Acta cirurgica brasileira最新文献

{"title":"Enemas with sucralfate and n-acetylcysteine can reduce inflammation and oxidative stress in colonic mucosa without fecal stream.","authors":"Marcelo César Zanesco, Mateus Magami Yoshitani, Felipe Leonardo Fagundes, Fábio Guilherme Campos, Poliana Pacciulli Pereira, Quélita Cristina Pereira, José Aires Pereira, Raquel de Cássia Santos, Carlos Augusto Real Martinez","doi":"10.1590/acb406325","DOIUrl":"https://doi.org/10.1590/acb406325","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether enemas containing sucralfate (SCF) alone or in combination with n-acetylcysteine (NAC) reduces inflammation and oxidative stress (OS) in the colonic mucosa without fecal stream.</p><p><strong>Methods: </strong>Forty-eight rats were subjected to left colostomy and distal rectal mucous fistula. During the procedure, 2 cm of the colon was collected to constitute the sham group. Twelve weeks after the surgical procedure, the animals were divided into two groups (n = 24) and received daily enemas containing saline, SCF (2 g/kg), NAC (100 mg/kg), or SCF + NAC (2 g/kg + 100 mg/kg, respectively) for two or four weeks. At the end of the intervention period, the animals were euthanized, and colonic segments without fecal stream were removed for histological and biochemical analyses. The diagnosis of colitis was made by histological analysis, and the inflammatory score was assessed using a validated scale. The neutrophilic infiltrate was evaluated by quantifying the content of myeloperoxidase (MPO) in the tissue. OS was determined by evaluating the activity of colonic antioxidant systems (superoxide dismutase, catalase, and reduced glutathione) and malondialdehyde (MDA) levels. The differences among subgroups were analyzed with the Mann-Whitney's test, whereas changes over time were analyzed via the Kruskal-Wallis' test, with the significance level of 5% (p < 0.05).</p><p><strong>Results: </strong>Enemas with SCF and NAC alone or in combination reduced colonic inflammation and the tissue levels of MPO and MDA and increased the levels of antioxidant enzymes.</p><p><strong>Conclusion: </strong>SCF and NAC enemas alone or in combination reduced inflammation activity and OS in colon segments without fecal stream.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e406325"},"PeriodicalIF":1.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A standardized protocol for anal fistula induction in a rat model.","authors":"Paulo Cesar de Castro Junior, Jenif Braga de Souza, Ruy Garcia Marques","doi":"10.1590/acb406125","DOIUrl":"https://doi.org/10.1590/acb406125","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate an experimental model of anal fistulas in rats, analyze the primary challenges associated with this model, and identify its key advantages.</p><p><strong>Methods: </strong>Twenty-six male Wistar rats underwent surgical induction of two anal fistulas each, using a metal seton. The setons remained in place for 30 days, after which they were removed. Animals were divided in two groups (n = 13 per group). Group 1 was euthanized two weeks post-seton removal, and Group 2 in four weeks post-seton removal. Two fistula tissue samples were collected from each animal for histopathological analysis.</p><p><strong>Results: </strong>All 26 animals tolerated the procedure well, with an average weight gain of 64.3 grams in 30 days. There was no animal loss during the experiment, but eight setons were lost due to poor fixation. One animal lost both setons and had to be excluded from the experiment, resulting in a 96% success rate. All 44 remaining fistulas could be identified by observing the scar on the external orifice, two and four weeks after the removal of the metal wire.</p><p><strong>Conclusion: </strong>The two groups showed no differences. The experimental model in this work proved to be quite effective, economically viable and easy to reproduce.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e406125"},"PeriodicalIF":1.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is arthrocentesis effective for temporomandibular joint disorders?","authors":"Eduardo Grossmann, Sigmar de Mello Rode","doi":"10.1590/acb406425","DOIUrl":"10.1590/acb406425","url":null,"abstract":"<p><p>This review covers the most recent articles on temporomandibular joint arthrocentesis, focusing on its mechanism of action, indications, clinical outcomes and efficacy, complications, comparison with other treatment modalities, and conclusions.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e406425"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol and temozolomide induce apoptosis and suppress proliferation in glioblastoma cells via the apoptotic signaling pathway.","authors":"Görkem Tutal Gürsoy, Mehmet Cudi Tuncer, İlhan Özdemir","doi":"10.1590/acb405525","DOIUrl":"10.1590/acb405525","url":null,"abstract":"<p><strong>Purpose: </strong>Glioblastoma (GBM) is the most common primary brain tumor in the central nervous system. Studies revealing the molecular mechanisms regulating GBM pathogenesis are currently limited. This study aimed to investigate the expression of genes responsible for the apoptotic pathway (p21, p27, p53) after separate and combined application of the natural components resveratrol (Res) and temozolomide (TMZ) in the GBM cell line (U118).</p><p><strong>Methods: </strong>In this study, the GBM cell line U118 was used. Apoptotic activation of Res and TMZ via the p21, p27, p53 signaling pathway was evaluated by quantitative reverse transcription polymerase chain reaction and TaLi cytometry. Cell viability was also assessed using the MTT assay.</p><p><strong>Results: </strong>Res and TMZ inhibited the proliferation and migration of U118 cells. Additionally, Res induced apoptosis by arresting the cell cycle. Moreover, Res treatment upregulated the expression of p27 and p53, which are associated with apoptosis, while it significantly downregulated the expression of the p21 gene.</p><p><strong>Conclusion: </strong>These results indicated that Res and TMZ suppressed the proliferation of GBM cells through apoptotic pathways. Together, Res and TMZ may represent a promising combination for suppressing tumors through apoptotic mechanisms.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e405525"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood concentrates for controlling postoperative complications from third molar surgeries: a scoping review.","authors":"Vinícius Lima de Almeida, Marcelo Dias Moreira de Assis Costa, Rômulo Dias Jesuino, Lívia Bonjardim Lima, Zuleni Alexandre da Silva, Rafael Rodrigues Lima, Sigmar de Mello Rode, Luiz Renato Paranhos","doi":"10.1590/acb405825","DOIUrl":"10.1590/acb405825","url":null,"abstract":"<p><strong>Purpose: </strong>To map the literature on blood concentrates for managing postoperative sequelae after third molar extraction through a scoping review.</p><p><strong>Methods: </strong>MedLine, Latin American and Caribbean Health Sciences Literature, Scientific Electronic Library Online, EMBASE, Cochrane Library, Scopus, and Web of Science were the search databases. MedRxiv and EASY provided the grey literature. The investigation included observational studies and clinical trials reporting at least one postoperative sequela. After selecting the articles, the extracted data included study author, year, and country, study design, sample size, age distribution, the type of third molar impaction, flap design, the presence of osteotomy and/or odontosection, co-interventions, blood concentrate type, centrifuge model, centrifugation protocol, collection tubes, outcomes, and the main findings for each outcome. After data extraction, an analysis of the geographic distribution of publications was carried out based on the MapChart website.</p><p><strong>Results: </strong>This review included 63 studies. The leading countries in publications were Turkey, India, and Brazil. Common postoperative sequelae included pain, edema, trismus, alveolar osteitis, and infection. Outcomes varied regarding the effectiveness of concentrates in controlling inflammation, edema, trismus, and alveolar osteitis. Advanced platelet-rich fibrin was the most applied concentrate in recent studies and was associated with reduced edema and trismus.</p><p><strong>Conclusion: </strong>All concentrates demonstrated some effectiveness in managing sequelae after third molar extraction, but most did not show significant outcomes in controlling inflammatory signs. It emphasizes the need for further randomized clinical trials and systematic reviews to strengthen the evidence on blood concentrates for managing postoperative sequelae.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e405825"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of immunophenotypic markers in blood mononuclear cells of patients with advanced head and neck squamous cells carcinoma.","authors":"Adriana Torres da Silva, Érica Leandro Marciano Vieira, Ana Cristina Simões E Silva, Andy Petroianu","doi":"10.1590/acb405425","DOIUrl":"10.1590/acb405425","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate peripheral blood mononuclear cells (PBMCs) from patients with advanced head and neck squamous cell carcinoma (HNSCC) in comparison with healthy volunteers, as they can be potential biomarkers.</p><p><strong>Methods: </strong>Immunophenotyping was performed using flow cytometry of blood mononuclear cells from two groups of adult men: group 1 (n = 14), diagnosed with HNSCC (mouth, larynx, and hypopharynx); and group 2 (n = 14), volunteers, healthy, and without the use of drugs. The cell groups studied were T lymphocytes (CD3, CD4, CD8, CD56 and CD69), B lymphocytes (CD19, CD69), neutrophils (CD11a, CD16, CD66b, HLA-DR), and monocytes (CD14, CD86).</p><p><strong>Results: </strong>In group 1, there were an increase in CD3+CD4+ T lymphocytes (p < 0.001) and NK 56+ cells (p = 0.009) and a decrease in CD3+CD8+ T lymphocytes (p = 0.02) in comparison with group 2. In patients with HNSCC, an increase was found in the expression of the CD69 marker in CD3+CD4+ T lymphocytes (p = 0.03) and CD19+ B lymphocytes (p = 0.01) when compared to healthy volunteers.</p><p><strong>Conclusion: </strong>HNSCC triggers a systemic inflammatory response with a decrease in CD8 T cells and an increase in CD4 T and CD56 natural killer cells. CD69 early activation marker was expressed by T and B cells.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e405425"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatibility of three-dimensional thermoplastic elastomer implants compared to that of the sternocephalic muscle flap in repairing partial tracheal defects in New Zealand white rabbits (Oryctolagus cuniculus).","authors":"Marcelo Carrijo da Costa, Ana Carolina Gasques Salgado Dos Santos, Ariadne Rein, Gabriel Luiz Montanhim, Gustavo Fernandes, Luis Gustavo Gosuen Gonçalves Dias, Marcella Dall Agnol Leite, Nicolle Pereira Soares, Thiago André Salvitti de Sá Rocha, Marcelo Emilio Beletti, Paola Castro Moraes","doi":"10.1590/acb405025","DOIUrl":"10.1590/acb405025","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness and biocompatibility of a three-dimensional (3D) thermoplastic elastomer (TPE) prosthesis for repairing partial tracheal defects using 3D printing with fused deposition modelling.</p><p><strong>Methods: </strong>Thirty-two rabbits underwent partial resection of five tracheal rings and were divided into two groups: the muscular flap group (GFM), which received a sternocephalic muscle flap over the defect; and the TPE group (GTPE), which received a 3D-printed TPE prosthesis. Clinical evaluations were performed at seven, 15, 30, and 60 days postoperatively.</p><p><strong>Results: </strong>Cough was significantly more frequent in the GFM group (p = 0.035). Thermography showed no significant differences in surgical site temperatures between groups or time points. Tracheoscopy revealed more intraluminal secretions in the GTPE group (p = 0.006) and more exuberant tissue formation in the GFM group (p = 0.001). Complete epithelialization was observed in the GFM group after 60 days.</p><p><strong>Conclusion: </strong>The 3D TPE prosthesis demonstrated tissue compatibility and viability as an implant for partial tracheal defects, with minimal respiratory complications during the 60-day evaluation period.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e405025"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective effect of Paederia foetida on paracetamol-induced hepatobiliary disease in rats via alteration of inflammatory and Nrf2/HO-1 pathway.","authors":"Zhenzhen Feng, Jianyin Li","doi":"10.1590/acb409925","DOIUrl":"10.1590/acb409925","url":null,"abstract":"<p><strong>Purpose: </strong>To scrutinize the hepatoprotective effect of Paederia foetida against paracetamol-induced hepatobiliary in rats.</p><p><strong>Methods: </strong>Rats were received the oral administration of paracetamol (3 mg/kg) empty stomach for the induction of hepatobiliary in rats except normal rats. the rats were received the oral administration of P. foetida. The hepatic, non-hepatic, antioxidant, and inflammatory parameters were estimated, as well as the mRNA expression.</p><p><strong>Results: </strong>Paederia foetida treatment remarkably suppressed the level of hepatic parameters such as alkaline phosphatase, alanine transaminase, aspartate aminotransferase; and non-hepatic parameters like creatinine, total protein, bilirubin, and blood urea nitrogen level at dose dependent manner. It also altered the level of antioxidant parameters such as lipid peroxidation, superoxide dismutase, glutathione peroxidase, glutathione, and catalase in the serum, as well as hepatic tissue, and also suppressed the level of cytokines such as tumor necrosis factor-α, interleukin-1β, interleukin-6; and inflammatory parameters such as cyclooxygenase-2, prostaglandin, and nuclear factor kappa B, respectively. Paederia foetida also altered the level of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).</p><p><strong>Conclusion: </strong>Paederia foetida exhibited the hepatoprotective effect against paracetamol-induced hepatobiliary disease in rats via inflammatory and Nrf2/HO-1 pathway.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e409925"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentions in reconstructive plastic surgery among post-bariatric patients in Brazil's public health service.","authors":"Priscila Chiarello de Souza Pinto Abdalla, Juan Carlos Montano Pedroso, Rafael Cauê Katayama, Sarhan Sydney Saad, Gabriel de Almeida Arruda Felix, Marília Baeninger, Alfredo Gragnani","doi":"10.1590/acb405725","DOIUrl":"10.1590/acb405725","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate post-bariatric patients' intentions to undergo reconstructive plastic surgery in Brazil's public health system.</p><p><strong>Methods: </strong>This cross-sectional study, conducted between May 2022 and February 2023, contacted 539 post-bariatric patients (≥ one year post surgery) via telephone, of whom 150 completed an online survey. Participants assessed their interest in reconstructive surgery and completed the validated Body-Q instrument to evaluate body image, sexual function, and related outcomes.</p><p><strong>Results: </strong>Most respondents were female (88%) and married (68%), with an average age of 43 years old. The preoperative and postoperative body mass indices were 44.5 and 28.1, respectively, with an average weight loss of 44 ± 12.8 kg. A total of 90.7% expressed interest in reconstructive surgery, particularly for the abdomen (75.3%) and breasts (68%). Lower education level was linked to higher aesthetic expectations (p = 0.014). Patients interested in arm surgery had significantly lower sexual function scores (p = 0.006). There was no significant correlation between total weight loss and surgical interest.</p><p><strong>Conclusion: </strong>Post-bariatric patients in Brazil's public healthcare system showed a high demand for reconstructive surgery, with education level and body satisfaction influencing interest more than weight loss. Targeted counseling may help align expectations and enhance post-bariatric care for patients.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e405725"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine protects against lung injury induced by liver transplantation through upregulating PPARγ and suppressing NF-κB-mediated pyroptosis pathway.","authors":"Wenna Liu, Xiaohui Liang, Mingxia Huo, Yongwang Wang, Guanghua Zhang","doi":"10.1590/acb404925","DOIUrl":"10.1590/acb404925","url":null,"abstract":"<p><strong>Purpose: </strong>We builted a orthotopic autologous liver transplantation (OALT) model in rats to evaluate the possible mechanisms of berberine against lung injury.</p><p><strong>Methods: </strong>Forty clean grade Sprague-Dawley rats (male, healthy, 250-280 g) were divided into five groups (n = 8): sham-operated group (group S), orthotopic autologous liver transplantation group (group T), berberine group (group B), peroxisome proliferator-activated receptor gamma (PPARγ) inhibitor GW9662 group (group G), and berberine + GW9662 group (group B+G). In group S, the relevant tissues around the liver were dissociated only. Orthotopic autologous liver transplantation was used in other groups, berberine 200 mg/kg/day was given one week before surgery in group B and group B+G. GW9662 1 mg/kg was intraperitoneally injected in group G and group B+G 4 hours before surgery. Blood samples were obtained for detecting PaO2 and the concentration of serum clam cell protein (CC16), surfactant protein-D (SP-D), interleukin (IL)-1β and IL-18. The immunohistochemical method detects the expression of PPARγ and nuclear factor-kappa B (NF-κB) in lung tissues. The expression of PPARγ, NF-κBand pyroptosis-related proteins were analysed by western blotting.</p><p><strong>Results: </strong>Rats exhibited increased histological lung injury following OALT. Liver transplantation caused upregulated CC16, SP-D, IL-18 and IL-1β levels, reduced PaO2 and the PPARγ expression, upregulated the NF-κB and pyroptosis-related protein expressions. BBR pretreatment greatly alleviates these lung damages induced by OALT. However, administration of GW9662 partially reversed the beneficial effects of BBR on lung injury.</p><p><strong>Conclusion: </strong>Berberine may play protective capacities against lung injury by upregulating PPARγ to downregulate the NF-κB-mediated pyroptosis pathway.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e404925"},"PeriodicalIF":1.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}