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Annual review of immunology最新文献

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Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy. JAK/STAT通路在T细胞淋巴瘤发病机制中的紊乱:免疫治疗的意义。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-110416-120628
T. Waldmann, Jing Chen
{"title":"Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy.","authors":"T. Waldmann, Jing Chen","doi":"10.1146/annurev-immunol-110416-120628","DOIUrl":"https://doi.org/10.1146/annurev-immunol-110416-120628","url":null,"abstract":"Common gamma receptor-dependent cytokines and their JAK/STAT pathways play pivotal roles in T cell immunity. Abnormal activation of this system was pervasive in diverse T cell malignancies assessed by pSTAT3/pSTAT5 phosphorylation. Activating mutations were described in some but not all cases. JAK1 and STAT3 were required for proliferation and survival of these T cell lines whether or not JAKs or STATs were mutated. Activating JAK and STAT mutations were not sufficient to initiate leukemic cell proliferation but rather only augmented signals from upstream in the cytokine pathway. Activation required the full pathway, including cytokine receptors acting as scaffolds and docking sites for required downstream JAK/STAT proteins. JAK kinase inhibitors have depressed leukemic T cell line proliferation. The insight that JAK/STAT system activation is pervasive in T cell malignancies suggests novel therapeutic approaches that include antibodies to common gamma cytokines, inhibitors of cytokine-receptor interactions, and JAK kinase inhibitors that may revolutionize therapy for T cell malignancies.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"533-550"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-110416-120628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49234312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 114
Microbes and Cancer. 微生物和癌症。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052133
Amiran H. Dzutsev, J. Badger, E. Peréz-Chanona, S. Roy, R. Salcedo, Carolyne Smith, G. Trinchieri
{"title":"Microbes and Cancer.","authors":"Amiran H. Dzutsev, J. Badger, E. Peréz-Chanona, S. Roy, R. Salcedo, Carolyne Smith, G. Trinchieri","doi":"10.1146/annurev-immunol-051116-052133","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052133","url":null,"abstract":"Commensal microorganisms (the microbiota) live on all the surface barriers of our body and are particularly abundant and diverse in the distal gut. The microbiota and its larger host represent a metaorganism in which the cross talk between microbes and host cells is necessary for health, survival, and regulation of physiological functions locally, at the barrier level, and systemically. The ancestral molecular and cellular mechanisms stemming from the earliest interactions between prokaryotes and eukaryotes have evolved to mediate microbe-dependent host physiology and tissue homeostasis, including innate and adaptive resistance to infections and tissue repair. Mostly because of its effects on metabolism, cellular proliferation, inflammation, and immunity, the microbiota regulates cancer at the level of predisposing conditions, initiation, genetic instability, susceptibility to host immune response, progression, comorbidity, and response to therapy. Here, we review the mechanisms underlying the interaction of the microbiota with cancer and the evidence suggesting that the microbiota could be targeted to improve therapy while attenuating adverse reactions.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"199-228"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41990388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 181
Heterogeneity of Human CD4(+) T Cells Against Microbes. 人CD4(+) T细胞抗微生物的异质性
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112056
Federica Sallusto
{"title":"Heterogeneity of Human CD4(+) T Cells Against Microbes.","authors":"Federica Sallusto","doi":"10.1146/annurev-immunol-032414-112056","DOIUrl":"https://doi.org/10.1146/annurev-immunol-032414-112056","url":null,"abstract":"<p><p>CD4(+) T helper (Th) cells play a central role in the adaptive immune response by providing help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to mediate protection against a wide range of pathogenic microorganisms. These functions are performed by different types of Th cells endowed with distinct migratory capacities and effector functions. Here we discuss how studies of the human T cell response to microbes have advanced our understanding of Th cell functional heterogeneity, in particular with the discovery of a distinct Th1 subset involved in the response to Mycobacteria and the characterization of two types of Th17 cells specific for extracellular bacteria or fungi. We also review new approaches to dissect at the clonal level the human CD4(+) T cell response induced by pathogens or vaccines that have revealed an unexpected degree of intraclonal diversification and propose a progressive and selective model of CD4(+) T cell differentiation.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"317-34"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-032414-112056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34378618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 257
Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System. 视黄酸和视黄酸受体作为免疫系统的多效调节剂。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-041015-055427
Alexandre Larange, Hilde Cheroutre
{"title":"Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System.","authors":"Alexandre Larange,&nbsp;Hilde Cheroutre","doi":"10.1146/annurev-immunol-041015-055427","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055427","url":null,"abstract":"<p><p>Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell involved in protective or regulatory adaptive or innate immunity. This is especially key at the intestinal border, where dietary vitamin A is first absorbed. Most effects of vitamin A are exerted by its metabolite, retinoic acid (RA), which through ligation of nuclear receptors controls transcriptional expression of RA target genes. In addition to this canonical function, RA and RA receptors (RARs), either as ligand-receptor or separately, play extranuclear, nongenomic roles that greatly expand the multiple mechanisms employed for their numerous and paradoxical functions that ultimately link environmental sensing with immune cell fate. This review discusses RA and RARs and their complex roles in innate and adaptive immunity.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"369-94"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34378620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 169
Fate Mapping and Quantitation of Hematopoiesis In Vivo. 体内造血的命运定位和定量。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112019
Thomas Höfer, Katrin Busch, Kay Klapproth, Hans-Reimer Rodewald
{"title":"Fate Mapping and Quantitation of Hematopoiesis In Vivo.","authors":"Thomas Höfer,&nbsp;Katrin Busch,&nbsp;Kay Klapproth,&nbsp;Hans-Reimer Rodewald","doi":"10.1146/annurev-immunol-032414-112019","DOIUrl":"https://doi.org/10.1146/annurev-immunol-032414-112019","url":null,"abstract":"<p><p>Hematopoietic stem cells (HSCs) and downstream progenitors have long been studied based on phenotype, cell purification, proliferation, and transplantation into myeloablated recipients. These experiments, complemented by data on expression profiles, mouse mutants, and humans with hematopoietic defects, are the foundation for the current hematopoietic differentiation tree. However, there are fundamental gaps in our knowledge of the quantitative and qualitative operation of the HSC/progenitor system under physiological and pathological conditions in vivo. The hallmarks of HSCs, self-renewal and multipotency, are observed in in vitro assays and cell transplantation experiments; however, the extent to which these features occur naturally in HSCs and progenitors remains uncertain. We focus here on work that strives to address these unresolved questions, with emphasis on fate mapping and modeling of the hematopoietic flow from stem cells toward myeloid and lymphoid lineages during development and adult life.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"449-78"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-032414-112019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34378621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 51
How One Thing Led to Another. 一件事如何导致另一件事。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112003
Irving Weissman
{"title":"How One Thing Led to Another.","authors":"Irving Weissman","doi":"10.1146/annurev-immunol-032414-112003","DOIUrl":"https://doi.org/10.1146/annurev-immunol-032414-112003","url":null,"abstract":"<p><p>I started research in high school, experimenting on immunological tolerance to transplantation antigens. This led to studies of the thymus as the site of maturation of T cells, which led to the discovery, isolation, and clinical transplantation of purified hematopoietic stem cells (HSCs). The induction of immune tolerance with HSCs has led to isolation of other tissue-specific stem cells for regenerative medicine. Our studies of circulating competing germline stem cells in colonial protochordates led us to document competing HSCs. In human acute myelogenous leukemia we showed that all preleukemic mutations occur in HSCs, and determined their order; the final mutations occur in a multipotent progenitor derived from the preleukemic HSC clone. With these, we discovered that CD47 is an upregulated gene in all human cancers and is a \"don't eat me\" signal; blocking it with antibodies leads to cancer cell phagocytosis. CD47 is the first known gene common to all cancers and is a target for cancer immunotherapy.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"1-30"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-032414-112003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34474783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Mechanisms of Pediatric Inflammatory Bowel Disease. 儿童炎症性肠病的机制。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112151
Joanna M Peloquin, Gautam Goel, Eduardo J Villablanca, Ramnik J Xavier
{"title":"Mechanisms of Pediatric Inflammatory Bowel Disease.","authors":"Joanna M Peloquin,&nbsp;Gautam Goel,&nbsp;Eduardo J Villablanca,&nbsp;Ramnik J Xavier","doi":"10.1146/annurev-immunol-032414-112151","DOIUrl":"https://doi.org/10.1146/annurev-immunol-032414-112151","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, is characterized by chronic intestinal inflammation due to a complex interaction of genetic determinants, disruption of mucosal barriers, aberrant inflammatory signals, loss of tolerance, and environmental triggers. Importantly, the incidence of pediatric IBD is rising, particularly in children younger than 10 years. In this review, we discuss the clinical presentation of these patients and highlight environmental exposures that may affect disease risk, particularly among people with a background genetic risk. With regard to both children and adults, we review advancements in understanding the intestinal epithelium, the mucosal immune system, and the resident microbiota, describing how dysfunction at any level can lead to diseases like IBD. We conclude with future directions for applying advances in IBD genetics to better understand pathogenesis and develop therapeutics targeting key pathogenic nodes.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"31-64"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-032414-112151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34474786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 122
Exploiting Mucosal Immunity for Antiviral Vaccines. 利用黏膜免疫进行抗病毒疫苗研究
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112315
Akiko Iwasaki
{"title":"Exploiting Mucosal Immunity for Antiviral Vaccines.","authors":"Akiko Iwasaki","doi":"10.1146/annurev-immunol-032414-112315","DOIUrl":"https://doi.org/10.1146/annurev-immunol-032414-112315","url":null,"abstract":"<p><p>Mucosal surfaces provide a remarkably effective barrier against potentially dangerous pathogens. Therefore, enhancing mucosal immunity through vaccines-strengthening that first line of defense-holds significant promise for reducing the burden of viral diseases. The large and varied class of viral pathogens, however, continues to present thorny challenges to vaccine development. Two primary difficulties exist: Viruses exhibit a stunning diversity of strategies for evading the host immune response, and even when we understand the nature of effective immune protection against a given virus, eliciting that protection is technically challenging. Only a few mucosal vaccines have surmounted these obstacles thus far. Recent developments, however, could greatly improve vaccine design. In this review, we first sketch out our understanding of mucosal immunity and then compare the herpes simplex virus, human immunodeficiency virus, and influenza virus to illustrate the distinct challenges of developing successful vaccines and to outline potential solutions.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"575-608"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-032414-112315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34378623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 100
Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design. 广泛中和的HIV抗体及其在疫苗设计中的作用。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-041015-055515
Dennis R Burton, Lars Hangartner
{"title":"Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.","authors":"Dennis R Burton,&nbsp;Lars Hangartner","doi":"10.1146/annurev-immunol-041015-055515","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055515","url":null,"abstract":"<p><p>HIV employs multiple means to evade the humoral immune response, particularly the elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies can act antivirally against a wide spectrum of viruses by targeting relatively conserved regions on the surface HIV envelope trimer spike. Elicitation of and recognition by bnAbs are hindered by the arrangement of spikes on virions and the relatively difficult access to bnAb epitopes on spikes, including the proximity of variable regions and a high density of glycans. Yet, in a small proportion of HIV-infected individuals, potent bnAb responses do develop, and isolation of the corresponding monoclonal antibodies has been facilitated by identification of favorable donors with potent bnAb sera and by development of improved methods for human antibody generation. Molecular studies of recombinant Env trimers, alone and in interaction with bnAbs, are providing new insights that are fueling the development and testing of promising immunogens aimed at the elicitation of bnAbs.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"635-59"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34384354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 456
The Innate Lymphoid Cell Precursor. 先天淋巴样细胞前体。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-041015-055549
Isabel E Ishizuka, Michael G Constantinides, Herman Gudjonson, Albert Bendelac
{"title":"The Innate Lymphoid Cell Precursor.","authors":"Isabel E Ishizuka,&nbsp;Michael G Constantinides,&nbsp;Herman Gudjonson,&nbsp;Albert Bendelac","doi":"10.1146/annurev-immunol-041015-055549","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055549","url":null,"abstract":"<p><p>The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing questions about their precise lineage relationship. Here we review advances in mapping the emergence of these lineages from early lymphoid precursors. We discuss the identification of a common innate lymphoid cell precursor characterized by transient expression of the transcription factor PLZF, and the lineage relationships of innate lymphoid cells with conventional natural killer cells and lymphoid tissue inducer cells. We also review the rapidly growing understanding of the network of transcription factors that direct the development of these lineages.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"34 ","pages":"299-316"},"PeriodicalIF":29.7,"publicationDate":"2016-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34474787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
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