Acta cirurgica brasileira最新文献

{"title":"Microsurgical education for medical students: systematic review.","authors":"Michelly Moreira Campos, Ana Cristina Aoun Tannuri, Edna Frasson de Souza Montero, Eric Toshiyuki Nakamura, Giovanna Mattos Ferreira, Pedro Carvalho Cassino, Cinthia Lanchotte, Lucas Albuquerque Chinelatto, Filipe Miranda de Oliveira Silva, Flavio Henrique Ferreira Galvão","doi":"10.1590/acb412726","DOIUrl":"10.1590/acb412726","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a systematic review about microsurgical training for medical students.</p><p><strong>Methods: </strong>A systematic search was conducted in several databases. Screening was performed by two independent reviewers based on predetermined criteria, following PRISMA 2020 guidelines.</p><p><strong>Results: </strong>A total of 433 articles were obtained. After screening, 40 were included. Teaching methods were heterogeneous and restricted to a few countries. There are specific methods to assess microsurgery training, general surgical activities, learning curve and anxiety. The most used materials were surgical gloves, silicone tubes, chicken thighs and rats. Animals were not essential in early stages of education. There was a variation between one and 24 sessions regarding teaching frequency and between 3 and 120 hours of teaching period. The average age of students was 23.7, and 67.5% were men. Teaching groups had an average of 5.8 students per group. Physical activity and anxiety had negative effect on microsurgical ability gain, while caffeine had positive effect. Alcohol and sleep deprivation had no significant effect.</p><p><strong>Conclusion: </strong>Students with adequate training could achieve performance similar to that obtained by experts. Microsurgical education is realistic during medical graduation and may enable better career choices. More investigations are needed to improve this training and expand knowledge to other medical schools.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e412726"},"PeriodicalIF":1.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Damage control resuscitation in resource-diverse settings: a survey-based comparison of trauma care practices worldwide.","authors":"Leticia Stefani Pacheco, Rafael Dib Possiedi, Thomas Michael Scalea, Marcelo Augusto Fontenelle Ribeiro Junior","doi":"10.1590/acb412826","DOIUrl":"10.1590/acb412826","url":null,"abstract":"<p><strong>Purpose: </strong>Trauma is a major global cause of death, with uncontrolled hemorrhage as its leading preventable cause. Damage control resuscitation (DCR) is a cornerstone strategy for hemorrhagic shock, yet implementation varies by resource availability. This study compared DCR practices between high-income countries (HICs) and low- and middle-income countries (LMICs), predominantly represented by institutions from Latin America, particularly Brazil.</p><p><strong>Methods: </strong>A cross-sectional survey of trauma care providers was conducted between 2024 and 2025, assessing DCR practices, resuscitation strategies, and adjunctive therapies. Data from a Brazilian national survey were incorporated into the LMIC cohort. Countries were classified using World Bank 2024 income criteria, and comparisons were analyzed using hierarchical logistic regression with adjustment for multiple comparisons.</p><p><strong>Results: </strong>Massive transfusion protocol availability result was significantly lower in LMICs than in HICs (47.4 vs. 89.1%; OR = 0.11, 95%CI 0.02-0.62; p(BH) < 0.001). LMICs also had reduced availability of fresh frozen plasma (OR = 0.04; p(BH) = 0.035), balanced crystalloids (OR = 0.21; p(BH) < 0.001), viscoelastic coagulation monitoring (TEG/ROTEM; OR = 0.04; p(BH) 0.001), prothrombin complex concentrate (OR = 0.01; p(BH) < 0.001), fibrinogen concentrate (OR = 0.10; p(BH) < 0.001), rapid infusers (OR = 0.04; p(BH) < 0.001), invasive temperature monitoring (OR = 0.02; p(BH) < 0.001), calcium replacement (OR = 0.17; p(BH) = 0.002), and active rewarming systems (OR = 0.21; p(BH) = 0.035). Whole blood use was lower in LMICs (5.8 vs. 17.4%) but did not reach statistical significance in the primary model (OR = 0.55, 95%CI 0.12-2.45). Tranexamic acid availability was nearly universal and did not differ between settings (96.1 vs. 97.8%).</p><p><strong>Conclusion: </strong>Although DCR principles are widely recognized, substantial disparities persist in access to critical resuscitation resources across income settings.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e412826"},"PeriodicalIF":1.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stepwise plication of abdominal mesh technique for open abdomen closure.","authors":"Diego Adão, Fauze Camargo Maluf, Gabriela Caetano Lopes Martins, Ramiro Colleoni Neto, Milton Scalabrini, Leonardo De Mello Del Grande","doi":"10.1590/acb413426","DOIUrl":"10.1590/acb413426","url":null,"abstract":"<p><strong>Purpose: </strong>To present the stepwise plication of abdominal mesh (SPAM) as a standardized dynamic closure technique that combines mesh-mediated fascial traction with negative pressure wound therapy for gradual abdominal wall approximation.</p><p><strong>Methods: </strong>In this technical report, we present SPAM for progressive closure of peritoneostomy with excessive abdominal wall retraction. It involves a central mesh incision followed by progressive tightening via hemostatic clamp rotation (similar to opening a can with a key), without full-thickness mesh cut. The mesh is secured with continuous suture and covered with a non-commercial negative pressure system. Cycles are repeated every 48-72 hours until fascial closure.</p><p><strong>Results: </strong>SPAM was applied in four patients: three successful cases (52-year-old male with rectal perforation, 36-year-old female post-Hartmann evisceration, 63-year-old female with gastrojejunal anastomosis leak) achieved primary fascial closure in a median of 10 days, with well-tolerated traction, no enteroatmospheric fistula, or incisional hernia. In one failure (59-year-old male with gastrojejunal leak post-laparoscopic gastrectomy), bleeding occurred during traction (controlled surgically), yet the technique was discontinued due to progressive clinical deterioration.</p><p><strong>Conclusion: </strong>SPAM offers a practical, standardized, reproducible approach to delayed fascial closure, particularly in resource-limited settings, enabling controlled progressive approximation without mesh resection.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413426"},"PeriodicalIF":1.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astaxanthin alleviates autophagy, inflammation, and oxidative stress in ventilator-associated lung injury rats by inhibiting MAPK/ERK1/2 pathway.","authors":"Jiayi Zhang, Yifan Wei, Zongyu Chen, Tao Luo, Shiyun Cheng, Jing Wang, Xianming Zhang","doi":"10.1590/acb411726","DOIUrl":"10.1590/acb411726","url":null,"abstract":"<p><strong>Purpose: </strong>Improper use of mechanical ventilation may result in ventilator-induced lung injury (VILI). This work seeks to explore the preventive impact of astaxanthin on VILI.</p><p><strong>Methods: </strong>In this study, we established the VILI rat and drug intervention model, then evaluated lung tissue damage by observing the appearance and hematoxylin-eosin staining. Oxidative stress was evaluated by determining the levels of myeloperoxidase, catalase, and malondialdehyde.</p><p><strong>Results: </strong>Our data showed that, compared with the control group, mechanical ventilation increased the mRNA and protein expression levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, LC3II/I, and Beclin1, as well as the phosphorylation level of ERK1/2 in the lung tissues of VILI rats (p < 0.0001), while the expression level of P62 protein decreased (p < 0.0001). After pretreatment with astaxanthin, autophagy and inflammatory response were significantly reduced. The phosphorylation of ERK1/2 was also inhibited. Notably, these effects were reversed after using the p-ERK agonist Ro67-7476.</p><p><strong>Conclusion: </strong>Astaxanthin can inhibit autophagy levels and suppress inflammation and oxidative stress in mechanically ventilated rat lung tissue through inhibiting the MAPK/ERK signaling pathway, thus alleviating lung tissue injury. Therefore, astaxanthin may represent a promising preventive strategy for VILI.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e411726"},"PeriodicalIF":1.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermalix enhances angiogenesis and collagen remodeling in an ischemic colon anastomosis rat model.","authors":"Yasemin Keskin, Alperen Irşat Keskin, Siyar Ersoz, Cevriye Cansız Ersoz, Ilknur Kepenekci Bayram, Ayhan Bülent Erkek","doi":"10.1590/acb413526","DOIUrl":"10.1590/acb413526","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of Dermalix on anastomotic healing in a rat model of ischemic colon anastomosis.</p><p><strong>Methods: </strong>Forty rats were divided into three groups: negative control (n = 10), control (n = 15), and experimental (n = 15). Only laparotomy was performed in the negative control group. In the control group, ischemia and end-to-end colon anastomosis were performed, while in the experimental group, Dermalix was applied circumferentially around the anastomosis. On postoperative day 7, anastomotic segments were evaluated for burst pressure, adhesion, and histopathological parameters.</p><p><strong>Results: </strong>Abscess formation related to anastomotic leakage occurred in two rats in the control group and in one rat in the experimental group. Mean burst pressure was 134.7 mmHg in the control group and 194.7 mmHg in the experimental group (p = 0.005). No significant differences were observed in inflammation, epithelial regeneration, or granulation tissue formation. Neovascularization (p < 0.001) and collagenization (p = 0.032) were significantly higher in the Dermalix group. There was no significant difference in adhesion or foreign body reaction.</p><p><strong>Conclusion: </strong>Dermalix improved key histological and mechanical indicators of anastomotic healing under ischemic conditions, providing preliminary evidence of its potential as a bioactive adjunct. Further studies are warranted to confirm these findings and assess clinical relevance.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413526"},"PeriodicalIF":1.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical study of peroneal longus and brevis innervation and its spatial relationship with trigger points.","authors":"Nazareth Cristina Delantonia, Lucas Yongsoo Park, Flávio Hojaij, Mauro Andrade, Alfredo Luiz Jacomo, Flavia Emi Akamatsu Jacomo","doi":"10.1590/acb412626","DOIUrl":"10.1590/acb412626","url":null,"abstract":"<p><strong>Purpose: </strong>Myofascial pain syndrome (MPS) is a common cause of chronic musculoskeletal pain. Long fibular syndrome is a symptom of lower-limb MPS. Research has associated MPS with motor end plates in the innervation zone. This study aimed to identify the anatomical entry points of the superficial peroneal nerve (SPN) in the peroneal longus (PL) and peroneal brevis (PB) muscles through dissection.</p><p><strong>Methods: </strong>The PL and PB muscles of 12 cadavers were dissected to identify the nerve entry points, which were mapped and organized into quadrants. Poisson marginal distribution, identity linkage function, and Bonferroni multiple comparisons were used for statistical analysis. Statistical analysis included summary measures, Student's and Mann-Whitney group comparisons, Pearson and Spearman correlations. Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>Quadrant I, followed by quadrant II (upper half of the PL and PB muscles), had the highest number of SPN entry points. Quadrants III and IV (lower half of the PL and PB muscles) had the lowest numbers of nerve entry points and did not differ statistically from each other.</p><p><strong>Conclusion: </strong>The SPN entrance positions in the PL and PB muscles matched literature trigger points. The anatomical relationship between trigger points can aid healthcare providers in procedures affecting muscle innervation and in pinpointing pain locations through spatial localization.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e412626"},"PeriodicalIF":1.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of polyhexamethylene biguanide on wound healing in dogs.","authors":"João Vitor Dos Santos Alves da Silva, Brenda Mendonça de Alcântara, Natália Helena Meneguin, Sergio Andrés Millán Guaita, Tryssia Scalon Magalhães Moi, Gabriel João Unger Carra, Josiane Morais Pazzini, Bruno Watanabe Minto","doi":"10.1590/acb413026","DOIUrl":"10.1590/acb413026","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the effects of polyhexamethylene biguanide (PHMB) on healing of clean surgical wounds in dogs.</p><p><strong>Methods: </strong>Thirty healthy, non-neutered dogs of different breeds underwent elective ovariohysterectomy or orchiectomy, and a 1-cm circular abdominal wound was created. Animals were divided into three groups (n = 10). Groups T1 and T2 received PHMB dressings changed once and twice daily. The control group (C) had wounds cleaned daily with saline and covered with gauze. Macroscopic evaluations were performed daily for 10 days, assessing edema, exudate, cosmetic appearance, and color. After 10 days, excisional biopsies were collected for histopathology evaluating vascular proliferation, inflammatory cells, fibroblastic proliferation, collagenization, necrosis, hyperplasia, and reepithelialization, and immunohistochemistry for reepithelialization and angiogenesis.</p><p><strong>Results: </strong>Macroscopic evaluations showed no significant differences among groups. Histopathology revealed greater collagenization in group C than in T2 (p < 0.05), while T1 did not differ from the others. Immunohistochemistry showed no differences in reepithelialization among groups. However, angiogenesis was higher in C and T2 than in T1 (p < 0.05).</p><p><strong>Conclusion: </strong>PHMB dressings neither demonstrate superior healing compared with gauze and saline cleaning nor impair healing and may represent an option for wound management in dogs.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e413026"},"PeriodicalIF":1.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemostatic net in cervical and facial surgeries: evidence from a systematic review and meta-analysis.","authors":"Felipe Giraldo Gonçalves, Leonardo Dexheimer da Silva, Emily Caroline da Fonseca Sampaio, Artur de Souza Almeida, Bruno Damico Terada, Guilherme Azeredo Malacarne, Ilan David Friedmann, Miguel Rodrigues Moreira, Rolf Gemperli, Cristina Pires Camargo","doi":"10.1590/acb412326","DOIUrl":"10.1590/acb412326","url":null,"abstract":"<p><strong>Purpose: </strong>Hematoma remains the most frequent complication of cervicofacial surgeries. The hemostatic net (HN), a transcutaneous suture designed to minimize dead space and bleeding, has shown promise, but pooled evidence of its safety and efficacy is limited. Thus, we conducted this study to clarify the safety profile and complication rates associated with the use of HN in cervical and facial surgeries.</p><p><strong>Methods: </strong>A systematic search of MEDLINE, Embase, Scopus, Cochrane, and Web of Science was performed through August 2025. Eligible studies involved adults undergoing cervical and/or facial surgery with HN, with no restrictions on suture caliber or spacing between stitches. The primary outcome was hematoma incidence; secondary outcomes included skin necrosis, seroma, infection, persistent skin marks, patient-reported satisfaction, and other adverse events.</p><p><strong>Results: </strong>Eleven studies including 3,393 patients (2,748 HN; 645 controls) were analyzed. Single-arm meta-analysis of HN cases showed low pooled rates for hematoma (0.6%; 95% confidence interval 0.4-1.0; low certainty), skin necrosis (0.4%; 95% confidence interval 0.1-1.0; low certainty), seroma (1.5%; 95% confidence interval 0.6-4.0; low certainty), infection (0.1%; 95% confidence interval 0.0-25.5), and persistent skin marks (0.6%; 95% confidence interval 0.2-2.1). Comparative analyses showed no significant difference for hematoma (risk ratio = 0.15; 95% confidence interval 0.01-3.20; very low certainty) or seroma (risk ratio = 1.06; 95% confidence interval 0.41-2.75; low certainty). Patient-reported satisfaction data were scarce and nonspecific.</p><p><strong>Conclusion: </strong>The HN is a safe technique with very low complication rates, though evidence of superiority over standard surgery remains inconclusive due to limited certainty of meta-analyzed data, heterogeneity of surgical procedures, and the paucity of patient-reported outcomes.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e412326"},"PeriodicalIF":1.3,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential molecular targets on which methylene blue acts to promote its effects on cardiac electrophysiology, myocardial injury, and oxidative stress in spontaneously hypertensive rats submitted to cardiac ischemia and reperfusion.","authors":"Rildo Yamaguti Lima, Tania Carmen Peñaranda Govato, Erisvaldo Amarante de Araújo, Marcelo Pires-Oliveira, Paulo Sérgio de Araujo Sousa, Jefferson Almeida Rocha, Leiz Maria Costa Véras, Sandra Augusta Gordinho Pinto, Afonso Caricati-Neto, Fernando Sabia Tallo, Célia Maria Camelo Silva, Francisco Sandro Menezes-Rodrigues","doi":"10.1590/acb411826","DOIUrl":"10.1590/acb411826","url":null,"abstract":"<p><strong>Purpose: </strong>Although methylene blue (MB) has long been used to treat vasoplegic syndrome, its pharmacodynamics and cardiovascular effects remain unclear. Therefore, we decided to evaluate the potential molecular targets of MB through molecular docking and its cardioprotective and antioxidant actions.</p><p><strong>Methods: </strong>Adult male spontaneously hypertensive rats (SHR) were allocated into four groups: sham-operated; treated with vehicle and subjected to cardiac ischemia and reperfusion (CIR) (SS+CIR); treated with 2 mg/kg of MB before cardiac ischemia and reperfusion (MB+ISQ); and treated with 2 mg/kg of MB before cardiac reperfusion (ISQ+MB). The animals were monitored with electrocardiogram to assess the incidence of ventricular arrhythmias (VA), atrioventricular blocks (AVB), and lethality (LET). Blood samples and hearts were collected for histopathological analysis, serum creatine kinase MB dosage, and measurement of lipid hydroperoxide (LH) in myocardium serum creatine kinase MB.</p><p><strong>Results: </strong>The incidences of AVB and LET, serum CK-MB concentration, and myocardial injury increased in the MB+ISQ group, but not in the ISQ+MB group when compared with the SS+CIR group. LH concentration decreased in both MB-treated groups when compared with the SS+CIR group.</p><p><strong>Conclusion: </strong>These results indicate that MB produces a cardiotoxic effect only when administered before CIR, but not when administered before cardiac reperfusion.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e411826"},"PeriodicalIF":1.3,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of agmatine efficacy in contrast-induced nephropathy: experimental evidence in rat model.","authors":"Murat Yeniçeri, Süleyman Baş, Mustafa Can Şenoymak, Musa Salmanoğlu, Alpaslan Tanoğlu","doi":"10.1590/acb412426","DOIUrl":"10.1590/acb412426","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the biochemical and histopathological efficacy of agmatine as a protective agent in experimental rat contrast-induced nephropathy (CIN) model.</p><p><strong>Methods: </strong>Twenty-eight male Sprague Dawley rats were randomized into four groups: sham (no intervention), contrast agent (single dose 10 mL/kg iohexol iv), contrast agent + agmatine (single dose 10 mL/kg iohexol iv + 20 mg/kg po agmatine three days) and contrast agent + placebo (single dose 10 mL/kg iohexol iv + 1 mL of 0.9% saline ip). Biochemical and histopathological evaluations were accomplished on the fourth day, including measurements of cystatin-C, malondialdehyde (MDA), glutathione peroxidase (GPx), interleukin (IL)-1 β, superoxide dismutase (SOD), and tumor necrosis factor (TNF)-α.</p><p><strong>Results: </strong>The contrast agent group exhibited elevated cystatin-C, IL-1β, TNF-α, and MDA levels, with decreased SOD and GPx levels. The agmatine treatment group showed decrease in cystatin-C, IL-1β, TNF-α, and MDA, along with increased GPx and SOD levels. Histopathological evaluation revealed nephrotoxic effects in the contrast agent and placebo groups, whereas agmatine-treated rats displayed a significant reduction in tubular damage.</p><p><strong>Conclusion: </strong>Agmatine administration along side contrast exposure demonstrated protective effects against CIN, evidenced by biochemical and histopathological improvements.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"41 ","pages":"e412426"},"PeriodicalIF":1.3,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}