Annual review of immunology最新文献

Neuroimmune Circuits in Allergic Diseases.

IF 26.9 1区医学

Annual review of immunology Pub Date : 2025-02-20 DOI: 10.1146/annurev-immunol-082423-032154

Cai Han, Xueping Zhu, Caroline L Sokol

{"title":"Neuroimmune Circuits in Allergic Diseases.","authors":"Cai Han, Xueping Zhu, Caroline L Sokol","doi":"10.1146/annurev-immunol-082423-032154","DOIUrl":"https://doi.org/10.1146/annurev-immunol-082423-032154","url":null,"abstract":"Communication between the nervous and immune systems is evolutionarily conserved. From primitive eukaryotes to higher mammals, neuroimmune communication utilizes multiple complex and complementary mechanisms to trigger effective but balanced responses to environmental dangers such as allergens and tissue damage. These responses result from a tight integration of the nervous and immune systems, and accumulating evidence suggests that this bidirectional communication is crucial in modulating the initiation and development of allergic inflammation. In this review, we discuss the basic mechanisms of neuroimmune communication, with a focus on the recent advances underlying the importance of such communication in the allergic immune response. We examine neuronal sensing of allergens, how neuropeptides and neurotransmitters regulate allergic immune cell functions, and how inflammatory factors derived from immune cells coordinate complex peripheral and central nervous system responses. Furthermore, we highlight how fundamental aspects of host biology, from aging to circadian rhythm, might affect these pathways. Appreciating neuroimmune communications as an evolutionarily conserved and functionally integrated system that is fundamentally involved in type 2 immunity will provide new insights into allergic inflammation and reveal exciting opportunities for the management of acute and chronic allergic diseases.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Immunobiology Through Genetic Errors of Immunity.

IF 26.9 1区医学

Annual review of immunology Pub Date : 2025-02-14 DOI: 10.1146/annurev-immunol-082323-124920

Mackenzie J Bender, Carrie L Lucas

{"title":"Decoding Immunobiology Through Genetic Errors of Immunity.","authors":"Mackenzie J Bender, Carrie L Lucas","doi":"10.1146/annurev-immunol-082323-124920","DOIUrl":"https://doi.org/10.1146/annurev-immunol-082323-124920","url":null,"abstract":"Throughout biology, the pursuit of genotype-phenotype relationships has provided foundational knowledge upon which new concepts and hypotheses are built. Genetic perturbation, whether occurring naturally or in experimental settings, is the mainstay of mechanistic dissection in biological systems. The unbiased discovery of causal genetic lesions via forward genetics in patients who have a rare disease elucidates a particularly impactful set of genotype-phenotype relationships. Here, we review the field of genetic errors of immunity, often termed inborn errors of immunity (IEIs), in a framework aimed at highlighting the powerful real-world immunology insights provided collectively and individually by these (approximately) 500 disorders. By conceptualizing essential immune functions in a model of the adaptive arsenal of rapid defenses, we organize IEIs based on immune circuits in which sensors, relays, and executioners cooperate to carry out pathogen clearance functions in an effective yet regulated manner. We review and discuss findings from IEIs that not only reinforce known immunology concepts but also offer surprising phenotypes, prompting an opportunity to refine our understanding of immune system function.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Functions of MAIT Cells.

IF 26.9 1区医学

Annual review of immunology Pub Date : 2025-01-29 DOI: 10.1146/annurev-immunol-082323-025943

Marion Salou, Rafael A Paiva, Olivier Lantz

引用次数: 0

Using the Key Characteristics Framework to Unlock the Mysteries of Aryl Hydrocarbon Receptor-Mediated Effects on the Immune System. 利用关键特征框架解开芳基烃受体介导免疫系统作用的奥秘。

IF 26.9 1区医学

Annual review of immunology Pub Date : 2025-01-15 DOI: 10.1146/annurev-immunol-083122-040107

Courtney E W Sulentic, Barbara L F Kaplan, B Paige Lawrence

{"title":"Using the Key Characteristics Framework to Unlock the Mysteries of Aryl Hydrocarbon Receptor-Mediated Effects on the Immune System.","authors":"Courtney E W Sulentic, Barbara L F Kaplan, B Paige Lawrence","doi":"10.1146/annurev-immunol-083122-040107","DOIUrl":"https://doi.org/10.1146/annurev-immunol-083122-040107","url":null,"abstract":"Initially discovered for its role mediating the deleterious effects of environmental contaminants, the aryl hydrocarbon receptor (AHR) is now known to be a crucial regulator of the immune system. The expanding list of AHR ligands includes synthetic and naturally derived molecules spanning pollutants, phytochemicals, pharmaceuticals, and substances derived from amino acids and microorganisms. The consequences of engaging AHR vary, depending on factors such as the AHR ligand, cell type, immune challenge, developmental state, dose, and timing of exposure relative to the immune stimulus. This review frames this complexity using the recently identified key characteristics of agents that affect immune system function (altered cell signaling, proliferation, differentiation, effector function, communication, trafficking, death, antigen presentation and processing, and tolerance). The use of these key characteristics provides a scaffold for continued discovery of how AHR and its myriad ligands influence the immune system, which will help harness the power of this enigmatic receptor to prevent or treat disease.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease. 杯状细胞和黏液功能在健康和疾病中的免疫调节。

IF 26.9 1区医学

Annual review of immunology Pub Date : 2025-01-03 DOI: 10.1146/annurev-immunol-101721-065224

Jenny K Gustafsson, Gunnar C Hansson

引用次数: 0

TNF/TNFR Superfamily Members in Costimulation of T Cell Responses-Revisited. TNF/TNFR超家族成员在共同刺激T细胞反应中的作用

IF 26.9 1区医学

Annual review of immunology Pub Date : 2025-01-02 DOI: 10.1146/annurev-immunol-082423-040557

Tania H Watts, Karen K M Yeung, Tianning Yu, Seungwoo Lee, Razieh Eshraghisamani

{"title":"TNF/TNFR Superfamily Members in Costimulation of T Cell Responses-Revisited.","authors":"Tania H Watts, Karen K M Yeung, Tianning Yu, Seungwoo Lee, Razieh Eshraghisamani","doi":"10.1146/annurev-immunol-082423-040557","DOIUrl":"https://doi.org/10.1146/annurev-immunol-082423-040557","url":null,"abstract":"Prosurvival tumor necrosis factor receptor (TNFR) superfamily (TNFRSF) members on T cells, including 4-1BB, CD27, GITR, and OX40, support T cell accumulation during clonal expansion, contributing to T cell memory. During viral infection, tumor necrosis factor superfamily (TNFSF) members on inflammatory monocyte-derived antigen-presenting cells (APCs) provide a postpriming signal (signal 4) for T cell accumulation, particularly in the tissues. Patients with loss-of-function mutations in TNFR/TNFSF members reveal a critical role for 4-1BB and CD27 in CD8 T cell control of Epstein-Barr virus and other childhood infections and of OX40 in CD4 T cell responses. Here, on the 20th anniversary of a previous Annual Review of Immunology article about TNFRSF signaling in T cells, we discuss the effects of endogenous TNFRSF signals in T cells upon recognition of TNFSF members on APCs; the role of TNFRSF members, including TNFR2, on regulatory T cells; and recent advances in the incorporation of TNFRSF signaling in T cells into immunotherapeutic strategies for cancer.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracing the Evolution of Human Immunity Through Ancient DNA. 通过古代DNA追踪人类免疫的进化。

IF 26.9 1区医学

Annual review of immunology Pub Date : 2024-12-20 DOI: 10.1146/annurev-immunol-082323-024638

Etienne Patin, Lluis Quintana-Murci

{"title":"Tracing the Evolution of Human Immunity Through Ancient DNA.","authors":"Etienne Patin, Lluis Quintana-Murci","doi":"10.1146/annurev-immunol-082323-024638","DOIUrl":"https://doi.org/10.1146/annurev-immunol-082323-024638","url":null,"abstract":"Infections have imposed strong selection pressures throughout human evolution, making the study of natural selection's effects on immunity genes highly complementary to disease-focused research. This review discusses how ancient DNA studies, which have revolutionized evolutionary genetics, increase our understanding of the evolution of human immunity. These studies have shown that interbreeding between modern humans and Neanderthals or Denisovans has influenced present-day immune responses, particularly to viruses. Additionally, ancient genomics enables the tracking of how human immunity has evolved across cultural transitions, highlighting strong selection since the Bronze Age in Europe (<4,500 years) and potential genetic adaptations to epidemics raging during the Middle Ages and the European colonization of the Americas. Furthermore, ancient genomic studies suggest that the genetic risk for noninfectious immune disorders has gradually increased over millennia because alleles associated with increased risk for autoimmunity and inflammation once conferred resistance to infections. The challenge now is to extend these findings to diverse, non-European populations and to provide a more global understanding of the evolution of human immunity.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T Cell Development and Responses in Human Immune System Mice. 人类免疫系统小鼠的T细胞发育和应答。

IF 26.9 1区医学

Annual review of immunology Pub Date : 2024-12-20 DOI: 10.1146/annurev-immunol-082223-041615

Mohsen Khosravi-Maharlooei, Hao Wei Li, Megan Sykes

引用次数: 0

SARS-CoV-2: The Interplay Between Evolution and Host Immunity. SARS-CoV-2：进化与宿主免疫的相互作用

IF 26.9 1区医学

Annual review of immunology Pub Date : 2024-12-20 DOI: 10.1146/annurev-immunol-083122-043054

James Brett Case, Shilpi Jain, Mehul S Suthar, Michael S Diamond

引用次数: 0

Peeking Into the Black Box of T Cell Receptor Signaling. 窥探T细胞受体信号传导的黑匣子。