Annual review of immunology最新文献_第10页

Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation. 代谢物感知G蛋白偶联受体-饮食相关免疫调节的促进者。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052235

Jian K Tan, Craig McKenzie, Eliana Mariño, Laurence Macia, Charles R Mackay

{"title":"Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation.","authors":"Jian K Tan, Craig McKenzie, Eliana Mariño, Laurence Macia, Charles R Mackay","doi":"10.1146/annurev-immunol-051116-052235","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052235","url":null,"abstract":"Nutrition and the gut microbiome regulate many systems, including the immune, metabolic, and nervous systems. We propose that the host responds to deficiency (or sufficiency) of dietary and bacterial metabolites in a dynamic way, to optimize responses and survival. A family of G protein-coupled receptors (GPCRs) termed the metabolite-sensing GPCRs bind to various metabolites and transmit signals that are important for proper immune and metabolic functions. Members of this family include GPR43, GPR41, GPR109A, GPR120, GPR40, GPR84, GPR35, and GPR91. In addition, bile acid receptors such as GPR131 (TGR5) and proton-sensing receptors such as GPR65 show similar features. A consistent feature of this family of GPCRs is that they provide anti-inflammatory signals; many also regulate metabolism and gut homeostasis. These receptors represent one of the main mechanisms whereby the gut microbiome affects vertebrate physiology, and they also provide a link between the immune and metabolic systems. Insufficient signaling through one or more of these metabolite-sensing GPCRs likely contributes to human diseases such as asthma, food allergies, type 1 and type 2 diabetes, hepatic steatosis, cardiovascular disease, and inflammatory bowel diseases.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"371-402"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34945303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 198

Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies. 感染性和炎症性疾病的遗传学:关联和外显子组测序研究的重叠发现。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052442

D. Langlais, N. Fodil, P. Gros

{"title":"Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies.","authors":"D. Langlais, N. Fodil, P. Gros","doi":"10.1146/annurev-immunol-051116-052442","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052442","url":null,"abstract":"Genome technologies have defined a complex genetic architecture in major infectious, inflammatory, and autoimmune disorders. High density marker arrays and Immunochips have powered genome-wide association studies (GWAS) that have mapped nearly 450 genetic risk loci in 22 major inflammatory diseases, including a core of common genes that play a central role in pathological inflammation. Whole-exome and whole-genome sequencing have identified more than 265 genes in which mutations cause primary immunodeficiencies and rare forms of severe inflammatory bowel disease. Combined analysis of inflammatory disease GWAS and primary immunodeficiencies point to shared proteins and pathways that are required for immune cell development and protection against infections and are also associated with pathological inflammation. Finally, sequencing of chromatin immunoprecipitates containing specific transcription factors, with parallel RNA sequencing, has charted epigenetic regulation of gene expression by proinflammatory transcription factors in immune cells, providing complementary information to characterize morbid genes at infectious and inflammatory disease loci.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"1-30"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44953888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Protective and Harmful Immunity to RSV Infection. 对呼吸道合胞病毒感染的保护性和有害免疫。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-06 DOI: 10.1146/annurev-immunol-051116-052206

Peter J M Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson

{"title":"Protective and Harmful Immunity to RSV Infection.","authors":"Peter J M Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson","doi":"10.1146/annurev-immunol-051116-052206","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052206","url":null,"abstract":"<p><p>Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects. It infects virtually all children by the age of three years and then repeatedly infects throughout life; this it does despite relatively slight variations in antigenicity, apparently by inducing selective immunological amnesia. Inappropriate or dysregulated responses to RSV can be pathogenic, causing disease-enhancing inflammation that contributes to short- and long-term effects. In addition, RSV's importance as a largely unrecognized pathogen of debilitated older people is increasingly evident. Vaccines that induce nonpathogenic protective immunity may soon be available, and it is possible that different vaccines will be optimal for infants; older children; young to middle-age adults (including pregnant women); and elderly persons. At the dawn of RSV vaccination, it is timely to review what is known (and unknown) about immune responses to this fascinating virus.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"501-532"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34756159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 163

Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy. JAK/STAT通路在T细胞淋巴瘤发病机制中的紊乱:免疫治疗的意义。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-110416-120628

T. Waldmann, Jing Chen

{"title":"Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy.","authors":"T. Waldmann, Jing Chen","doi":"10.1146/annurev-immunol-110416-120628","DOIUrl":"https://doi.org/10.1146/annurev-immunol-110416-120628","url":null,"abstract":"Common gamma receptor-dependent cytokines and their JAK/STAT pathways play pivotal roles in T cell immunity. Abnormal activation of this system was pervasive in diverse T cell malignancies assessed by pSTAT3/pSTAT5 phosphorylation. Activating mutations were described in some but not all cases. JAK1 and STAT3 were required for proliferation and survival of these T cell lines whether or not JAKs or STATs were mutated. Activating JAK and STAT mutations were not sufficient to initiate leukemic cell proliferation but rather only augmented signals from upstream in the cytokine pathway. Activation required the full pathway, including cytokine receptors acting as scaffolds and docking sites for required downstream JAK/STAT proteins. JAK kinase inhibitors have depressed leukemic T cell line proliferation. The insight that JAK/STAT system activation is pervasive in T cell malignancies suggests novel therapeutic approaches that include antibodies to common gamma cytokines, inhibitors of cytokine-receptor interactions, and JAK kinase inhibitors that may revolutionize therapy for T cell malignancies.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"533-550"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-110416-120628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49234312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 114

Microbes and Cancer. 微生物和癌症。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052133

Amiran H. Dzutsev, J. Badger, E. Peréz-Chanona, S. Roy, R. Salcedo, Carolyne Smith, G. Trinchieri

{"title":"Microbes and Cancer.","authors":"Amiran H. Dzutsev, J. Badger, E. Peréz-Chanona, S. Roy, R. Salcedo, Carolyne Smith, G. Trinchieri","doi":"10.1146/annurev-immunol-051116-052133","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052133","url":null,"abstract":"Commensal microorganisms (the microbiota) live on all the surface barriers of our body and are particularly abundant and diverse in the distal gut. The microbiota and its larger host represent a metaorganism in which the cross talk between microbes and host cells is necessary for health, survival, and regulation of physiological functions locally, at the barrier level, and systemically. The ancestral molecular and cellular mechanisms stemming from the earliest interactions between prokaryotes and eukaryotes have evolved to mediate microbe-dependent host physiology and tissue homeostasis, including innate and adaptive resistance to infections and tissue repair. Mostly because of its effects on metabolism, cellular proliferation, inflammation, and immunity, the microbiota regulates cancer at the level of predisposing conditions, initiation, genetic instability, susceptibility to host immune response, progression, comorbidity, and response to therapy. Here, we review the mechanisms underlying the interaction of the microbiota with cancer and the evidence suggesting that the microbiota could be targeted to improve therapy while attenuating adverse reactions.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"199-228"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41990388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 181

Heterogeneity of Human CD4(+) T Cells Against Microbes. 人CD4(+) T细胞抗微生物的异质性

IF 29.7 1区医学

Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112056

Federica Sallusto

引用次数: 257

Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System. 视黄酸和视黄酸受体作为免疫系统的多效调节剂。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-041015-055427

Alexandre Larange, Hilde Cheroutre

引用次数: 169

Fate Mapping and Quantitation of Hematopoiesis In Vivo. 体内造血的命运定位和定量。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112019

Thomas Höfer, Katrin Busch, Kay Klapproth, Hans-Reimer Rodewald

引用次数: 51

How One Thing Led to Another. 一件事如何导致另一件事。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112003

Irving Weissman

引用次数: 17

Mechanisms of Pediatric Inflammatory Bowel Disease. 儿童炎症性肠病的机制。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2016-05-20 DOI: 10.1146/annurev-immunol-032414-112151

Joanna M Peloquin, Gautam Goel, Eduardo J Villablanca, Ramnik J Xavier

引用次数: 122