发布求助
文献互助 智能选刊 最新文献

Annual review of immunology最新文献

筛选
英文 中文
The Innate Immune Response to Mycobacterium tuberculosis Infection. 对结核分枝杆菌感染的先天免疫反应。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 Epub Date: 2021-02-26 DOI: 10.1146/annurev-immunol-093019-010426
Mariëtta M Ravesloot-Chávez, Erik Van Dis, Sarah A Stanley
{"title":"The Innate Immune Response to <i>Mycobacterium tuberculosis</i> Infection.","authors":"Mariëtta M Ravesloot-Chávez,&nbsp;Erik Van Dis,&nbsp;Sarah A Stanley","doi":"10.1146/annurev-immunol-093019-010426","DOIUrl":"https://doi.org/10.1146/annurev-immunol-093019-010426","url":null,"abstract":"<p><p>Infection with <i>Mycobacterium tuberculosis</i> causes >1.5 million deaths worldwide annually. Innate immune cells are the first to encounter <i>M. tuberculosis</i>, and their response dictates the course of infection. Dendritic cells (DCs) activate the adaptive response and determine its characteristics. Macrophages are responsible both for exerting cell-intrinsic antimicrobial control and for initiating and maintaining inflammation. The inflammatory response to <i>M. tuberculosis</i> infection is a double-edged sword. While cytokines such as TNF-α and IL-1 are important for protection, either excessive or insufficient cytokine production results in progressive disease. Furthermore, neutrophils-cells normally associated with control of bacterial infection-are emerging as key drivers of a hyperinflammatory response that results in host mortality. The roles of other innate cells, including natural killer cells and innate-like T cells, remain enigmatic. Understanding the nuances of both cell-intrinsic control of infection and regulation of inflammation will be crucial for the successful development of host-targeted therapeutics and vaccines.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25409662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Genetics of Pediatric Immune-Mediated Diseases and Human Immunity. 儿童免疫介导疾病和人类免疫的遗传学。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 Epub Date: 2021-02-03 DOI: 10.1146/annurev-immunol-093019-124513
Erica G Schmitt, Megan A Cooper
{"title":"Genetics of Pediatric Immune-Mediated Diseases and Human Immunity.","authors":"Erica G Schmitt,&nbsp;Megan A Cooper","doi":"10.1146/annurev-immunol-093019-124513","DOIUrl":"https://doi.org/10.1146/annurev-immunol-093019-124513","url":null,"abstract":"<p><p>Primary immunodeficiency diseases (PIDs) are a rapidly growing, heterogeneous group of genetically determined diseases characterized by defects in the immune system. While individually rare, collectively PIDs affect between 1/1,000 and 1/5,000 people worldwide. The clinical manifestations of PIDs vary from susceptibility to infections to autoimmunity and bone marrow failure. Our understanding of the human immune response has advanced by investigation and discovery of genetic mechanisms of PIDs. Studying patients with isolated genetic variants in proteins that participate in complex signaling pathways has led to an enhanced understanding of host response to infection, and mechanisms of autoimmunity and autoinflammation. Identifying genetic mechanisms of PIDs not only furthers immunological knowledge but also benefits patients by dictating targeted therapies or hematopoietic stem cell transplantation. Here, we highlight several of these areas in the field of primary immunodeficiency, with a focus on the most recent advances.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25326859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation. 小胶质细胞和中枢神经系统相关巨噬细胞——从起源到疾病调节。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 Epub Date: 2021-02-08 DOI: 10.1146/annurev-immunol-093019-110159
Marco Prinz, Takahiro Masuda, Michael A Wheeler, Francisco J Quintana
{"title":"Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation.","authors":"Marco Prinz,&nbsp;Takahiro Masuda,&nbsp;Michael A Wheeler,&nbsp;Francisco J Quintana","doi":"10.1146/annurev-immunol-093019-110159","DOIUrl":"https://doi.org/10.1146/annurev-immunol-093019-110159","url":null,"abstract":"<p><p>The immune system of the central nervous system (CNS) consists primarily of innate immune cells. These are highly specialized macrophages found either in the parenchyma, called microglia, or at the CNS interfaces, such as leptomeningeal, perivascular, and choroid plexus macrophages. While they were primarily thought of as phagocytes, their function extends well beyond simple removal of cell debris during development and diseases. Brain-resident innate immune cells were found to be plastic, long-lived, and host to an outstanding number of risk genes for multiple pathologies. As a result, they are now considered the most suitable targets for modulating CNS diseases. Additionally, recent single-cell technologies enhanced our molecular understanding of their origins, fates, interactomes, and functional cell statesduring health and perturbation. Here, we review the current state of our understanding and challenges of the myeloid cell biology in the CNS and treatment options for related diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085109/pdf/nihms-1685925.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25344939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 180
Cytokine Regulation and Function in T Cells. 细胞因子在T细胞中的调节和功能。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 Epub Date: 2021-01-11 DOI: 10.1146/annurev-immunol-061020-053702
Chen Dong
{"title":"Cytokine Regulation and Function in T Cells.","authors":"Chen Dong","doi":"10.1146/annurev-immunol-061020-053702","DOIUrl":"https://doi.org/10.1146/annurev-immunol-061020-053702","url":null,"abstract":"<p><p>T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflammation and regulate other types of immune cells. Work in the last three decades has revealed significant heterogeneity in CD4<sup>+</sup> T cells, in terms of their cytokine expression, leading to the discoveries of T helper 1 (Th1), Th2, Th17, and T follicular helper (Tfh) cell subsets. These cells possess unique developmental and regulatory pathways and play distinct roles in immunity and immune-mediated pathologies. Other types of T cells, including regulatory T cells and γδ T cells, as well as innate lymphocytes, display similar features of subpopulations, which may play differential roles in immunity. Mechanisms exist to prevent cytokine production by T cells to maintain immune tolerance to self-antigens, some of which may also underscore immune exhaustion in the context of tumors. Understanding cytokine regulation and function has offered innovative treatment of many human diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38807011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 153
Control of Immunity by the Microbiota. 微生物群对免疫的控制。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-093019-112348
Eduard Ansaldo, Taylor K Farley, Yasmine Belkaid
{"title":"Control of Immunity by the Microbiota.","authors":"Eduard Ansaldo,&nbsp;Taylor K Farley,&nbsp;Yasmine Belkaid","doi":"10.1146/annurev-immunol-093019-112348","DOIUrl":"https://doi.org/10.1146/annurev-immunol-093019-112348","url":null,"abstract":"<p><p>The immune system has coevolved with extensive microbial communities living on barrier sites that are collectively known as the microbiota. It is increasingly clear that microbial antigens and metabolites engage in a constant dialogue with the immune system, leading to microbiota-specific immune responses that occur in the absence of inflammation. This form of homeostatic immunity encompasses many arms of immunity, including B cell responses, innate-like T cells, and conventional T helper and T regulatory responses. In this review we summarize known examples of innate-like T cell and adaptive immunity to the microbiota, focusing on fundamental aspects of commensal immune recognition across different barrier sites. Furthermore, we explore how this cross talk is established during development, emphasizing critical temporal windows that establish long-term immune function. Finally, we highlight how dysregulation of immunity to the microbiota can lead to inflammation and disease, and we pinpoint outstanding questions and controversies regarding immune system-microbiota interactions.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38911292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 97
Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity. T细胞介导免疫的线粒体代谢调控。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-101819-082015
Elizabeth M Steinert, Karthik Vasan, Navdeep S Chandel
{"title":"Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity.","authors":"Elizabeth M Steinert,&nbsp;Karthik Vasan,&nbsp;Navdeep S Chandel","doi":"10.1146/annurev-immunol-101819-082015","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101819-082015","url":null,"abstract":"<p><p>Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403253/pdf/nihms-1916344.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Origins, Biology, and Diseases of Tissue Macrophages. 组织巨噬细胞的起源、生物学和疾病。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-093019-111748
Nehemiah Cox, Maria Pokrovskii, Rocio Vicario, Frederic Geissmann
{"title":"Origins, Biology, and Diseases of Tissue Macrophages.","authors":"Nehemiah Cox, Maria Pokrovskii, Rocio Vicario, Frederic Geissmann","doi":"10.1146/annurev-immunol-093019-111748","DOIUrl":"10.1146/annurev-immunol-093019-111748","url":null,"abstract":"<p><p>Tissue-resident macrophages are present in most tissues with developmental, self-renewal, or functional attributes that do not easily fit into a textbook picture of a plastic and multifunctional macrophage originating from hematopoietic stem cells; nor does it fit a pro- versus anti-inflammatory paradigm. This review presents and discusses current knowledge on the developmental biology of macrophages from an evolutionary perspective focused on the function of macrophages, which may aid in study of developmental, inflammatory, tumoral, and degenerative diseases. We also propose a framework to investigate the functions of macrophages in vivo and discuss how inherited germline and somatic mutations may contribute to the roles of macrophages in diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38911295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense. 反社会网络:宿主防御中细胞死亡程序之间的串扰。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 Epub Date: 2021-01-13 DOI: 10.1146/annurev-immunol-112019-072301
Annelise G Snyder, Andrew Oberst
{"title":"The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense.","authors":"Annelise G Snyder,&nbsp;Andrew Oberst","doi":"10.1146/annurev-immunol-112019-072301","DOIUrl":"10.1146/annurev-immunol-112019-072301","url":null,"abstract":"<p><p>Nearly all animal cells contain proteins evolved to trigger the destruction of the cell in which they reside. The activation of these proteins occurs via sequential programs, and much effort has been expended in delineating the molecular mechanisms underlying the resulting processes of programmed cell death (PCD). These efforts have led to the definition of apoptosis as a form of nonimmunogenic PCD that is required for normal development and tissue homeostasis, and of pyroptosis and necroptosis as forms of PCD initiated by pathogen infection that are associated with inflammation and immune activation. While this paradigm has served the field well, numerous recent studies have highlighted cross talk between these programs, challenging the idea that apoptosis, pyroptosis, and necroptosis are linear pathways with defined immunological outputs. Here, we discuss the emerging idea of cell death as a signaling network, considering connections between cell death pathways both as we observe them now and in their evolutionary origins. We also discuss the engagement and subversion of cell death pathways by pathogens, as well as the key immunological outcomes of these processes.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594462/pdf/nihms-1754457.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38815857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
Current Concepts and Advances in Graft-Versus-Host Disease Immunology. 移植物抗宿主病免疫学的当前概念与进展》（Current Concepts and Advances in Graft-Versus-Host Disease Immunology）。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2021-04-26 Epub Date: 2021-01-11 DOI: 10.1146/annurev-immunol-102119-073227
Geoffrey R Hill, Brian C Betts, Victor Tkachev, Leslie S Kean, Bruce R Blazar
{"title":"Current Concepts and Advances in Graft-Versus-Host Disease Immunology.","authors":"Geoffrey R Hill, Brian C Betts, Victor Tkachev, Leslie S Kean, Bruce R Blazar","doi":"10.1146/annurev-immunol-102119-073227","DOIUrl":"10.1146/annurev-immunol-102119-073227","url":null,"abstract":"<p><p>Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency, metabolic disease, or a life-threatening bone marrow failure syndrome. Despite substantial advances in donor selection and conditioning regimens and greater availability of allograft sources, transplant recipients still endure the morbidity and mortality of graft-versus-host disease (GVHD). Herein, we identify key aspects of acute and chronic GVHD pathophysiology, including host/donor cell effectors, gut dysbiosis, immune system and cytokine imbalance, and the interface between inflammation and tissue fibrosis. In particular, we also summarize the translational application of this heightened understanding of immune dysregulation in the design of novel therapies to prevent and treat GVHD.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":26.9,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085043/pdf/nihms-1668678.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38807014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells. 记忆性B细胞和浆细胞的转录和代谢控制。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2021-04-26 Epub Date: 2021-02-08 DOI: 10.1146/annurev-immunol-093019-125603
Tyler J Ripperger, Deepta Bhattacharya
{"title":"Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells.","authors":"Tyler J Ripperger,&nbsp;Deepta Bhattacharya","doi":"10.1146/annurev-immunol-093019-125603","DOIUrl":"https://doi.org/10.1146/annurev-immunol-093019-125603","url":null,"abstract":"<p><p>For many infections and almost all vaccines, neutralizing-antibody-mediated immunity is the primary basis and best functional correlate of immunological protection. Durable long-term humoral immunity is mediated by antibodies secreted by plasma cells that preexist subsequent exposures and by memory B cells that rapidly respond to infections once they have occurred. In the midst of the current pandemic of coronavirus disease 2019, it is important to define our current understanding of the unique roles of memory B cells and plasma cells in immunity and the factors that control the formation and persistence of these cell types. This fundamental knowledge is the basis to interpret findings from natural infections and vaccines. Here, we review transcriptional and metabolic programs that promote and support B cell fates and functions, suggesting points at which these pathways do and do not intersect.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25344937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信