A C S Lopes, A A de Macedo, F S Mendes, I M Costa, L M S Dusse, P N Alpoim
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The bibliographic search was conducted from September 2021 to August 2024 and was performed on MEDLINE/PubMed, EMBASE, and Web of Science. This systematic review followed the methodological guidelines of the Cochrane Collaboration Manual for Systematic Intervention Reviews and was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Of the 1362 studies identified, 263 articles were selected as the sample of this study. The most frequently cited upregulated microRNAs were: miR-210, miR-155, miR-518b, miR-181a, miR-125b, miR-183, and miR-16. The most frequently cited downregulated microRNAs were: miR-363, miR-18a, miR-144, miR-149, miR-16, miR-18b, and miR-195. This study will serve as a reference to guide future experimental research. 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引用次数: 0
摘要
子痫前期(PE)是一种以妊娠20周后新发高血压伴蛋白尿和/或其他母体器官功能障碍体征为特征的妊娠疾病。MicroRNAs (miRNAs)是一种小的非编码rna(19-25个核苷酸),在基因表达的转录后调控中起作用。许多研究表明,不同的microRNA表达谱可能与PE的发生有关。因此,本研究旨在报道可能与PE发病机制相关的差异表达的microrna,并探讨不同的miRNA表达谱是否与不同的PE分类和不同的妊娠期相关。文献检索于2021年9月至2024年8月在MEDLINE/PubMed、EMBASE和Web of Science上进行。本系统评价遵循Cochrane系统干预评价合作手册的方学指南,并根据系统评价和荟萃分析首选报告项目(PRISMA)撰写。在1362项研究中,选取263篇文章作为本研究的样本。最常被引用的上调microrna是:miR-210、miR-155、miR-518b、miR-181a、miR-125b、miR-183和miR-16。最常被引用的下调microrna是:miR-363、miR-18a、miR-144、miR-149、miR-16、miR-18b和miR-195。本研究将为指导今后的实验研究提供参考。此外,了解与PE相关的microrna的表达谱可以帮助开发早期预测该疾病的新方案。
Changes in microRNA expression associated with preeclampsia: a systematic review.
Preeclampsia (PE) is a disease of pregnancy characterized by the new onset of hypertension accompanied by proteinuria and/or other signs of maternal organ dysfunction that manifests after 20 weeks of gestation. MicroRNAs (miRNAs) are small non-coding RNAs (19-25 nucleotides) that function in the post-transcriptional regulation of gene expression. Many studies have suggested that different microRNA expression profiles may be associated with the development of PE. Hence, this study aims to report differentially expressed microRNAs that may be associated with the pathogenesis of PE and investigate whether different miRNA expression profiles are associated with different PE classifications and different phases of pregnancy. The bibliographic search was conducted from September 2021 to August 2024 and was performed on MEDLINE/PubMed, EMBASE, and Web of Science. This systematic review followed the methodological guidelines of the Cochrane Collaboration Manual for Systematic Intervention Reviews and was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Of the 1362 studies identified, 263 articles were selected as the sample of this study. The most frequently cited upregulated microRNAs were: miR-210, miR-155, miR-518b, miR-181a, miR-125b, miR-183, and miR-16. The most frequently cited downregulated microRNAs were: miR-363, miR-18a, miR-144, miR-149, miR-16, miR-18b, and miR-195. This study will serve as a reference to guide future experimental research. In addition, knowledge of the expression profiles of microRNAs associated with PE can help in the development of new protocols for early prediction of the disease.
期刊介绍:
The Brazilian Journal of Medical and Biological Research, founded by Michel Jamra, is edited and published monthly by the Associação Brasileira de Divulgação Científica (ABDC), a federation of Brazilian scientific societies:
- Sociedade Brasileira de Biofísica (SBBf)
- Sociedade Brasileira de Farmacologia e Terapêutica Experimental (SBFTE)
- Sociedade Brasileira de Fisiologia (SBFis)
- Sociedade Brasileira de Imunologia (SBI)
- Sociedade Brasileira de Investigação Clínica (SBIC)
- Sociedade Brasileira de Neurociências e Comportamento (SBNeC).