Brazilian Journal of Medical and Biological Research最新文献_第5页

The emerging role of the microbiome in bladder cancer: prognostic implications and treatment response. 微生物组在膀胱癌中的新作用：预后意义和治疗反应。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-27 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e15526

J Côrtes, J C S Trindade Filho, S R Rogatto

{"title":"The emerging role of the microbiome in bladder cancer: prognostic implications and treatment response.","authors":"J Côrtes, J C S Trindade Filho, S R Rogatto","doi":"10.1590/1414-431X2026e15526","DOIUrl":"10.1590/1414-431X2026e15526","url":null,"abstract":"Bladder cancer (BCa) is a histologically and molecularly heterogeneous disease and is one of the leading causes of cancer death globally. The main risk factors are sex (with incidence 3 to 4 times higher in men), tobacco usage, occupational exposure to carcinogens, and persistent infections, such as those caused by Schistosoma haematobium. Urine and the bladder were recently confirmed to be non-sterile, prompting investigations into the urinary and intratumoral microbiomes and their roles in tumor stage, prognosis, and therapy response. In this context, the role of the urinary and intratumoral microbiome in bladder carcinoma is among the most promising areas in translational uro-oncology. Recent evidence demonstrates the presence and diversity of microbial communities in both urine and bladder cancer tissue, with patterns associated with tumor stage and prognosis. Chronic inflammation, genotoxin production, altered carcinogen metabolism, and modulation of the immune microenvironment are biological processes that provide a rationale for the functional role of these microorganisms in the bladder. Furthermore, microbial profiles have been correlated with responses to intravesical therapies (such as BCG - Bacillus Calmette-Guérin) and, potentially, with systemic immunotherapies. The microbiome can help identify predictors of treatment response and potential adjuvant interventions, and offers a non-invasive, translational pathway for diagnosis and surveillance. This review summarizes current evidence on the microbiome in bladder cancer patients and its prognostic and therapeutic potential.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e15526"},"PeriodicalIF":1.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 mortality risk among women with ovarian cancer: a matched case-control study. 卵巢癌妇女COVID-19死亡风险：一项匹配病例对照研究

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-27 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e15084

K P I Peruchi, V A F Bastos, L A Teixeira, F F Pimentel, F J Candido Dos Reis

{"title":"COVID-19 mortality risk among women with ovarian cancer: a matched case-control study.","authors":"K P I Peruchi, V A F Bastos, L A Teixeira, F F Pimentel, F J Candido Dos Reis","doi":"10.1590/1414-431X2026e15084","DOIUrl":"10.1590/1414-431X2026e15084","url":null,"abstract":"Women with ovarian cancer may be at increased risk of severe COVID-19 outcomes. This study aimed to compare mortality and clinical outcomes between women with severe COVID-19, with and without a history of ovarian cancer. We conducted a matched case-control study using national surveillance data. Cases included women with severe COVID-19 and a history of ovarian cancer; controls were women with severe COVID-19 without such history. Matching was done at a 1:4 ratio using age, comorbidities, vaccination status, diagnosis date, and region. The primary outcome was COVID-19-related mortality. A total of 474 ovarian cancer cases and 1,896 controls were included. Mortality was significantly higher in women with ovarian cancer (54.9 vs 32.7%, P<0.001). Multivariate analysis showed that ovarian cancer increased the risk of death (OR: 2.76, 95%CI: 2.22-3.43). Age also influenced mortality: OR 2.57 (95%CI: 2.11-3.13) for women aged 65-84, and OR 3.86 (95%CI: 2.52-5.97) for those 85 and older. Vaccination provided protection: complete vaccination (OR: 0.67, 95%CI: 0.51-0.88) and complete vaccination plus booster (OR: 0.35, 95%CI: 0.27-0.47). Women with ovarian cancer had a significantly higher risk of death from severe COVID-19. Vaccination, particularly with a booster, was associated with 65% reduced mortality.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e15084"},"PeriodicalIF":1.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brazilian science through the looking glass: a scientometric perspective from within and beyond. 透过镜子看巴西科学：科学计量学的内外视角。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-27 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e15002

A Sá-Nunes, Y M Pessoa-Gonçalves, C J F Oliveira

{"title":"Brazilian science through the looking glass: a scientometric perspective from within and beyond.","authors":"A Sá-Nunes, Y M Pessoa-Gonçalves, C J F Oliveira","doi":"10.1590/1414-431X2026e15002","DOIUrl":"10.1590/1414-431X2026e15002","url":null,"abstract":"Citation analysis has emerged as a key area in scientometrics. However, the global movement toward open science, alongside the pervasive \"publish or perish\" culture, underscores the need to reevaluate the paradigm of citations as a measure of impact and quality. Brazil, a top 15 producer of scientific articles, has established the Lattes Platform, a comprehensive resource data on virtually active researchers in the country. Herein, the Brazilian scientific landscape was analyzed by integrating a widely used global ranking based on large-scale citation metrics with individual-level data from the Lattes Platform. The analysis assessed the impact, distribution, and disparities of Brazilian science across disciplines, geographic regions, and institutional affiliations from 2019-2023. Results showed that Brazilian researchers account for approximately 0.43% of the world's most cited scientists, a significant underrepresentation relative to Brazil's population share and scientific potential. Most highly cited scientists are concentrated in three states within the Southeast region, reflecting longstanding economic and infrastructural advantages. The majority of top Brazilian scientists work in Life Sciences, with particular representation in the subfields Zoology, Tropical Medicine, and Mycology & Parasitology. While Brazil's scientific output compares favorably with other South American and African countries, it remains behind nations with higher gross domestic products per capita and Human Development Index. Nonetheless, 73% of the most cited researchers receive national Research Productivity Grants, indicating a positive correlation between citation and qualified scientific excellence. These findings offer a deeper understanding of Brazilian scientific production from a citation perspective and advocate for strategic policy shifts.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e15002"},"PeriodicalIF":1.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardizing the lateral fluid percussion model of trauma in marmosets (Callithrix jacchus): regional vulnerability and inflammatory response. 规范绒猴创伤侧流冲击模型：区域易损性和炎症反应。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-27 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e15289

V Sanabria, C Gimenes, S Romariz, M Braga, A S Gois, M L Foresti, L E Mello, B M Longo

{"title":"Standardizing the lateral fluid percussion model of trauma in marmosets (Callithrix jacchus): regional vulnerability and inflammatory response.","authors":"V Sanabria, C Gimenes, S Romariz, M Braga, A S Gois, M L Foresti, L E Mello, B M Longo","doi":"10.1590/1414-431X2026e15289","DOIUrl":"10.1590/1414-431X2026e15289","url":null,"abstract":"Traumatic brain injury (TBI) is a major global health concern. The lateral fluid percussion injury (LFPI) model, widely used in rodents to simulate nonpenetrating TBI, has limited translational applicability due to anatomical differences between rodent and human brains. The common marmoset (Callithrix jacchus), a New World primate with a quasi-gyrencephalic brain, offers a promising alternative. This study aimed to standardize the LFPI model in marmosets by comparing trauma responses across parietal and temporal lobes. Ten adult marmosets underwent LFPI in these regions. Lesion volume was measured using Nissl staining; astrocytic and microglial responses were assessed via GFAP and Iba-1 immunofluorescence, and degenerating neurons were identified with Fluoro-Jade B. Righting reflex time and hemorrhage presence were evaluated as injury markers. Percussion aiming at the temporal lobe injury resulted in the most prominent lesions, epidural and subdural hematomas, and significant neuronal degeneration. Astrocytes showed longer processes after temporal trauma in the cortex and fewer branches in the hippocampal region CA1 than in the naive group. In contrast, hippocampal microglia showed fewer elongated branches in CA1 and dentate gyrus (DG), indicative of a reactive phenotype. Our results highlighted region-specific vulnerability, with temporal injury triggering the most pronounced inflammatory and degenerative responses. The marmoset LFPI model effectively mirrored key aspects of human TBI, supporting its translational relevance.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e15289"},"PeriodicalIF":1.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ferroptosis in vascular endothelial cells and its role in the pathogenesis of cervical spondylosis of vertebral artery type: a comprehensive review. 血管内皮细胞中铁下垂的作用及其在椎动脉型颈椎病发病中的作用：综合综述。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e15287

Xiaoyi Fan, Sisi Xu, Huiquan Gao

引用次数: 0

Assessing the significance of cytomegalovirus reactivation in recipients of allogeneic hematopoietic stem cell transplantation: a cohort study. 评估巨细胞病毒再激活在异基因造血干细胞移植受者中的意义：一项队列研究

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e15073

L P de Oliveira, E J A Paton, M F Giovanardi, A F da Silva, L G Tavares, C G Fernandes, J O Dias, R A Fabreti-Oliveira

{"title":"Assessing the significance of cytomegalovirus reactivation in recipients of allogeneic hematopoietic stem cell transplantation: a cohort study.","authors":"L P de Oliveira, E J A Paton, M F Giovanardi, A F da Silva, L G Tavares, C G Fernandes, J O Dias, R A Fabreti-Oliveira","doi":"10.1590/1414-431X2026e15073","DOIUrl":"10.1590/1414-431X2026e15073","url":null,"abstract":"Cytomegalovirus (CMV) infection increases morbidity in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Despite advancements in prevention and treatment, CMV reactivation remains a considerable concern following allo-HSCT. In this study, we aimed to evaluate the impact of CMV reactivation in allo-HSCT recipients on clinical outcomes and patient survival, as well as to identify the risk factors associated with CMV reactivation. This retrospective observational cohort study included data from 67 transplantations performed between 2019 and 2022 at a private hospital in Belo Horizonte, Brazil. Clinical, laboratory, and procedural data were collected. The median age of the patients was 47.0 years, and 52.2% of them were women. The most frequent indication for allo-HSCT was acute myeloid leukemia (28.4%), followed by myelodysplastic syndrome (16.4%). CMV reactivation occurred in 62.7% of the recipients, and the median time to CMV reactivation was 32.5 days. Six patients (9.0%) presented with CMV end-organ disease (83.3% were free of systemic disease); however, when present, gastrointestinal involvement was the most common disease (4.5%). In the multivariate analysis, the risk factors for CMV reactivation included acute lymphoblastic leukemia (P=0.006), mismatched human leukocyte antigen (HLA)-unrelated donors (P=0.002), and graft-versus-host disease (P=0.024). One-year overall survival was 57.7%. However, CMV reactivation was not significantly associated with mortality after controlling for confounding factors. CMV reactivation remains a common complication following allo-HSCT, with leukemia type, donor type, and graft-versus-host disease affecting the risk of disease recurrence. No direct correlation was observed between CMV recurrence and increased mortality or patient survival.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e15073"},"PeriodicalIF":1.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined antiretroviral therapy with low- or normal-protein, high-calorie diets appears to induce significant deleterious electrocardiographic changes in a rodent model. 在啮齿动物模型中，抗逆转录病毒治疗与低蛋白或正常蛋白、高热量饮食相结合似乎会诱发显著的有害心电图变化。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e14744

B M Chege, P W Mwangi, C G Githinji, F Bukachi

{"title":"Combined antiretroviral therapy with low- or normal-protein, high-calorie diets appears to induce significant deleterious electrocardiographic changes in a rodent model.","authors":"B M Chege, P W Mwangi, C G Githinji, F Bukachi","doi":"10.1590/1414-431X2026e14744","DOIUrl":"10.1590/1414-431X2026e14744","url":null,"abstract":"The introduction of combination antiretroviral therapy (cART) has significantly reduced AIDS-related morbidity and mortality. However, the prevalence of age-associated comorbidities, particularly cardiovascular diseases (CVD), has increased, becoming a leading cause of mortality in people living with HIV. This study investigated the interaction between cART regimens and dietary composition on electrocardiographic (ECG) parameters and myocardial histopathology. A total of 120 weanling Sprague Dawley rats were allocated to one of three diets for 15 weeks: normal chow, a calorie-dense low protein (CDLP) diet, or a calorie-dense normal protein (CDNP) diet. Each dietary group was then subdivided into four treatment groups for a further 9 weeks: a standard group (normal saline), Test group 1 (dolutegravir (DTG) plus tesamorelin), Test group 2 (DTG only), and a positive control (classical cART regimen). ECG recordings and histological assessments were performed at week 24. Significant intergroup variations in ECG indices were observed, including Q, R, S, and T wave amplitudes, PR interval, QRS duration, ST height, and QTc (all P<0.0001). Myocardial fibrosis (P<0.0001) was evident in animals from the TG2 (DTG only) and PC (classical regimen) groups maintained on CDLP and CDNP diets. These findings demonstrated that CDLP and CDNP diets, combined with DTG-based or classical cART regimens, exerted deleterious cardiac effects, promoting myocardial fibrosis that disrupts normal electrical conduction and may predispose to arrhythmogenesis. Tesamorelin prevented these effects, implicating growth hormone pathway dysfunction in the underlying pathology.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e14744"},"PeriodicalIF":1.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical stability and compatibility of acetaminophen injection with six common opioid drugs: implications for clinical use. 对乙酰氨基酚注射液与六种常见阿片类药物的化学稳定性和相容性：对临床使用的影响。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2026e15263

Weilin Huang, Shuyang He, Miao Zhao, Shunyuan Hong, Junhong Xu, Limin Chen, Xianping Wu

{"title":"Chemical stability and compatibility of acetaminophen injection with six common opioid drugs: implications for clinical use.","authors":"Weilin Huang, Shuyang He, Miao Zhao, Shunyuan Hong, Junhong Xu, Limin Chen, Xianping Wu","doi":"10.1590/1414-431X2026e15263","DOIUrl":"10.1590/1414-431X2026e15263","url":null,"abstract":"Despite the clinical importance of combining acetaminophen and opioids in multimodal analgesia, their compatibility has not been determined. This study aimed to investigate the stability and feasibility of mixing acetaminophen injection with six commonly used opioid drugs. Acetaminophen injection was mixed with each of the six opioid drugs at room temperature (25°C). Changes in appearance, pH, and acetaminophen concentrations were monitored at different time intervals to evaluate compatibility. Compatibility was defined as no visible changes, pH variation <1.0, and acetaminophen concentration ≥90% of baseline. The results indicated that acetaminophen injection, when mixed with six commonly used opioid drugs, remained stable for up to 48 h at room temperature. No significant changes were observed in the appearance of the mixtures, which remained clear and free of precipitation. The pH of the mixtures fluctuated by less than 1.0 unit, and the acetaminophen concentration remained above 90% of the baseline value, with a variation of less than 10%. Acetaminophen injection was compatible with morphine, sufentanil, hydromorphone, pentazocine, butorphanol, and nalbuphine for at least 48 h at 25°C, supporting their co-use in patient-controlled intravenous analgesia. Further studies should define pharmacokinetics and adverse effects of these combinations.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e15263"},"PeriodicalIF":1.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How sexual behavior in male rats is inhibited by repeated maternal separation during early postnatal development. 雄性大鼠的性行为如何在出生后早期发育过程中被反复的母性分离所抑制。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2025e14808

M R Ferraz, L N Santos, J S Guimarães, J S Casimiro E Silva, E S Barbosa, S S da Silva, V U Monteiro

{"title":"How sexual behavior in male rats is inhibited by repeated maternal separation during early postnatal development.","authors":"M R Ferraz, L N Santos, J S Guimarães, J S Casimiro E Silva, E S Barbosa, S S da Silva, V U Monteiro","doi":"10.1590/1414-431X2025e14808","DOIUrl":"10.1590/1414-431X2025e14808","url":null,"abstract":"Perinatal stress can have lasting effects on hormone regulation and behavior. An association between maternal separation and depressive illness is well established. The present study was undertaken to investigate the effects of maternal separation on both motivational and consummatory measures and on the temporal patterning of sexual behavior in male rats. Litters were separated from their mothers for 180 min per day from P1 to P21 (birth=P0) and placed in an isolated box. Control litters remained with their mothers and were not disturbed. At 90 days of age, the sexual behavior of the male rats was assessed using both standard behavioral parameters and mount bout analysis. The forced swim test, open field test, and elevated plus maze test were used to assess anxious and depressive behavior. Each rat was subjected to a single type of behavioral protocol. The inhibitory effect of maternal separation on the sexual behavior of male rats was shown by an increase in mount, intromission, and ejaculation latencies, mount and intromission frequency, and interintromission interval, and a decrease in intromission ratio. Maternally separated rats showed a delayed temporal patterning of sexual behavior. In addition, there was an increase in depressive and anxiety-like behavior in maternally separated rats. The present results suggest that perinatal stress induced by maternal separation leads to changes in sexual behavior and depressive and anxiety-like behavior in male rats. In this sense, early postnatal stress may cause behavioral changes that persist into adulthood.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e14808"},"PeriodicalIF":1.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of mind map-guided nursing on pain control after transurethral resection of the prostate. 思维导图引导护理对经尿道前列腺切除术后疼痛控制的影响。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.1590/1414-431X2025e15233

Nan Zhao, Eryun Tian

{"title":"Effect of mind map-guided nursing on pain control after transurethral resection of the prostate.","authors":"Nan Zhao, Eryun Tian","doi":"10.1590/1414-431X2025e15233","DOIUrl":"10.1590/1414-431X2025e15233","url":null,"abstract":"We aimed to analyze the effect of mind map-guided nursing on pain control after transurethral resection of the prostate (TURP). Eighty patients with benign prostatic hyperplasia undergoing TURP were randomly separated into either a control group (routine perioperative nursing) or an intervention group (mind map-guided nursing). Visual Analog Scale (VAS) scores were employed to compare pain levels at 24 and 48 h postoperatively. Additional outcomes included the number of patient-controlled analgesia activations, time to first flatus, and length of hospital stay. Quality of life (Short Form-36 (SF-36)), sleep quality (Pittsburgh Sleep Quality Index (PSQI)), anxiety and depression (Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS)), and prostate function (International Prostate Symptom Score (IPSS)) were evaluated before and after nursing interventions. Patient satisfaction with nursing care was also compared. After nursing interventions, the intervention group exhibited lower VAS scores at 24 and 48 h postoperatively, fewer analgesia pump activations, shorter time to first flatus, and reduced length of hospital stay, higher SF-36 scores across all dimensions, lower PSQI, SAS, SDS, and IPSS scores, as well as higher nursing satisfaction versus the control group (all P<0.05). Mind map-guided nursing alleviated postoperative pain following TURP, enhanced quality of life, sleep quality, and mental state, promoted prostate function recovery, and enhanced patient satisfaction with nursing.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"59 ","pages":"e15233"},"PeriodicalIF":1.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0