Brazilian Journal of Medical and Biological Research最新文献_第10页

Influence of reminiscence therapy on mental health and quality of life in elderly patients with unresectable, metastatic gastrointestinal cancer. 回忆疗法对患有无法切除的转移性胃肠癌的老年患者的心理健康和生活质量的影响。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13344

Yu Liang, Limin Zhang

{"title":"Influence of reminiscence therapy on mental health and quality of life in elderly patients with unresectable, metastatic gastrointestinal cancer.","authors":"Yu Liang, Limin Zhang","doi":"10.1590/1414-431X2024e13344","DOIUrl":"10.1590/1414-431X2024e13344","url":null,"abstract":"Reminiscence therapy (RT) attenuates psychological disorders in cancer patients. This study aimed to evaluate the effect of RT on anxiety, depression, spiritual well-being, and quality of life in elderly patients with unresectable, metastatic gastrointestinal cancer. A total of 222 elderly patients with unresectable, metastatic gastrointestinal cancer were randomized into RT group (RT plus usual care, n=112) or control group (usual care, n=110) with a 6-month intervention. Hospital Anxiety and Depression Scale for Anxiety (HADS-A) and Depression (HADS-D), Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp), and Quality of Life Questionnaire-Core 30 (QLQ-C30) were evaluated at month (M)0, M1, M3, and M6. Concerning the primary outcome, HADS-A score at M6 decreased in the RT group compared to the control group (P=0.005). As to secondary outcomes, the RT group showed decreased HADS-A scores at M3, anxiety rate at M3, HADS-D scores at M3 and M6, depression rate at M6, as well as greater FACIT-Sp scores at M1, M3, and M6 vs the control group (all P<0.050). Additionally, QLQ-C30 global health score was elevated at M1 (P=0.046) and M6 (P=0.005), functions score was greater at M6 (P=0.038), and symptoms score was lower at M3 (P=0.019) in the RT group than in the control group. Subgroup analysis revealed that the addition of RT was more effective for patients with anxiety or depression at baseline. In summary, RT alleviated anxiety and depression, and improved the spiritual well-being and quality of life within 6 months in elderly patients with unresectable, metastatic gastrointestinal cancer.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13344"},"PeriodicalIF":1.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The essential role of adenine nucleotide translocase 4 on male reproductive function in mice. 腺嘌呤核苷酸转位酶 4 对小鼠雄性生殖功能的重要作用

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13590

Fengyuan Yang, Xiali Yang, Hui Zhu, Xinbo Wang, Xin Liao, Yinxu Fu, Ting Fu, Xiandan Chen, Aliaksei Sysa, Jianxin Lyu, Huaibin Zhou

{"title":"The essential role of adenine nucleotide translocase 4 on male reproductive function in mice.","authors":"Fengyuan Yang, Xiali Yang, Hui Zhu, Xinbo Wang, Xin Liao, Yinxu Fu, Ting Fu, Xiandan Chen, Aliaksei Sysa, Jianxin Lyu, Huaibin Zhou","doi":"10.1590/1414-431X2024e13590","DOIUrl":"10.1590/1414-431X2024e13590","url":null,"abstract":"Adenine nucleotide translocator 4 (Ant4), an ATP/ADP transporter expressed in the early phases of spermatogenesis, plays a crucial role in male fertility. While Ant4 loss causes early arrest of meiosis and increased apoptosis of spermatogenic cells in male mice, its other potential functions in male fertility remain unexplored. Here, we utilized Ant4 knockout mice to delineate the effects of Ant4-deficiency on male reproduction. Our observations demonstrated that Ant4-deficiency led to infertility and impaired testicular development, which was further investigated by evaluating testicular oxidative stress, autophagy, and inflammation. Specifically, the loss of Ant4 led to an imbalance of oxidation and antioxidants. Significant ultrastructural alterations were identified in the testicular tissues of Ant4-deficient mice, including swelling of mitochondria, loss of cristae, and accumulation of autophagosomes. Our results also showed that autophagic flux and AKT-AMPK-mTOR signaling pathway were affected in Ant4-deficient mice. Moreover, Ant4 loss increased the expression of pro-inflammatory factors. Overall, our findings underscored the importance of Ant4 in regulating oxidative stress, autophagy, and inflammation in testicular tissues. Taken together, these insights provided a nuanced understanding of the significance of Ant4 in testicular development.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13590"},"PeriodicalIF":1.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial. 老年人补充谷氨酰胺的耐受性：双盲安慰剂对照随机临床试验。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13468

T C M de Nóbrega, M A R C P da Silva, E M Rampani, R Curi, R B Bazotte

{"title":"Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial.","authors":"T C M de Nóbrega, M A R C P da Silva, E M Rampani, R Curi, R B Bazotte","doi":"10.1590/1414-431X2024e13468","DOIUrl":"10.1590/1414-431X2024e13468","url":null,"abstract":"In this double-blind placebo-controlled randomized investigation, we assessed the tolerability of glutamine in older adults recruited from three daycare centers. The relevance of studying glutamine supplementation in elderly patients lies in its potential to provide a well-tolerated intervention. Glutamine, a crucial amino acid, plays a vital role in various physiological processes, including immune function and protein synthesis. Understanding its impact on older adults is essential, given the potential implications for their health and well-being. Participants received a daily dose of 12.4 g of oral effervescent glutamine (EGln group) or maltodextrin (placebo group) for 60 days. Fifteen patients from each group completed the study. The mean ages were 77.0±9.1 and 79.0±6.9 years for the EGln and placebo groups, respectively. We evaluated body mass index, aminogram, hemogram, plasma levels of glucose, prealbumin, albumin, urea, creatinine, uric acid, C-reactive protein, vitamin D, calcium, sodium, potassium, and the plasma activities of aspartate aminotransferase and alanine aminotransferase. Notably, we quantified a broad array of inflammatory markers and growth factors providing a holistic understanding of the potential effects of glutamine supplementation. The results demonstrated that oral glutamine did not induce significant changes in any evaluated parameters, and no adverse effects were reported. This finding suggested that the dosage of glutamine used in this study was well-tolerated and safe. This information contributes to the broader understanding of glutamine supplementation, emphasizing its safety and supporting its potential as a viable intervention for maintaining health in aging individuals.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13468"},"PeriodicalIF":1.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats. 电针通过靶向BAX和TRPV4调节miR-214的表达，防止骨关节炎大鼠软骨细胞凋亡并减轻疼痛

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13238

Jia He, Jia Zuo, Xiaochen Fan, Zhe Li

{"title":"Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats.","authors":"Jia He, Jia Zuo, Xiaochen Fan, Zhe Li","doi":"10.1590/1414-431X2024e13238","DOIUrl":"10.1590/1414-431X2024e13238","url":null,"abstract":"Osteoarthritis (OA) is a highly prevalent joint disorder characterized by progressive degeneration of articular cartilage, subchondral bone remodeling, osteophyte formation, synovial inflammation, and meniscal damage. Although the etiology of OA is multifactorial, pro-inflammatory processes appear to play a key role in disease pathogenesis. Previous studies indicate that electroacupuncture (EA) exerts chondroprotective, anti-inflammatory, and analgesic effects in preclinical models of OA, but the mechanisms underlying these potential therapeutic benefits remain incompletely defined. This study aimed to investigate the effects of EA on OA development in a rat model, as well as to explore associated molecular mechanisms modulated by EA treatment. Forty rats were divided into OA, EA, antagomiR-214, and control groups. Following intra-articular injection of monosodium iodoacetate to induce OA, EA and antagomiR-214 groups received daily EA stimulation at acupoints around the knee joint for 21 days. Functional pain behaviors and chondrocyte apoptosis were assessed as outcome measures. The expression of microRNA-214 (miR-214) and its downstream targets involved in apoptosis and nociception, BAX and TRPV4, were examined. Results demonstrated that EA treatment upregulated miR-214 expression in OA knee cartilage. By suppressing pro-apoptotic BAX and pro-nociceptive TRPV4, this EA-induced miR-214 upregulation ameliorated articular pain and prevented chondrocyte apoptosis. These findings suggested that miR-214 plays a key role mediating EA's therapeutic effects in OA pathophysiology, and represents a promising OA treatment target for modulation by acupuncture.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13238"},"PeriodicalIF":1.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudogene CSPG4P12 inhibits colorectal cancer progression by attenuating epithelial-mesenchymal transition. 伪基因CSPG4P12通过抑制上皮-间质转化抑制结直肠癌的进展。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13645

Qinqin Song, Hongxue Xu, Hongjiao Wu, Jing Dong, Shanshan Ji, Xuemei Zhang, Zhi Zhang, Wanning Hu

{"title":"Pseudogene CSPG4P12 inhibits colorectal cancer progression by attenuating epithelial-mesenchymal transition.","authors":"Qinqin Song, Hongxue Xu, Hongjiao Wu, Jing Dong, Shanshan Ji, Xuemei Zhang, Zhi Zhang, Wanning Hu","doi":"10.1590/1414-431X2024e13645","DOIUrl":"10.1590/1414-431X2024e13645","url":null,"abstract":"Colorectal cancer is one of the most common malignant cancers. Pseudogenes have been identified as oncogenes or tumor suppressor genes in the development of various cancers. However, the function of pseudogene CSPG4P12 in colorectal cancer remains unclear. Therefore, the aim of this study was to investigate the potential role of CSPG4P12 in colorectal cancer and explore the possible underlying mechanism. The difference of CSPG4P12 expression between colorectal cancer tissues and adjacent normal tissues was analyzed using the online Gene Expression Profiling Interactive Analysis 2 (GEPIA2) database. Cell viability and colony formation assays were conducted to evaluate cell viability. Transwell and wound healing assays were performed to assess cell migration and invasion capacities. Western blot was used to measure the expression levels of epithelial-mesenchymal transition-related proteins. Colorectal cancer tissues had lower CSPG4P12 expression than adjacent normal tissues. The overexpression of CSPG4P12 inhibited cell proliferation, invasion, and migration in colorectal cancer cells. Overexpressed CSPG4P12 promoted the expression of E-cadherin, whereas it inhibited the expression of vimentin, N-cadherin, and MMP9. These findings suggested that CSPG4P12 inhibits colorectal cancer development and may serve as a new potential target for colorectal cancer.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13645"},"PeriodicalIF":1.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways. 辅酶Q10通过使PI3K/AKT/mTOR和MAPK途径失活来促进自噬，从而防止RANKL诱导的破骨细胞生成。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13474

Delu Zheng, Chenli Cui, Chengsong Ye, Chen Shao, Xiujing Zha, Ying Xu, Xu Liu, Can Wang

{"title":"Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways.","authors":"Delu Zheng, Chenli Cui, Chengsong Ye, Chen Shao, Xiujing Zha, Ying Xu, Xu Liu, Can Wang","doi":"10.1590/1414-431X2024e13474","DOIUrl":"10.1590/1414-431X2024e13474","url":null,"abstract":"Coenzyme Q10 (CoQ10) is a potent antioxidant that is implicated in the inhibition of osteoclastogenesis, but the underlying mechanism has not been determined. We explored the underlying molecular mechanisms involved in this process. RAW264.7 cells received receptor activator of NF-κB ligand (RANKL) and CoQ10, after which the differentiation and viability of osteoclasts were assessed. After the cells were treated with CoQ10 and/or H2O2 and RANKL, the levels of reactive oxygen species (ROS) and proteins involved in the PI3K/AKT/mTOR and MAPK pathways and autophagy were tested. Moreover, after the cells were pretreated with or without inhibitors of the two pathways or with the mitophagy agonist, the levels of autophagy-related proteins and osteoclast markers were measured. CoQ10 significantly decreased the number of TRAP-positive cells and the level of ROS but had no significant impact on cell viability. The relative phosphorylation levels of PI3K, AKT, mTOR, ERK, and p38 were significantly reduced, but the levels of FOXO3/LC3/Beclin1 were significantly augmented. Moreover, the levels of FOXO3/LC3/Beclin1 were significantly increased by the inhibitors and mitophagy agonist, while the levels of osteoclast markers showed the opposite results. Our data showed that CoQ10 prevented RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways in RAW264.7 cells.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13474"},"PeriodicalIF":2.3,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11085036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant uterine tumor and miscarriage: how to proceed? 巨大子宫肿瘤和流产：如何处理？

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13549

E A Hase, L L Iervolino, H A Antico, N Bozzini, R P V Francisco

引用次数: 0

Moderate physical exercise and ATP modulate the P2X7 receptor and improve cisplatin-induced gastric emptying delay in rats. 适度运动和 ATP 可调节 P2X7 受体并改善顺铂诱导的大鼠胃排空延迟。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13234

Y A Gomes, W L L Santos, C S Pinheiro, J S Severo, J C C Oliveira Júnior, A C A da Silva, B L B Dos Santos, C H L Rocha, A A Dos Santos, M T B da Silva

{"title":"Moderate physical exercise and ATP modulate the P2X7 receptor and improve cisplatin-induced gastric emptying delay in rats.","authors":"Y A Gomes, W L L Santos, C S Pinheiro, J S Severo, J C C Oliveira Júnior, A C A da Silva, B L B Dos Santos, C H L Rocha, A A Dos Santos, M T B da Silva","doi":"10.1590/1414-431X2024e13234","DOIUrl":"10.1590/1414-431X2024e13234","url":null,"abstract":"Patients undergoing chemotherapy with cisplatin commonly present gastrointestinal effects such as constipation and gastric emptying (GE) delay. Both the purinergic system and physical exercise modulate the gastrointestinal (GI) tract. In the current study, we investigated the role of ATP, physical exercise, and P2X7 receptor blocking on GE delay induced by cisplatin in rats. Male rats were divided into the following groups: control (C), cisplatin (Cis), exercise (Ex), Brilliant Blue G (BBG), ATP, Cis+Ex, Cis+ATP, Cis+BBG, Cis+Ex+BBG, Cis+Ex+BBG+ATP, and Cis+ATP+BBG. GE delay was induced by treatment with 1 mg/kg cisplatin (1 time/week for 5 weeks, ip). The moderate physical exercise was swimming (1 h/day, 5 days/week for 5 weeks). At the end of the treatment or exercise and 30 min before the GE assessment, some groups received BBG (50 mg/kg, sc) or ATP (2 mg/kg, sc). Then, GE was assessed after a 10-min postprandial period. Chronic use of Cis decreased GE delay (P<0.05) compared to the control group. Both exercise and ATP prevented (P<0.05) GE delay compared to Cis. The pretreatment with BBG significantly inhibited (P<0.05) the effect of exercise and ATP. On the other hand, the association between exercise and ATP reversed (P<0.05) the effect of the BBG and prevented GE delay. Therefore, we suggest that both exercise and treatment with ATP activate P2X7 receptors and prevent GE delay induced by cisplatin in rats.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13234"},"PeriodicalIF":2.3,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11085034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture for generalized anxiety disorder: a study protocol for a randomized controlled trial. 针灸治疗广泛性焦虑症：随机对照试验的研究方案。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13389

Xiayun Zhou, Guoao Shi, Ruiming Chen, Lingsan Hu, Zhongxian Li, Yifu Zhou, Pan Zhang, Xiang Ji, Min Peng, Kengyu Chen, Luda Yan, Peng Zhou

{"title":"Acupuncture for generalized anxiety disorder: a study protocol for a randomized controlled trial.","authors":"Xiayun Zhou, Guoao Shi, Ruiming Chen, Lingsan Hu, Zhongxian Li, Yifu Zhou, Pan Zhang, Xiang Ji, Min Peng, Kengyu Chen, Luda Yan, Peng Zhou","doi":"10.1590/1414-431X2024e13389","DOIUrl":"10.1590/1414-431X2024e13389","url":null,"abstract":"During the COVID-19 outbreak, there was a sharp increase in generalized anxiety disorder (GAD). Acupuncture therapy has the advantages of accurate clinical efficacy, safety and reliability, few adverse reactions, and no dependence, and is gradually becoming one of the emerging therapies for treating GAD. We present a study protocol for a randomized clinical trial with the aim of exploring the mechanism of brain plasticity in patients with GAD and evaluate the effectiveness and reliability of acupuncture treatment. Transcranial magnetic stimulation (TMS) will be used to assess cortical excitability in GAD patients and healthy people. Sixty-six GAD patients meeting the inclusion criteria will be randomly divided into two groups: TA group, (treatment with acupuncture and basic western medicine treatment) and SA group (sham acupuncture and basic western medicine treatment). Twenty healthy people will be recruited as the control group (HC). The parameters that will be evaluated are amplitude of motor evoked potentials (MEPs), cortical resting period (CSP), resting motor threshold (RMT), and Hamilton Anxiety Scale (HAMA) score. Secondary results will include blood analysis of γ-aminobutyric acid (GABA), glutamate (Glu), glutamine (Gln), serotonin (5-HT), and brain-derived nerve growth factor (BDNF). Outcomes will be assessed at baseline and after the intervention (week 8). This study protocol is the first clinical trial designed to detect differences in cerebral cortical excitability between healthy subjects and patients with GAD, and the comparison of clinical efficacy and reliability before and after acupuncture intervention is also one of the main contents of the protocol. We hope to find a suitable non-pharmacological alternative treatment for patients with GAD.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13389"},"PeriodicalIF":2.3,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11085035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crescentic glomerulonephritis due to linear IgA anti-glomerular basement membrane disease: report of a rare case. 线性 IgA 抗肾小球基底膜病引起的新月体肾小球肾炎：一例罕见病例的报告。

IF 2.3 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13466

A G Monich, R F Romani, J L S Carneiro

{"title":"Crescentic glomerulonephritis due to linear IgA anti-glomerular basement membrane disease: report of a rare case.","authors":"A G Monich, R F Romani, J L S Carneiro","doi":"10.1590/1414-431X2024e13466","DOIUrl":"10.1590/1414-431X2024e13466","url":null,"abstract":"Anti-glomerular basement membrane (GBM) disease is a rare and severe vasculitis that affects the glomerular and pulmonary capillaries and has an incidence of less than 2 cases per million individuals per year. Anti-GBM disease is mediated by autoantibodies against the α3 chain of type IV collagen. In the majority of cases, the autoantibodies are of the immunoglobulin G (IgG) class, with rare cases being mediated by immunoglobulin M (IgM) or immunoglobulin A (IgA); there are less than 15 IgA-mediated cases reported in the literature worldwide. The classic form of this disease manifests with rapidly progressive glomerulonephritis (RPGN), with or without pulmonary hemorrhage, and the diagnosis consists of identifying high titers of autoantibodies in the serum and/or deposited in the tissues. IgA antibodies are not identified in routine immunoassay tests, and renal biopsy with immunofluorescence is essential for diagnosis. We present a case of RPGN due to anti-GBM disease with linear IgA deposition, whose diagnosis was made exclusively by renal biopsy and with an unfavorable prognosis.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":"57 ","pages":"e13466"},"PeriodicalIF":2.3,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11085031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0