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Annual review of immunology最新文献

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T Cell Development and Responses in Human Immune System Mice.
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-12-20 DOI: 10.1146/annurev-immunol-082223-041615
Mohsen Khosravi-Maharlooei, Hao Wei Li, Megan Sykes
{"title":"T Cell Development and Responses in Human Immune System Mice.","authors":"Mohsen Khosravi-Maharlooei, Hao Wei Li, Megan Sykes","doi":"10.1146/annurev-immunol-082223-041615","DOIUrl":"https://doi.org/10.1146/annurev-immunol-082223-041615","url":null,"abstract":"<p><p>Human Immune System (HIS) mice constructed with mature human immune cells or with human hematopoietic stem cells and thymic tissue have provided an important tool for human immunological research. In this article, we first review the different types of HIS mice based on human tissues transplanted and sources of the tissues. We then focus on knowledge of human T cell development and responses obtained using HIS mouse models. These areas include the development of human T cell subsets, with a focus on $upalpha$$upbeta$ conventional T cells and regulatory T cells, and human T cell responses in the settings of infection, transplantation rejection and tolerance, autoimmune disease, cancer immunotherapy, and regulatory T cell therapy. We also discuss the limitations and potential future applications of HIS mouse models.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing the Evolution of Human Immunity Through Ancient DNA.
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-12-20 DOI: 10.1146/annurev-immunol-082323-024638
Etienne Patin, Lluis Quintana-Murci
{"title":"Tracing the Evolution of Human Immunity Through Ancient DNA.","authors":"Etienne Patin, Lluis Quintana-Murci","doi":"10.1146/annurev-immunol-082323-024638","DOIUrl":"https://doi.org/10.1146/annurev-immunol-082323-024638","url":null,"abstract":"<p><p>Infections have imposed strong selection pressures throughout human evolution, making the study of natural selection's effects on immunity genes highly complementary to disease-focused research. This review discusses how ancient DNA studies, which have revolutionized evolutionary genetics, increase our understanding of the evolution of human immunity. These studies have shown that interbreeding between modern humans and Neanderthals or Denisovans has influenced present-day immune responses, particularly to viruses. Additionally, ancient genomics enables the tracking of how human immunity has evolved across cultural transitions, highlighting strong selection since the Bronze Age in Europe (<4,500 years) and potential genetic adaptations to epidemics raging during the Middle Ages and the European colonization of the Americas. Furthermore, ancient genomic studies suggest that the genetic risk for noninfectious immune disorders has gradually increased over millennia because alleles associated with increased risk for autoimmunity and inflammation once conferred resistance to infections. The challenge now is to extend these findings to diverse, non-European populations and to provide a more global understanding of the evolution of human immunity.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SARS-CoV-2: The Interplay Between Evolution and Host Immunity.
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-12-20 DOI: 10.1146/annurev-immunol-083122-043054
James Brett Case, Shilpi Jain, Mehul S Suthar, Michael S Diamond
{"title":"SARS-CoV-2: The Interplay Between Evolution and Host Immunity.","authors":"James Brett Case, Shilpi Jain, Mehul S Suthar, Michael S Diamond","doi":"10.1146/annurev-immunol-083122-043054","DOIUrl":"https://doi.org/10.1146/annurev-immunol-083122-043054","url":null,"abstract":"<p><p>The persistence of SARS-CoV-2 infections at a global level reflects the repeated emergence of variant strains encoding unique constellations of mutations. These variants have been generated principally because of a dynamic host immune landscape, the countermeasures deployed to combat disease, and selection for enhanced infection of the upper airway and respiratory transmission. The resulting viral diversity creates a challenge for vaccination efforts to maintain efficacy, especially regarding humoral aspects of protection. Here, we review our understanding of how SARS-CoV-2 has evolved during the pandemic, the immune mechanisms that confer protection, and the impact viral evolution has had on transmissibility and adaptive immunity elicited by natural infection and/or vaccination. Evidence suggests that SARS-CoV-2 evolution initially selected variants with increased transmissibility but currently is driven by immune escape. The virus likely will continue to drift to maintain fitness until countermeasures capable of disrupting transmission cycles become widely available.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":""},"PeriodicalIF":26.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peeking Into the Black Box of T Cell Receptor Signaling. 窥探T细胞受体信号传导的黑匣子。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090222-112028
Arthur Weiss
{"title":"Peeking Into the Black Box of T Cell Receptor Signaling.","authors":"Arthur Weiss","doi":"10.1146/annurev-immunol-090222-112028","DOIUrl":"10.1146/annurev-immunol-090222-112028","url":null,"abstract":"<p><p>I have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"1-20"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmunology of the Lung. 肺中的神经免疫相互作用。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-083122-042512
Rossana Azzoni, Olaf Perdijk, Nicola L Harris, Benjamin J Marsland
{"title":"Neuroimmunology of the Lung.","authors":"Rossana Azzoni, Olaf Perdijk, Nicola L Harris, Benjamin J Marsland","doi":"10.1146/annurev-immunol-083122-042512","DOIUrl":"10.1146/annurev-immunol-083122-042512","url":null,"abstract":"<p><p>Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in close proximity to both stromal and immune cell populations. Together with a growing awareness of the far-reaching consequences of neuroimmune interactions, recent studies have uncovered key mechanisms through which they contribute to organ homeostasis and immunity. It has also become clear that dysregulation of such interactions is implicated in the development of chronic lung diseases. This review describes the characteristics of the lung nervous system and discusses the molecular mechanisms that underlie lung neuroimmune interactions in infection and disease. We have contextualized the current literature and identified opportune areas for further investigation. Indeed, both the lung-brain axis and local neuroimmune interactions hold enormous potential for the exploration and development of novel therapeutic strategies targeting lung diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"57-81"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138290118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities. 抗癌免疫中的昼夜节律：机制与治疗机会。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-090122-050842
Robert Pick, Chen Wang, Qun Zeng, Zeynep Melis Gül, Christoph Scheiermann
{"title":"Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities.","authors":"Robert Pick, Chen Wang, Qun Zeng, Zeynep Melis Gül, Christoph Scheiermann","doi":"10.1146/annurev-immunol-090122-050842","DOIUrl":"https://doi.org/10.1146/annurev-immunol-090122-050842","url":null,"abstract":"<p><p>Circadian rhythms of approximately 24 h have emerged as important modulators of the immune system. These oscillations are important for mounting short-term, innate immune responses, but surprisingly also long-term, adaptive immune responses. Recent data indicate that they play a central role in antitumor immunity, in both mice and humans. In this review, we discuss the evolving literature on circadian antitumor immune responses and the underlying mechanisms that control them. We further provide an overview of circadian treatment regimens-chrono-immunotherapies-that harness time-of-day differences in immunity for optimal efficacy. Our aim is to provide an overview for researchers and clinicians alike, for a better understanding of the circadian immune system and how to best harness it for chronotherapeutic interventions. This knowledge is important for a better understanding of immune responses per se and could revolutionize the way we approach the treatment of cancer and a range of other diseases, ultimately improving clinical practice.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"83-102"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunology of Kidney Disease. 肾脏疾病免疫学。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090122-045843
Orestes Foresto-Neto, Luísa Menezes-Silva, Jefferson Antônio Leite, Magaiver Andrade-Silva, Niels Olsen Saraiva Câmara
{"title":"Immunology of Kidney Disease.","authors":"Orestes Foresto-Neto, Luísa Menezes-Silva, Jefferson Antônio Leite, Magaiver Andrade-Silva, Niels Olsen Saraiva Câmara","doi":"10.1146/annurev-immunol-090122-045843","DOIUrl":"10.1146/annurev-immunol-090122-045843","url":null,"abstract":"<p><p>The immune system and the kidneys are closely related. Immune components mediate acute kidney disease and are crucial to the progression of chronic kidney disease. Beyond its pathogenic functions, the immune system supports immunological homeostasis in healthy kidneys. The kidneys help maintain immune equilibrium by removing metabolic waste products and toxins, thereby limiting local and systemic inflammation. In this review, we describe the close relationship between the immune system and the kidneys. We discuss how the imbalance in the immune response can be deleterious to the kidneys and how immunomodulation can be important in preventing end-stage renal disease. In addition, recent tools such as in silico platforms and kidney organoids can help unveil the relationship between immune cells and kidney homeostasis.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"207-233"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Metabolites and Gut Immunology. 微生物代谢物与肠道免疫学
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-090222-102035
Tadashi Takeuchi, Yumiko Nakanishi, Hiroshi Ohno
{"title":"Microbial Metabolites and Gut Immunology.","authors":"Tadashi Takeuchi, Yumiko Nakanishi, Hiroshi Ohno","doi":"10.1146/annurev-immunol-090222-102035","DOIUrl":"https://doi.org/10.1146/annurev-immunol-090222-102035","url":null,"abstract":"<p><p>The intestine is the largest peripheral lymphoid organ in animals, including humans, and interacts with a vast array of microorganisms called the gut microbiota. Comprehending the symbiotic relationship between the gut microbiota and our immune system is essential not only for the field of immunology but also for understanding the pathogenesis of various systemic diseases, including cancer, cardiometabolic disorders, and extraintestinal autoimmune conditions. Whereas microbe-derived antigens are crucial for activating the intestinal immune system, particularly T and B cells, as environmental cues, microbes and their metabolites play a critical role in directing the differentiation of these immune cells. Microbial metabolites are regarded as messengers from the gut microbiota, since bacteria have the ability to produce unique molecules that humans cannot, and many immune cells in the intestine express receptors for these molecules. This review highlights the distinct relationships between microbial metabolites and the differentiation and function of the immune system.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"153-178"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ontogeny and Function of Plasmacytoid Dendritic Cells. 质体树突状细胞的本体和功能
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-090122-041105
Nicholas M Adams, Annesa Das, Tae Jin Yun, Boris Reizis
{"title":"Ontogeny and Function of Plasmacytoid Dendritic Cells.","authors":"Nicholas M Adams, Annesa Das, Tae Jin Yun, Boris Reizis","doi":"10.1146/annurev-immunol-090122-041105","DOIUrl":"https://doi.org/10.1146/annurev-immunol-090122-041105","url":null,"abstract":"<p><p>Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune system. Their defining property is the recognition of pathogen-derived nucleic acids through endosomal Toll-like receptors and the ensuing production of type I interferon and other soluble mediators, which orchestrate innate and adaptive responses. We review several aspects of pDC biology that have recently come to the fore. We discuss emerging questions regarding the lineage affiliation and origin of pDCs and argue that these cells constitute an integral part of the dendritic cell lineage. We emphasize the specific function of pDCs as innate sentinels of virus infection, particularly their recognition of and distinct response to virus-infected cells. This essential evolutionary role of pDCs has been particularly important for the control of coronaviruses, as demonstrated by the recent COVID-19 pandemic. Finally, we highlight the key contribution of pDCs to systemic lupus erythematosus, in which therapeutic targeting of pDCs is currently underway.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"347-373"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B Cell-Directed Therapy in Autoimmunity. 自身免疫的B细胞定向治疗。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-083122-044829
Ilana Abeles, Chris Palma, Nida Meednu, Aimee S Payne, R John Looney, Jennifer H Anolik
{"title":"B Cell-Directed Therapy in Autoimmunity.","authors":"Ilana Abeles, Chris Palma, Nida Meednu, Aimee S Payne, R John Looney, Jennifer H Anolik","doi":"10.1146/annurev-immunol-083122-044829","DOIUrl":"10.1146/annurev-immunol-083122-044829","url":null,"abstract":"<p><p>Autoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines and indirect functions via antigen presentation to T cells. The efficacy of B cell-depleting strategies varies across diseases and likely reflects the complexity of disease pathogenesis and relative contribution of B cell roles. Additionally, B cell-depleting therapies do not equally target all B cell subsets in all patients, and this likely explains some of the variability in responses. Recent reports of B cell depletion with novel chimeric antigen receptor (CAR) T cell approaches in an expanding number of autoimmune diseases highlight the potential role of B cell depletion in resetting immune tolerance. The relative importance of eliminating autoreactive B cells and plasma cells and approaches to doing so will also be discussed.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"103-126"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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