Brazilian Journal of Medical and Biological Research最新文献_第4页

Effect of high-intensity childhood games on heart rate variability, saliva leptin concentrations, and body composition in children. 高强度儿童游戏对儿童心率变异性、唾液瘦素浓度和身体成分的影响。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14479

C Y Rodriguez-Triviño, S Quintana, C E Osorio-Vélez, M Garcia-Florez

{"title":"Effect of high-intensity childhood games on heart rate variability, saliva leptin concentrations, and body composition in children.","authors":"C Y Rodriguez-Triviño, S Quintana, C E Osorio-Vélez, M Garcia-Florez","doi":"10.1590/1414-431X2025e14479","DOIUrl":"10.1590/1414-431X2025e14479","url":null,"abstract":"The aim of this study was to evaluate the effect of high-intensity childhood games on cardiac autonomic regulation, obesity biomarkers, and body composition in overweight or obese children compared to moderate-intensity games. A single-blind, randomized controlled study was conducted including children aged 6 to 9 years with overweight or obesity. Participants were randomly assigned to two groups: 33 in the moderate-intensity interval game group (MIIG) and 29 in the high-intensity interval game group (HIIG). The intervention lasted 16 weeks, with measurements conducted under double blinding. The study followed institutional ethical standards and was registered on ClinicalTrials.gov (CT NCT05294601). A total of 74 children were recruited, with 7 excluded after sports medicine assessment, leaving 67 children randomized. Five participants dropped out during the study. HRV analysis revealed significant differences in frequency dominance in the HIIG group. High-frequency power, linked to parasympathetic dominance, increased from 59.3 to 65.8 nu (P=0.03), while low-frequency power, related to sympathetic activity, decreased from 40.6 to 34.13 nu (P=0.04). Salivary leptin concentrations decreased significantly from 0.33 to 0.32 ng/mL (P=0.008) in the MIIG group and from 0.35 to 0.32 ng/mL (P=0.004) in the HIIG group. Childhood games positively impacted anthropometry, HRV, and leptin concentrations in both intensity groups, indicating metabolic improvement. However, only the high-intensity strategy enhanced parasympathetic dominance and sympathetic-parasympathetic balance, potentially reducing long-term cardiovascular risk.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14479"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress-stimulated epinephrine induces premature senescence in dermal fibroblasts and contributes to impaired skin wound healing. 应激刺激肾上腺素诱导真皮成纤维细胞过早衰老，并有助于皮肤伤口愈合受损。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14472

J T da Silva, C O S Meira, J S Nogueira, M Lanzetti, B Romana-Souza

{"title":"Stress-stimulated epinephrine induces premature senescence in dermal fibroblasts and contributes to impaired skin wound healing.","authors":"J T da Silva, C O S Meira, J S Nogueira, M Lanzetti, B Romana-Souza","doi":"10.1590/1414-431X2025e14472","DOIUrl":"10.1590/1414-431X2025e14472","url":null,"abstract":"External factors accelerate cellular senescence in the skin and compromise its repair process. Psychological stress impairs skin wound healing, but no study examined its role in cellular senescence during skin tissue repair. Thus, this study evaluated the effect of stress on cellular senescence during skin wound healing. Human dermal fibroblasts (HDFs) and human skin from aged and young donors were treated with a non-lethal dose of epinephrine or hydrogen peroxide following a stress-induced premature senescence protocol. In vitro, epinephrine or hydrogen peroxide promoted the expression of senescence-associated β-galactosidase, p53, and notch target gene hairy and enhancer of split 1 (HES1) in HDFs, confirming the induction of premature senescence. A higher expression of matrix metalloproteinase-9 and interleukin-8 was observed in HDFs incubated with epinephrine or hydrogen peroxide, confirming a pro-inflammatory senescence-associated secretory phenotype. The protein levels of silent information regulator sirtuin 1, which is associated with a longer lifespan, were not changed in HDFs submitted to stressful conditions. In ex vivo experiments, epinephrine administration impaired wound closure and increased HES1 expression in aged human skin. In conclusion, stress-induced high epinephrine level induced premature senescence in HDFs, which contributes to impaired wound healing in young and aged skin.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14472"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of Aloe vera extract against doxorubicin-induced degeneration in ovarian follicles and stromal cells in mice. 芦荟提取物对阿霉素诱导小鼠卵巢滤泡和间质细胞变性的保护作用。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14402

E I T de Assis, A N Godinho, J M O Freire, M F de Lima Neto, J J N Costa, A L P Souza, A P O do Monte, M H T Matos, A L M de Sousa, J R V Silva, A W B Silva

{"title":"Protective effects of Aloe vera extract against doxorubicin-induced degeneration in ovarian follicles and stromal cells in mice.","authors":"E I T de Assis, A N Godinho, J M O Freire, M F de Lima Neto, J J N Costa, A L P Souza, A P O do Monte, M H T Matos, A L M de Sousa, J R V Silva, A W B Silva","doi":"10.1590/1414-431X2025e14402","DOIUrl":"10.1590/1414-431X2025e14402","url":null,"abstract":"The present study aimed to evaluate the protective effects of Aloe vera on doxorubicin (DOX)-induced degeneration in ovarian follicles and stromal cells in mice. Mice (n=48) were randomly divided into six groups. The positive control group mice received pretreatment of N-acetylcysteine orally (po), followed by a single intraperitoneal (ip) dose of DOX after 1 h (NAC+DOX). The negative control group mice were pre-treated with saline (po) and administered a single DOX dose (ip) after 1 h (SAL+DOX). The other groups of mice were pre-treated with different concentrations (0.1, 1.0, or 10.0 mg/kg; po) of Aloe vera and then received a single dose of DOX (ip) after 1 h (AV0.1+DOX, AV1.0+DOX, and AV10.0+DOX). The control group received saline po and ip (SAL+SAL). Aloe vera was administered once daily for 3 consecutive days. On the fourth day, the ovaries were processed for histological analysis, immunohistochemistry, and real-time PCR (mRNA for superoxide dismutase (SOD), catalase (CAT), nuclear factor erythroid 2-related factor 2 (NRF2), and tumor necrosis factor-α (TNF-α). Results showed that 0.1 and 1.0 mg/kg Aloe vera protected ovarian follicles and stromal density against DOX-induced degeneration. Furthermore, 0.1 and 1.0 mg/kg Aloe vera reduced TNF-α protein expression and increased NRF2, SOD, and CAT mRNA levels. In conclusion, 0.1 and 1.0 mg/kg Aloe vera had protective effects against DOX-induced degeneration in ovarian follicles and stromal cells in mice.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14402"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microencapsulation of fish oil by spray-drying using two different wall materials: a comparison. 用两种不同壁材喷雾干燥制备鱼油微胶囊：比较。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14007

S C B Pinto, A M Kluczkovski, H B Lemos, V G Torres, A V B Jesus, T P Souza

{"title":"Microencapsulation of fish oil by spray-drying using two different wall materials: a comparison.","authors":"S C B Pinto, A M Kluczkovski, H B Lemos, V G Torres, A V B Jesus, T P Souza","doi":"10.1590/1414-431X2025e14007","DOIUrl":"10.1590/1414-431X2025e14007","url":null,"abstract":"Oils and fats have a wide range of health benefits, especially those that have a high concentration of polyunsaturated fatty acids, like fish oils. Unfortunately, oils are highly susceptible to heat, light, and oxygen degradation, causing them to lose the qualities that would make them interesting for the public. With this in mind, this study compared two methods of spray-drying, a technique that helps preserve the stability of oils in storage for longer periods of time. Emulsions made with skimmed milk powder and with maltodextrin and whey protein hydrolysate were spray-dried, resulting in 2 different microencapsulated fish oils. They were compared regarding encapsulation efficiency, water activity, moisture content, and peroxide index. The skimmed milk showed better results, with a 28.17% lower peroxide index than the non-encapsulated oil and lower water activity and moisture content compared to the emulsion using maltodextrin (2.690±0.19% vs 6.747±0.29% moisture content and 0.376±0.013 vs 0.554±0.006 water activity). Since skimmed milk powder is rather cheap, it is ideal for spray-drying, a simple and fast technique. In this way, fish oil can be safely microencapsulated in powder form, lasting longer than the oil capsules currently available, since the oil is protected from light, temperature, moisture, and oxidation. In addition, the oily odor is masked, making it more appealing to the consumer, and it may be combined with other powders, like vitamins and minerals, which opens up new possibilities for the production of supplements.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14007"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utility of an artificial intelligence model based on decision tree and evolution algorithm to evaluate steatotic liver disease in a primary care setting. 基于决策树和进化算法的人工智能模型在初级保健环境中评估脂肪变性肝病的效用。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14538

A C Goulart, A P Alencar, G Tunes, L L T Bianchi, M H Miname, C M Padilha, J M S Pescuma, A L C C Rodrigues, B B Henares, M S de Almeida, T A O Machado, D H Syllos, Y P Wang, M Rienzo

{"title":"The utility of an artificial intelligence model based on decision tree and evolution algorithm to evaluate steatotic liver disease in a primary care setting.","authors":"A C Goulart, A P Alencar, G Tunes, L L T Bianchi, M H Miname, C M Padilha, J M S Pescuma, A L C C Rodrigues, B B Henares, M S de Almeida, T A O Machado, D H Syllos, Y P Wang, M Rienzo","doi":"10.1590/1414-431X2025e14538","DOIUrl":"10.1590/1414-431X2025e14538","url":null,"abstract":"Many ways of classifying steatotic liver disease (SLD) with metabolic conditions have been proposed. Thus, SLD-related variables were verified using a decision tree. We tested if the suggested components of the actual classification (metabolic dysfunction-associated steatotic liver disease, MASLD) are also present in young and middle-aged adults. In a cross-sectional study involving 6,839 adults (median age: 46 years, 69.5% men) in a primary care setting, a decision tree was created to determine potential clinical and laboratory variables related to SLD. The odds ratio (OR) with a respective 95% confidence interval (95%CI) was calculated for both sexes. SLD frequency was 26.6% (23% in men). More variables and with higher ORs for the association with SLD were identified in women: category 1 (body mass index (BMI) ≥29 kg/m2, age <51 years, high-sensitivity C-reactive protein (hs-CRP) ≥0.195 mg/dL): OR=10.9, 95%CI: 4.40-26.6; category 2 (BMI <9 kg/m2, metabolic syndrome (MS), age ≥50 years, neck circumference (NC) ≥36 cm): OR=8.1, 95%CI: 2.2-29.9; and category 3 (BMI ≥29 kg/m2, age <51 y-old, dyslipidemia, high-density lipoprotein cholesterol (HDL-c) <42 mg/dL): OR=4.7, 95%CI: 2.20-10.7. For men: category 1 (waist circumference (WC) ≥101 cm, alanine aminotransferase (ALT) <28 mg/dL, glycated hemoglobin (HbA1c) ≥5.7%): OR=4.7, 95%CI: 2.8-7.9; and category 2 (WC ≥101 cm, ALT ≥28 mg/dL): OR=3.2, 95%CI: 2.5-4.0). The decision tree identified more variables related to SLD, particularly in women, such as age of more than 50 years, elevated hs-CRP, and NC≥36 cm than variables related to MASLD.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14538"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and factors associated with the presence of oral infections in pregnant women in a medium-sized municipality in Brazil. 巴西一个中等城市孕妇口腔感染的患病率及其相关因素

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14436

A P N Godoi, G C S Bernardes, L N Godoi, L S Nogueira, G M Rocha, M Barros-Pinheiro

{"title":"Prevalence and factors associated with the presence of oral infections in pregnant women in a medium-sized municipality in Brazil.","authors":"A P N Godoi, G C S Bernardes, L N Godoi, L S Nogueira, G M Rocha, M Barros-Pinheiro","doi":"10.1590/1414-431X2025e14436","DOIUrl":"10.1590/1414-431X2025e14436","url":null,"abstract":"The objective of this study was to estimate the prevalence and factors associated with oral changes, including infections and other oral conditions in pregnant women who underwent prenatal care in public health units in the city of Divinópolis, Minas Gerais. This was a cross-sectional study carried out with baseline data from a cohort of 588 pregnant women (aged 14 to 43 years) from 2019 to 2023. Data were collected through interviews and oral clinical examination, using a structured questionnaire. The event of interest was the presence of oral infection. The absolute and relative frequencies of the variables were calculated. Logistic regression was used to evaluate the association between the explanatory variables and the presence of oral infection, with estimation of odds ratios and 95% confidence intervals. Among the participants, 47.8% had oral infections. In the multivariate analysis, the variables that showed a significant association with oral infection were: lower education, last visit to the dentist more than 6 months ago, lower frequency of flossing, regular intake of alcoholic beverages, and self-report of poor oral health. This study highlighted sociodemographic and behavioral disparities and the importance of prenatal dental care. Insights for adapting interventions were provided, although further studies are needed.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14436"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-intensity sciatic nerve-stretch injury increases nociception, anxiety-like behaviors, and astrocyte activity in male Wistar rats. 低强度坐骨神经拉伸损伤增加雄性Wistar大鼠的伤害感受、焦虑样行为和星形胶质细胞活性。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14481

G K Silva-Cardoso, P E Bello-Junior, W Lazarini-Lopes, A A Ferrarese-Tiballi, C R A Leite-Panissi

{"title":"Low-intensity sciatic nerve-stretch injury increases nociception, anxiety-like behaviors, and astrocyte activity in male Wistar rats.","authors":"G K Silva-Cardoso, P E Bello-Junior, W Lazarini-Lopes, A A Ferrarese-Tiballi, C R A Leite-Panissi","doi":"10.1590/1414-431X2025e14481","DOIUrl":"10.1590/1414-431X2025e14481","url":null,"abstract":"The incidence of chronic pain in the general population is highly correlated to anxiety disorders, which promote negative effects on the quality of life. Stretch injury is the primary cause of nerve dysfunction and injury in the civilian population. Here, we characterized changes in nociception, anxiogenic-like behaviors, and astrocyte expression in the low-intensity sciatic nerve-stretch injury (NSI) model. Male Wistar rats were submitted to NSI, chronic constriction injury of the sciatic nerve (CCI), or sham surgery (SHAM). Animals were submitted to nociceptive tests (von Frey, acetone, and hot plate) before surgery and 6, 12, 18, and 24 days post-surgery. Anxiety-like behaviors were assessed in the open field test (OFT) 23 days after surgery. Immunofluorescence for astrocyte activity (glial fibrillary acidic protein (GFAP)) was performed in cortical, thalamic, and brainstem areas involved with pain and emotional processing. Animals submitted to NSI showed increased mechanical allodynia and thermal hyperalgesia, similar to those submitted to CCI. In the OFT, both NSI and CCI animals showed an increase in anxiety-like behaviors. Also, NSI animals presented an increased expression of GFAP in all analyzed areas, similar to CCI animals. In conclusion, the NSI model produced behavioral alterations comparable to those observed in the CCI model, including hypersensitivity to mechanical and thermal (heat) stimuli that lasted for more than three weeks. Additionally, both models induced a similar increase in GFAP expression in cortical, thalamic, and brainstem regions.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14481"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in microRNA expression associated with preeclampsia: a systematic review. 与子痫前期相关的microRNA表达变化：一项系统综述。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e13988

A C S Lopes, A A de Macedo, F S Mendes, I M Costa, L M S Dusse, P N Alpoim

{"title":"Changes in microRNA expression associated with preeclampsia: a systematic review.","authors":"A C S Lopes, A A de Macedo, F S Mendes, I M Costa, L M S Dusse, P N Alpoim","doi":"10.1590/1414-431X2025e13988","DOIUrl":"10.1590/1414-431X2025e13988","url":null,"abstract":"Preeclampsia (PE) is a disease of pregnancy characterized by the new onset of hypertension accompanied by proteinuria and/or other signs of maternal organ dysfunction that manifests after 20 weeks of gestation. MicroRNAs (miRNAs) are small non-coding RNAs (19-25 nucleotides) that function in the post-transcriptional regulation of gene expression. Many studies have suggested that different microRNA expression profiles may be associated with the development of PE. Hence, this study aims to report differentially expressed microRNAs that may be associated with the pathogenesis of PE and investigate whether different miRNA expression profiles are associated with different PE classifications and different phases of pregnancy. The bibliographic search was conducted from September 2021 to August 2024 and was performed on MEDLINE/PubMed, EMBASE, and Web of Science. This systematic review followed the methodological guidelines of the Cochrane Collaboration Manual for Systematic Intervention Reviews and was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Of the 1362 studies identified, 263 articles were selected as the sample of this study. The most frequently cited upregulated microRNAs were: miR-210, miR-155, miR-518b, miR-181a, miR-125b, miR-183, and miR-16. The most frequently cited downregulated microRNAs were: miR-363, miR-18a, miR-144, miR-149, miR-16, miR-18b, and miR-195. This study will serve as a reference to guide future experimental research. In addition, knowledge of the expression profiles of microRNAs associated with PE can help in the development of new protocols for early prediction of the disease.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e13988"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The body weight-walking distance product as a superior parameter in determining the VO2 on-kinetics in coronary artery disease. 体重-步行距离乘积作为确定冠状动脉疾病VO2动力学的优越参数。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14367

I S Rocco, W J Gomes, M Viceconte, B C Matos-Garcia, F S Menezes-Rodrigues, F S Tallo, R M Arida, N A Hossne Junior, R Arena, S Guizilini

{"title":"The body weight-walking distance product as a superior parameter in determining the VO2 on-kinetics in coronary artery disease.","authors":"I S Rocco, W J Gomes, M Viceconte, B C Matos-Garcia, F S Menezes-Rodrigues, F S Tallo, R M Arida, N A Hossne Junior, R Arena, S Guizilini","doi":"10.1590/1414-431X2025e14367","DOIUrl":"10.1590/1414-431X2025e14367","url":null,"abstract":"The 6-minute walk test is frequently used to assess the functional capacity of the cardiac disease population. Nevertheless, anthropometric differences can confound or misestimate performance, which highlights the need for new parameters. This study aimed to investigate the potential of the body weight-walking distance product (D·W) compared to the 6-minute walk test distance to predict exercise capacity measured by oxygen uptake (VO2) on-kinetics in coronary artery disease (CAD) patients. A cross-sectional study was conducted in a tertiary-care reference institution. Forty-six participants with multivessel CAD with and without left ventricular dysfunction underwent a 6-minute walk test with simultaneous use of mobile telemetric cardiopulmonary monitoring to evaluate VO2 kinetics and other cardiorespiratory responses. The Borg rating of perceived exertion for lower limb discomfort was only correlated with the D·W (P=0.007). The percent predicted and actual distance were only modestly to moderately correlated with VO2 on-kinetics (R2=0.12 and R2=0.29, P<0.05). All the associations of VO2 on-kinetics parameters were improved, showing a stronger correlation to the D·W (R2=0.49, P<0.0001), which also had a larger effect size to identify differences between coronary disease patients compared to distance walked (d=1.32 vs d=0.84). The D·W demonstrated potential to be better than the distance walked in determining VO2 on-kinetics in participants with CAD with and without left ventricular dysfunction.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14367"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Montelukast reduced docetaxel-induced peripheral neuropathy in rats by altering oxidative stress, histopathological damage, and gene expressions. 孟鲁司特通过改变氧化应激、组织病理学损伤和基因表达来减少多西他赛诱导的大鼠周围神经病变。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI: 10.1590/1414-431X2025e14602

M D Karakoç, Ö Özmen, M N Zengin, O Çiftçi

{"title":"Montelukast reduced docetaxel-induced peripheral neuropathy in rats by altering oxidative stress, histopathological damage, and gene expressions.","authors":"M D Karakoç, Ö Özmen, M N Zengin, O Çiftçi","doi":"10.1590/1414-431X2025e14602","DOIUrl":"10.1590/1414-431X2025e14602","url":null,"abstract":"Peripheral neuropathy (PN) is a common side effect of docetaxel (DTX). In this study, we aimed to evaluate the effects of montelukast (MNT), a leukotriene receptor antagonist drug, against DTX-induced PN in rats. Thirty-two male rats were divided into four groups and treated for four weeks: control (sham), DTX (5 mg/kg per week, ip), MNT (10 mg/kg per day, po), and DTX+MNT (5 mg/kg per week, ip + 10 mg/kg per day, po). Behavioral tests (hot plate, tail flick, and rotarod) were conducted. Histopathological, molecular (RT-PCR), and biochemical (ELISA) analyses were performed on sciatic nerve, liver, and serum samples. MNT reduced the malondialdehyde (MDA) levels and increased the superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) parameters in sciatic nerve tissues. Unlike DTX, MNT resulted in increased Bcl-2 gene expression and decreased caspase-3 (Cas-3) and Bax expressions. DTX caused sensory and motor neuropathy, as revealed by the hot plate, tail flick, and rotarod tests. The co-administration of MNT significantly mitigated the sensory and motor neuropathy induced by DTX. MNT improved the levels of NCAM, p38α MAPK, and nuclear factor kappa B (NF-κB), which were impaired in the sciatic nerve tissues due to DTX administration. Additionally, it reduced the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), which had increased due to DTX. Histopathological examination revealed that DTX-related sciatic nerve damage was mitigated by MNT administration. The results indicated that MNT may have a protective effect against DTX-induced PN in rats.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"58 ","pages":"e14602"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0