Annual review of immunology最新文献_第9页

Immunobiology of Long Noncoding RNAs. 长链非编码rna的免疫生物学。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-041015-055459

Maninjay K. Atianand, Daniel R. Caffrey, K. Fitzgerald

引用次数: 349

The Lymphatic System: Integral Roles in Immunity. 淋巴系统：免疫的整体作用。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-041015-055354

G. Randolph, Stoyan Ivanov, B. Zinselmeyer, J. Scallan

引用次数: 223

Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics. 通过转录组学了解人类自身免疫和自身炎症。

IF 26.9 1区医学

Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-01-30 DOI: 10.1146/annurev-immunol-051116-052225

Romain Banchereau, Alma-Martina Cepika, Jacques Banchereau, Virginia Pascual

引用次数: 0

Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. 肠内稳态和组织愈合的上皮和免疫细胞粘膜生态网络。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052424

Y. Kurashima, H. Kiyono

{"title":"Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing.","authors":"Y. Kurashima, H. Kiyono","doi":"10.1146/annurev-immunol-051116-052424","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052424","url":null,"abstract":"The intestinal epithelial barrier includes columnar epithelial, Paneth, goblet, enteroendocrine, and tuft cells as well as other cell populations, all of which contribute properties essential for gastrointestinal homeostasis. The intestinal mucosa is covered by mucin, which contains antimicrobial peptides and secretory IgA and prevents luminal bacteria, fungi, and viruses from stimulating intestinal immune responses. Conversely, the transport of luminal microorganisms-mediated by M, dendritic, and goblet cells-into intestinal tissues facilitates the harmonization of active and quiescent mucosal immune responses. The bacterial population within gut-associated lymphoid tissues creates the intratissue cohabitations for harmonized mucosal immunity. Intermolecular and intercellular communication among epithelial, immune, and mesenchymal cells creates an environment conducive for epithelial regeneration and mucosal healing. This review summarizes the so-called intestinal mucosal ecological network-the complex but vital molecular and cellular interactions of epithelial mesenchymal cells, immune cells, and commensal microbiota that achieve intestinal homeostasis, regeneration, and healing.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"119-147"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47603602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 188

Microglia Function in the Central Nervous System During Health and Neurodegeneration. 健康和神经退行性变期间中枢神经系统的小胶质细胞功能。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-09 DOI: 10.1146/annurev-immunol-051116-052358

Marco Colonna, Oleg Butovsky

{"title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration.","authors":"Marco Colonna, Oleg Butovsky","doi":"10.1146/annurev-immunol-051116-052358","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052358","url":null,"abstract":"Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct from other tissue macrophages owing to their unique homeostatic phenotype and tight regulation by the central nervous system (CNS) microenvironment. They are responsible for the elimination of microbes, dead cells, redundant synapses, protein aggregates, and other particulate and soluble antigens that may endanger the CNS. Furthermore, as the primary source of proinflammatory cytokines, microglia are pivotal mediators of neuroinflammation and can induce or modulate a broad spectrum of cellular responses. Alterations in microglia functionality are implicated in brain development and aging, as well as in neurodegeneration. Recent observations about microglia ontogeny combined with extensive gene expression profiling and novel tools to study microglia biology have allowed us to characterize the spectrum of microglial phenotypes during development, homeostasis, and disease. In this article, we review recent advances in our understanding of the biology of microglia, their contribution to homeostasis, and their involvement in neurodegeneration. Moreover, we highlight the complexity of targeting microglia for therapeutic intervention in neurodegenerative diseases.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"441-468"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34756088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1246

Intracellular Nucleic Acid Detection in Autoimmunity. 自身免疫的细胞内核酸检测。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052331

John T. Crowl, Elizabeth E Gray, K. Pestal, Hannah E. Volkman, Daniel B. Stetson

引用次数: 162

A Perspective on the Role of Computational Models in Immunology. 计算模型在免疫学中的作用展望。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-06 DOI: 10.1146/annurev-immunol-041015-055325

Arup K Chakraborty

{"title":"A Perspective on the Role of Computational Models in Immunology.","authors":"Arup K Chakraborty","doi":"10.1146/annurev-immunol-041015-055325","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055325","url":null,"abstract":"This is an exciting time for immunology because the future promises to be replete with exciting new discoveries that can be translated to improve health and treat disease in novel ways. Immunologists are attempting to answer increasingly complex questions concerning phenomena that range from the genetic, molecular, and cellular scales to that of organs, whole animals or humans, and populations of humans and pathogens. An important goal is to understand how the many different components involved interact with each other within and across these scales for immune responses to emerge, and how aberrant regulation of these processes causes disease. To aid this quest, large amounts of data can be collected using high-throughput instrumentation. The nonlinear, cooperative, and stochastic character of the interactions between components of the immune system as well as the overwhelming amounts of data can make it difficult to intuit patterns in the data or a mechanistic understanding of the phenomena being studied. Computational models are increasingly important in confronting and overcoming these challenges. I first describe an iterative paradigm of research that integrates laboratory experiments, clinical data, computational inference, and mechanistic computational models. I then illustrate this paradigm with a few examples from the recent literature that make vivid the power of bringing together diverse types of computational models with experimental and clinical studies to fruitfully interrogate the immune system.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"403-439"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34756089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation. 代谢物感知G蛋白偶联受体-饮食相关免疫调节的促进者。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052235

Jian K Tan, Craig McKenzie, Eliana Mariño, Laurence Macia, Charles R Mackay

{"title":"Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation.","authors":"Jian K Tan, Craig McKenzie, Eliana Mariño, Laurence Macia, Charles R Mackay","doi":"10.1146/annurev-immunol-051116-052235","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052235","url":null,"abstract":"Nutrition and the gut microbiome regulate many systems, including the immune, metabolic, and nervous systems. We propose that the host responds to deficiency (or sufficiency) of dietary and bacterial metabolites in a dynamic way, to optimize responses and survival. A family of G protein-coupled receptors (GPCRs) termed the metabolite-sensing GPCRs bind to various metabolites and transmit signals that are important for proper immune and metabolic functions. Members of this family include GPR43, GPR41, GPR109A, GPR120, GPR40, GPR84, GPR35, and GPR91. In addition, bile acid receptors such as GPR131 (TGR5) and proton-sensing receptors such as GPR65 show similar features. A consistent feature of this family of GPCRs is that they provide anti-inflammatory signals; many also regulate metabolism and gut homeostasis. These receptors represent one of the main mechanisms whereby the gut microbiome affects vertebrate physiology, and they also provide a link between the immune and metabolic systems. Insufficient signaling through one or more of these metabolite-sensing GPCRs likely contributes to human diseases such as asthma, food allergies, type 1 and type 2 diabetes, hepatic steatosis, cardiovascular disease, and inflammatory bowel diseases.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"371-402"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34945303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 198

Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies. 感染性和炎症性疾病的遗传学:关联和外显子组测序研究的重叠发现。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052442

D. Langlais, N. Fodil, P. Gros

{"title":"Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies.","authors":"D. Langlais, N. Fodil, P. Gros","doi":"10.1146/annurev-immunol-051116-052442","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052442","url":null,"abstract":"Genome technologies have defined a complex genetic architecture in major infectious, inflammatory, and autoimmune disorders. High density marker arrays and Immunochips have powered genome-wide association studies (GWAS) that have mapped nearly 450 genetic risk loci in 22 major inflammatory diseases, including a core of common genes that play a central role in pathological inflammation. Whole-exome and whole-genome sequencing have identified more than 265 genes in which mutations cause primary immunodeficiencies and rare forms of severe inflammatory bowel disease. Combined analysis of inflammatory disease GWAS and primary immunodeficiencies point to shared proteins and pathways that are required for immune cell development and protection against infections and are also associated with pathological inflammation. Finally, sequencing of chromatin immunoprecipitates containing specific transcription factors, with parallel RNA sequencing, has charted epigenetic regulation of gene expression by proinflammatory transcription factors in immune cells, providing complementary information to characterize morbid genes at infectious and inflammatory disease loci.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"1-30"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44953888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Protective and Harmful Immunity to RSV Infection. 对呼吸道合胞病毒感染的保护性和有害免疫。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-06 DOI: 10.1146/annurev-immunol-051116-052206

Peter J M Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson

{"title":"Protective and Harmful Immunity to RSV Infection.","authors":"Peter J M Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson","doi":"10.1146/annurev-immunol-051116-052206","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052206","url":null,"abstract":"Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects. It infects virtually all children by the age of three years and then repeatedly infects throughout life; this it does despite relatively slight variations in antigenicity, apparently by inducing selective immunological amnesia. Inappropriate or dysregulated responses to RSV can be pathogenic, causing disease-enhancing inflammation that contributes to short- and long-term effects. In addition, RSV's importance as a largely unrecognized pathogen of debilitated older people is increasingly evident. Vaccines that induce nonpathogenic protective immunity may soon be available, and it is possible that different vaccines will be optimal for infants; older children; young to middle-age adults (including pregnant women); and elderly persons. At the dawn of RSV vaccination, it is timely to review what is known (and unknown) about immune responses to this fascinating virus.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"501-532"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34756159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 163