Effects of curcumin supplementation on the severity of intra-abdominal adhesions in rats.

IF 1.3
Acta cirurgica brasileira Pub Date : 2025-07-11 eCollection Date: 2025-01-01 DOI:10.1590/acb404425
Pedro Afonso Kono, Rivair Gonçalves Junior, Adriana Yuriko Koga, Melquesedeque Dos Santos, Matheus Von Jelita Salina, Elder Dalazoana Filho, Alceu Toledo Junior, Leandro Cavalcante Lipinski, Marcos Ricardo da Silva Rodrigues, Eurico Cleto Ribeiro de Campos
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Abstract

Purpose: To evaluate the effect of curcumin administered by gavage, on reducing intra-abdominal adhesions and attenuating the inflammatory process, assessed by a serum marker.

Methods: Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The curcumin group received curcumin by gavage at the dose of 200 mg/kg over the seven days preceding and the seven days following surgery. In the control group, an isovolumetric administration of 0.9% saline solution was given by gavage. Both groups underwent a median laparotomy and left-sided colotomy. On the eighth postoperative day, the animals were euthanized for intracavitary adhesion analysis and left colon resection for histological examination. Intra-abdominal adhesions were classified from grade 0 to 4 based on increases in number, intensity, and ease of lysis.

Results: Curcumin administration did not significantly reduce the severity of intra-abdominal adhesions (p = 0.7143) nor the severity of colonic inflammatory infiltration. However, a significant reduction in C-reactive protein levels was observed preoperatively in the curcumin group (p 0.05).

Conclusion: While curcumin was not able to reduce the severity of intra-abdominal adhesions, it demonstrated the ability to attenuate the inflammatory process associated with the surgical procedure.

补充姜黄素对大鼠腹内粘连严重程度的影响。
目的:评价姜黄素灌胃对减少腹腔粘连和减轻炎症过程的作用。方法:40只Wistar大鼠随机分为姜黄素组和对照组。姜黄素组术前、术后7天灌胃姜黄素200mg /kg。对照组给予0.9%生理盐水等体积灌胃。两组均行正中剖腹术和左侧结肠切开术。术后第8天安乐死,进行腔内粘连分析,切除左结肠进行组织学检查。根据腹内粘连的数量、强度和溶解的难易程度,将腹内粘连分为0级至4级。结果:姜黄素未显著降低腹腔内粘连的严重程度(p = 0.7143),也未显著降低结肠炎性浸润的严重程度。然而,姜黄素组术前c反应蛋白水平明显降低(p < 0.05)。结论:虽然姜黄素不能减轻腹内粘连的严重程度,但它可以减轻与手术过程相关的炎症过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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