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Annual review of immunology最新文献

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Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. 合成免疫学:入侵免疫细胞以扩大其治疗能力。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052302
Kole T Roybal, Wendell A Lim
{"title":"Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.","authors":"Kole T Roybal,&nbsp;Wendell A Lim","doi":"10.1146/annurev-immunol-051116-052302","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052302","url":null,"abstract":"<p><p>The ability of immune cells to survey tissues and sense pathologic insults and deviations makes them a unique platform for interfacing with the body and disease. With the rapid advancement of synthetic biology, we can now engineer and equip immune cells with new sensors and controllable therapeutic response programs to sense and treat diseases that our natural immune system cannot normally handle. Here we review the current state of engineered immune cell therapeutics and their unique capabilities compared to small molecules and biologics. We then discuss how engineered immune cells are being designed to combat cancer, focusing on how new synthetic biology tools are providing potential ways to overcome the major roadblocks for treatment. Finally, we give a long-term vision for the use of synthetic biology to engineer immune cells as a general sensor-response platform to precisely detect disease, to remodel disease microenvironments, and to treat a potentially wide range of challenging diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"229-253"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34945306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 88
Th2 Cells in Health and Disease. Th2细胞在健康和疾病中的作用。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052350
T. Nakayama, K. Hirahara, A. Onodera, Yusuke Endo, H. Hosokawa, K. Shinoda, D. Tumes, Y. Okamoto
{"title":"Th2 Cells in Health and Disease.","authors":"T. Nakayama, K. Hirahara, A. Onodera, Yusuke Endo, H. Hosokawa, K. Shinoda, D. Tumes, Y. Okamoto","doi":"10.1146/annurev-immunol-051116-052350","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052350","url":null,"abstract":"Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases. Molecular analysis of Th2 cell differentiation and maintenance of function has led to recent discoveries that have refined our understanding of Th2 cell biology. Epigenetic regulation of Gata3 expression by chromatin remodeling complexes such as Polycomb and Trithorax is crucial for maintaining Th2 cell identity. In the context of allergic diseases, memory-type pathogenic Th2 cells have been identified in both mice and humans. To better understand these disease-driving cell populations, we have developed a model called the pathogenic Th population disease induction model. The concept of defined subsets of pathogenic Th cells may spur new, effective strategies for treating intractable chronic inflammatory disorders.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"53-84"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44399775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 240
Memory B Cells of Mice and Humans. 小鼠和人类的记忆B细胞。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-041015-055531
Florian J. Weisel, M. Shlomchik
{"title":"Memory B Cells of Mice and Humans.","authors":"Florian J. Weisel, M. Shlomchik","doi":"10.1146/annurev-immunol-041015-055531","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055531","url":null,"abstract":"We comprehensively review memory B cells (MBCs), covering the definition of MBCs and their identities and subsets, how MBCs are generated, where they are localized, how they are maintained, and how they are reactivated. Whereas naive B cells adopt multiple fates upon stimulation, MBCs are more restricted in their responses. Evolving work reveals that the MBC compartment in mice and humans consists of distinct subpopulations with differing effector functions. We discuss the various approaches to define subsets and subset-specific roles. A major theme is the need to both deliver faster effector function upon reexposure and readapt to antigenically variant pathogens while avoiding burnout, which would be the result if all MBCs generated only terminal effector function. We discuss cell-intrinsic differences in gene expression and signaling that underlie differences in function between MBCs and naive B cells and among MBC subsets and how this leads to memory responses.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"255-284"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47161913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 210
Thymic Epithelial Cells. 胸腺上皮细胞。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-10 DOI: 10.1146/annurev-immunol-051116-052320
Jakub Abramson, Graham Anderson
{"title":"Thymic Epithelial Cells.","authors":"Jakub Abramson, Graham Anderson","doi":"10.1146/annurev-immunol-051116-052320","DOIUrl":"10.1146/annurev-immunol-051116-052320","url":null,"abstract":"<p><p>Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity. These properties are collectively required to bias thymocyte development toward production of self-tolerant and functionally competent T cells. The importance of thymic epithelial cells (TECs) is evidenced by clear links between their dysfunction and multiple diseases where autoimmunity and immunodeficiency are major components. Consequently, TECs are an attractive target for cell therapies to restore effective immune system function. The pathways and molecular regulators that control TEC development are becoming clearer, as are their influences on particular stages of T cell development. Here, we review both historical and the most recent advances in our understanding of the cellular and molecular mechanisms controlling TEC development, function, dysfunction, and regeneration.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"85-118"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34756158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signaling by Antibodies: Recent Progress. 抗体信号传导:最新进展。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052433
Stylianos Bournazos, Taia T Wang, Rony Dahan, Jad Maamary, Jeffrey V Ravetch
{"title":"Signaling by Antibodies: Recent Progress.","authors":"Stylianos Bournazos,&nbsp;Taia T Wang,&nbsp;Rony Dahan,&nbsp;Jad Maamary,&nbsp;Jeffrey V Ravetch","doi":"10.1146/annurev-immunol-051116-052433","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052433","url":null,"abstract":"<p><p>IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"285-311"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34945304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 156
Immunobiology of Long Noncoding RNAs. 长链非编码rna的免疫生物学。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-041015-055459
Maninjay K. Atianand, Daniel R. Caffrey, K. Fitzgerald
{"title":"Immunobiology of Long Noncoding RNAs.","authors":"Maninjay K. Atianand, Daniel R. Caffrey, K. Fitzgerald","doi":"10.1146/annurev-immunol-041015-055459","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055459","url":null,"abstract":"The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that interact with RNA, DNA, or proteins to promote or restrain the expression of protein-coding genes. Activation of immune cells is associated with dynamic changes in expression of genes, the products of which combat infectious microorganisms, initiate repair, and resolve inflammatory responses in cells and tissues. Recent evidence indicates that lncRNAs play important roles in directing the development of diverse immune cells and controlling the dynamic transcriptional programs that are a hallmark of immune cell activation. The importance of these molecules is underscored by their newly recognized roles in inflammatory diseases. In this review, we discuss the contribution of lncRNAs in the development and activation of immune cells and their roles in immune-related diseases. We also discuss challenges faced in identifying biological functions for this large and complex class of genes.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"177-198"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47950352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 349
The Lymphatic System: Integral Roles in Immunity. 淋巴系统：免疫的整体作用。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-041015-055354
G. Randolph, Stoyan Ivanov, B. Zinselmeyer, J. Scallan
{"title":"The Lymphatic System: Integral Roles in Immunity.","authors":"G. Randolph, Stoyan Ivanov, B. Zinselmeyer, J. Scallan","doi":"10.1146/annurev-immunol-041015-055354","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055354","url":null,"abstract":"The lymphatic vasculature is not considered a formal part of the immune system, but it is critical to immunity. One of its major roles is in the coordination of the trafficking of antigen and immune cells. However, other roles in immunity are emerging. Lymphatic endothelial cells, for example, directly present antigen or express factors that greatly influence the local environment. We cover these topics herein and discuss how other properties of the lymphatic vasculature, such as mechanisms of lymphatic contraction (which immunologists traditionally do not take into account), are nonetheless integral in the immune system. Much is yet unknown, and this nascent subject is ripe for exploration. We argue that to consider the impact of lymphatic biology in any given immunological interaction is a key step toward integrating immunology with organ physiology and ultimately many complex pathologies.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"31-52"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49595355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 223
The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules. 外源抗原在mhc - 1分子上交叉呈递的生物学和潜在机制。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-01-11 DOI: 10.1146/annurev-immunol-041015-055254
Freidrich M Cruz, Jeff D Colbert, Elena Merino, Barry A Kriegsman, Kenneth L Rock
{"title":"The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.","authors":"Freidrich M Cruz, Jeff D Colbert, Elena Merino, Barry A Kriegsman, Kenneth L Rock","doi":"10.1146/annurev-immunol-041015-055254","DOIUrl":"10.1146/annurev-immunol-041015-055254","url":null,"abstract":"<p><p>To monitor the health of cells, the immune system tasks antigen-presenting cells with gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides bound to MHC-I molecules. Most cells would be unable to perform this function because they use their MHC-I molecules to exclusively present peptides derived from the cell's own proteins. However, the immune system evolved mechanisms for dendritic cells and some other phagocytes to sample and present antigens from the extracellular milieu on MHC-I through a process called cross-presentation. How this important task is accomplished, its role in health and disease, and its potential for exploitation are the subject of this review.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"149-176"},"PeriodicalIF":26.9,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47726078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics. 通过转录组学了解人类自身免疫和自身炎症。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-01-30 DOI: 10.1146/annurev-immunol-051116-052225
Romain Banchereau, Alma-Martina Cepika, Jacques Banchereau, Virginia Pascual
{"title":"Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics.","authors":"Romain Banchereau, Alma-Martina Cepika, Jacques Banchereau, Virginia Pascual","doi":"10.1146/annurev-immunol-051116-052225","DOIUrl":"10.1146/annurev-immunol-051116-052225","url":null,"abstract":"<p><p>Transcriptomics, the high-throughput characterization of RNAs, has been instrumental in defining pathogenic signatures in human autoimmunity and autoinflammation. It enabled the identification of new therapeutic targets in IFN-, IL-1- and IL-17-mediated diseases. Applied to immunomonitoring, transcriptomics is starting to unravel diagnostic and prognostic signatures that stratify patients, track molecular changes associated with disease activity, define personalized treatment strategies, and generally inform clinical practice. Herein, we review the use of transcriptomics to define mechanistic, diagnostic, and predictive signatures in human autoimmunity and autoinflammation. We discuss some of the analytical approaches applied to extract biological knowledge from high-dimensional data sets. Finally, we touch upon emerging applications of transcriptomics to study eQTLs, B and T cell repertoire diversity, and isoform usage.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"337-370"},"PeriodicalIF":26.9,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42694539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. 肠内稳态和组织愈合的上皮和免疫细胞粘膜生态网络。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052424
Y. Kurashima, H. Kiyono
{"title":"Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing.","authors":"Y. Kurashima, H. Kiyono","doi":"10.1146/annurev-immunol-051116-052424","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052424","url":null,"abstract":"The intestinal epithelial barrier includes columnar epithelial, Paneth, goblet, enteroendocrine, and tuft cells as well as other cell populations, all of which contribute properties essential for gastrointestinal homeostasis. The intestinal mucosa is covered by mucin, which contains antimicrobial peptides and secretory IgA and prevents luminal bacteria, fungi, and viruses from stimulating intestinal immune responses. Conversely, the transport of luminal microorganisms-mediated by M, dendritic, and goblet cells-into intestinal tissues facilitates the harmonization of active and quiescent mucosal immune responses. The bacterial population within gut-associated lymphoid tissues creates the intratissue cohabitations for harmonized mucosal immunity. Intermolecular and intercellular communication among epithelial, immune, and mesenchymal cells creates an environment conducive for epithelial regeneration and mucosal healing. This review summarizes the so-called intestinal mucosal ecological network-the complex but vital molecular and cellular interactions of epithelial mesenchymal cells, immune cells, and commensal microbiota that achieve intestinal homeostasis, regeneration, and healing.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"119-147"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47603602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 188
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