Performance of blood concentrates in controlling inflammatory signs and symptoms after lower third molar extractions: an overview.

Acta cirurgica brasileira Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI:10.1590/acb401825

Vinícius Lima de Almeida, Marcelo Dias Moreira de Assis Costa, Caio Melo Mesquita, Walbert Andrade Vieira, Rafael Rodrigues Lima, Livia Bonjardim Lima, Sigmar de Mello Rode, Luiz Renato Paranhos

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Abstract

Purpose: To summarize the available evidence and answer the following question: What is the current knowledge on the performance of blood concentrates in handling sequelae after lower third molar extractions with the evidence available in systematic reviews?

Methods: An electronic search was conducted across nine databases. The study included systematic reviews with or without meta-analyses investigating the performance of blood concentrates in managing sequelae after lower third molar extractions. The four outcomes analyzed were pain, edema, mouth opening, and alveolar osteitis. The AMSTAR-2 tool assessed the methodological quality of the included systematic reviews, while ROBIS evaluated the risk of bias.

Results: The electronic search revealed 690 records, of which 15 were eligible systematic reviews for the present study. Overall, these reviews evaluated 75 primary studies published from 2007 to 2023. According to AMSTAR-2, only one systematic review presented high methodological quality. The ROBIS tool showed two systematic reviews with a low risk, and the others had a high risk of bias.

Conclusion: The current evidence is based on only one systematic review with high methodological quality and a low risk of bias, while the others exhibited a high risk of bias and low methodological quality. Therefore, the evidence regarding the efficacy of blood concentrates in controlling sequelae following lower third molar extractions is inconclusive.

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血液浓缩物在控制下第三磨牙拔牙后炎症体征和症状中的作用：综述

目的：总结现有的证据并回答以下问题：目前关于血液浓缩物处理下第三磨牙拔牙后后遗症的知识与系统评价中现有的证据是什么？方法：对9个数据库进行电子检索。该研究包括有或没有荟萃分析的系统评价，调查血液浓缩物在处理下第三磨牙拔牙后的后遗症方面的表现。分析的四个结果是疼痛、水肿、张嘴和牙槽骨炎。AMSTAR-2工具评估纳入系统评价的方法学质量，ROBIS评估偏倚风险。结果：电子检索显示690条记录，其中15条符合本研究的系统评价。总的来说，这些综述评估了2007年至2023年发表的75项主要研究。根据AMSTAR-2，只有一个系统评价具有较高的方法学质量。ROBIS工具显示了两个低风险的系统评价，其他的有高偏倚风险。结论：目前的证据仅基于一篇高方法学质量、低偏倚风险的系统综述，而其他文献均表现出高偏倚风险和低方法学质量。因此，关于血浓缩物在控制下第三磨牙拔除后的后遗症方面的有效性的证据是不确定的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta cirurgica brasileira

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