size higher than 7 cm (RR: 4.13 [95%CI 2.42-7.04]; p 0.00001) as a predictive factor of re-stricture.Conclusions: These findings may improve understanding the risk factors for this type of urethroplasty and help surgical decisions. For a more effective analysis, larger and better-distributed study groups and cohorts are needed in the future to clarify whether the combination of a previous disease and the urethroplasty etiology may impact a recurrence-free outcome after stricture correction.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403525"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats. 超生理剂量癸酸诺龙对大鼠睾丸的即时和后期影响。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402925

Bruno Felix-Patricio, Roger Gaspar Marchon, Bianca Martins Gregório, Diogo Benchimol De Souza

{"title":"Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats.","authors":"Bruno Felix-Patricio, Roger Gaspar Marchon, Bianca Martins Gregório, Diogo Benchimol De Souza","doi":"10.1590/acb402925","DOIUrl":"10.1590/acb402925","url":null,"abstract":"Purpose: To investigate the effects of supraphysiologic doses of nandrolone decanoate on the testicular morphology of rats and if these effects could be transitory or permanent.Methods: Twenty-five male rats were divided in four groups. C28 and C40 were control rats killed with 28 and 40 weeks old, respectively; and T28 and T40 were treated with nandrolone decanoate (10 mg/kg) and killed immediately after the treatment (T28) or 12 weeks after the end of treatment (T40). The testis weight and volume were measured, and the seminiferous tubule area and epithelium height were assessed by histomorphometric methods.Results: The seminiferous tubules area and epithelium height of group T28 were reduced in comparison to C28. Group T40 showed reduced testicular weight and volume, as well as seminiferous tubule area and epithelium height in comparison to C40.Conclusion: The use of nandrolone decanoate promotes major structural modifications on the testes of rats. These modifications are even worse 12 weeks after ending the use of the anabolic androgenic steroid.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402925"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new eggshell-derived calcium phosphate bioceramic for tissue engineering: cytotoxicity and histomorphometric study. 一种用于组织工程的新型蛋壳来源的磷酸钙生物陶瓷：细胞毒性和组织形态学研究。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402625

Conrado Dias do Nascimento Neto, Laisa Kindely Ramos de Oliveira, Amy Brian Costa E Silva, Patrícia Roccon Bianchi, André Gustavo de Sousa Galdino, Daniela Nascimento Silva

{"title":"A new eggshell-derived calcium phosphate bioceramic for tissue engineering: cytotoxicity and histomorphometric study.","authors":"Conrado Dias do Nascimento Neto, Laisa Kindely Ramos de Oliveira, Amy Brian Costa E Silva, Patrícia Roccon Bianchi, André Gustavo de Sousa Galdino, Daniela Nascimento Silva","doi":"10.1590/acb402625","DOIUrl":"10.1590/acb402625","url":null,"abstract":"Purpose: To evaluate cytotoxicity and tissue repair of a new chicken eggshell-derived bioceramic (hydroxyapatite/dicalcium phosphate anhydrous-HA/DCPA).Methods: Cytotoxicity was evaluated in fibroblasts (L cell, L-929) by MTT test. Tissue repair of HA/DCPA was compared to HA/β-TCP bioceramic (Maxresorb-MXR). Two critical-sized bone defects (CSDs) were drilled in the calvarial of 24 Wistar rats and filled with one of the biomaterials. The animals were euthanized after 30, 60, and 90 days, and bone specimens were examined by histomorphometric analyses, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The percentages of newly formed bone, connective tissue, remaining biomaterial, and total tissue repair area were compared between groups using Student's t-test and analysis of variance (p ≤ 0.05).Results: HA/DCPA did not exhibit any cytotoxicity. CSDs contained newly formed bone from the defect margins and from ossification centers interspersed throughout the biomaterials. At 30 days, HA/DCPA group had a significantly larger total tissue repair area than MXR group (p = 0.047). No differences were observed between groups regarding variables studied (p > 0.05).Conclusion: HA/DCPA is non-cytotoxic. This cement promoted new bone formation and tissue filling of the entire defect area with degree of biomaterial degradation similar to HA/β-TCP, proving to be equally suitable and successful for bone regeneration.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402625"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I and type III collagen immunoexpression in rabbit skin biopsy samples treated with rosuvastatin gel and autologous platelet-rich plasma. 用洛伐他汀凝胶和自体富血小板血浆处理兔皮肤活检样本的 I 型和 III 型胶原蛋白免疫表达。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402725

Cristoffer da Silva Santana, Maria Rosa Santos Breda, Yuri Ferreira Vicentini, Sérgio Alexandre Alcantara Dos Santos, Luis Antonio Justulin, Anthony Cesar de Souza Castilho, Gisele Alborghetti Nai, Cecília Laposy Santarém

{"title":"Type I and type III collagen immunoexpression in rabbit skin biopsy samples treated with rosuvastatin gel and autologous platelet-rich plasma.","authors":"Cristoffer da Silva Santana, Maria Rosa Santos Breda, Yuri Ferreira Vicentini, Sérgio Alexandre Alcantara Dos Santos, Luis Antonio Justulin, Anthony Cesar de Souza Castilho, Gisele Alborghetti Nai, Cecília Laposy Santarém","doi":"10.1590/acb402725","DOIUrl":"10.1590/acb402725","url":null,"abstract":"Purpose: To evaluate whether the joint use of autologous platelet-rich plasma (aPRP) and rosuvastatin (RSV) in biopsies of dermal wounds induced in rabbits results in an additive effect on the immunoexpression of collagens type I and III, optimizing the healing process and increasing collagen production during the proliferative phase of healing to improve the quality of tissue repair.Methods: Thirty-two biopsy samples from eight clinically healthy adult male New Zealand rabbits were used. They were treated with aPRP, RSV, or aPRP + RSV and analyzed zero, three, seven, ten, and 14 days post wound induction.Results: Type I collagen immunoexpression was significantly higher in wounds treated with aPRP when compared to the control group. This study demonstrated that type III collagen is predominant during the proliferation phase of the healing process, highlighting its critical role in tissue repair and regeneration.Conclusion: The association of aPRP and RSV in wound treatment may have an additive effect in the immunoexpression of type III collagen and can thus be used as an alternative in tissue repair and collagen formation, optimizing the healing process.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402725"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between biliary plastic stents with and without application of silver nanoparticles: an in-vitro study of the biofilm formation. 使用和不使用纳米银的胆道塑料支架的比较：生物膜形成的体外研究。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402825

Victor Kalil Flumignan, Marcelo de Palma Sircili, Marcia Regina Franzolin, Ana Marisa Chudzinski Tavassi, Lígia Garcia Germano, Ana Vitória Dos Santos Souza, Nicole Fernandes Silva, Newton Kiyoshi Fukumasu, Raphaela Marques Dos Anjos, Jose Pinhata Otoch, Everson Luiz de Almeida Artifon

{"title":"Comparison between biliary plastic stents with and without application of silver nanoparticles: an in-vitro study of the biofilm formation.","authors":"Victor Kalil Flumignan, Marcelo de Palma Sircili, Marcia Regina Franzolin, Ana Marisa Chudzinski Tavassi, Lígia Garcia Germano, Ana Vitória Dos Santos Souza, Nicole Fernandes Silva, Newton Kiyoshi Fukumasu, Raphaela Marques Dos Anjos, Jose Pinhata Otoch, Everson Luiz de Almeida Artifon","doi":"10.1590/acb402825","DOIUrl":"10.1590/acb402825","url":null,"abstract":"Purpose: Plastic biliary stents are a cost-effective treatment for biliary obstruction. Unfortunately, they have low patency, related to intraluminal biofilm formation. Silver nanoparticles (AgNPs) have been increasingly used in biomedicine because of its antibacterial properties. This study aimed to compare biofilm formation on stents with and without silver nanoparticle coatings when in contact with different bacterial culture medium.Methods: Different types of silver coatings were tested on plastic biliary stents. Two groups of stents were analyzed: one group with various types of silver nanoparticle coatings, and a negative control group with no coating. The stents were placed in different bacterial culture media and assessed for biofilm formation. Analysis was performed using confocal microscopy and direct colony-forming unit (CFU/cm2).Results: Quantitative analysis showed promising results with C16 coating, as Escherichia coli ATCC and Pseudomonas aeruginosa ATCC exhibited reduced growth in the AgNP-coated group (p < 0.05). However, when mixed samples, including clinical strains and Staphylococcus aureus, were tested, the AgNP coating did not inhibit bacterial growth.Conclusion: AgNP-coated stents are effective against certain strains, such as E. coli ATCC and P. aeruginosa. Further research is needed to explore potential improvements in the coating mechanism.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402825"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological profile trends and cost of sickle cell disease in Brazil from 2008 to 2022. 2008 至 2022 年巴西镰状细胞病的流行病学概况趋势和费用。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb403025

Luiza Telles, Paulo Henrique Moreira Melo, Gabriele Eckerdt Lech, Luana Baptistele Dornelas, Natália Zaneti Sampaio, Ayla Gerk, Madeleine Carroll, Cristina Camargo

{"title":"Epidemiological profile trends and cost of sickle cell disease in Brazil from 2008 to 2022.","authors":"Luiza Telles, Paulo Henrique Moreira Melo, Gabriele Eckerdt Lech, Luana Baptistele Dornelas, Natália Zaneti Sampaio, Ayla Gerk, Madeleine Carroll, Cristina Camargo","doi":"10.1590/acb403025","DOIUrl":"10.1590/acb403025","url":null,"abstract":"Purpose: This study aimed to evaluate the epidemiological profile trends and economic impact of sickle cell disease (SCD) in Brazil from 2008 to 2022, focusing on incidence, mortality, and healthcare costs.Methods: A cross-sectional analysis was conducted using data from the Fundação Oswaldo Cruz's platform, Plataforma de Ciência de Dados Aplicada à Saúde, encompassing hospitalizations related to SCD from January 2008 to December 2022. The International Classification of Diseases codes for SCD were used to retrieve data on incidence, mortality, procedures performed, and healthcare costs.Results: The study included 151,535 hospitalizations for SCD, with 69.92% associated with SCD crises and 22.48% without crises. The mean annual hospitalizations were higher for crises (6,883.06) compared to those without crises (2,221.12). Mortality rates were significantly higher for patients hospitalized with crises compared to those without crises (p < 0.001). The economic impact of SCD was substantial, with annual costs exceeding 413 million USD.Conclusion: This study revealed a significant burden of SCD in Brazil, characterized by high hospitalization rates, particularly among younger patients, and elevated mortality rates associated with crises. Prospective studies and public health interventions are warranted to address SCD and mitigate its impact on public health.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403025"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoprotective effect of nimbolide against N-methyl-N-nitrosourea induced gastric cancer via alteration of apoptosis and NF-κB signaling pathway. nimbolide通过改变细胞凋亡和NF-κB信号通路对n -甲基-n -亚硝基脲诱导胃癌的化学保护作用。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402125

Yizhong Gu, Binguo Liu, Xiaoting Xia, Chunlei Luo, Yi Ren

{"title":"Chemoprotective effect of nimbolide against N-methyl-N-nitrosourea induced gastric cancer via alteration of apoptosis and NF-κB signaling pathway.","authors":"Yizhong Gu, Binguo Liu, Xiaoting Xia, Chunlei Luo, Yi Ren","doi":"10.1590/acb402125","DOIUrl":"10.1590/acb402125","url":null,"abstract":"Purpose: Gastric cancer (GC) ranks as the third most common cause of cancer related mortality and as the fifth most frequently diagnosed cancer globally. Less than 30% of people with GC survive for more than five years.Methods: Nimbolide has been shown to have anticancer, anti-inflammatory, antiparasitic, and antioxidant properties. The current investigation showed the anticancer effect of nimbolide against N-methyl-N-nitrosourea (MNU) induced GC in rats. Rats were given MNU (100 mg/kg) orally to induce GC and received the oral administration of nimbolide (10, 20 and 40 mg/kg). The different biochemical parameters were estimated.Results: Nimbolide significantly (p < 0.001) altered the level of lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cytochrome P450, cytochrome B5 and histone deacetylase (HDAC) activity. Nimbolide treatment significantly (p < 0.001) altered the level of antioxidant parameters like superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA); cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-2, IL-6; inflammatory parameters viz., cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), vascular endothelial growth factor (VEGF), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in the serum and stomach tissue. Nimbolide considerably altered (p < 0.001) the level of apoptosis parameters (Bcl-2, Bax and caspase-3), and the mRNA expression of VCAM-1, ICAM-1, TNF-α, IL-1β, IL-6, MCP-1, TLR4 and NF-κB.Conclusion: Nimbolide treatment considerably altered the GC against MNU induced GC via alteration of apoptosis and NF-κB signaling pathway.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402125"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the effect of thymoquinone and doxorubicin on the EGFR/FOXP3 signaling pathway in OVCAR3 human ovarian adenocarcinoma cells. 百里醌和阿霉素对OVCAR3人卵巢腺癌细胞EGFR/FOXP3信号通路影响的研究

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb401725

İlhan Özdemir, Ayfer Şanli Aktaş, Mehmet Cudi Tuncer

{"title":"Investigation of the effect of thymoquinone and doxorubicin on the EGFR/FOXP3 signaling pathway in OVCAR3 human ovarian adenocarcinoma cells.","authors":"İlhan Özdemir, Ayfer Şanli Aktaş, Mehmet Cudi Tuncer","doi":"10.1590/acb401725","DOIUrl":"10.1590/acb401725","url":null,"abstract":"Purpose: To investigate the cytotoxic and apoptotic effects of the combination of doxorubicin (Dox) and thymoquinone (TQ) on ovarian adenocarcinoma cells (OVCAR3) via the EGFR/FOXP3 signaling pathway.Methods: We used human OVCAR3 and human skin keratinocyte cells (HaCaT). Different concentrations of TQ and Dox were applied to the cells for 24, 48, and 72 hours, and the cytotoxicity level was determined via the MTT method. Expression levels of EGFR/FOXP3 for cell proliferation and apoptosis were determined by quantitative reverse transcription polymerase chain reaction (RT-qPCR) and Western blot analysis. The colony counting was performed after DAPI staining, and the effect on cell proliferation was determined.Results: Cytotoxicity was found to be highest with TQ and Dox treatments, and cell migration was prevented, especially in the group that received combined TQ and Dox treatment. Moreover, using RT-qPCR analysis, activity in the EGFR and FOXP3 pathway was found to be downregulated the most with TQ, and the amount of protein decreased with TQ and Dox.Conclusions: The findings showed that the greatest cytotoxic effect and the most apoptosis occurred during TQ treatment. Additionally, it was determined that a significant decrease in EGFR and FOXP3 levels occurred with the application of TQ and Dox.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e401725"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of photobiomodulation therapy in treating and preventing antineoplastic-induced oral mucositis: a systematic review. 光生物调节治疗和预防抗肿瘤性口腔黏膜炎的机制：系统综述。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb403125

Paulo Victor Alves de Sales, Isabella Piassi Dias Godói, Gerly Anne de Castro Brito, Renata Carvalho Leitão, Aurigena Antunes de Araújo, Caroline Addison Carvalho Xavier de Medeiros

{"title":"Mechanisms of photobiomodulation therapy in treating and preventing antineoplastic-induced oral mucositis: a systematic review.","authors":"Paulo Victor Alves de Sales, Isabella Piassi Dias Godói, Gerly Anne de Castro Brito, Renata Carvalho Leitão, Aurigena Antunes de Araújo, Caroline Addison Carvalho Xavier de Medeiros","doi":"10.1590/acb403125","DOIUrl":"10.1590/acb403125","url":null,"abstract":"Purpose: To conduct a systematic review of the mechanisms of photobiomodulation therapy (PBMT) for treating or preventing oral mucositis (OM) caused by antineoplastic therapy.Methods: Following PRISMA 2020 guidelines, a search was conducted in Medline, Latin American and Caribbean Health Sciences Literature (LILACS), Scientific Electronic Library Online (SciELO), and Bibliografia Brasileira de Odontologia from August to September 2023 using descriptors related to OM and laser therapy. Studies on the mechanisms of photobiomodulation in OM were included. Randomized (RCTs) or non-randomized trials from the past 10 years were reviewed. Risk of bias was assessed using RoB 2.0 and ROBINS-I tools.Results: A total of 355 studies was identified. After the screening, seven met the eligibility criteria. The RCTs showed a low risk of bias. PBMT reduced OM incidence in patients undergoing chemotherapy/radiotherapy. PBMT decreased pro-inflammatory cytokines (interleukin-6, tumor necrosis factor-α) and increased anti-inflammatory cytokines (interleukin-4, interleukin-10). It also modulated inflammatory mediators, enhancing the antioxidant enzyme superoxide dismutase and overexpressing genes for keratinocyte differentiation, aiding injury repair.Conclusion: The findings suggested that the mechanism of action of PBMT in OM involves modulation of the inflammatory response, balancing oxygen reactive species generation, and expression of factors related to healing or repair. Further studies are needed to elucidate these mechanisms and optimize treatment protocols.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403125"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal histological injury in pigs subjected to triple stent interposition in the thoracoabdominal aorta. 猪胸腹主动脉支架置入后的胃肠道组织学损伤。

Acta cirurgica brasileira Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI: 10.1590/acb402425

Angela Claudia Paixão Soares de Magalhães, Gutenberg do Amaral Gurgel, Svetlana Maria Wanderley de Barros, Miguel Lucas Silva Valente, Maurício de Amorim Aquino, Sthefanie da Silva Bessa, Rogério Ferraz Baquette, Aldemar Araújo Castro, Guilherme Benjamim Brandão Pitta

{"title":"Gastrointestinal histological injury in pigs subjected to triple stent interposition in the thoracoabdominal aorta.","authors":"Angela Claudia Paixão Soares de Magalhães, Gutenberg do Amaral Gurgel, Svetlana Maria Wanderley de Barros, Miguel Lucas Silva Valente, Maurício de Amorim Aquino, Sthefanie da Silva Bessa, Rogério Ferraz Baquette, Aldemar Araújo Castro, Guilherme Benjamim Brandão Pitta","doi":"10.1590/acb402425","DOIUrl":"10.1590/acb402425","url":null,"abstract":"Purpose: To evaluate gastrointestinal histological injury in pigs subjected to triple stent interposition versus a control group, hypothesizing no significant injury increase with triple stents.Methods: A prospective study with 15 pigs divided into a control group (G0, n = 5) undergoing arteriography only, and a triple stent group (G3, n = 10) undergoing arteriography and three stent implantations in the thoracoabdominal aorta. After an eight-day observation, arteriography, euthanasia, and en bloc gastrointestinal harvesting were performed. Lesions were graded using the Park/Chiu classification, and serum markers were analyzed pre- and post-procedure.Results: Arteriography confirmed mesenteric artery patency in all animals. Histological analysis showed ischemic lesions in 88.9% of G3, mainly in the colon (89%), compared to 60% in G0, primarily in the colon (60%) and stomach (40%). Most G3 lesions were grade 1, while G0 had higher-grade lesions. Serum markers showed no significant intergroup differences.Conclusion: Triple stent interposition did not significantly increase gastrointestinal injury, indicating its safety for maintaining gastrointestinal perfusion in this model.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402425"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0