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Annual review of immunology最新文献

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Systemic Immune Modulation by Gastrointestinal Nematodes. 肠道线虫对全身免疫的调节作用
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090222-101331
Darshan N Kasal, Lindsey M Warner, Astra S Bryant, Elia Tait Wojno, Jakob von Moltke
{"title":"Systemic Immune Modulation by Gastrointestinal Nematodes.","authors":"Darshan N Kasal, Lindsey M Warner, Astra S Bryant, Elia Tait Wojno, Jakob von Moltke","doi":"10.1146/annurev-immunol-090222-101331","DOIUrl":"10.1146/annurev-immunol-090222-101331","url":null,"abstract":"<p><p>Gastrointestinal nematode (GIN) infection has applied significant evolutionary pressure to the mammalian immune system and remains a global economic and human health burden. Upon infection, type 2 immune sentinels activate a common antihelminth response that mobilizes and remodels the intestinal tissue for effector function; however, there is growing appreciation of the impact GIN infection also has on the distal tissue immune state. Indeed, this effect is observed even in tissues through which GINs never transit. This review highlights how GIN infection modulates systemic immunity through (<i>a</i>) induction of host resistance and tolerance responses, (<i>b</i>) secretion of immunomodulatory products, and (<i>c</i>) interaction with the intestinal microbiome. It also discusses the direct consequences that changes to distal tissue immunity can have for concurrent and subsequent infection, chronic noncommunicable diseases, and vaccination efficacy.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"259-288"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraepithelial Lymphocytes of the Intestine. 肠上皮内淋巴细胞
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090222-100246
Ainsley Lockhart, Daniel Mucida, Angelina M Bilate
{"title":"Intraepithelial Lymphocytes of the Intestine.","authors":"Ainsley Lockhart, Daniel Mucida, Angelina M Bilate","doi":"10.1146/annurev-immunol-090222-100246","DOIUrl":"10.1146/annurev-immunol-090222-100246","url":null,"abstract":"<p><p>The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying tissue, harbors one of the largest lymphocyte populations in the body, intestinal intraepithelial lymphocytes (IELs). IELs must balance tolerance, resistance, and tissue protection to maintain epithelial homeostasis and barrier integrity. This review discusses the ontogeny, environmental imprinting, T cell receptor (TCR) repertoire, and function of intestinal IELs. Despite distinct developmental pathways, IEL subsets share core traits including an epithelium-adapted profile, innate-like properties, cytotoxic potential, and limited TCR diversity. IELs also receive important developmental and functional cues through interactions with epithelial cells, microbiota, and dietary components. The restricted TCR diversity of IELs suggests that a limited set of intestinal antigens drives IEL responses, with potential functional consequences. Finally, IELs play a key role in promoting homeostatic immunity and epithelial barrier integrity but can become pathogenic upon dysregulation. Therefore, IELs represent intriguing but underexamined therapeutic targets for inflammatory diseases and cancer.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"289-316"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Activation in Alzheimer Disease. 阿尔茨海默病的免疫激活。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-101921-035222
Arnaud Mary, Renzo Mancuso, Michael T Heneka
{"title":"Immune Activation in Alzheimer Disease.","authors":"Arnaud Mary, Renzo Mancuso, Michael T Heneka","doi":"10.1146/annurev-immunol-101921-035222","DOIUrl":"10.1146/annurev-immunol-101921-035222","url":null,"abstract":"<p><p>Alzheimer disease (AD) is the most common neurodegenerative disease, and with no efficient curative treatment available, its medical, social, and economic burdens are expected to dramatically increase. AD is historically characterized by amyloid β (Aβ) plaques and tau neurofibrillary tangles, but over the last 25 years chronic immune activation has been identified as an important factor contributing to AD pathogenesis. In this article, we review recent and important advances in our understanding of the significance of immune activation in the development of AD. We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"585-613"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T Cell Exhaustion. T 细胞衰竭
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090222-110914
Andrew Baessler, Dario A A Vignali
{"title":"T Cell Exhaustion.","authors":"Andrew Baessler, Dario A A Vignali","doi":"10.1146/annurev-immunol-090222-110914","DOIUrl":"10.1146/annurev-immunol-090222-110914","url":null,"abstract":"<p><p>T cell responses must be balanced to ensure adequate protection against malignant transformation and an array of pathogens while also limiting damage to healthy cells and preventing autoimmunity. T cell exhaustion serves as a regulatory mechanism to limit the activity and effector function of T cells undergoing chronic antigen stimulation. Exhausted T cells exhibit poor proliferative potential; high inhibitory receptor expression; altered transcriptome, epigenome, and metabolism; and, most importantly, reduced effector function. While exhaustion helps to restrain damage caused by aberrant T cells in settings of autoimmune disease, it also limits the ability of cells to respond against persistent infection and cancer, leading to disease progression. Here we review the process of T cell exhaustion, detailing the key characteristics and drivers as well as highlighting our current understanding of the underlying transcriptional and epigenetic programming. We also discuss how exhaustion can be targeted to enhance T cell functionality in cancer.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"179-206"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innate Immunity in Protection and Pathogenesis During Coronavirus Infections and COVID-19. 先天免疫在冠状病毒感染和 COVID-19 期间的保护和致病机制中的作用
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-083122-043545
R K Subbarao Malireddi, Bhesh Raj Sharma, Thirumala-Devi Kanneganti
{"title":"Innate Immunity in Protection and Pathogenesis During Coronavirus Infections and COVID-19.","authors":"R K Subbarao Malireddi, Bhesh Raj Sharma, Thirumala-Devi Kanneganti","doi":"10.1146/annurev-immunol-083122-043545","DOIUrl":"10.1146/annurev-immunol-083122-043545","url":null,"abstract":"<p><p>The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2. SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide to date. The innate immune system is the first line of defense against infections, including the detection and response to SARS-CoV-2. Here, we discuss the innate immune mechanisms that sense coronaviruses, with a focus on SARS-CoV-2 infection and how these protective responses can become detrimental in severe cases of COVID-19, contributing to cytokine storm, inflammation, long-COVID, and other complications. We also highlight the complex cross talk among cytokines and the cellular components of the innate immune system, which can aid in viral clearance but also contribute to inflammatory cell death, cytokine storm, and organ damage in severe COVID-19 pathogenesis. Furthermore, we discuss how SARS-CoV-2 evades key protective innate immune mechanisms to enhance its virulence and pathogenicity, as well as how innate immunity can be therapeutically targeted as part of the vaccination and treatment strategy. Overall, we highlight how a comprehensive understanding of innate immune mechanisms has been crucial in the fight against SARS-CoV-2 infections and the development of novel host-directed immunotherapeutic strategies for various diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"615-645"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11373870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The CD4 Versus CD8 T Cell Fate Decision: A Multiomics-Informed Perspective. CD4 与 CD8 T 细胞命运的决定：从多组学的角度看问题。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-083122-040929
Zoë Steier, Esther Jeong Yoon Kim, Dominik A Aylard, Ellen A Robey
{"title":"The CD4 Versus CD8 T Cell Fate Decision: A Multiomics-Informed Perspective.","authors":"Zoë Steier, Esther Jeong Yoon Kim, Dominik A Aylard, Ellen A Robey","doi":"10.1146/annurev-immunol-083122-040929","DOIUrl":"10.1146/annurev-immunol-083122-040929","url":null,"abstract":"<p><p>The choice of developing thymocytes to become CD8+ cytotoxic or CD4+ helper T cells has been intensely studied, but many of the underlying mechanisms remain to be elucidated. Recent multiomics approaches have provided much higher resolution analysis of gene expression in developing thymocytes than was previously achievable, thereby offering a fresh perspective on this question. Focusing on our recent studies using CITE-seq (cellular indexing of transcriptomes and epitopes) analyses of mouse thymocytes, we present a detailed timeline of RNA and protein expression changes during CD8 versus CD4 T cell differentiation. We also revisit our current understanding of the links between T cell receptor signaling and expression of the lineage-defining transcription factors ThPOK and RUNX3. Finally, we propose a sequential selection model to explain the tight linkage between MHC-I versus MHC-II recognition and T cell lineage choice. This model incorporates key aspects of previously proposed kinetic signaling, instructive, and stochastic/selection models.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"235-258"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer. 免疫系统中的 TET 酶：从 DNA 去甲基化到免疫疗法、炎症和癌症。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-080223-044610
Isaac F López-Moyado, Myunggon Ko, Patrick G Hogan, Anjana Rao
{"title":"TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer.","authors":"Isaac F López-Moyado, Myunggon Ko, Patrick G Hogan, Anjana Rao","doi":"10.1146/annurev-immunol-080223-044610","DOIUrl":"10.1146/annurev-immunol-080223-044610","url":null,"abstract":"<p><p>Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). All three epigenetic modifications are intermediates in DNA demethylation. TET proteins are recruited by transcription factors and by RNA polymerase II to modify 5mC at enhancers and gene bodies, thereby regulating gene expression during development, cell lineage specification, and cell activation. It is not yet clear, however, how the established biochemical activities of TET enzymes in oxidizing 5mC and mediating DNA demethylation relate to the known association of TET deficiency with inflammation, clonal hematopoiesis, and cancer. There are hints that the ability of TET deficiency to promote cell proliferation in a signal-dependent manner may be harnessed for cancer immunotherapy. In this review, we draw upon recent findings in cells of the immune system to illustrate established as well as emerging ideas of how TET proteins influence cellular function.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"455-488"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Immunobiology and Treatment of Food Allergy. 食物过敏的免疫生物学和治疗。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090122-043501
Suzanne Barshow, Jyothi Tirumalasetty, Vanitha Sampath, Xiaoying Zhou, Hana Seastedt, Jackson Schuetz, Kari Nadeau
{"title":"The Immunobiology and Treatment of Food Allergy.","authors":"Suzanne Barshow, Jyothi Tirumalasetty, Vanitha Sampath, Xiaoying Zhou, Hana Seastedt, Jackson Schuetz, Kari Nadeau","doi":"10.1146/annurev-immunol-090122-043501","DOIUrl":"10.1146/annurev-immunol-090122-043501","url":null,"abstract":"<p><p>IgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that leads to a detrimental type 2 helper T cell (T<sub>H</sub>2) adaptive immune response. While the processes governing this loss of tolerance are incompletely understood, several host-related and environmental factors impacting the risk of IgE-FA development have been identified. Mounting evidence supports the role of an impaired epithelial barrier in the development of IgE-FA, with exposure of allergens through damaged skin and gut epithelium leading to the aberrant production of alarmins and activation of T<sub>H</sub>2-type allergic inflammation. The treatment of IgE-FA has historically been avoidance with acute management of allergic reactions, but advances in allergen-specific immunotherapy and the development of biologics and other novel therapeutics are rapidly changing the landscape of food allergy treatment. Here, we discuss the pathogenesis and immunobiology of IgE-FA in addition to its diagnosis, prognosis, and treatment.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"401-425"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune Interactions in the Intestine. 肠道中的神经免疫相互作用
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-101921-042929
Antonia Wallrapp, Isaac M Chiu
{"title":"Neuroimmune Interactions in the Intestine.","authors":"Antonia Wallrapp, Isaac M Chiu","doi":"10.1146/annurev-immunol-101921-042929","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-042929","url":null,"abstract":"<p><p>Recent advances have contributed to a mechanistic understanding of neuroimmune interactions in the intestine and revealed an essential role of this cross talk for gut homeostasis and modulation of inflammatory and infectious intestinal diseases. In this review, we describe the innervation of the intestine by intrinsic and extrinsic neurons and then focus on the bidirectional communication between neurons and immune cells. First, we highlight the contribution of neuronal subtypes to the development of colitis and discuss the different immune and epithelial cell types that are regulated by neurons via the release of neuropeptides and neurotransmitters. Next, we review the role of intestinal inflammation in the development of visceral hypersensitivity and summarize how inflammatory mediators induce peripheral and central sensitization of gut-innervating sensory neurons. Finally, we outline the importance of immune cells and gut microbiota for the survival and function of different neuronal populations at homeostasis and during bacterial and helminth infection.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"489-519"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging Implementation Science to Advance Environmental Justice Research and Achieve Health Equity through Neighborhood and Policy Interventions. 利用实施科学推进环境正义研究，通过邻里和政策干预实现健康公平。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI: 10.1146/annurev-publhealth-060222-033003
Laura Ellen Ashcraft, Keven I Cabrera, Meghan B Lane-Fall, Eugenia C South
{"title":"Leveraging Implementation Science to Advance Environmental Justice Research and Achieve Health Equity through Neighborhood and Policy Interventions.","authors":"Laura Ellen Ashcraft, Keven I Cabrera, Meghan B Lane-Fall, Eugenia C South","doi":"10.1146/annurev-publhealth-060222-033003","DOIUrl":"10.1146/annurev-publhealth-060222-033003","url":null,"abstract":"<p><p>Environmental justice research is increasingly focused on community-engaged, participatory investigations that test interventions to improve health. Such research is primed for the use of implementation science-informed approaches to optimize the uptake and use of interventions proven to be effective. This review identifies synergies between implementation science and environmental justice with the goal of advancing both disciplines. Specifically, the article synthesizes the literature on neighborhood-, community-, and policy-level interventions in environmental health that address underlying structural determinants (e.g., structural racism) and social determinants of health. Opportunities to facilitate and scale the equitable implementation of evidence-based environmental health interventions are highlighted, using urban greening as an illustrative example. An environmental justice-focused version of the implementation science subway is provided, which highlights these principles: Remember and Reflect, Restore and Reclaim, and Reinvest. The review concludes with existing gaps and future directions to advance the science of implementation to promote environmental justice.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"89-108"},"PeriodicalIF":29.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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