Acta cirurgica brasileira最新文献

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Simulators in urology resident's training in retrograde intrarenal surgery. 模拟器在泌尿科住院医师逆行肾内手术培训中的应用。
Acta cirurgica brasileira Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1590/acb394724
Luis Otávio Amaral Duarte Pinto, Renata Cunha Silva, Helder Clay Fares Dos Santos Junior, Lívia Guerreiro de Barros Bentes, Mateus Itiro Tamazawskas Otake, Herick Pampolha Huet de Bacelar, Kátia Simone Kietzer
{"title":"Simulators in urology resident's training in retrograde intrarenal surgery.","authors":"Luis Otávio Amaral Duarte Pinto, Renata Cunha Silva, Helder Clay Fares Dos Santos Junior, Lívia Guerreiro de Barros Bentes, Mateus Itiro Tamazawskas Otake, Herick Pampolha Huet de Bacelar, Kátia Simone Kietzer","doi":"10.1590/acb394724","DOIUrl":"10.1590/acb394724","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of simulators on the training of urology residents in retrograde intrarenal surgery (RIRS).</p><p><strong>Methods: </strong>The study involved training eight urology residents, using two artificial simulators; one developed by the Universidade Estadual do Pará, using three-dimensional printing technology, and the other one patented by the medical equipment manufacturer Boston Scientific The qualification of residents took place through a training course, consisting of an adaptation phase (S0), followed by three training sessions, with weekly breaks between them (S1, S2 and S3). Study members should carry out a RIRS in a standardized way, with step-by-step supervision by the evaluator using a checklist. The participants' individual performance was verified through a theoretical assessment, before and after training (pre- and post-training), as well as by the score achieved in each session on a scale called global psychomotor skill score. In S3, residents performed an analysis of the performance and quality of the simulation, by completing the scale of student satisfaction and self confidence in learning (SSSCL).</p><p><strong>Results: </strong>At the end of the course, everyone was able to perform the procedure in accordance with the standard. The training provided a learning gain and a considerable improvement in skills and competencies in RIRS, with p < 0.05. SSSCL demonstrated positive feedback, with an overall approval rating of 96%.</p><p><strong>Conclusions: </strong>Artificial simulators proved to be excellent auxiliary tools in the training of urology residents in RIRS.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e394724"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forty years of a Postgraduate Program in Cardiology at a Brazilian public university: indicators of its graduates. 巴西一所公立大学开设心脏病学研究生课程四十年:毕业生指标。
Acta cirurgica brasileira Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1590/acb394824
Carlos Eduardo Braga Filho, Talita Dias da Silva, Claudia Joanete da Silva, Cleidivan Alves Dos Santos, Frank Menezes Rodrigues, Adriano Henrique Pereira Barbosa, Adriano Caixeta, Maria Cristina de Oliveira Izar, Bráulio Luna-Filho, Francisco Antonio Helfenstein Fonseca, Fernando Sabia Tallo, Leonardo Roever, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
{"title":"Forty years of a Postgraduate Program in Cardiology at a Brazilian public university: indicators of its graduates.","authors":"Carlos Eduardo Braga Filho, Talita Dias da Silva, Claudia Joanete da Silva, Cleidivan Alves Dos Santos, Frank Menezes Rodrigues, Adriano Henrique Pereira Barbosa, Adriano Caixeta, Maria Cristina de Oliveira Izar, Bráulio Luna-Filho, Francisco Antonio Helfenstein Fonseca, Fernando Sabia Tallo, Leonardo Roever, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues","doi":"10.1590/acb394824","DOIUrl":"10.1590/acb394824","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the profile of graduates of the Postgraduate Program (PGP) in Cardiology of a public federal university, according to sociodemographic factors and professional trajectory.</p><p><strong>Methods: </strong>The variables were collected from databases from the observed institution and digital platforms. The analysis of differences between the various levels of degrees was carried out in three cohorts: the entire historical series (graduates from 1978-2021), the first 20 years (1978-1997) and the second 20 years (1998-2018).</p><p><strong>Results: </strong>The results demonstrated that most students from the PGP completed a PhD and are men over 30 years old, they came from public universities and the Southeast region. In the first 20 years, significant differences were observed in the distribution of masters and doctors working professionally at the institution analyzed, as well as in the age of the students. In the 20 years of the second half, there were differences between masters and PhD working professionally in the institution itself, as they came from private universities, they are women and PhD.</p><p><strong>Conclusions: </strong>The changes in the profile of masters and PhD that graduated from this PGP in cardiology reflect transformations that occurred in the job market and academy over the decades.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e394824"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shoeshine maneuver for cystic duct dissection: a simple technique to make Calot-triangle dissection smooth. 用于囊管解剖的 "擦鞋动作":使卡洛特三角解剖顺利进行的简单技术。
Acta cirurgica brasileira Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1590/acb395224
Marcelo Augusto Fontenelle Ribeiro Junior, Roberto Rizzi, Sariya Khan, Maryam Makki, Shahin Mohseni
{"title":"Shoeshine maneuver for cystic duct dissection: a simple technique to make Calot-triangle dissection smooth.","authors":"Marcelo Augusto Fontenelle Ribeiro Junior, Roberto Rizzi, Sariya Khan, Maryam Makki, Shahin Mohseni","doi":"10.1590/acb395224","DOIUrl":"10.1590/acb395224","url":null,"abstract":"<p><strong>Purpose: </strong>Laparoscopic cholecystectomy, introduced in 1985 by Prof. Dr. Erich Mühe, has become the gold standard for treating chronic symptomatic calculous cholecystopathy and acute cholecystitis, with an estimated 750,000 procedures performed annually in the United States of America. The risk of iatrogenic bile duct injury persists, ranging from 0.2 to 1.3%. Risk factors include male gender, obesity, acute cholecystitis, previous hepatobiliary surgery, and anatomical variations in Calot's triangle. Strategies to mitigate bile duct injury include the Critical View of Safety and fundus-first dissection, along with intraoperative cholangiography and alternative approaches like subtotal cholecystectomy.</p><p><strong>Methods: </strong>This paper introduces the shoeshine technique, a maneuver designed to achieve atraumatic exposure of anatomical structures, local hemostatic control, and ease of infundibulum mobilization. This technique involves the use of a blunt dissection tool and gauze to create traction and enhance visibility in Calot's triangle, particularly beneficial in cases of severe inflammation. Steps include using the critical view of safety and Rouviere's sulcus line for orientation, followed by careful dissection and traction with gauze to maintain stability and reduce the risk of instrument slippage.</p><p><strong>Results: </strong>The technique, routinely used by the authors in over 2000 cases, has shown to enhance patient safety and reduce bile duct injury risks.</p><p><strong>Conclusion: </strong>The shoeshine technique represents a simple and easy way to apply maneuver that can help surgeon during laparoscopic cholecystectomies exposing the hepatocystic area and promote blunt dissection.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e395224"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury. 人类 SOD2 基因在小鼠脑缺血/再灌注损伤中的功能和机制。
Acta cirurgica brasileira Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1590/acb393124
Xitong Yang, Guangming Wang
{"title":"Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury.","authors":"Xitong Yang, Guangming Wang","doi":"10.1590/acb393124","DOIUrl":"10.1590/acb393124","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion.</p><p><strong>Methods: </strong>SOD2 transgenic mice were engineered using transcription activator-like effector nucleases, and the genotype was identified using PCR after every three generations. Transgenic and C57BL/6J wild type mice were simultaneously subjected to the middle cerebral artery occlusion model.</p><p><strong>Results: </strong>SOD2 expression in the brain, heart, kidney, and skeletal muscle of transgenic mice was significantly higher than that in the wild type. Following ischemia reperfusion, the infarct volume of wild type mice decreased after treatment with fenofibrate compared to the CMC group. Infarction volume in SOD2 transgenic mice after CMC and fenofibrate treatment was significantly reduced. The recovery of cerebral blood flow in wild type mice treated with fenofibrate was significantly enhanced compared with that in the CMC group.</p><p><strong>Conclusions: </strong>The expression of SOD2 in transgenic mice was significantly higher than that in wild type mice, the neuroprotective role of fenofibrate depends on an increase in SOD2 expression.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e393124"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional models of physeal fractures in the femur for the teaching of veterinary medicine. 用于兽医学教学的股骨趾骨骨折三维模型。
Acta cirurgica brasileira Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1590/acb395424
Kleber Dos Anjos Lucas, Siham Kassab, Rodrigo Gomes de Souza, Nongnuch Inpanbutr, Marco Aurélio Pereira-Sampaio, Yuri Karaccas de Carvalho
{"title":"Three-dimensional models of physeal fractures in the femur for the teaching of veterinary medicine.","authors":"Kleber Dos Anjos Lucas, Siham Kassab, Rodrigo Gomes de Souza, Nongnuch Inpanbutr, Marco Aurélio Pereira-Sampaio, Yuri Karaccas de Carvalho","doi":"10.1590/acb395424","DOIUrl":"10.1590/acb395424","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and assess three-dimensional models of physeal fractures in dog femurs (3D MPFDF) using radiographic imaging.</p><p><strong>Methods: </strong>The study was conducted in three phases: development of 3D MPFDF; radiographic examination of the 3D MPFDF; and comparative analysis of the anatomical and radiographic features of the 3D MPFDF.</p><p><strong>Results: </strong>The base model and the 3D MPFDF achieved high fidelity in replicating the bone structures, accurately maintaining the morphological characteristics and dimensions such as length, width, and thickness, closely resembling natural bone. The radiographs of the 3D MPFDF displayed distinct radiopaque and radiolucent areas, enabling clear visualization of the various anatomical structures of the femur. However, in these radiographs, it was challenging to distinguish between the cortical and medullary regions due to the use of 99% internal padding in the printing process. Despite this limitation, the radiographs successfully demonstrated the representation of the Salter-Harris classification.</p><p><strong>Conclusions: </strong>This paper presents a pioneering project focused on technological advancement aimed at developing a method for the rapid and cost-effective production of three-printed models and radiographs of physeal fractures in dogs.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e395424"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amorphophallus campanulatus tuber extract protects diabetic nephropathy in streptozotocin-induced diabetic nephropathy rat model by regulating oxidative stress and TNF-α inflammatory pathway. 野漆树块茎提取物通过调节氧化应激和 TNF-α 炎症途径保护链脲佐菌素诱导的糖尿病肾病大鼠模型。
Acta cirurgica brasileira Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1590/acb395324
Li Fan, Xiaoying Li, Alok Shiomurti Tripathi
{"title":"Amorphophallus campanulatus tuber extract protects diabetic nephropathy in streptozotocin-induced diabetic nephropathy rat model by regulating oxidative stress and TNF-α inflammatory pathway.","authors":"Li Fan, Xiaoying Li, Alok Shiomurti Tripathi","doi":"10.1590/acb395324","DOIUrl":"10.1590/acb395324","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effect of Amorphophallus campanulatus tuber (Ac) extract in the protection of diabetic nephropathy in streptozotocin (STZ) induced diabetic nephropathy (DN) rat model.</p><p><strong>Methods: </strong>Diabetes was induced with STZ (60 mg/kg, i.p.), and DN was confirmed after six weeks of STZ administration with the estimation of kidney function test. Further rats were treated with Ac 250 and 500 mg/kg p.o. for next four week. Oxidative stress and level of inflammatory cytokines were estimated in the kidney tissue of DN rats. Histopathology of kidney tissue was performed using hematoxylin and eosin staining.</p><p><strong>Results: </strong>There was improvement in the body weight of Ac treated groups than DN group of rats. Blood glucose level was observed to be reduced in Ac treated groups than DN group on 42nd and 70th day of protocol. Treatment with Ac ameliorated the altered level of kidney function tests (creatinine and BUN), enzymes of liver function (aspartate aminotransferase and alanine aminotransferase), and lipid profile in the serum of DN rats. Oxidative stress parameters (malondialdehyde and reactive oxygen species enhances and reduction in the level of glutathione and superoxide dismutase) and inflammatory cytokines such as interleukin-6, tumour necrosis factor-α, and monocyte chemoattractant protein-1 reduces in the tissue of Ac treated group than DN group. Treatment with Ac also attenuates the altered histopathological changes in the kidney tissue of DN rats.</p><p><strong>Conclusions: </strong>The report suggests that Ac protects renal injury in DN rats by regulating inflammatory cytokines and oxidative stress.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e395324"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effects of the combined treatment of resveratrol and urapidil in experimental cerebral ischemia-reperfusion injury in rats. 白藜芦醇和乌拉地尔联合治疗对大鼠实验性脑缺血再灌注损伤的神经保护作用
Acta cirurgica brasileira Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1590/acb395329
Rıdvan Çetin, Sinan Bahadir, İbrahim Basar, Barış Aslanoglu, Burak Atlas, Seval Kaya, Barış Can Güzel, Yahya Turan
{"title":"Neuroprotective effects of the combined treatment of resveratrol and urapidil in experimental cerebral ischemia-reperfusion injury in rats.","authors":"Rıdvan Çetin, Sinan Bahadir, İbrahim Basar, Barış Aslanoglu, Burak Atlas, Seval Kaya, Barış Can Güzel, Yahya Turan","doi":"10.1590/acb395329","DOIUrl":"10.1590/acb395329","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the neuroprotective effect of resveratrol, urapidil, and a combined administration of these drugs against middle cerebral artery occlusion (MCAO) induced ischemia/reperfusion (IR) injury model in rats.</p><p><strong>Methods: </strong>Thirty-five rats were divided into five groups of seven animals each. Animals in IR, IR resveratrol (IRr), IR urapidil (IRu), and IR + combination of resveratrol and urapidil (IRc) were exposed to MCAO induced cerebral ischemia reperfusion injury model. Rats in IRr and IRu groups received 30-mg/kg resveratrol and 5-mg/kg urapidil respectively. Animals in IRc received a combined treatment of both drugs. At the end of the study, brain tissues were used for oxidative stress (malondialdehyde, glutathione, and superoxide dismutase), pro-apoptotic caspase-3, anti-apoptotic Bcl-2, and pro-inflammatory tumor necrosis factor-α cytokine level measurements.</p><p><strong>Results: </strong>The MCAO model successfully replicated IR injury with significant histopathological changes, elevated tissue oxidative stress, and upregulated apoptotic and inflammatory protein expression in IR group compared to control group (p < 0.001). All parameters were significantly alleviated in IRr group compared to IR group (all p < 0.05). In IRu group, all parameters except for caspase-3 and Bcl-2 were also significantly different than IR group (all p < 0.05). The IRc group showed the biggest difference compared to IR group in all parameters (all p < 0.001). The IRc had higher superoxide dismutase and Bcl-2 levels, and lower caspase-3 levels compared to both IRr and IRu groups (all p < 0.05). Also, the IRc group had lower MDA and TNF-α levels compared to IRu group (all p < 0.05).</p><p><strong>Conclusions: </strong>The results indicate that combined treatment of resveratrol and urapidil may be a novel strategy to downregulate neurodegeneration in cerebral IR injury.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e395329"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ocimum basilicum L. (basil) presents pro-apoptotic activity in an Ehrlich's experimental tumor murine model. 罗勒(Ocimum basilicum L.)在艾氏实验性肿瘤小鼠模型中具有促进凋亡的活性。
Acta cirurgica brasileira Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.1590/acb393924
Phelipe Gabriel Dos Santos Sant'Ana, William Gustavo Lima, Gabriela Francine Martins Lopes, Sabrina Elisa de Oliveira, Guilherme Augusto Ferreira da Costa, Luciana Alves Rodrigues Dos Santos Lima, Elisângela Elduina Ferreira, Ivan Carlos Dos Santos, Laila Cristina Moreira Damázio, Rosy Iara Maciel Azambuja Ribeiro, Flávia Carmo Horta Pinto
{"title":"Ocimum basilicum L. (basil) presents pro-apoptotic activity in an Ehrlich's experimental tumor murine model.","authors":"Phelipe Gabriel Dos Santos Sant'Ana, William Gustavo Lima, Gabriela Francine Martins Lopes, Sabrina Elisa de Oliveira, Guilherme Augusto Ferreira da Costa, Luciana Alves Rodrigues Dos Santos Lima, Elisângela Elduina Ferreira, Ivan Carlos Dos Santos, Laila Cristina Moreira Damázio, Rosy Iara Maciel Azambuja Ribeiro, Flávia Carmo Horta Pinto","doi":"10.1590/acb393924","DOIUrl":"10.1590/acb393924","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the therapeutic effect of an ethanol extract of Ocimum basilicum L. (EEOb) aerial parts against Ehrlich's experimental tumor (EET) in mice.</p><p><strong>Methods: </strong>Swiss mice were divided into two groups (control and treated; n = 6). On day 21, all mice were inoculated subcutaneously with 2 × 106 (0.05 mL) EET cells in the left paw for solid tumor development. This study lasted 28 days. Treatment began 24 hours after inoculation with EET. Measurements of dorsoplantar thickness were used to assess tumor growth. The paw pad was collected for histopathological analysis and stained using the argyrophilic nucleolar organizing regions (AgNOR) technique and immunohistochemistry for proliferating cell nuclear antigen, Bcl-2 and Bax.</p><p><strong>Results: </strong>The treatment of animals with EEOb at 100 mg/kg intraperitoneally was able to reduce the growth (Control = 3.7 ± 0.1 mm vs. EEOb = 5.7 ± 0.2 mm) and the number of AgNORs of solid Ehrlich tumor. The antitumor effect of EEOb was associated with the induction of apoptosis of tumoral cell, as suggested by the reduction of the content of Bcl-2 induced by extract.</p><p><strong>Conclusions: </strong>The study demonstrated that daily administration of EEOb is able to reduce the growth of EET by induce apoptosis of tumoral cells.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e393924"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic cholecystectomy for symptomatic cholelithiasis in children and adolescents: analysis of 50 cases from a single institution. 针对儿童和青少年无症状胆石症的腹腔镜胆囊切除术:对一家医疗机构 50 例病例的分析。
Acta cirurgica brasileira Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI: 10.1590/acb394124
Renato Queiroga de Almeida, Vicente Antonio Gerardi Filho, José Luiz Ferreira Dias, Manuela Corrêa de Toledo Peres, Jaques Waisberg
{"title":"Laparoscopic cholecystectomy for symptomatic cholelithiasis in children and adolescents: analysis of 50 cases from a single institution.","authors":"Renato Queiroga de Almeida, Vicente Antonio Gerardi Filho, José Luiz Ferreira Dias, Manuela Corrêa de Toledo Peres, Jaques Waisberg","doi":"10.1590/acb394124","DOIUrl":"10.1590/acb394124","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical characteristics of symptomatic cholecystolithiasis and laparoscopic cholecystectomy complications in pediatric patients.</p><p><strong>Methods: </strong>The medical records of 50 children and adolescents who underwent laparoscopic cholecystectomy were analyzed. We evaluated gender, age, body mass index, preoperative clinical aspects, perioperative complications, and gallstone composition.</p><p><strong>Results: </strong>Among the patients, 33 (66%) were female, and 17 (34%) were male. The mean age was 11.4 ± 3.6. All patients were diagnosed with cholecystolithiasis by abdominal ultrasonography. Twelve patients (24%) had hematological disease: eight (16%) with sickle cell anemia and four (8%) with hereditary spherocytosis. Thirteen patients (26%) were obese. Twelve patients (24%) had complicated biliary disease. During the intraoperative period, three patients (6%) had excessive bleeding in the hepatic hilum, and one had an accidental injury to the common bile duct. Three (6%) postoperative complications (acute pancreatitis, common bile duct stenosis, and intestinal obstruction) were observed. Among 28 patients (56%), 25 (50%) had cholesterol gallstones, and three (6%) had bile pigment gallstones.</p><p><strong>Conclusions: </strong>The evolution of cholecystolithiasis in the pediatric population can present serious complications, emphasizing the need to avoid temporizing cholecystolithiasis in children and adolescents because laparoscopic cholecystectomy in this group is safe, with low complication rates.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e394124"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of postoperative complications in oncologic gastro-esophageal surgeries: a cross-sectional study. 胃食管肿瘤手术术后并发症的发生率:一项横断面研究。
Acta cirurgica brasileira Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI: 10.1590/acb394424
Laura Mota Vieira Lima, Paula Costa Guimarães, Daniele de Oliveira Montenegro, Fernanda de Sousa Filgueira, José Gomes Neto Júnior, Ricardo Ney Cobucci, Kleyton Santos de Medeiros, Irami Araújo-Filho
{"title":"Prevalence of postoperative complications in oncologic gastro-esophageal surgeries: a cross-sectional study.","authors":"Laura Mota Vieira Lima, Paula Costa Guimarães, Daniele de Oliveira Montenegro, Fernanda de Sousa Filgueira, José Gomes Neto Júnior, Ricardo Ney Cobucci, Kleyton Santos de Medeiros, Irami Araújo-Filho","doi":"10.1590/acb394424","DOIUrl":"10.1590/acb394424","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the prevalence of complications in the postoperative period of esophagogastric oncological surgeries.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional study, adhering to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. The study size implied 163 patients who underwent surgical treatment for esophageal and gastric cancer and experienced postoperative complications between January 2018 and December 2022. These patients were treated at the Liga Norte Riograndense Contra o Câncer, a high-complexity oncology center and a reference for cancer treatment in Northeast Brazil.</p><p><strong>Results: </strong>The prevalence found was 88.3%. The most prevalent complications were Clavien-Dindo I and II, and infection was the most common. According to our statistics analysis, hypoalbuminemia showed a positive correspondence with the occurrence of postoperative complications (odds ratio = 8.60; 95% confidence interval 1.35-54.64, p = 0.0358).</p><p><strong>Conclusions: </strong>Postoperative complications of gastroesophageal surgeries increase patient morbidity and mortality.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"39 ","pages":"e394424"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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