Brazilian Journal of Medical and Biological Research最新文献_第10页

The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT. Tim-3+CD8+T细胞的水平可作为一种潜在的标志物，用于评估单倍体骨髓造血干细胞移植后急性移植物抗宿主疾病的严重程度。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-12-18 eCollection Date: 2023-01-01 DOI: 10.1590/1414-431X2023e12997

Nannan Pang, Mingkai Yu, Jianli Xu, Hailong Yuan, Gang Chen, Dong Wang, Chunxia Han, Weiguo Wang, Jianbing Ding, Ming Jiang

{"title":"The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT.","authors":"Nannan Pang, Mingkai Yu, Jianli Xu, Hailong Yuan, Gang Chen, Dong Wang, Chunxia Han, Weiguo Wang, Jianbing Ding, Ming Jiang","doi":"10.1590/1414-431X2023e12997","DOIUrl":"10.1590/1414-431X2023e12997","url":null,"abstract":"Early and accurate diagnosis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation is crucial for the prognosis of patients. This study identified a potential biomarker for the severity of aGVHD after human leukocyte antigen (HLA)-haploidentical peripheral blood hematopoietic stem cell transplantation (haplo-PBSCT). We included 20 healthy subjects and 57 patients who underwent haplo-PBSCT. Of these patients, 22 developed aGVHD after haplo-PBSCT. The results showed that patients with aGVHD had significantly increased levels of Tim-3+/Perforin+/Granzyme B+CD8+ T cells, but significantly decreased Galectin-9. The differences in Galectin-9 and Tim-3+/Granzyme B+CD8+ T cells between grade I-II aGVHD and III-IV aGVHD were also significant. In vitro, the apoptosis of CD8+ T cells from aGVHD patients was significantly increased after Tim-3/Galectin-9 pathway activation, which decreased Granzyme B secretion. As revealed by univariate analysis, the level of Tim-3+CD8+ T cells was a risk factor for severe aGVHD. ROC analysis demonstrated that high levels of Tim-3+CD8+ T cells had a significant diagnostic value for severe aGVHD, with an area under the curve of 0.854 and cut-off value of 14.155%. In conclusion, the binding of Tim-3 with exogenous Galectin-9 can promote apoptosis of CD8+ T cells and affect the secretion of Granzyme B. Tim-3+CD8+ T cells have the potential to serve as immunological markers for assessing the severity of aGVHD after haplo-PBSCT and identifying patients at a higher risk for severe aGVHD.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis. 血液透析抑郁症患者的生活质量和功能能力：系统回顾和荟萃分析。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-12-18 eCollection Date: 2023-01-01 DOI: 10.1590/1414-431X2023e12850

M B Moreira, N P Cavalli, N C Righi, F B Schuch, L U Signori, A M V da Silva

{"title":"Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis.","authors":"M B Moreira, N P Cavalli, N C Righi, F B Schuch, L U Signori, A M V da Silva","doi":"10.1590/1414-431X2023e12850","DOIUrl":"10.1590/1414-431X2023e12850","url":null,"abstract":"Depression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, SPORTDiscus, Web of Science, and Cochrane (CENTRAL) databases were used to search for studies. The New Castle-Ottawa Quality Assessment scale was used to measure the quality of the studies. A total of 4,626 studies were found and, after applying the selection criteria, 16 studies (2,175 patients) remained for qualitative analysis and 10 for meta-analysis (1,484 patients). The physical component summary (MD=-6.563; 95%CI: -9.702 to -3.424) and mental component summary (MD=-18.760; 95%CI: -28.641 to -8.879) were lower in depressive patients, as in all Short Form Health Survey 36 (SF-36) domains. Only one study provided data regarding functional capacity, but it was not evaluated by the defined outcome measure. Twelve studies were classified as \"moderate quality\" (5 to 6 stars) and four were classified as \"low-quality\" (0 to 4 stars). This meta-analysis with CKD patients on hemodialysis showed a negative relationship between depression and quality of life, with worsening in all physical and mental domains of the SF-36 in depressed patients.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sialic acid as the potential link between lipid metabolism and inflammation in the pathogenesis of atherosclerosis 唾液酸是动脉粥样硬化发病机制中脂质代谢和炎症之间的潜在联系

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-12-11 DOI: 10.1590/1414-431X2023e12972

A. Poznyak, D. Kashirskikh, A. Y. Postnov, 00 M.A, Popov, V. N. Sukhorukov, A. Orekhov

{"title":"Sialic acid as the potential link between lipid metabolism and inflammation in the pathogenesis of atherosclerosis","authors":"A. Poznyak, D. Kashirskikh, A. Y. Postnov, 00 M.A, Popov, V. N. Sukhorukov, A. Orekhov","doi":"10.1590/1414-431X2023e12972","DOIUrl":"https://doi.org/10.1590/1414-431X2023e12972","url":null,"abstract":"In the modern world, cardiovascular diseases have a special place among the most common causes of death. Naturally, this widespread problem cannot escape the attention of scientists and researchers. One of the main conditions preceding the development of fatal cardiovascular diseases is atherosclerosis. Despite extensive research into its pathogenesis and possible prevention and treatment strategies, many gaps remain in our understanding of this disease. For example, the concept of multiple low-density lipoprotein modifications was recently stated, in which desialylation is of special importance. Apart from this, sialic acids are known to be important contributors to processes such as endothelial dysfunction and inflammation, which in turn are major components of atherogenesis. In this review, we have collected information on sialic acid metabolism, analyzed various aspects of its implication in atherosclerosis at different stages, and provided an overview of the role of particular groups of enzymes responsible for sialic acid metabolism in the context of atherosclerosis.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing multiple factors affecting the gut microbiome structure of very preterm infants 评估影响早产儿肠道微生物群结构的多种因素

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-12-11 DOI: 10.1590/1414-431X2023e13186

Wenlong Xiu, Jiajia Lin, Yanhua Hu, Heng Tang, Shuangchan Wu, Changyi Yang

{"title":"Assessing multiple factors affecting the gut microbiome structure of very preterm infants","authors":"Wenlong Xiu, Jiajia Lin, Yanhua Hu, Heng Tang, Shuangchan Wu, Changyi Yang","doi":"10.1590/1414-431X2023e13186","DOIUrl":"https://doi.org/10.1590/1414-431X2023e13186","url":null,"abstract":"The composition and diversity of the gut microbiota are essential for the health and development of the immune system of infants. However, there is limited information on factors that influence the gut microbiota of very preterm infants. In this study, we analyzed factors that affect the gut microbiota of very preterm infants. The stool samples from 64 very preterm infants with a gestational age less than 32 weeks were collected for 16S rRNA gene sequencing. The infants were divided according to the delivery mode, antibiotic use during pregnancy, and feeding methods. The abundance of Proteobacteria was high in both cesarean (92.7%) and spontaneous (55.5%) delivery groups and then shifted to Firmicutes after the first week of birth. In addition, Proteobacteria was also the dominant phylum of infant gut microbiome for mothers with antibiotic use, with more than 50% after the first week of birth. In comparison, the dominant phylum for mothers without antibiotic use was Firmicutes. Proteobacteria level was also high in breastfeeding and mixed-feeding groups, consisting of more than 90% of the community. By contrast, Proteobacteria was the dominant phylum at the first week of birth but then shifted to Firmicutes for the formula-fed group. The alterations of gut microbiota in infants can affect their health condition during growth. This study confirmed that the different feeding types, delivery modes, and use of antibiotics during pregnancy can significantly affect the composition of the gut microbiota of very preterm infants.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroblastoma with superficial soft tissue mass as the first symptom: case reports with atypical ultrasonic image and literature review 以浅表软组织肿块为首发症状的神经母细胞瘤：伴有非典型超声图像的病例报告和文献综述

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-12-11 DOI: 10.1590/1414-431X2023e12975

Jiale Hu, Bei Xia, Xiuli Yuan, Haixing Chen, Fuxiang Ou, Longlong Huang, Lei Xu, Xia Feng

引用次数: 0

Rectangular method: a modified technique for sampling the ischemic border zone in a rat model of transient middle cerebral artery occlusion 矩形法：在大鼠一过性大脑中动脉闭塞模型中对缺血边界区取样的改良技术

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-12-11 DOI: 10.1590/1414-431X2023e13140

Sui-Yi Xu, Mao-mei Song, Xue Pan, Shi-na Song, Qi Zhang, Changpei Li

{"title":"Rectangular method: a modified technique for sampling the ischemic border zone in a rat model of transient middle cerebral artery occlusion","authors":"Sui-Yi Xu, Mao-mei Song, Xue Pan, Shi-na Song, Qi Zhang, Changpei Li","doi":"10.1590/1414-431X2023e13140","DOIUrl":"https://doi.org/10.1590/1414-431X2023e13140","url":null,"abstract":"To date, there have been three common methods for sampling the cerebral ischemic border zone in a rat model of transient middle cerebral artery occlusion (tMCAO): the “two o'clock method”, the “diagonal method”, and the “parallel line method”. However, these methods have their own advantages and limitations. Here, we propose a modified technique (the “rectangular method“) for sampling the ischemic border zone. A rat tMCAO model was prepared under the support of a compact small animal anesthesia machine. Cerebral blood flow was monitored by high-resolution laser Doppler to control the quality of modeling, and 2,3,5-triphenyl tetrazolium chloride (TTC) staining was used for cerebral infarction location assessment. Superoxide dismutase 2 (SOD2), cysteinyl aspartate specific proteinase (caspase)-3, caspase-9, and heat shock protein 70 (HSP70) were used to verify the reliability and reproducibility of the rectangular method. The expression of biomarkers (SOD2, caspase-3, caspase-9, and HSP70) in the traditional (two o'clock method after TTC staining) and modified (rectangular method) groups were increased. There were no significant differences between the groups. The rectangular method proposed herein is based on a modification of the diagonal method and parallel line method, which could provide a directly observable infarct borderline and a sufficient sampling area for subsequent experimental operations regardless of the cerebral infarct location. The assessed biomarkers (SOD2, caspase-3, caspase-9, and HSP70) demonstrated the reliability and reproducibility of the rectangular method, which may facilitate inter-laboratory comparisons.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory oscillometry and functional analyses in patients with idiopathic scoliosis. 特发性脊柱侧凸患者的呼吸示波测定和功能分析。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-11-03 eCollection Date: 2023-01-01 DOI: 10.1590/1414-431X2023e12898

C M S Sousa, A L C Pessoa, L E Carelli, C O Ribeiro, A J Lopes, P L Melo

{"title":"Respiratory oscillometry and functional analyses in patients with idiopathic scoliosis.","authors":"C M S Sousa, A L C Pessoa, L E Carelli, C O Ribeiro, A J Lopes, P L Melo","doi":"10.1590/1414-431X2023e12898","DOIUrl":"10.1590/1414-431X2023e12898","url":null,"abstract":"Scoliosis is a condition that affects the spine and causes chest rotation and trunk distortion. Individuals with severe deformities may experience dyspnea on exertion and develop respiratory failure. Respiratory oscillometry is a simple and non-invasive method that provides detailed information on lung mechanics. This work aims to investigate the potential of oscillometry in the evaluation of respiratory mechanics in patients with scoliosis and its association with physical performance. We analyzed 32 volunteers in the control group and 32 in the scoliosis group. The volunteers underwent traditional pulmonary function tests, oscillometry, and the 6-minute walk test (6MWT). Oscillometric analysis showed increased values of resistance at 4 Hz (R4, P<0.01), 12 Hz (R12, P<0.0001), and 20 Hz (R20, P<0.01). Similar analysis showed reductions in dynamic compliance (Cdyn, P<0.001) and ventilation homogeneity, as evaluated by resonance frequency (fr, P<0.001) and reactance area (Ax, P<0.001). Respiratory work, described by the impedance modulus, also showed increased values (Z4, P<0.01). Functional capacity was reduced in the group with scoliosis (P<0.001). A significant direct correlation was found between Cobb angle and R12, AX, and Z4 (P=0.0237, P=0.0338, and P=0.0147, respectively), and an inverse correlation was found between Cdyn and Cobb angle (P=0.0190). These results provided new information on respiratory mechanics in scoliosis and are consistent with the involved pathophysiology, suggesting that oscillometry may improve lung function tests for patients with scoliosis.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of N-butanol extract of Amygdalus mongolica on rats with bleomycin-induced pulmonary fibrosis based on metabolomics. 基于代谢组学的蒙古苦杏仁正丁醇提取物对博莱霉素诱导的大鼠肺纤维化的影响。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-11-03 eCollection Date: 2023-01-01 DOI: 10.1590/1414-431X2023e13045

Chen Gao, Yingchun Bai, Hongbing Zhou, Hongyu Meng, Tong Wu, Wanfu Bai, Jia Wang, Liya Fan, Yuxi Yang, Hong Chang, Songli Shi

{"title":"Effects of N-butanol extract of Amygdalus mongolica on rats with bleomycin-induced pulmonary fibrosis based on metabolomics.","authors":"Chen Gao, Yingchun Bai, Hongbing Zhou, Hongyu Meng, Tong Wu, Wanfu Bai, Jia Wang, Liya Fan, Yuxi Yang, Hong Chang, Songli Shi","doi":"10.1590/1414-431X2023e13045","DOIUrl":"10.1590/1414-431X2023e13045","url":null,"abstract":"Pulmonary fibrosis (PF) is a major public health issue with limited treatment options. As the active ingredient of the n-butanol extract of Amygdalus mongolica (BUT), amygdalin inhibits PF. However, its mechanisms of action are unclear and need further verification. Therefore, the purpose of the present studies was to investigate the anti-fibrotic effects of BUT on PF by serum metabolomics and the transforming growth factor β (TGF-β) pathway. Sixty male Sprague-Dawley rats were randomly divided into control, untreated PF, prednisone-treated (5 mg/kg), and BUT-treated (1.75, 1.25, 0.75 g/kg) groups, and the respective drugs were administered intragastrically for 21 days. The serum metabolomics profiles were determined by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) and metabolism network analysis. The expression of TGF-β1, Smad-3, Smad-7, and α-smooth muscle actin (α-SMA) was measured using a real-time polymerase chain reaction in the lung tissue. BUT significantly alleviated fibrosis by reducing the mRNA expressions of TGF-β1 (from 1.73 to 1.13), Smad-3 (from 2.01 to 1.19), and α-SMA (from 2.14 to 1.19) and increasing that of Smad7 (from 0.17 to 0.62). Twenty-eight potential biomarkers associated with PF were identified. In addition, four key biomarkers were restored to baseline levels following BUT treatment, with the lowest dose showing optimal effect. Furthermore, A. mongolica BUT was found to improve PF by the pentose phosphate pathway and by taurine, hypotaurine, and arachidonic acid metabolism. These findings revealed the mechanism of A. mongolica BUT antifibrotic effects and metabolic activity in PF rats and provided the experimental basis for its clinical application.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary phytate induces subclinical mechanical allodynia in mice. 膳食植酸酶诱导小鼠亚临床机械性异常性疼痛。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-11-03 eCollection Date: 2023-01-01 DOI: 10.1590/1414-431X2023e12955

D O Matias, T Sisnande, A F Martins, M J do Amaral, B L R Santos, A L P Miranda, L M T R Lima

引用次数: 0

Evaluating the dissemination of evolutionary biology concepts in medicine. 评估进化生物学概念在医学中的传播。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2023-10-27 eCollection Date: 2023-01-01 DOI: 10.1590/1414-431X2023e13052

C Mermelstein, M L Costa, C C Coutinho

{"title":"Evaluating the dissemination of evolutionary biology concepts in medicine.","authors":"C Mermelstein, M L Costa, C C Coutinho","doi":"10.1590/1414-431X2023e13052","DOIUrl":"https://doi.org/10.1590/1414-431X2023e13052","url":null,"abstract":"Darwin's theory of evolution, which is based on variation, heredity, and selection, includes all biological fields and spreads to other areas such as philosophy. Medicine is an example of how the evolutionary perspective can greatly improve the understanding of concepts in an area, as human health and pathological conditions are under the effect of evolution. Evolutionary medicine is an emerging paradigm for understanding human heterogeneity, health, and diseases. Nevertheless, there are indications that medical research and practice are only marginally affected by these ideas. Here, we investigate how concepts of biological evolution are employed in medical research. We use a bibliometric approach to look for the presence and frequency of biological evolution-related concepts in medical articles. The distribution of these concepts over the years is analyzed according to the medical specialty and the impact of the journal. Our data showed that: i) only a small percentage of articles in medical journals have an evolutionary perspective; ii) medical journals where these evolution-based articles are published focus on basic science, theoretical medicine, and less frequently, on applied medicine; iii) these articles are mostly from the microbiology, immunology, neurology, psychology, behavior, and oncology fields; and iv) viruses are the most frequently covered microorganisms, followed by bacteria, fungi, and protozoans. The collection of our results, considering the importance of evolutionary medicine in the medical field, highlights the need for a decisive change in perspective in medical research.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0