Acta cirurgica brasileira最新文献_第4页

Protective effect of proteins extracted from Plumeria pudica latex on ethanol-induced gastric injury in mice. 鸡蛋花乳胶提取蛋白对乙醇致小鼠胃损伤的保护作用。

Acta cirurgica brasileira Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI: 10.1590/acb404025

Lucas Arruda Moita, Bruna da Silva Souza, Naylla Veras de Moraes Oliveira, Ana Clara Silva Sales, Lucas Eduardo Silva Oliveira, Ana Patrícia de Oliveira, Francisca Beatriz Melo Sousa, Jand-Venes Rolim Medeiros, Jefferson Soares de Oliveira

{"title":"Protective effect of proteins extracted from Plumeria pudica latex on ethanol-induced gastric injury in mice.","authors":"Lucas Arruda Moita, Bruna da Silva Souza, Naylla Veras de Moraes Oliveira, Ana Clara Silva Sales, Lucas Eduardo Silva Oliveira, Ana Patrícia de Oliveira, Francisca Beatriz Melo Sousa, Jand-Venes Rolim Medeiros, Jefferson Soares de Oliveira","doi":"10.1590/acb404025","DOIUrl":"10.1590/acb404025","url":null,"abstract":"Purpose: To evaluate proteins from Plumeria pudica latex (LPPp) for their protective effect against ethanol-induced gastric injury in mice.Methods: The LPPp fraction was obtained by collecting P. pudica latex in tubes containing distilled water, followed by centrifugation and dialysis. The female Swiss mice (Mus musculus) received saline or LPPp (40 mg/kg) intraperitoneally 1 hour before oral administration of 500 μL of 50% ethanol. One hour later, the animals were euthanized, and their stomachs were removed for evaluation of tissue lesion area, histopathological analysis, and measurements of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and nitrate/nitrite (NO3/NO2). An independent experiment assessed the effect of LPPp on gastric mucus production.Results: The LPPp-treated animals showed a significant reduction in the mean injured areas of gastric tissue (0.73 ± 1.01 mm2) compared to the ethanol group (37.99 ± 3.11 mm2). Histopathological analysis revealed significant preservation of tissue architecture in the LPPp group compared to ethanol group. Additionally, LPPp maintained tissue levels of MDA, GSH, SOD, and NO3/NO2 comparable to the saline group and influenced gastric mucus production favorably (p < 0.05).Conclusion: These results suggested that LPPp has a protective effect against ethanol-induced gastric lesions, likely involving antioxidant activity and increased gastric mucus production.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e404025"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naringin in cholestatic liver ischemia-reperfusion injury. 柚皮苷在胆汁淤积性肝缺血再灌注损伤中的作用。

Acta cirurgica brasileira Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI: 10.1590/acb404225

Arif Aslaner, Kemal Eyvaz, Erhan Aydemir, Şenay Yıldırım, Kübra Kılıç Kartal, Hamit Yaşar Ellidağ, Uğur Doğan

{"title":"Naringin in cholestatic liver ischemia-reperfusion injury.","authors":"Arif Aslaner, Kemal Eyvaz, Erhan Aydemir, Şenay Yıldırım, Kübra Kılıç Kartal, Hamit Yaşar Ellidağ, Uğur Doğan","doi":"10.1590/acb404225","DOIUrl":"10.1590/acb404225","url":null,"abstract":"Purpose: To evaluate the potential protective effects of naringin on liver by oxidative parameters and signal peptide-CUB-EGF-like domain-containing protein (SCUBE)-1 and 2 in an experimental cholestatic liver ischemia reperfusion (IR) model.Methods: Twenty-four female rats were divided into three groups; sham, control, and treatment. Groups 2 and 3 underwent bile duct ligation, and one week later, 45 min of ischemia and 1 hour of relaparotomy and reperfusion were performed. To the treatment group, naringin was administered through relaparotomy. Liver tissue and blood samples were taken. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), ischemia-modified albumin (IMA), SCUBE-1, SCUBE-2, total antioxidant status (TAS), and total oxidant status (TOS) levels were also examined.Results: Serum ALT, AST, ALP, TBIL, DBIL, and IMA levels were higher in groups 2 and 3. There was no significant difference in terms of SCUBE-1 and 2 levels (p > 0.05). TAS was the highest in group 3, and TOS was the highest in group 2 and lower in group 3. In histopathological analysis, all parameters were statistically significant between group 3 and the other groups (p < 0.05).Conclusion: Naringin has promising results in the treatment of experimental IR injury in cholestatic liver due to its antioxidant effects. We think that it can be used in clinical studies after more comprehensive studies investigating its effects on IR damage in cholestatic liver.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e404225"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective role of pinocembrin in a rat model of intestinal ischemia-reperfusion injury. 内皮素在大鼠肠缺血再灌注损伤模型中的保护作用。

Acta cirurgica brasileira Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI: 10.1590/acb403925

Osman Bardakçı, Hakim Çelik, İlyas Özardalı, Ali Uzunköy

{"title":"Protective role of pinocembrin in a rat model of intestinal ischemia-reperfusion injury.","authors":"Osman Bardakçı, Hakim Çelik, İlyas Özardalı, Ali Uzunköy","doi":"10.1590/acb403925","DOIUrl":"10.1590/acb403925","url":null,"abstract":"Purpose: To determine whether pinocembrin (PC) confers protective effects against experimentally induced intestinal ischemia-reperfusion (I/R) injury in rats.Methods: Thirty Wistar albino rats were randomly divided into three groups (n = 10 each): sham (underwent laparotomy only); I/R (superior mesenteric artery occlusion for 60 min followed by 60 min reperfusion); and I/R + PC (5 mg/kg PC intraperitoneally before ischemia and again prior to reperfusion). Total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in both plasma and intestinal tissue. Histopathological evaluation was performed using hematoxylin and eosin staining and a modified Chiu scoring system.Results: Although TAC values did not show significant intergroup differences (p > 0.05), TOS and OSI values were significantly lower in the I/R + PC group than in the I/R group (p < 0.05). Histologically, the I/R + PC group displayed noticeably reduced mucosal damage compared to the untreated I/R group. These results suggest that PC alleviates oxidative stress and improves histological outcomes in intestinal I/R.Conclusion: PC exhibits a protective effect against intestinal I/R injury by decreasing oxidative stress and preserving tissue architecture. Further studies are warranted to optimize PC's dosing, timing, and mechanistic actions for clinical application.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403925"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of grape seed proanthocyanidin B2 pretreatment on mitochondrial oxidative stress, endoplasmic reticulum stress, and apoptosis in renal tubular epithelial cells during in-vitro hypoxia-reoxygenation. 葡萄籽原花青素B2预处理对体外缺氧再氧化过程中线粒体氧化应激、内质网应激和肾小管上皮细胞凋亡的影响

Acta cirurgica brasileira Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI: 10.1590/acb404125

Zhi-Shun Wang, Qi Han, Hao Shen, Bo Shu, Cheng-Cheng Ying, Guo-Hao Li, Yong-Lian Guo

{"title":"Impact of grape seed proanthocyanidin B2 pretreatment on mitochondrial oxidative stress, endoplasmic reticulum stress, and apoptosis in renal tubular epithelial cells during in-vitro hypoxia-reoxygenation.","authors":"Zhi-Shun Wang, Qi Han, Hao Shen, Bo Shu, Cheng-Cheng Ying, Guo-Hao Li, Yong-Lian Guo","doi":"10.1590/acb404125","DOIUrl":"10.1590/acb404125","url":null,"abstract":"Purpose: To investigate the impact of grape seed proanthocyanidin B2 (GSPB2) pretreatment on hypoxia-reoxygenation model of HK-2 cells in vitro.Methods: The experiment was divided into five groups: control group (control), GSPB2 group (GSPB2), hypoxia-reoxygenation group (HR), GSPB2 + HR group (GSPB2+HR), and GSPB2 + brusatol (BRU) + HR group (GSPB2 + BRU + HR). Flow cytometry was used to detect apoptosis of cells. Transmission electron microscopy was employed to observe ultrastructural changes of cells. Mitochondrial membrane potential (MMP) was measured. Cellular immunofluorescence was used to assess intracellular Ca²+ concentration. Immunofluorescence staining and Western blotting were conducted to detect expression levels of Nrf2, HO-1, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), and cleaved-caspase3.Results: Compared to HR group, GSPB2 + HR group showed significantly increased cell viability, and reduced mitochondrial damage in the cytoplasm. MMP in GSPB2 + HR group was significantly restored, and intracellular Ca²+ concentration was significantly decreased. The expression of Nrf2 and HO-1 proteins was significantly upregulated, while the expression of GRP78, CHOP, and cleaved-caspase3 proteins was markedly downregulated.Conclusion: GSPB2 pretreatment can alleviate oxidative stress damage, mitochondrial injury, and endoplasmic reticulum stress induced by hypoxia-reoxygenation in HK-2 cells in vitro. This effect may be related to the ability of GSPB2 pretreatment to activate the endogenous antioxidant system, particularly through the activation of the Nrf2/HO-1 signaling pathway.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e404125"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial experiences of the Optima™ coil system in intracranial aneurysm treatment: surgical and interventional approach to safety and efficacy in terms of cerebral arteries. Optima线圈系统在颅内动脉瘤治疗中的初步经验：手术和介入方法在脑动脉方面的安全性和有效性

Acta cirurgica brasileira Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.1590/acb403425

Bekir Sıtkı Said Ulusoy, Çetin Murat Altay, Mehmet Onay, Ali Burak Binboga, Murat Kaya

{"title":"Initial experiences of the Optima™ coil system in intracranial aneurysm treatment: surgical and interventional approach to safety and efficacy in terms of cerebral arteries.","authors":"Bekir Sıtkı Said Ulusoy, Çetin Murat Altay, Mehmet Onay, Ali Burak Binboga, Murat Kaya","doi":"10.1590/acb403425","DOIUrl":"https://doi.org/10.1590/acb403425","url":null,"abstract":"Purpose: To evaluate the angiographic outcomes of the Optima™ coil system in the endovascular treatment of saccular intracranial aneurysms to present real-world experiences.Methods: The study encompassed patients with both ruptured and unruptured aneurysms who underwent treatment with the Optima™ coil system. A retrospective analysis was conducted to examine patient and aneurysm characteristics, complication rates, and angiographic outcomes.Results: The total of 326 Optima™ coil implantations was performed in 64 aneurysms, with a mean maximum diameter of 7.49 ± 3.08 mm (range: 2.5-16.5 mm), among 64 patients (37 females and 27 males, mean age: 53.34 ± 14 years old). The average number of implanted coils was 5.06 ± 1.73. The mean packing density was 26.2% (range = 19.2-34.6), observed to be significantly higher in aneurysms with complete occlusion and neck remnants compared to those with a residual dome (p < 0.01). The mean follow-up period was 15.9 ± 8.1 months. One case (1.5%) reported a coil malfunction attributed to coil stretching. The mortality rate was 3.1% (n = 2).Conclusion: The Optima™ coil system exhibited safety and efficacy in the endovascular treatment of both ruptured and unruptured intracranial aneurysms, demonstrating favorable angiographic outcomes. Nevertheless, further studies are necessary to validate these results over the long term.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403425"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of smart glasses in telementoring for simulated medical procedures. 智能眼镜在模拟医疗过程远程监控中的集成。

Acta cirurgica brasileira Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.1590/acb403625

Tiago Francisco Meleiro Zubiolo, Vlaudimir Dias Marques, Miyoko Massago, Aline Cardoso Machado, Felipe Hideaki Ueda, Mateus de Amorim Aboboreira, Eduardo Filgueiras Damasceno, Sanderland José Tavares Gurgel, Carlos Edmundo Rodrigues Fontes, Luciano de Andrade

{"title":"Integration of smart glasses in telementoring for simulated medical procedures.","authors":"Tiago Francisco Meleiro Zubiolo, Vlaudimir Dias Marques, Miyoko Massago, Aline Cardoso Machado, Felipe Hideaki Ueda, Mateus de Amorim Aboboreira, Eduardo Filgueiras Damasceno, Sanderland José Tavares Gurgel, Carlos Edmundo Rodrigues Fontes, Luciano de Andrade","doi":"10.1590/acb403625","DOIUrl":"https://doi.org/10.1590/acb403625","url":null,"abstract":"Purpose: To demonstrate the complete process of telementoring implementation using augmented-reality smart glasses for performing a simulated medical procedure.Methods: Fifteen participants, including physicians and medical students, were recruited to participate in a telementoring session with an educational focus during simulated thoracostomy with closed pleural drainage. A questionnaire assessing technology usability and usefulness was administered, and the results were analyzed by Cronbach's alfa and multiple correspondence analysis (MCA).Results: The mean age of the participants was 28.8 and 66.67% of them were women. The test results indicated a Cronbach's alpha of 78% and an MCA of 49.48% for the first three dimensions.Conclusion: The results showed that smart glasses are easy to use and facilitate communication among the professionals involved, providing comfort and safety to participants of care simulations. Additionally, smart glasses were considered to have perceived usefulness.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403625"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rabbit-based experimental model for scalp reimplantation: advancing microsurgical training and translational research. 兔头皮再植实验模型：推进显微外科训练与转化研究。

Acta cirurgica brasileira Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1590/acb403725

Rui Sergio Monteiro de Barros, José Maciel Caldas Dos Reis, Deivid Ramos Dos Santos, Vitor Nagai Yamaki, Renan Kleber Costa Teixeira, André Lopes Valente

{"title":"Rabbit-based experimental model for scalp reimplantation: advancing microsurgical training and translational research.","authors":"Rui Sergio Monteiro de Barros, José Maciel Caldas Dos Reis, Deivid Ramos Dos Santos, Vitor Nagai Yamaki, Renan Kleber Costa Teixeira, André Lopes Valente","doi":"10.1590/acb403725","DOIUrl":"https://doi.org/10.1590/acb403725","url":null,"abstract":"Purpose: To develop an experimental model of microsurgical scalp reimplantation in rabbits.Methods: Ten male albino New Zealand rabbits (Oryctolagus cuniculus) were scalped and subjected to scalp reimplantation. The rabbits' scalp regions, including their ears, were surgically amputated. Based on a previous anatomical study, the superficial temporal artery and the central auricular vein were chosen for microanastomosis. Data on the morphometric parameters (vessel weight and caliber), surgical procedure (surgical time and number of stitches), and surgical recovery parameters (venous return, patency, and necrosis) were collected for up to 30 days postoperatively (PO) using a research protocol.Results: Morphometric and surgical recovery parameters did not significantly differ in our sample. No animals died during the intraoperative period. Three animals were euthanized because they developed partial or total scalp necrosis. The venous return was impaired from three to ten days PO, with spontaneous regression after this period, which significantly improved (p = 0.02) after 14 days PO. Superficial necrosis was observed starting at two days PO with complete resolution by day 21 PO (p <0.01).Conclusion: The rabbit provides a realistic biological model for training scalp reimplantation with high fidelity to human vascular structures.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403725"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway. 水蛭素通过靶向STAT3/NLRP3信号通路抑制铁下垂改善肾纤维化。

Acta cirurgica brasileira Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1590/acb403325

Fang Lan, Chunli Long, Huimin Huang, Yongxiang Xie, Wei Shi

{"title":"Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway.","authors":"Fang Lan, Chunli Long, Huimin Huang, Yongxiang Xie, Wei Shi","doi":"10.1590/acb403325","DOIUrl":"https://doi.org/10.1590/acb403325","url":null,"abstract":"Purpose: To reveal the role and underlying mechanism of hirudin in renal fibrosis.Methods: The unilateral ureteral obstruction (UUO) rat model and ferroptosis activator RSL3-induced human kidney proximal tubular epithelial cells (HK-2) were established. Hematoxylin-eosin staining, commercial kits, and immunohistochemistry were used to assess the effect of hirudin on renal function and renal fibrosis. Cell counting kit-8 assay was employed to test cell viability. Ferroptosis indicator levels were detected using commercial kits. The protein levels were examined by Western blot. The STAT3 activator colivelin was introduced to verify the role of the STAT3/NLRP3 signaling pathway in ferroptosis.Results: Hirudin alleviated renal injury and improved renal fibrosis in UUO rats. The cell viability of RSL3-treated HK-2 cells was increased after hirudin treatment. In the model group, GPX4, SLC7A11, and glutathione expression decreased, while malondialdehyde and iron content levels increased, indicating that ferroptosis was activated. Besides, p-STAT3 and NLRP3 protein levels were also upregulated. However, hirudin treatment reversed these changes. When the STAT3 activator colivelin was added, the effect of hirudin was altered.Conclusion: Hirudin improved renal fibrosis by inhibiting ferroptosis via the STAT3/NLRP3 signaling pathway.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403325"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-stricture after buccal mucosal graft urethroplasty: a systematic review and meta-analysis. 口腔粘膜移植尿道成形术后再狭窄：系统回顾和荟萃分析。

IF 1.3

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb403525

Gustavo Bono Yoshikawa, Gabriella Giandotti Gomar, Giovanna Ceccatto Gadens, Beatriz França Zanetti Saes, Maria Eduarda Andrade Galiciolli, Meire Ellen Pereira, Quelen Iane Garlet, Cláudia Sirlene Oliveira

{"title":"Re-stricture after buccal mucosal graft urethroplasty: a systematic review and meta-analysis.","authors":"Gustavo Bono Yoshikawa, Gabriella Giandotti Gomar, Giovanna Ceccatto Gadens, Beatriz França Zanetti Saes, Maria Eduarda Andrade Galiciolli, Meire Ellen Pereira, Quelen Iane Garlet, Cláudia Sirlene Oliveira","doi":"10.1590/acb403525","DOIUrl":"10.1590/acb403525","url":null,"abstract":"Purpose: To determine risk factors for re-stricture after buccal mucosal graft urethroplasty (BMGU) through a systematic review and meta-analysis.Methods: Following PRISMA guidelines, we collected data from PubMed, Scientific Electronic Library Online (SciELO), and Web of Science databases. The eligibility criteria included studies with male patients over 18 years old with urethral stricture recurrence after BMGU.Results: We retrieved 646 papers from three electronic databases. Records that did not meet the eligibility criteria and duplicates were excluded, resulting in 14 papers (3,240 patients) that underwent qualitative analysis, from which nine papers were suitable for meta-analysis. The meta-analysis identified diabetes mellitus (relative risk - RR: 1.58 [95% confidence interval - 95%CI 1.02-2.46];p = 0.04), penile/peno-bulbar site (RR: 1.57 [95%CI 1.04-2.37]; p = 0.03), and stricture size higher than 7 cm (RR: 4.13 [95%CI 2.42-7.04]; p 0.00001) as a predictive factor of re-stricture.Conclusions: These findings may improve understanding the risk factors for this type of urethroplasty and help surgical decisions. For a more effective analysis, larger and better-distributed study groups and cohorts are needed in the future to clarify whether the combination of a previous disease and the urethroplasty etiology may impact a recurrence-free outcome after stricture correction.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e403525"},"PeriodicalIF":1.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats. 超生理剂量癸酸诺龙对大鼠睾丸的即时和后期影响。

Acta cirurgica brasileira Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1590/acb402925

Bruno Felix-Patricio, Roger Gaspar Marchon, Bianca Martins Gregório, Diogo Benchimol De Souza

{"title":"Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats.","authors":"Bruno Felix-Patricio, Roger Gaspar Marchon, Bianca Martins Gregório, Diogo Benchimol De Souza","doi":"10.1590/acb402925","DOIUrl":"10.1590/acb402925","url":null,"abstract":"Purpose: To investigate the effects of supraphysiologic doses of nandrolone decanoate on the testicular morphology of rats and if these effects could be transitory or permanent.Methods: Twenty-five male rats were divided in four groups. C28 and C40 were control rats killed with 28 and 40 weeks old, respectively; and T28 and T40 were treated with nandrolone decanoate (10 mg/kg) and killed immediately after the treatment (T28) or 12 weeks after the end of treatment (T40). The testis weight and volume were measured, and the seminiferous tubule area and epithelium height were assessed by histomorphometric methods.Results: The seminiferous tubules area and epithelium height of group T28 were reduced in comparison to C28. Group T40 showed reduced testicular weight and volume, as well as seminiferous tubule area and epithelium height in comparison to C40.Conclusion: The use of nandrolone decanoate promotes major structural modifications on the testes of rats. These modifications are even worse 12 weeks after ending the use of the anabolic androgenic steroid.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e402925"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0