Acta cirurgica brasileira最新文献_第10页

Do good things really come to those who wait? An analysis of the average time of acceptance in Brazilian surgery journals. 好事真的会降临在等待的人身上吗？对巴西外科期刊平均收稿时间的分析。

Acta cirurgica brasileira Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI: 10.1590/acb393824

Lívia Guerreiro de Barros Bentes, Maria Fernanda de Almeida Cavalcante Aranha, Mariana Kondo Obara, Larissa Yoshie Shibata, Pablo Rodrigues Nunes de Souza, José Felipe Teixeira Borges, Leonardo Barbosa Duarte, Luiz Felipe Silva Marcião, Rui Sérgio Monteiro de Barros

{"title":"Do good things really come to those who wait? An analysis of the average time of acceptance in Brazilian surgery journals.","authors":"Lívia Guerreiro de Barros Bentes, Maria Fernanda de Almeida Cavalcante Aranha, Mariana Kondo Obara, Larissa Yoshie Shibata, Pablo Rodrigues Nunes de Souza, José Felipe Teixeira Borges, Leonardo Barbosa Duarte, Luiz Felipe Silva Marcião, Rui Sérgio Monteiro de Barros","doi":"10.1590/acb393824","DOIUrl":"10.1590/acb393824","url":null,"abstract":"Purpose: To analyze the average time between submission and acceptance of national journals in seven Brazilian surgery journals from 2017 to 2022.Methods: It consists of a cross-sectional and observational study with a quantitative approach to analyze the acceptance time of articles approved by Brazilian journals on general surgery and its subspecialties, including Acta Cirúrgica Brasileira, Jornal Vascular Brasileiro, Arquivos Brasileiros de Cirurgia de Digestiva, Revista do Colégio Brasileiro de Cirurgiões, Journal of Coloproctology, Revista Brasileira de Cirurgia Plástica, and International Brazilian Journal of Urology.Results: The journals with the lowest average waiting times were Revista do Colégio Brasileiro de Cirurgiões, Acta Cirúrgica Brasileira, and Journal of Coloproctology, respectively, and, with the lowest interquartile range there is Acta Cirúrgica Brasileira. There was no significant difference between the pre-pandemic and pandemic periods. The study designs with the highest and lowest means were, respectively, ideas and innovations - also with the highest interquartile range - and expert opinion, while with the lowest interquartile range was technical skill.Conclusions: The acceptance time for articles in Brazilian surgery journals is extremely variable. Identifying these discrepancies highlights the importance of understanding editorial processes and seeking ways to improve consistency and efficiency in reviewing articles.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e393824"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological evaluation of critical bone defect regeneration using hydroxyapatite/ alginate composite granules. 使用羟基磷灰石/海藻酸盐复合颗粒进行临界骨缺损再生的生物学评估。

Acta cirurgica brasileira Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI: 10.1590/acb392824

Iorrana Índira Dos Anjos Ribeiro, Renata Dos Santos Almeida, Ana Maria Guerreiro Braga da Silva, Aryon de Almeida Barbosa Júnior, Alexandre Malta Rossi, Fúlvio Borges Miguel, Fabiana Paim Rosa

{"title":"Biological evaluation of critical bone defect regeneration using hydroxyapatite/ alginate composite granules.","authors":"Iorrana Índira Dos Anjos Ribeiro, Renata Dos Santos Almeida, Ana Maria Guerreiro Braga da Silva, Aryon de Almeida Barbosa Júnior, Alexandre Malta Rossi, Fúlvio Borges Miguel, Fabiana Paim Rosa","doi":"10.1590/acb392824","DOIUrl":"10.1590/acb392824","url":null,"abstract":"Purpose: to evaluate biocompatibility and osteogenic potential of hydroxyapatite/alginate composite after its implantation on rat calvarian critical bone defect.Methods: thirty adults male Wistar rats were randomly distributed into two groups: GHA - critical bone defect filled with hydroxyapatite/alginate composite granules (HA/Alg) and CG - critical bone defect without biomaterial; evaluated at biological points of 15, 45 and 120 days.Results: the histomorphometrically analyses for GHA showed osteoid matrix deposition (OM) among the granules and towards the center of the defect in centripetal direction throughout the study, with evident new bone formation at 120 days, resulting in filling 4/5 of the initial bone defect. For CG, this finding was restricted to the edges of the bone margins and formation of connective tissue on the residual area was found in all biological points. Inflammatory response on GHA was chronic granulomatous type, discrete and regressive for all biological points. Throughout the study, the CG presented mononuclear inflammatory infiltrate diffuse and regressive. Histomorphometry analyses showed that OM percentage was evident for GHA group when compared to CG group in all analyzed periods (p > 0.05).Conclusions: the biomaterial evaluated at this study showed to be biocompatible, bioactive, osteoconductive and biodegradable synchronously with bone formation.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e392824"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

End-to-side neurorrhaphy in the reconstruction of peripheral segmental neural loss: an experimental study. 外周节段性神经缺失重建中的端侧神经出血术：一项实验研究。

Acta cirurgica brasileira Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI: 10.1590/acb394024

Rafael Silva Lemos, Livia Guerreiro de Barros Bentes, Maria Eduarda Dos Santos Lopes Vasconcelos, Daniela Ferreira Tramontin, Luís Vinícius Pires da Costa, Antonio Leonardo Jatahi Cavalcanti Pimentel, Nayara Pontes de Araújo, Mariseth Carvalho de Andrade, Danusa Neves Somensi, Rui Sérgio Monteiro de Barros

{"title":"End-to-side neurorrhaphy in the reconstruction of peripheral segmental neural loss: an experimental study.","authors":"Rafael Silva Lemos, Livia Guerreiro de Barros Bentes, Maria Eduarda Dos Santos Lopes Vasconcelos, Daniela Ferreira Tramontin, Luís Vinícius Pires da Costa, Antonio Leonardo Jatahi Cavalcanti Pimentel, Nayara Pontes de Araújo, Mariseth Carvalho de Andrade, Danusa Neves Somensi, Rui Sérgio Monteiro de Barros","doi":"10.1590/acb394024","DOIUrl":"10.1590/acb394024","url":null,"abstract":"Purpose: To evaluate the effects on peripheral neural regeneration of the end-to-side embracing repair technique compared to the autograft repair technique in Wistar rats.Methods: Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracing group (EG). For the evaluation, the grasping test, electroneuromyography (ENMG), and muscle weight assessment were used.Results: Muscle weight assessment and ENMG did not show significant neural regeneration at the end of 12 weeks in the DG and GE groups, but only in GA. The grasping test showed an increase in strength between the surgery and the fourth week in all groups, and only the GA maintained this trend until the 12th week.Conclusions: The present study indicates that the neural regeneration observed in the end-to-side embracing neurorrhaphy technique, in the repair of segmental neural loss, is inferior to autograft repair in Wistar rats.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e394024"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of rainbow trout skin treated with glutaraldehyde as a mesh for abdominal hernioplasty in rats. 用戊二醛处理过的虹鳟鱼皮作为大鼠腹部疝成形术的网片。

Acta cirurgica brasileira Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI: 10.1590/acb393024

Carolina Seabra da Costa, Siria da Fonseca Jorge, Marcelo Abidu Figueiredo, Danielle Rangel Neves, Maurício Alves Chagas

{"title":"Use of rainbow trout skin treated with glutaraldehyde as a mesh for abdominal hernioplasty in rats.","authors":"Carolina Seabra da Costa, Siria da Fonseca Jorge, Marcelo Abidu Figueiredo, Danielle Rangel Neves, Maurício Alves Chagas","doi":"10.1590/acb393024","DOIUrl":"10.1590/acb393024","url":null,"abstract":"Purpose: To test the use of rainbow trout skin as a surgical mesh in abdominal hernioplasties in rats.Methods: The experiment involved 20 Wistar rats receiving implants of trout skin processed for disinfection in 0.5% glutaraldehyde and preserved in 100% glycerin. The animals were divided into four groups, divided at 7, 15, 30, and 90 days postoperatively. Clinical and infrared thermography evaluations were performed, and after euthanasia, assessments of adhesion formations and sample collection for histological evaluation were conducted.Results: The implant was observed to be intact, ensuring the integrity of the abdominal wall, support for the viscera, and normal mobility for the rats for up to 90 days. Low rates of clinical alterations were observed, with an intense inflammatory reaction up to day 7, chronic inflammation and the onset of angiogenesis at day 15, and a low inflammatory reaction with collagenous infiltrate and fibrosis at day 30. At day 90, the implants showed a collagenous and fibrotic infiltrate with a minimal inflammatory infiltrate.Conclusions: The surgical mesh of trout skin performed well, making it a potential alternative for surgical procedures in muscle aponeurotic corrections in the abdominal wall.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e393024"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in xenotransplantation: paving the way for revolutionary developments in reconstructive plastic surgery. 异种移植的进展：为整形外科的革命性发展铺平道路。

Acta cirurgica brasileira Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI: 10.1590/acb393424

Vitor Penteado Figueiredo Pagotto, Fábio de Freitas Busnardo, Silvano Mário Attílio Raia, Rolf Gemperli

引用次数: 0

Influence of zoledronic acid and low-intensity laser on collagen fibers during the bone repair process. 唑来膦酸和低强度激光对骨修复过程中胶原纤维的影响

Acta cirurgica brasileira Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI: 10.1590/acb393724

Paola Aguilar, Angélica Cristina Fonseca, Gustavo Pompermaier Garlet, Jéssica Lemos Gulinelli, Pâmela Letícia Santos

{"title":"Influence of zoledronic acid and low-intensity laser on collagen fibers during the bone repair process.","authors":"Paola Aguilar, Angélica Cristina Fonseca, Gustavo Pompermaier Garlet, Jéssica Lemos Gulinelli, Pâmela Letícia Santos","doi":"10.1590/acb393724","DOIUrl":"10.1590/acb393724","url":null,"abstract":"Purpose: To evaluate collagen fibers during the bone repair process in critical defects created in the tibias of rats, treated with zoledronic acid (AZ) associated with low-level laser therapy (LLLT).Methods: Ten rats were distributed according to treatment: group 1) saline solution; group 2) LLLT; group 3) AZ; group 4) AZ and LLLT. AZ was administered at the dose of 0.035 mg/kg at fortnightly intervals over eight weeks. Next, 2-mm bone defects were created in the tibias of all animals. The bone defects in groups 2 and 4 were irradiated LLLT in the immediate postoperative period. After periods 14 and 28 of application, the animals were euthanized, and birefringence analysis was performed.Results: Approximately 90% of the total area was occupied by collagen fibers within the red color spectrum, this area being statistically larger in relation to the area occupied by collagen fibers within the green and yellow spectrum, in the four groups. Over the 14-day period, there was no statistically significant difference between the groups. In the 28-day period, group 2 (14.02 ± 15.9%) was superior in quantifying green birefringent fibers compared to group 1 (3.06 ± 3.24%), with p = 0.009.Conclusions: LLLT associated with ZA is effective in stimulating the neoformation of collagen fibers. The LLLT group without the association with ZA showed a greater amount of immature and less organized matrix over a period of 28 days.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e393724"},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial nanocellulose/calcium alginate hydrogel for the treatment of burns. 用于治疗烧伤的细菌纳米纤维素/海藻酸钙水凝胶。

Acta cirurgica brasileira Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI: 10.1590/acb393324

Lauriene Luiza de Souza Munhoz, Luiz Carlos Guillens, Beatriz Candido Alves, Maria Gabriela Oliveira Ferreira do Nascimento, Andréia Bagliotti Meneguin, Fernanda Mansano Carbinatto, Gabriela Arruda, Hernane da Silva Barud, Andrea de Aro, Laura de Roch Casagrande, Paulo Cesar Lock Silveira, Thiago Antônio Moretti Andrade, Glaucia Maria Tech Dos Santos, Guilherme Ferreira Caetano

{"title":"Bacterial nanocellulose/calcium alginate hydrogel for the treatment of burns.","authors":"Lauriene Luiza de Souza Munhoz, Luiz Carlos Guillens, Beatriz Candido Alves, Maria Gabriela Oliveira Ferreira do Nascimento, Andréia Bagliotti Meneguin, Fernanda Mansano Carbinatto, Gabriela Arruda, Hernane da Silva Barud, Andrea de Aro, Laura de Roch Casagrande, Paulo Cesar Lock Silveira, Thiago Antônio Moretti Andrade, Glaucia Maria Tech Dos Santos, Guilherme Ferreira Caetano","doi":"10.1590/acb393324","DOIUrl":"10.1590/acb393324","url":null,"abstract":"Purpose: Bacterial cellulose (BC) has shown high capacity for the treatment of wounds and burns, providing a moisty environment. Calcium alginate can be associated with BC to create gels that aid in wound debridement and contribute to appropriate wound healing. This study is aimed at characterizing and evaluating the use of bacterial cellulose/alginate gel in skin burns in rats.Methods: Cellulose and cellulose/alginate gels were compared regarding the capacity of liquid absorption, moisture, viscosity, and potential cytotoxicity. The 2nd degree burns were produced using an aluminum metal plate (2.0cm) at 120ºC for 20s on the back of rats. The animals were divided into non-treated, CMC(Carboxymethylcellulose), Cellulose(CMC with bacterial cellulose), and Cellulose/alginate(CMC with bacterial cellulose and alginate). The animals received topical treatment 3 times/week. Biochemical (MPO, NAG and oxidative stress), histomorphometry and immunohistochemical assays (IL-1β IL-10 and VEGF) were conducted on the 14th, 21st, 28th, and 35th days.Results: Cellulose/Alginate gel showed higher absorption capacity and viscosity compared to Cellulose gel, with no cytotoxic effects. Cellulose/alginate presented lower MPO values, a higher percentage of IL-10, with greater and balanced oxidative stress profile.Conclusions: The use of cellulose/alginate gel reduced neutrophils and macrophage activation and showed greater anti-inflammatory response, which can contribute to healing chronic wounds and burns.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e393324"},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds. 将生物纤维素水凝胶敷料作为治疗慢性动脉伤口的一种策略。

Acta cirurgica brasileira Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.1590/acb392924

Carolina Magro Barreiros de Moraes, Arthur Mestriner Bassanelli, Lenize da Silva Rodrigues, Hernane da Silva Barud, Marina de Lima Fontes, Pedro Luiz Toledo de Arruda Lourenção, Meire Cristina Novelli E Castro, Matheus Bertanha

{"title":"Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds.","authors":"Carolina Magro Barreiros de Moraes, Arthur Mestriner Bassanelli, Lenize da Silva Rodrigues, Hernane da Silva Barud, Marina de Lima Fontes, Pedro Luiz Toledo de Arruda Lourenção, Meire Cristina Novelli E Castro, Matheus Bertanha","doi":"10.1590/acb392924","DOIUrl":"10.1590/acb392924","url":null,"abstract":"Purpose: To evaluate using a biocellulose-based hydrogel as an adjuvant in the healing process of arterial ulcers.Methods: A prospective single group quasi-experimental study was carried out with chronic lower limb arterial ulcer patients. These patients received biocellulose-based hydrogel dressings and outpatient guidance on dressing and periodic reassessments. The primary outcomes were the ulcer-healing rate and product safety, which were assessed by ulcer area measured in photographic records of pre-treatment and posttreatment after 7, 30, and 60 days. Secondary outcomes were related to clinical assessment by the quality-of-life scores (SF-36 and EQ-5D) and pain, evaluated by the visual analogue scale (VAS).Results: Seventeen participants were included, and one of them was excluded. Six patients (37%) had complete wound healing, and all patients had a significant reduction in the ulcer area during follow-up (233.6mm2 versus 2.7mm2) and reduction on the score PUSH 3.0 (p < 0.0001). The analysis of the SF-36 and EQ-5D questionnaires showed a statistically significant improvement in almost all parameters analyzed and with a reduction of pain assessed by the VAS.Conclusions: The biocellulose-based hydrogel was safe and showed a good perspective to promoting the necessary conditions to facilitate partial or complete healing of chronic arterial ulcers within a 60-day follow-up. Quality of life and pain were positively affected by the treatment.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e392924"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Description of the Dunning-Kruger effect in general surgery residents during laparoscopic cholecystectomy: a blinded prospective study. 腹腔镜胆囊切除术中普外科住院医师邓宁-克鲁格效应的描述：一项盲法前瞻性研究。

Acta cirurgica brasileira Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.1590/acb393224

Breno Cordeiro Porto, Rodrigo Marcus Cunha Frati, Rafael Guisalberte Maltez, Amanda Ferreira da Silva Lima, Tatiane Alves Ferreira, Larissa Cunha Baron, Carlo Camargo Passerotti, Everson Luiz Artifon, José Pinhata Otoch, Jose Arnaldo Shiomi da Cruz

{"title":"Description of the Dunning-Kruger effect in general surgery residents during laparoscopic cholecystectomy: a blinded prospective study.","authors":"Breno Cordeiro Porto, Rodrigo Marcus Cunha Frati, Rafael Guisalberte Maltez, Amanda Ferreira da Silva Lima, Tatiane Alves Ferreira, Larissa Cunha Baron, Carlo Camargo Passerotti, Everson Luiz Artifon, José Pinhata Otoch, Jose Arnaldo Shiomi da Cruz","doi":"10.1590/acb393224","DOIUrl":"10.1590/acb393224","url":null,"abstract":"Purpose: The purpose of this study is to assess whether the Dunning-Kruger effect occurs in surgical residents when performing laparoscopic cholecystectomy in a porcine model.Methods: Prospective blinded study, which counted with forty PGY-1 general surgery residents who agreed to participate in the study were blindly recruited to perform a laparoscopic cholecystectomy in a porcine model. At the end of the procedure, the participants assigned a score of 0-10 for their own performance and the video of the operation was independently assessed by 2 experienced laparoscopic surgeons using a validated tool.Results: Participants were divided into groups of 10 individuals according to objective performance and compared. The group with the worst objective result was inferior to the group with the best objective result (3.77 ± 0.44 vs. 8.1 ± 0.44, p < 0.001), but they were similar in self-perception of performance (5.11 ± 1.69 vs. 6.1 ± 1.79, p = 0.999).Conclusions: In the studied sample, it was possible to demonstrate the presence of the Dunning-Kruger effect.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e393224"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear factor kappa-light-chain-enhancer of activated B cells gene expression involvement in porcine liver transplant experimental model. 猪肝移植实验模型中活化 B 细胞核因子卡巴轻链增强子基因表达的参与。

Acta cirurgica brasileira Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.1590/acb392724

Lucas Souto Nacif, Flávio Galvão, Márcia Saldanha Kubrusly, Leonardo Yuri Kasputis Zanini, Paola Espinoza, Daniel Reis Waisberg, Rafael Soares Nunes Pinheiro, Amadeo Batista da Silva Neto, Vinicius Rocha-Santos, Venâncio Avancini Ferreira Alves, Luiz Carneiro-D'Albuquerque, Wellington Andraus

{"title":"Nuclear factor kappa-light-chain-enhancer of activated B cells gene expression involvement in porcine liver transplant experimental model.","authors":"Lucas Souto Nacif, Flávio Galvão, Márcia Saldanha Kubrusly, Leonardo Yuri Kasputis Zanini, Paola Espinoza, Daniel Reis Waisberg, Rafael Soares Nunes Pinheiro, Amadeo Batista da Silva Neto, Vinicius Rocha-Santos, Venâncio Avancini Ferreira Alves, Luiz Carneiro-D'Albuquerque, Wellington Andraus","doi":"10.1590/acb392724","DOIUrl":"10.1590/acb392724","url":null,"abstract":"Purpose: Gene expressions of vascular Endothelial Growth Factor Alpha (VEGFa), Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B cells (NFkB) and cytokines could be useful for identifying potential therapeutic targets to alleviate ischemia-reperfusion injury after liver transplantation. Cytokine gene expressions, VEGFa and NFkB were investigated in a preclinical swine model of liver transplantation.Methods: A total of 12 pigs were used as donors and recipients in liver transplantation without venovenous bypass or aortic clamping. NFkB, IL-6, IL-10, VEGFa and Notch1 gene expression were assessed. These samples were collected in two specific times: group 1 (n= 6) - control, samples were collected before recipient's total hepatectomy and group 2 - liver transplantation group (n=6), where the samples were collected one hour after graft reperfusion.Results: Liver transplantation was successfully performed in all recipients. Liver enzymes were elevated in the transplantation group. NFkB gene expression was significantly decreased in the transplantation group in comparison with the control group (0.62±0.19 versus 0.39±0.08; p= 0.016). No difference was observed between groups Interleucine 6 (IL-6), interleucine 10 (IL-10), VEGFa and Notch homolog 1 (Notch1).Conclusions: In this survey a decreased NFkB gene expression in a porcine model of liver transplantation was observed.","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e392724"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0