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Annual review of immunology最新文献

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T Follicular Helper Cell Heterogeneity T 滤泡辅助细胞的异质性
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-12-07 DOI: 10.1146/annurev-immunol-090222-102834
Wenzhi Song, Joe Craft
{"title":"T Follicular Helper Cell Heterogeneity","authors":"Wenzhi Song, Joe Craft","doi":"10.1146/annurev-immunol-090222-102834","DOIUrl":"https://doi.org/10.1146/annurev-immunol-090222-102834","url":null,"abstract":"T follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which they emerge. We review recent advances in understanding the heterogeneity within Tfh cell subsets along with their differentiation and migratory trajectory, the phenotype they adopt, their ontological relationships with one another, and their function in their respective environments.Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"19 1","pages":""},"PeriodicalIF":29.7,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138554786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond. 系统性红斑狼疮的发病机制:干扰素及其他。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-042422
Simone Caielli, Zurong Wan, Virginia Pascual
{"title":"Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond.","authors":"Simone Caielli,&nbsp;Zurong Wan,&nbsp;Virginia Pascual","doi":"10.1146/annurev-immunol-101921-042422","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-042422","url":null,"abstract":"<p><p>Autoreactive B cells and interferons are central players in systemic lupus erythematosus (SLE) pathogenesis. The partial success of drugs targeting these pathways, however, supports heterogeneity in upstream mechanisms contributing to disease pathogenesis. In this review, we focus on recent insights from genetic and immune monitoring studies of patients that are refining our understanding of these basic mechanisms. Among them, novel mutations in genes affecting intrinsic B cell activation or clearance of interferogenic nucleic acids have been described. Mitochondria have emerged as relevant inducers and/or amplifiers of SLE pathogenesis through a variety of mechanisms that include disruption of organelle integrity or compartmentalization, defective metabolism, and failure of quality control measures. These result in extra- or intracellular release of interferogenic nucleic acids as well as in innate and/or adaptive immune cell activation. A variety of classic and novel SLE autoantibody specificities have been found to recapitulate genetic alterations associated with monogenic lupus or to trigger interferogenic amplification loops. Finally, atypical B cells and novel extrafollicular T helper cell subsets have been proposed to contribute to the generation of SLE autoantibodies. Overall, these novel insights provide opportunities to deepen the immunophenotypic surveillance of patients and open the door to patient stratification and personalized, rational approaches to therapy.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"533-560"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9398125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action. IgE、IgE 受体和抗 IgE 生物制剂：蛋白质结构和作用机制。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-02-03 DOI: 10.1146/annurev-immunol-061020-053712
J M McDonnell, B Dhaliwal, B J Sutton, H J Gould
{"title":"IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action.","authors":"J M McDonnell, B Dhaliwal, B J Sutton, H J Gould","doi":"10.1146/annurev-immunol-061020-053712","DOIUrl":"10.1146/annurev-immunol-061020-053712","url":null,"abstract":"<p><p>The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the environment. The IgE immune response employs potent expulsive and inflammatory forces against local antigen provocation, at the risk of damaging host tissues and causing allergic disease. Two well-known IgE receptors, the high-affinity FcεRI and low-affinity CD23, mediate the activities of IgE. Unlike other known antibody receptors, CD23 also regulates IgE expression, maintaining IgE homeostasis. This mechanism evolved by adapting the function of the complement receptor CD21. Recent insights into the dynamic character of IgE structure, its resultant capacity for allosteric modulation, and the potential for ligand-induced dissociation have revealed previously unappreciated mechanisms for regulation of IgE and IgE complexes. We describe recent research, highlighting structural studies of the IgE network of proteins to analyze the uniquely versatile activities of IgE and anti-IgE biologics.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"255-275"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9396219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systems Immunology Approaches to Metabolism. 代谢的系统免疫学方法。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101220-031513
Denis A Mogilenko, Alexey Sergushichev, Maxim N Artyomov
{"title":"Systems Immunology Approaches to Metabolism.","authors":"Denis A Mogilenko,&nbsp;Alexey Sergushichev,&nbsp;Maxim N Artyomov","doi":"10.1146/annurev-immunol-101220-031513","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101220-031513","url":null,"abstract":"<p><p>Over the last decade, immunometabolism has emerged as a novel interdisciplinary field of research and yielded significant fundamental insights into the regulation of immune responses. Multiple classical approaches to interrogate immunometabolism, including bulk metabolic profiling and analysis of metabolic regulator expression, paved the way to appreciating the physiological complexity of immunometabolic regulation in vivo. Studying immunometabolism at the systems level raised the need to transition towards the next-generation technology for metabolic profiling and analysis. Spatially resolved metabolic imaging and computational algorithms for multi-modal data integration are new approaches to connecting metabolism and immunity. In this review, we discuss recent studies that highlight the complex physiological interplay between immune responses and metabolism and give an overview of technological developments that bear the promise of capturing this complexity most directly and comprehensively.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"317-342"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TGF-β Regulation of T Cells. TGF-β对T细胞的调控。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-045939
WanJun Chen
{"title":"TGF-β Regulation of T Cells.","authors":"WanJun Chen","doi":"10.1146/annurev-immunol-101921-045939","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-045939","url":null,"abstract":"<p><p>Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4<sup>+</sup> T cells, TGF-β maintains the quiescence and controls the activation of naive T cells. While inhibiting the differentiation and function of Th1 and Th2 cells, TGF-β promotes the differentiation of Th17 and Th9 cells. TGF-β is required for the induction of Foxp3 in naive T cells and the development of regulatory T cells. TGF-β is crucial in the differentiation of tissue-resident memory CD8<sup>+</sup> T cells and their retention in the tissue, whereas it suppresses effector T cell function. In addition, TGF-β also regulates the generation or function of natural killer T cells, γδ T cells, innate lymphoid cells, and gut intraepithelial lymphocytes. Here I highlight the major findings and recent advances in our understanding of TGF-β regulation of T cells and provide a personal perspective of the field.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"483-512"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9412424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation. NLRP3 炎症小体组装和激活的结构机制
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-02-07 DOI: 10.1146/annurev-immunol-081022-021207
Jianing Fu, Hao Wu
{"title":"Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.","authors":"Jianing Fu, Hao Wu","doi":"10.1146/annurev-immunol-081022-021207","DOIUrl":"10.1146/annurev-immunol-081022-021207","url":null,"abstract":"<p><p>As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1. The three major components of the NLRP3 inflammasome are NLRP3, which captures the danger signals and recruits downstream molecules; caspase-1, which elicits maturation of the cytokines IL-1β and IL-18 and processing of gasdermin D to mediate cytokine release and pyroptosis; and ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), which functions as a bridge connecting NLRP3 and caspase-1. In this article, we review the structural information that has been obtained on the NLRP3 inflammasome and its components or subcomplexes, with special focus on the inactive NLRP3 cage, the active NLRP3-NEK7 (NIMA-related kinase 7)-ASC inflammasome disk, and the PYD-PYD and CARD-CARD homotypic filamentous scaffolds of the inflammasome. We further implicate structure-derived mechanisms for the assembly and activation of the NLRP3 inflammasome.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"301-316"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9417635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing Cancer Immunotherapies That Engage T Cells and NK Cells. 设计能吸引 T 细胞和 NK 细胞的癌症免疫疗法。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2022-11-29 DOI: 10.1146/annurev-immunol-101921-044122
Oleksandr Kyrysyuk, Kai W Wucherpfennig
{"title":"Designing Cancer Immunotherapies That Engage T Cells and NK Cells.","authors":"Oleksandr Kyrysyuk, Kai W Wucherpfennig","doi":"10.1146/annurev-immunol-101921-044122","DOIUrl":"10.1146/annurev-immunol-101921-044122","url":null,"abstract":"<p><p>T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy. Recent work has also shown that NK cells play an important role in recruiting dendritic cells to tumors and thus enhance induction of CD8 T cell responses, while IL-2 secreted by T cells activates NK cells. Targeting of immune evasion mechanisms from the activating NKG2D receptor and its MICA and MICB ligands on tumor cells offers opportunities for therapeutic intervention. Interestingly, T cells and NK cells share several important inhibitory and activating receptors that can be targeted to enhance T cell- and NK cell-mediated immunity. These inhibitory receptor-ligand systems include CD161-CLEC2D, TIGIT-CD155, and NKG2A/CD94-HLA-E. We also discuss emerging therapeutic strategies based on inhibitory and activating cytokines that profoundly impact the function of both lymphocyte populations within tumors.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"17-38"},"PeriodicalIF":26.9,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159905/pdf/nihms-1873672.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9426625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging. 极度分化的T细胞亚群有助于衰老过程中的组织退化。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-064501
Gonzalo Soto-Heredero, Manuel M Gómez de Las Heras, J Ignacio Escrig-Larena, María Mittelbrunn
{"title":"Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging.","authors":"Gonzalo Soto-Heredero,&nbsp;Manuel M Gómez de Las Heras,&nbsp;J Ignacio Escrig-Larena,&nbsp;María Mittelbrunn","doi":"10.1146/annurev-immunol-101721-064501","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101721-064501","url":null,"abstract":"<p><p>There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"181-205"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils. 组织髓样细胞的起源和异质性:关注gmp衍生的单核细胞和中性粒细胞。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-081022-113627
Lai Guan Ng, Zhaoyuan Liu, Immanuel Kwok, Florent Ginhoux
{"title":"Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils.","authors":"Lai Guan Ng,&nbsp;Zhaoyuan Liu,&nbsp;Immanuel Kwok,&nbsp;Florent Ginhoux","doi":"10.1146/annurev-immunol-081022-113627","DOIUrl":"https://doi.org/10.1146/annurev-immunol-081022-113627","url":null,"abstract":"<p><p>Myeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various myeloid cells that perform separate but complementary functions during homeostasis and disease, our understanding of tissue myeloid cells has evolved significantly. Exciting findings from transcriptomics profiling and fate-mapping mouse models have facilitated the identification of their developmental origins, maturation, and tissue-specific specializations. This review highlights the current understanding of tissue myeloid cells and the contributing factors of functional heterogeneity to better comprehend the complex and dynamic immune interactions within the healthy or inflamed tissue. Specifically, we discuss the new understanding of the contributions of granulocyte-monocyte progenitor-derived phagocytes to tissue myeloid cell heterogeneity as well as the impact of niche-specific factors on monocyte and neutrophil phenotype and function. Lastly, we explore the developing paradigm of myeloid cell heterogeneity during inflammation and disease.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"375-404"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
RNA Modification in the Immune System. 免疫系统中的RNA修饰。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-045401
Dali Han, Meng Michelle Xu
{"title":"RNA Modification in the Immune System.","authors":"Dali Han,&nbsp;Meng Michelle Xu","doi":"10.1146/annurev-immunol-101921-045401","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-045401","url":null,"abstract":"<p><p>Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of these diverse, dynamic RNA modifications in various immune cells within healthy and diseased contexts. Further, we explore our current understanding of the mechanisms whereby aberrant RNA modifications modulate the immune milieu of the tumor microenvironment and point out outstanding research questions.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"73-98"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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