Acta cirurgica brasileira最新文献

Initial experiences of the Optima™ coil system in intracranial aneurysm treatment: surgical and interventional approach to safety and efficacy in terms of cerebral arteries. Optima线圈系统在颅内动脉瘤治疗中的初步经验：手术和介入方法在脑动脉方面的安全性和有效性

Acta cirurgica brasileira Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.1590/acb403425

Bekir Sıtkı Said Ulusoy, Çetin Murat Altay, Mehmet Onay, Ali Burak Binboga, Murat Kaya

{"title":"Initial experiences of the Optima™ coil system in intracranial aneurysm treatment: surgical and interventional approach to safety and efficacy in terms of cerebral arteries.","authors":"Bekir Sıtkı Said Ulusoy, Çetin Murat Altay, Mehmet Onay, Ali Burak Binboga, Murat Kaya","doi":"10.1590/acb403425","DOIUrl":"https://doi.org/10.1590/acb403425","url":null,"abstract":"Purpose: To evaluate the angiographic outcomes of the Optima™ coil system in the endovascular treatment of saccular intracranial aneurysms to present real-world experiences.Methods: The study encompassed patients with both ruptured and unruptured aneurysms who underwent treatment with the Optima™ coil system. A retrospective analysis was conducted to examine patient and aneurysm characteristics, complication rates, and angiographic outcomes.Results: The total of 326 Optima™ coil implantations was performed in 64 aneurysms, with a mean maximum diameter of 7.49 ± 3.08 mm (range: 2.5-16.5 mm), among 64 patients (37 females and 27 males, mean age: 53.34 ± 14 years old). The average number of implanted coils was 5.06 ± 1.73. The mean packing density was 26.2% (range = 19.2-34.6), observed to be significantly higher in aneurysms with complete occlusion and neck remnants compared to those with a residual dome (p < 0.01). The mean follow-up period was 15.9 ± 8.1 months. One case (1.5%) reported a coil malfunction attributed to coil stretching. The mortality rate was 3.1% (n = 2).Conclusion: The Optima™ coil system exhibited safety and efficacy in the endovascular treatment of both ruptured and unruptured intracranial aneurysms, demonstrating favorable angiographic outcomes. Nevertheless, further studies are necessary to validate these results over the long term.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403425"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of smart glasses in telementoring for simulated medical procedures. 智能眼镜在模拟医疗过程远程监控中的集成。

Acta cirurgica brasileira Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.1590/acb403625

Tiago Francisco Meleiro Zubiolo, Vlaudimir Dias Marques, Miyoko Massago, Aline Cardoso Machado, Felipe Hideaki Ueda, Mateus de Amorim Aboboreira, Eduardo Filgueiras Damasceno, Sanderland José Tavares Gurgel, Carlos Edmundo Rodrigues Fontes, Luciano de Andrade

{"title":"Integration of smart glasses in telementoring for simulated medical procedures.","authors":"Tiago Francisco Meleiro Zubiolo, Vlaudimir Dias Marques, Miyoko Massago, Aline Cardoso Machado, Felipe Hideaki Ueda, Mateus de Amorim Aboboreira, Eduardo Filgueiras Damasceno, Sanderland José Tavares Gurgel, Carlos Edmundo Rodrigues Fontes, Luciano de Andrade","doi":"10.1590/acb403625","DOIUrl":"https://doi.org/10.1590/acb403625","url":null,"abstract":"Purpose: To demonstrate the complete process of telementoring implementation using augmented-reality smart glasses for performing a simulated medical procedure.Methods: Fifteen participants, including physicians and medical students, were recruited to participate in a telementoring session with an educational focus during simulated thoracostomy with closed pleural drainage. A questionnaire assessing technology usability and usefulness was administered, and the results were analyzed by Cronbach's alfa and multiple correspondence analysis (MCA).Results: The mean age of the participants was 28.8 and 66.67% of them were women. The test results indicated a Cronbach's alpha of 78% and an MCA of 49.48% for the first three dimensions.Conclusion: The results showed that smart glasses are easy to use and facilitate communication among the professionals involved, providing comfort and safety to participants of care simulations. Additionally, smart glasses were considered to have perceived usefulness.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403625"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rabbit-based experimental model for scalp reimplantation: advancing microsurgical training and translational research. 兔头皮再植实验模型：推进显微外科训练与转化研究。

Acta cirurgica brasileira Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1590/acb403725

Rui Sergio Monteiro de Barros, José Maciel Caldas Dos Reis, Deivid Ramos Dos Santos, Vitor Nagai Yamaki, Renan Kleber Costa Teixeira, André Lopes Valente

{"title":"Rabbit-based experimental model for scalp reimplantation: advancing microsurgical training and translational research.","authors":"Rui Sergio Monteiro de Barros, José Maciel Caldas Dos Reis, Deivid Ramos Dos Santos, Vitor Nagai Yamaki, Renan Kleber Costa Teixeira, André Lopes Valente","doi":"10.1590/acb403725","DOIUrl":"https://doi.org/10.1590/acb403725","url":null,"abstract":"Purpose: To develop an experimental model of microsurgical scalp reimplantation in rabbits.Methods: Ten male albino New Zealand rabbits (Oryctolagus cuniculus) were scalped and subjected to scalp reimplantation. The rabbits' scalp regions, including their ears, were surgically amputated. Based on a previous anatomical study, the superficial temporal artery and the central auricular vein were chosen for microanastomosis. Data on the morphometric parameters (vessel weight and caliber), surgical procedure (surgical time and number of stitches), and surgical recovery parameters (venous return, patency, and necrosis) were collected for up to 30 days postoperatively (PO) using a research protocol.Results: Morphometric and surgical recovery parameters did not significantly differ in our sample. No animals died during the intraoperative period. Three animals were euthanized because they developed partial or total scalp necrosis. The venous return was impaired from three to ten days PO, with spontaneous regression after this period, which significantly improved (p = 0.02) after 14 days PO. Superficial necrosis was observed starting at two days PO with complete resolution by day 21 PO (p <0.01).Conclusion: The rabbit provides a realistic biological model for training scalp reimplantation with high fidelity to human vascular structures.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403725"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway. 水蛭素通过靶向STAT3/NLRP3信号通路抑制铁下垂改善肾纤维化。

Acta cirurgica brasileira Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1590/acb403325

Fang Lan, Chunli Long, Huimin Huang, Yongxiang Xie, Wei Shi

{"title":"Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway.","authors":"Fang Lan, Chunli Long, Huimin Huang, Yongxiang Xie, Wei Shi","doi":"10.1590/acb403325","DOIUrl":"https://doi.org/10.1590/acb403325","url":null,"abstract":"Purpose: To reveal the role and underlying mechanism of hirudin in renal fibrosis.Methods: The unilateral ureteral obstruction (UUO) rat model and ferroptosis activator RSL3-induced human kidney proximal tubular epithelial cells (HK-2) were established. Hematoxylin-eosin staining, commercial kits, and immunohistochemistry were used to assess the effect of hirudin on renal function and renal fibrosis. Cell counting kit-8 assay was employed to test cell viability. Ferroptosis indicator levels were detected using commercial kits. The protein levels were examined by Western blot. The STAT3 activator colivelin was introduced to verify the role of the STAT3/NLRP3 signaling pathway in ferroptosis.Results: Hirudin alleviated renal injury and improved renal fibrosis in UUO rats. The cell viability of RSL3-treated HK-2 cells was increased after hirudin treatment. In the model group, GPX4, SLC7A11, and glutathione expression decreased, while malondialdehyde and iron content levels increased, indicating that ferroptosis was activated. Besides, p-STAT3 and NLRP3 protein levels were also upregulated. However, hirudin treatment reversed these changes. When the STAT3 activator colivelin was added, the effect of hirudin was altered.Conclusion: Hirudin improved renal fibrosis by inhibiting ferroptosis via the STAT3/NLRP3 signaling pathway.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403325"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-stricture after buccal mucosal graft urethroplasty: a systematic review and meta-analysis. 口腔粘膜移植尿道成形术后再狭窄：系统回顾和荟萃分析。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb403525

Gustavo Bono Yoshikawa, Gabriella Giandotti Gomar, Giovanna Ceccatto Gadens, Beatriz França Zanetti Saes, Maria Eduarda Andrade Galiciolli, Meire Ellen Pereira, Quelen Iane Garlet, Cláudia Sirlene Oliveira

{"title":"Re-stricture after buccal mucosal graft urethroplasty: a systematic review and meta-analysis.","authors":"Gustavo Bono Yoshikawa, Gabriella Giandotti Gomar, Giovanna Ceccatto Gadens, Beatriz França Zanetti Saes, Maria Eduarda Andrade Galiciolli, Meire Ellen Pereira, Quelen Iane Garlet, Cláudia Sirlene Oliveira","doi":"10.1590/acb403525","DOIUrl":"10.1590/acb403525","url":null,"abstract":"Purpose: To determine risk factors for re-stricture after buccal mucosal graft urethroplasty (BMGU) through a systematic review and meta-analysis.Methods: Following PRISMA guidelines, we collected data from PubMed, Scientific Electronic Library Online (SciELO), and Web of Science databases. The eligibility criteria included studies with male patients over 18 years old with urethral stricture recurrence after BMGU.Results: We retrieved 646 papers from three electronic databases. Records that did not meet the eligibility criteria and duplicates were excluded, resulting in 14 papers (3,240 patients) that underwent qualitative analysis, from which nine papers were suitable for meta-analysis. The meta-analysis identified diabetes mellitus (relative risk - RR: 1.58 [95% confidence interval - 95%CI 1.02-2.46];p = 0.04), penile/peno-bulbar site (RR: 1.57 [95%CI 1.04-2.37]; p = 0.03), and stricture size higher than 7 cm (RR: 4.13 [95%CI 2.42-7.04]; p 0.00001) as a predictive factor of re-stricture.Conclusions: These findings may improve understanding the risk factors for this type of urethroplasty and help surgical decisions. For a more effective analysis, larger and better-distributed study groups and cohorts are needed in the future to clarify whether the combination of a previous disease and the urethroplasty etiology may impact a recurrence-free outcome after stricture correction.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403525"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats. 超生理剂量癸酸诺龙对大鼠睾丸的即时和后期影响。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402925

Bruno Felix-Patricio, Roger Gaspar Marchon, Bianca Martins Gregório, Diogo Benchimol De Souza

{"title":"Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats.","authors":"Bruno Felix-Patricio, Roger Gaspar Marchon, Bianca Martins Gregório, Diogo Benchimol De Souza","doi":"10.1590/acb402925","DOIUrl":"10.1590/acb402925","url":null,"abstract":"Purpose: To investigate the effects of supraphysiologic doses of nandrolone decanoate on the testicular morphology of rats and if these effects could be transitory or permanent.Methods: Twenty-five male rats were divided in four groups. C28 and C40 were control rats killed with 28 and 40 weeks old, respectively; and T28 and T40 were treated with nandrolone decanoate (10 mg/kg) and killed immediately after the treatment (T28) or 12 weeks after the end of treatment (T40). The testis weight and volume were measured, and the seminiferous tubule area and epithelium height were assessed by histomorphometric methods.Results: The seminiferous tubules area and epithelium height of group T28 were reduced in comparison to C28. Group T40 showed reduced testicular weight and volume, as well as seminiferous tubule area and epithelium height in comparison to C40.Conclusion: The use of nandrolone decanoate promotes major structural modifications on the testes of rats. These modifications are even worse 12 weeks after ending the use of the anabolic androgenic steroid.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402925"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new eggshell-derived calcium phosphate bioceramic for tissue engineering: cytotoxicity and histomorphometric study. 一种用于组织工程的新型蛋壳来源的磷酸钙生物陶瓷：细胞毒性和组织形态学研究。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402625

Conrado Dias do Nascimento Neto, Laisa Kindely Ramos de Oliveira, Amy Brian Costa E Silva, Patrícia Roccon Bianchi, André Gustavo de Sousa Galdino, Daniela Nascimento Silva

{"title":"A new eggshell-derived calcium phosphate bioceramic for tissue engineering: cytotoxicity and histomorphometric study.","authors":"Conrado Dias do Nascimento Neto, Laisa Kindely Ramos de Oliveira, Amy Brian Costa E Silva, Patrícia Roccon Bianchi, André Gustavo de Sousa Galdino, Daniela Nascimento Silva","doi":"10.1590/acb402625","DOIUrl":"10.1590/acb402625","url":null,"abstract":"Purpose: To evaluate cytotoxicity and tissue repair of a new chicken eggshell-derived bioceramic (hydroxyapatite/dicalcium phosphate anhydrous-HA/DCPA).Methods: Cytotoxicity was evaluated in fibroblasts (L cell, L-929) by MTT test. Tissue repair of HA/DCPA was compared to HA/β-TCP bioceramic (Maxresorb-MXR). Two critical-sized bone defects (CSDs) were drilled in the calvarial of 24 Wistar rats and filled with one of the biomaterials. The animals were euthanized after 30, 60, and 90 days, and bone specimens were examined by histomorphometric analyses, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The percentages of newly formed bone, connective tissue, remaining biomaterial, and total tissue repair area were compared between groups using Student's t-test and analysis of variance (p ≤ 0.05).Results: HA/DCPA did not exhibit any cytotoxicity. CSDs contained newly formed bone from the defect margins and from ossification centers interspersed throughout the biomaterials. At 30 days, HA/DCPA group had a significantly larger total tissue repair area than MXR group (p = 0.047). No differences were observed between groups regarding variables studied (p > 0.05).Conclusion: HA/DCPA is non-cytotoxic. This cement promoted new bone formation and tissue filling of the entire defect area with degree of biomaterial degradation similar to HA/β-TCP, proving to be equally suitable and successful for bone regeneration.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402625"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I and type III collagen immunoexpression in rabbit skin biopsy samples treated with rosuvastatin gel and autologous platelet-rich plasma. 用洛伐他汀凝胶和自体富血小板血浆处理兔皮肤活检样本的 I 型和 III 型胶原蛋白免疫表达。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402725

Cristoffer da Silva Santana, Maria Rosa Santos Breda, Yuri Ferreira Vicentini, Sérgio Alexandre Alcantara Dos Santos, Luis Antonio Justulin, Anthony Cesar de Souza Castilho, Gisele Alborghetti Nai, Cecília Laposy Santarém

{"title":"Type I and type III collagen immunoexpression in rabbit skin biopsy samples treated with rosuvastatin gel and autologous platelet-rich plasma.","authors":"Cristoffer da Silva Santana, Maria Rosa Santos Breda, Yuri Ferreira Vicentini, Sérgio Alexandre Alcantara Dos Santos, Luis Antonio Justulin, Anthony Cesar de Souza Castilho, Gisele Alborghetti Nai, Cecília Laposy Santarém","doi":"10.1590/acb402725","DOIUrl":"10.1590/acb402725","url":null,"abstract":"Purpose: To evaluate whether the joint use of autologous platelet-rich plasma (aPRP) and rosuvastatin (RSV) in biopsies of dermal wounds induced in rabbits results in an additive effect on the immunoexpression of collagens type I and III, optimizing the healing process and increasing collagen production during the proliferative phase of healing to improve the quality of tissue repair.Methods: Thirty-two biopsy samples from eight clinically healthy adult male New Zealand rabbits were used. They were treated with aPRP, RSV, or aPRP + RSV and analyzed zero, three, seven, ten, and 14 days post wound induction.Results: Type I collagen immunoexpression was significantly higher in wounds treated with aPRP when compared to the control group. This study demonstrated that type III collagen is predominant during the proliferation phase of the healing process, highlighting its critical role in tissue repair and regeneration.Conclusion: The association of aPRP and RSV in wound treatment may have an additive effect in the immunoexpression of type III collagen and can thus be used as an alternative in tissue repair and collagen formation, optimizing the healing process.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402725"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between biliary plastic stents with and without application of silver nanoparticles: an in-vitro study of the biofilm formation. 使用和不使用纳米银的胆道塑料支架的比较：生物膜形成的体外研究。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402825

Victor Kalil Flumignan, Marcelo de Palma Sircili, Marcia Regina Franzolin, Ana Marisa Chudzinski Tavassi, Lígia Garcia Germano, Ana Vitória Dos Santos Souza, Nicole Fernandes Silva, Newton Kiyoshi Fukumasu, Raphaela Marques Dos Anjos, Jose Pinhata Otoch, Everson Luiz de Almeida Artifon

{"title":"Comparison between biliary plastic stents with and without application of silver nanoparticles: an in-vitro study of the biofilm formation.","authors":"Victor Kalil Flumignan, Marcelo de Palma Sircili, Marcia Regina Franzolin, Ana Marisa Chudzinski Tavassi, Lígia Garcia Germano, Ana Vitória Dos Santos Souza, Nicole Fernandes Silva, Newton Kiyoshi Fukumasu, Raphaela Marques Dos Anjos, Jose Pinhata Otoch, Everson Luiz de Almeida Artifon","doi":"10.1590/acb402825","DOIUrl":"10.1590/acb402825","url":null,"abstract":"Purpose: Plastic biliary stents are a cost-effective treatment for biliary obstruction. Unfortunately, they have low patency, related to intraluminal biofilm formation. Silver nanoparticles (AgNPs) have been increasingly used in biomedicine because of its antibacterial properties. This study aimed to compare biofilm formation on stents with and without silver nanoparticle coatings when in contact with different bacterial culture medium.Methods: Different types of silver coatings were tested on plastic biliary stents. Two groups of stents were analyzed: one group with various types of silver nanoparticle coatings, and a negative control group with no coating. The stents were placed in different bacterial culture media and assessed for biofilm formation. Analysis was performed using confocal microscopy and direct colony-forming unit (CFU/cm2).Results: Quantitative analysis showed promising results with C16 coating, as Escherichia coli ATCC and Pseudomonas aeruginosa ATCC exhibited reduced growth in the AgNP-coated group (p < 0.05). However, when mixed samples, including clinical strains and Staphylococcus aureus, were tested, the AgNP coating did not inhibit bacterial growth.Conclusion: AgNP-coated stents are effective against certain strains, such as E. coli ATCC and P. aeruginosa. Further research is needed to explore potential improvements in the coating mechanism.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402825"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological profile trends and cost of sickle cell disease in Brazil from 2008 to 2022. 2008 至 2022 年巴西镰状细胞病的流行病学概况趋势和费用。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb403025

Luiza Telles, Paulo Henrique Moreira Melo, Gabriele Eckerdt Lech, Luana Baptistele Dornelas, Natália Zaneti Sampaio, Ayla Gerk, Madeleine Carroll, Cristina Camargo

{"title":"Epidemiological profile trends and cost of sickle cell disease in Brazil from 2008 to 2022.","authors":"Luiza Telles, Paulo Henrique Moreira Melo, Gabriele Eckerdt Lech, Luana Baptistele Dornelas, Natália Zaneti Sampaio, Ayla Gerk, Madeleine Carroll, Cristina Camargo","doi":"10.1590/acb403025","DOIUrl":"10.1590/acb403025","url":null,"abstract":"Purpose: This study aimed to evaluate the epidemiological profile trends and economic impact of sickle cell disease (SCD) in Brazil from 2008 to 2022, focusing on incidence, mortality, and healthcare costs.Methods: A cross-sectional analysis was conducted using data from the Fundação Oswaldo Cruz's platform, Plataforma de Ciência de Dados Aplicada à Saúde, encompassing hospitalizations related to SCD from January 2008 to December 2022. The International Classification of Diseases codes for SCD were used to retrieve data on incidence, mortality, procedures performed, and healthcare costs.Results: The study included 151,535 hospitalizations for SCD, with 69.92% associated with SCD crises and 22.48% without crises. The mean annual hospitalizations were higher for crises (6,883.06) compared to those without crises (2,221.12). Mortality rates were significantly higher for patients hospitalized with crises compared to those without crises (p < 0.001). The economic impact of SCD was substantial, with annual costs exceeding 413 million USD.Conclusion: This study revealed a significant burden of SCD in Brazil, characterized by high hospitalization rates, particularly among younger patients, and elevated mortality rates associated with crises. Prospective studies and public health interventions are warranted to address SCD and mitigate its impact on public health.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403025"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0