西心梗叶水醇提取物在实验性结肠炎模型中的抗溃疡和抗氧化作用。

IF 1.3
Acta cirurgica brasileira Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI:10.1590/acb406025
Victor Pedro, Maria do Socorro Medeiros Amarante, Everlândja Gomes de Almeida, Manoel André de Souza Neto, Silvana Maria Zucolotto, Matheus Augusto de Bittencourt Pasquali, Sérgio Adriane Bezerra de Moura, Fabiane Ferreira Martins, Christina da Silva Camillo
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引用次数: 0

摘要

目的:探讨西方心梗水酒精叶提取物(HEA)对实验性结肠炎大鼠的抗溃疡和抗氧化作用。方法:将雄性大鼠分为6组(每组10只):C组(对照组)、CC组(结肠炎对照组)、SZC组(磺胺嘧啶500 mg/kg)、HEA组(HEA50 = 50 mg/kg、HEA100 = 100 mg/kg、HEA200 = 200 mg/kg)。结果:HEA100治疗7 d,腹泻减少,进食量增加,体重减轻,结肠宏观和组织学参数恢复,减轻了结肠炎的严重程度,恢复了诱导性结肠炎动物的肠道形态生理。此外,HEA50和HEA100处理增加了超氧化物歧化酶、过氧化氢酶和硫醇的活性,降低了硫代巴比妥酸活性物质和羰基的水平,有助于重建抗氧化稳态。结论:本研究提供了临床前证据,证明西叶提取物,特别是浓度为100 mg/kg时,可能是由于抗氧化系统的正向调节,作为一种抗溃疡剂,可以减轻大鼠的结肠炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiulcerative and antioxidant action of hydroalcoholic extract of Anacardium occidentale L. leaves in an induced experimental colitis model.

Purpose: To examine the antiulcerative and antioxidant action of the Anacardium occidentale hydroalcoholic leaf extract (HEA) on experimentally induced colitis in rats via acetic acid (AA).

Methods: Male rats were distributed into six groups (n = 10 per group): C (control), CC (colitis control), SZC (sulfasalazine 500 mg/kg), and three doses of HEA (HEA50 = 50 mg/kg, HEA100 = 100 mg/kg, HEA200 = 200 mg/kg).

Results: The treatment with HEA100 for seven days decreased diarrhea, increased food intake, attenuated weight loss, and recovered the macroscopic and histological parameters of the colon, mitigating the severity of colitis and restoring the intestinal morphophysiology of animals with induced colitis. Additionally, HEA50 and HEA100 treatment increased the activity of superoxide dismutase, catalase, and thiol, and reduced the levels of thiobarbituric acid reactive substances and carbonyl, contributing to the re-establishment of antioxidant homeostasis.

Conclusion: This study provided preclinical evidence of the potential of A. occidentale leaf extract, particularly at the concentration of 100 mg/kg, as an antiulcer agent for attenuating colitis in rats, likely due to the positive modulation of the antioxidant system.

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