Acta cirurgica brasileira最新文献

{"title":"Trauma care in Brazil: a comparative study of patient characteristics at public versus private hospitals.","authors":"Brenda Feres, Sarah Lopes Salomão, Luiza Telles, Paulo Henrique Melo, Lauren Kratky, Jaqueline Dourado, Esther Louise Freire Costa, David Patrick Mooney, Gabriel Schnitman","doi":"10.1590/acb414026","DOIUrl":"10.1590/acb414026","url":null,"abstract":"<p><strong>Purpose: </strong>Trauma remains a leading cause of hospital admissions worldwide, particularly in low- and middle-income countries. Brazil's dual healthcare system reflects disparities in resource availability and clinical outcomes. This study compared epidemiological profiles of trauma patients treated at a public versus a private hospital in Salvador, Bahia, Brazil.</p><p><strong>Methods: </strong>We retrospectively analyzed 6,472 trauma-related hospitalizations from August 2021 to August 2023. Data were extracted from Hospital Information System/Department of Informatics of the Unified Health System and a private hospital database. Patients admitted under the 10th revision of the International Classification of Diseases, categories S00-T88, were included, excluding burns and orthopedic injuries. A χ2 test assessed associations between trauma mechanisms and hospitals.</p><p><strong>Results: </strong>Among the 6,472 cases, 6,342 occurred in the public hospital and 130 in the private hospital. In the public hospital, males accounted for 82.1% of the cases, and the leading causes were motorcycle crashes (21.7%) and gunshot wounds (16.2%). At the private hospital 58.4% of patients were males, with falls (50.8%) predominating among older adults. Violence-related injuries predominated in the public hospital, while falls predominated in the private hospital.</p><p><strong>Conclusion: </strong>This study revealed distinct trauma patterns in the public versus the private hospital in one Brazilian city. The public hospital treated younger male victims of violence, while the private hospital treated older patients with falls. These findings underscore the need for policies addressing trauma care disparities.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e414026"},"PeriodicalIF":1.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent protective effects of syringic acid following testicular torsion-detorsion: an experimental rat model.","authors":"Kenan Sabuncu, Mehmet Ali Sezgin, Emre Can Polat, Erkan Merder, Alper Ötünçtemur, Mustafa Baki Çekmen, Saniye Koç Ada, Cem Çomunoğlu, Levent Özcan","doi":"10.1590/acb414226","DOIUrl":"10.1590/acb414226","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the protective effects of syringic acid (SA) against testicular ischemia-reperfusion (I/R) injury during different reperfusion periods in an experimental rat model.</p><p><strong>Methods: </strong>Forty-eight male Wistar albino rats were randomly assigned to six groups: control, sham, torsion/detorsion (T/D) 4 h, T/D + SA 4 h, T/D 24 h, and T/D + SA 24 h. Testicular torsion was induced by 720° rotation of the left testis for 2 h, followed by detorsion and 4 or 24 h reperfusion. SA (10 mg/kg) was administered intraperitoneally 30 min before detorsion. Oxidative stress markers, histopathological alterations, and immunohistochemical expressions of apoptotic protease activating factor-1 (APAF-1) and inducible nitric oxide synthase were evaluated.</p><p><strong>Results: </strong>T/D significantly decreased total antioxidant status and glutathione levels while increasing myeloperoxidase activity and APAF-1/inducible nitric oxide synthase (iNOS) expressions compared with controls (p < 0.001). SA treatment restored antioxidant capacity and attenuated inflammatory and apoptotic responses (p < 0.05). Histopathological analyses demonstrated lower Cosentino scores and higher Johnsen scores in SA-treated groups than in untreated T/D groups (p < 0.05). Malondialdehyde levels showed no significant intergroup differences.</p><p><strong>Conclusion: </strong>SA attenuates testicular I/R injury by reducing oxidative stress, inflammation, and apoptosis while preserving spermatogenic function and histological integrity.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e414226"},"PeriodicalIF":1.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatibility, biodegradation, and antioxidative potential of alginate-dragon's blood sap microbeads implanted subcutaneously in mice.","authors":"Diego Armando Leite Carvalho, Gustavo Sousa Marques, Yanna Ribeiro Macêdo, Igor Iuco Castro-Silva","doi":"10.1590/acb414126","DOIUrl":"10.1590/acb414126","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate alginate-dragon's blood sap microbeads (DBSM) regarding biocompatibility, biodegradation, and antioxidative potential.</p><p><strong>Methods: </strong>Three DBSMs at concentrations of 1, 2, and 5% were developed by the drop spherification, and alginate-1% glycerin microbeads (GM) were used as control. Biocompatibility and biodegradation were evaluated by subcutaneous assay in 50 Swiss male mice, divided in the groups G1 (1% DBSM), G2 (2% DBSM) and G3 (5% DBSM), which were compared to C+ (1% GM) and C- (sham) at three and nine weeks. The histopathology of tissue irritation followed the ISO 10993-6 standard and the integrity of the biomaterials scored by quartiles. Metabolic analysis of intensity of catalase was carried out in the liver, kidneys, and tibias of the tested animals.</p><p><strong>Results: </strong>All microbeads were biocompatible, with less tissue irritation and greater partial resorption in G3 in subcutaneous tissue and preserved systemic antioxidant potential.</p><p><strong>Conclusion: </strong>The controlled release of dragon's blood sap from Croton lechleri using alginate microbeads suggests a local anti-inflammatory action dependent on the concentration of the bioactive compound. Its role in repairing specialized connective tissues such as bone should be elucidated by future in-vivo orthotopic tests.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e414126"},"PeriodicalIF":1.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical study of the innervation of the tibialis anterior muscle and its relationship with myofascial trigger points.","authors":"Jéssica Bevilaqua Congio, César Rocha de Alencar, Flávio Carneiro Hojaij, Mauro Figueiredo Carvalho de Andrade, Alfredo Luiz Jacomo, Flávia Emi Akamatsu","doi":"10.1590/acb414326","DOIUrl":"10.1590/acb414326","url":null,"abstract":"<p><strong>Purpose: </strong>Myofascial trigger points (MTPs) in the tibialis anterior muscle (TAM) are located in the upper third of the muscle and can be activated by various pathologies such as sprains, fractures, and muscle overload. Although the pathophysiology of MTPs is unclear, they often coincide with motor plates in the innervation zone. This study aimed to describe the innervation of the deep fibular nerve (DFN) into the TAM and relate it to clinically described MTPs.</p><p><strong>Methods: </strong>The TAMs of 12 cadavers were dissected from their origins to observe the exact point at which the DFN penetrates the muscle belly. Entry points were mapped by dividing the muscle into four areas. Statistical analysis was performed using a Poisson marginal distribution and identity linkage function, followed by Bonferroni multiple comparisons. Statistical analysis included summary measures, group comparisons using Student and Mann-Whitney's tests, and Pearson and Spearman's correlations. Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>Quadrants I and II had significantly more DFN branches than quadrants III and IV (p < 0.001), whereas quadrants I versus II and areas III versus IV showed no significant differences (p < 0.05).</p><p><strong>Conclusion: </strong>Consistent with the clinical literature, the branches of the DFN in the TAM correspond to the described areas of the MTPs. The anatomical relationships between MTPs may help explain the pathophysiology of various disorders and provide rational treatment options.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e414326"},"PeriodicalIF":1.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and preliminary evaluation of a camera-assisted endovascular simulator using a three-dimensional printing.","authors":"Bruno Tavares de Andrade, Carlo Átila Holanda Lopes, Yury Tavares de Lima, Victor Rocha Pincanço, Natan Rolim de Assunção Bisio, Henrique Luis do Carmo E Sa, Josué Viana de Castro Neto","doi":"10.1590/acb413826","DOIUrl":"10.1590/acb413826","url":null,"abstract":"<p><strong>Purpose: </strong>This study described the development and preliminary evaluation of a simulator that combines a three-dimensional-printed vascular model with a camera-assisted system for training basic endovascular skills.</p><p><strong>Methods: </strong>A hollow mannequin torso housed a transparent, three-dimensional-printed aorta. Guidewire and catheter manipulation were visualized in real time using a manually controlled camera. Fifteen medical students (novices) and five vascular surgeons (experts) performed simulated tasks in two sessions. Experts also assessed realism and educational value.</p><p><strong>Results: </strong>Novices demonstrated shorter completion times across all exercises in session 2, particularly in exercise 4, with mean time decreasing from 229.3 ± 134.8 to 83.5 ± 31.1 seconds, a mean difference of 145.8 seconds (p = 0.001). Experts showed no significant improvement in most tasks, although exercise 3 improved from 115.4 ± 29.7 to 91.6 ± 21.5 seconds, a mean difference of 23.8 seconds (p = 0.012). Performance differed between groups (construct validity). Surgeons provided favorable ratings for the realism and usefulness (face and content validity).</p><p><strong>Conclusion: </strong>This preliminary device appears feasible and may facilitate early skill acquisition in low-resource educational settings without radiation exposure.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413826"},"PeriodicalIF":1.3,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of steroid-impregnated polypropylene mesh on foreign body reaction in an experimental rat study.","authors":"Hatice Yilmaz Dogru, Akgul Arici","doi":"10.1590/acb412926","DOIUrl":"10.1590/acb412926","url":null,"abstract":"<p><strong>Purpose: </strong>Foreign body reaction is a tissue response in which excessive reactions may lead to complications such as chronic inflammation, mesh contraction, and impaired tissue integration. The present study aimed to evaluate the effects of steroid-impregnated polypropylene mesh on foreign body reaction and fibrosis in a rat abdominal wall model.</p><p><strong>Methods: </strong>Forty adults female Wistar rats were randomly assigned into four groups (n = 10 each): polypropylene mesh in the acute period (group A), steroid-impregnated polypropylene mesh in the acute period (group AS), polypropylene mesh in the chronic period (group C), and steroid-impregnated polypropylene mesh in the chronic period (group CS). Standardized 1 × 1-cm meshes were implanted on the right rectus abdominis muscle. Acute groups were assessed at three days post-implantation, and chronic groups at nine weeks. Histopathological evaluation included grading of polymorphonuclear leukocyte infiltration, neovascularization, foreign-body giant cell reaction, muscle invasion, necrosis, and fibrosis. Immunohistochemical staining for CD15, CD68, CD3, and CD20 was performed to characterize inflammatory cell subtypes.</p><p><strong>Results: </strong>The mean grading of polymorphonuclear leukocyte infiltration, neovascularization, foreign-body reaction, muscle invasion, and necrosis showed no difference among groups, in which fibrosis levels were significantly higher in group C and group CS compared to group A (p = 0.004, p = 0.004, respectively). The fibrosis levels were also elevated in group CS than in group AS (p = 0.001, p = 0.001, respectively).</p><p><strong>Conclusion: </strong>Local corticosteroid impregnation of polypropylene mesh slightly attenuated early inflammatory responses but did not prevent chronic fibrosis.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e412926"},"PeriodicalIF":1.3,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative assessment of anal function in swine model for research in colorectal surgery: development of the swine anal function assessment table.","authors":"Julia Belotto Guaraná, Silvio Henrique de Freitas, Juliana Barreto Salem, Julia Merilis Silva, Fernanda Vieira da Silva, Cinthia Ferreira Lanchotte, Flávio Viera Meirelles, Flávio Henrique Ferreira Galvão","doi":"10.1590/acb413726","DOIUrl":"10.1590/acb413726","url":null,"abstract":"<p><strong>Purpose: </strong>The porcine model is widely used in preclinical studies of anorectal function due to its anatomical and physiological similarity to humans. However, appropriate behavioral and functional evaluation methods of anorectal segment are still lacking.</p><p><strong>Methods: </strong>This study introduces the swine anal function assessment table (SAFAT), a standardized qualitative tool developed to evaluate anorectal function. Six male Landrace × Large White pigs underwent evaluation following anorectal transplantation over up to one year.</p><p><strong>Results: </strong>The functional parameters assessed included cleanliness, fecal distribution, stool consistency, anal tone, anal skin sensitivity, anal reflexes, and other ones. Each indicator was rated using semi-quantitative scales based on behavioral observations.</p><p><strong>Conclusion: </strong>SAFAT was effective for behavioral and functional evaluation after anorectal transplantation and may improve the reproducibility and reliability of functional evaluations in swine models of major anorectal surgeries, supporting translational research in colorectal treatments.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413726"},"PeriodicalIF":1.3,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic strategies in the management of postoperative pain following uterine artery embolization for symptomatic fibroids: a systematic review.","authors":"Manoela Massa Moura, Karen Ruggeri Saad, Edson Ferreira Gonçalves Junior, Larissa Freire Golveia Silveira, Henrique Pereira Castro, Antônio Felipe Neto, Paulo Fernandes Saad","doi":"10.1590/acb413626","DOIUrl":"10.1590/acb413626","url":null,"abstract":"<p><strong>Purpose: </strong>To identify and compare anesthetic and analgesic strategies employed during uterine artery embolization for symptomatic leiomyomas, assessing their effectiveness in reducing postoperative pain and opioid use and evaluating complication rates.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Searches were performed in PubMed, Embase, Web of Science, and Scientific Electronic Library Online. Randomized controlled trials and prospective cohort or case-control studies, published in the last 10 years, evaluating pain, opioid consumption, and/or complications, were included.</p><p><strong>Results: </strong>The total of 3,433 studies were screened, of which six met eligibility criteria. Superior hypogastric plexus block reduced pain and opioid use. Intra-arterial lidocaine decreased pain within 2-4 h and opioid consumption, with a transient effect; administration after vascular stasis was preferable. Controlled-release oxycodone reduced pain at 24 h and need for rescue medication without lowering mean consumption. Dexamethasone reduced pain at 12-24 h without impacting opioid use. No significant complications were reported.</p><p><strong>Conclusion: </strong>In the ischemic phase of post-uterine artery embolization pain, a superior hypogastric nerve block appears to provide the most consistent relief, with intra-arterial lidocaine representing an alternative when resources are limited. For the inflammatory phase, intravenous dexamethasone is the preferred option, whereas controlled-release oxycodone may be considered only in refractory cases.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413626"},"PeriodicalIF":1.3,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of captopril and losartan on early wound healing in hypertensive rats.","authors":"Anne Caroline Braz, Bruna Carla Hendges, Maria de Lourdes Pessole Biondo Simões, Sergio Ossamu Ioshii","doi":"10.1590/acb413126","DOIUrl":"10.1590/acb413126","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of captopril and losartan on inflammatory response, angiogenesis, and fibroblast activity during the early phase of wound healing in hypertensive rats.</p><p><strong>Methods: </strong>Twenty-seven paraffin-embedded skin wound samples from hypertensive rats were analyzed: control group (n = 8), losartan-treated group (n = 9), and captopril-treated group (n = 10). Histological and immunohistochemical analyses were performed on postoperative day 4. Hematoxylin-eosin staining was used to evaluate general wound structure, and immunohistochemistry with anti-leukocyte common antigen, anti-CD34, and anti-smooth muscle actin was performed to assess inflammatory cells, angiogenesis, and fibroblast activity, respectively.</p><p><strong>Results: </strong>No significant differences were observed in angiogenesis (p > 0.05) or fibroblast number (p > 0.05) between groups. However, the inflammatory reaction was significantly higher in captopril-treated (p = 0.0459) and losartan-treated (p = 0.0452) groups compared with the control group, with no significant difference between the two treated groups.</p><p><strong>Conclusion: </strong>Neither captopril nor losartan influenced angiogenesis or fibroblast proliferation in the early healing phase. However, both drugs increased inflammatory cell infiltration.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413126"},"PeriodicalIF":1.3,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13361032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vancomycin-impregnated decellularized bovine pericardium membranes coating silicone implants: in-vivo biocompatibility and antibacterial efficacy in a rat model.","authors":"Aryzone Mendes de Araujo Filho, Letícia Ramos Dantas, Renato Bespalez, Thais Andrade Costa Casagrande, Paula Hansen Suss, Gustavo Henrique Loesch, Maíra de Mayo Oliveira Nogueira Loesch, Marcelo de Paula Loureiro, Felipe Francisco Tuon","doi":"10.1590/acb413326","DOIUrl":"10.1590/acb413326","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the inflammatory response, fibrotic encapsulation, tissue integration, and antibacterial effectiveness of silicone implants coated with decellularized bovine pericardium membranes, with or without vancomycin impregnation.</p><p><strong>Methods: </strong>Seventy-two Wistar rats received subcutaneous silicone implants and were allocated to six groups: uncoated silicone under aseptic conditions; uncoated silicone under infected conditions; silicone coated with decellularized bovine pericardium under aseptic conditions; silicone coated with decellularized bovine pericardium under infected conditions; silicone coated with vancomycin-impregnated pericardium under aseptic conditions; and silicone coated with vancomycin-impregnated pericardium under infected conditions. Infected groups were challenged with Staphylococcus aureus and evaluated at day 7. Aseptic groups were analyzed at 30, 60, and 180 days. Histological assessment included semi-quantitative scoring of inflammatory cells, fibroblasts, angiogenesis, implant infiltration, and resorption. Antibacterial activity was quantified by colony-forming unit counts. Data were analyzed using non-parametric statistics.</p><p><strong>Results: </strong>Vancomycin-impregnated pericardium coatings significantly reduced S. aureus colonization compared with uncoated and pericardium-only implants. At day 7, these coatings markedly attenuated neutrophil infiltration and acute inflammation. At 30 and 60 days, pericardium-coated implants exhibited lower fibroblast scores and enhanced implant infiltration compared with uncoated silicone. At 180 days, vancomycin-impregnated coatings consistently showed reduced fibrotic and inflammatory markers, despite reduced sample size.</p><p><strong>Conclusions: </strong>Decellularized bovine pericardium coatings modulate the host response to silicone implants, and vancomycin impregnation provides additional antibacterial and anti-inflammatory benefits without impairing tissue integration.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413326"},"PeriodicalIF":1.3,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13361034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}