Results of the use of human platelet-rich fibrin membrane applied on colorrhaphy in nourished and malnourished rats.

Acta cirurgica brasileira Pub Date : 2024-11-08 eCollection Date: 2024-01-01 DOI:10.1590/acb397824

Fábio Henrique de Oliveira, Lucas Silva de Oliveira, Luciana Xavier Pereira, Vinicius Silva Belo, Fernanda Elias Ferreira Rabelo, Guilherme Santos Couto, Antonio Lacerda-Filho

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Abstract

Purpose: To evaluate the effects of platelet-rich fibrin (PRF) on the healing of intestinal sutures in rats.

Methods: Forty rats were distributed into four groups. Two groups were treated with a standard diet and considered nourished (I and II). Two other groups were treated with cornmeal and considered malnourished (III and IV). All animals underwent cecotomy and cecorrhaphy. Groups II and IV had sutures overlapped with human PRF membrane. The following parameters were evaluated: animal weight, death, rupture site, rupture pressure, collagen, and reticulin dosage in the suture line.

Results: The use of PRF did not influence deaths, rupture pressure or rupture location. For malnourished animals, a significant difference was observed in relation to the rupture site, corresponding to the suture line (p = 0.038) and reticulin dosage (p = 0.040), when PRF was used. There was no difference in relation to burst pressures.

Conclusions: The use of PRF did not influence intestinal healing in nourished rats. In the group of malnourished animals, its use favored healing.

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使用富含血小板的人纤维蛋白膜对营养不良和营养不良大鼠进行彩超检查的结果。

目的：评估富血小板纤维蛋白（PRF）对大鼠肠缝合愈合的影响：方法：将 40 只大鼠分为四组。方法：将 40 只大鼠分成四组，两组用标准饮食治疗，被视为营养组（I 组和 II 组）。另外两组使用玉米粉，被视为营养不良（III 和 IV）。所有动物都接受了盲肠切除术和盲肠痔切除术。第二组和第四组的缝合线与人PRF膜重叠。对以下参数进行了评估：动物体重、死亡、破裂部位、破裂压力、缝合线中胶原蛋白和网状纤维素的用量：结果：使用 PRF 不会影响死亡、破裂压力或破裂部位。对于营养不良的动物，在使用 PRF 时，与缝合线相对应的破裂部位（p = 0.038）和网状纤维素剂量（p = 0.040）存在显著差异。结论：结论：使用 PRF 不会影响营养大鼠的肠道愈合。结论：使用 PRF 不会影响营养大鼠的肠道愈合，而在营养不良动物组中，使用 PRF 则有利于肠道愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta cirurgica brasileira

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