微生物代谢物与肠道免疫学

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Tadashi Takeuchi, Yumiko Nakanishi, Hiroshi Ohno
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引用次数: 0

摘要

肠道是包括人类在内的动物体内最大的外周淋巴器官,它与被称为肠道微生物群的大量微生物相互作用。理解肠道微生物群与我们免疫系统之间的共生关系不仅对免疫学领域至关重要,而且对理解各种全身性疾病(包括癌症、心脏代谢紊乱和肠道外自身免疫疾病)的发病机制也至关重要。微生物衍生的抗原作为环境线索对激活肠道免疫系统(尤其是 T 细胞和 B 细胞)至关重要,而微生物及其代谢物则在引导这些免疫细胞分化方面发挥着关键作用。微生物代谢物被视为来自肠道微生物群的信使,因为细菌有能力产生人类无法产生的独特分子,而肠道中的许多免疫细胞都表达这些分子的受体。本综述强调了微生物代谢物与免疫系统的分化和功能之间的独特关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbial Metabolites and Gut Immunology.

The intestine is the largest peripheral lymphoid organ in animals, including humans, and interacts with a vast array of microorganisms called the gut microbiota. Comprehending the symbiotic relationship between the gut microbiota and our immune system is essential not only for the field of immunology but also for understanding the pathogenesis of various systemic diseases, including cancer, cardiometabolic disorders, and extraintestinal autoimmune conditions. Whereas microbe-derived antigens are crucial for activating the intestinal immune system, particularly T and B cells, as environmental cues, microbes and their metabolites play a critical role in directing the differentiation of these immune cells. Microbial metabolites are regarded as messengers from the gut microbiota, since bacteria have the ability to produce unique molecules that humans cannot, and many immune cells in the intestine express receptors for these molecules. This review highlights the distinct relationships between microbial metabolites and the differentiation and function of the immune system.

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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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