Annual review of immunology最新文献_第9页

T Cell Responses to the Microbiota. T 细胞对微生物群的反应。

IF 26.9 1区医学

Annual review of immunology Pub Date : 2022-04-26 Epub Date: 2022-02-03 DOI: 10.1146/annurev-immunol-101320-011829

Ivaylo I Ivanov, Timur Tuganbaev, Ashwin N Skelly, Kenya Honda

{"title":"T Cell Responses to the Microbiota.","authors":"Ivaylo I Ivanov, Timur Tuganbaev, Ashwin N Skelly, Kenya Honda","doi":"10.1146/annurev-immunol-101320-011829","DOIUrl":"10.1146/annurev-immunol-101320-011829","url":null,"abstract":"The immune system employs recognition tools to communicate with its microbial evolutionary partner. Among all the methods of microbial perception, T cells enable the widest spectrum of microbial recognition resolution, ranging from the crudest detection of whole groups of microbes to the finest detection of specific antigens. The application of this recognition capability to the crucial task of combatting infections has been the focus of classical immunology. We now appreciate that the coevolution of the immune system and the microbiota has led to development of a lush immunological decision tree downstream of microbial recognition, of which an inflammatory response is but one branch. In this review we discuss known T cell-microbe interactions in the gut and place them in the context of an algorithmic framework of recognition, context-dependent interpretation, and response circuits across multiple levels of microbial recognition resolution. The malleability of T cells in response to the microbiota presents an opportunity to edit immune response cellularity, identity, and functionality by utilizing microbiota-controlled pathways to promote human health.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"40 ","pages":"559-587"},"PeriodicalIF":26.9,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296687/pdf/nihms-1823890.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9354672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies. 嗜酸性粒细胞敲除人类:通过嗜酸性粒细胞导向的生物疗法揭示嗜酸性粒细胞的作用。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-093019-125918

Elizabeth A Jacobsen, David J Jackson, Enrico Heffler, Sameer K Mathur, Albert J Bredenoord, Ian D Pavord, Praveen Akuthota, Florence Roufosse, Marc E Rothenberg

{"title":"Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies.","authors":"Elizabeth A Jacobsen, David J Jackson, Enrico Heffler, Sameer K Mathur, Albert J Bredenoord, Ian D Pavord, Praveen Akuthota, Florence Roufosse, Marc E Rothenberg","doi":"10.1146/annurev-immunol-093019-125918","DOIUrl":"https://doi.org/10.1146/annurev-immunol-093019-125918","url":null,"abstract":"The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"39 ","pages":"719-757"},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317994/pdf/nihms-1721148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9517653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity. T细胞介导免疫的线粒体代谢调控。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-101819-082015

Elizabeth M Steinert, Karthik Vasan, Navdeep S Chandel

引用次数: 26

Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma. 先天淋巴样细胞:调节哮喘的团队成员。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-110119-091711

Noe Rodriguez-Rodriguez, Mayuri Gogoi, Andrew N J McKenzie

{"title":"Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma.","authors":"Noe Rodriguez-Rodriguez, Mayuri Gogoi, Andrew N J McKenzie","doi":"10.1146/annurev-immunol-110119-091711","DOIUrl":"https://doi.org/10.1146/annurev-immunol-110119-091711","url":null,"abstract":"Type 2 immunity helps protect the host from infection, but it also plays key roles in tissue homeostasis, metabolism, and repair. Unfortunately, inappropriate type 2 immune reactions may lead to allergy and asthma. Group 2 innate lymphoid cells (ILC2s) in the lungs respond rapidly to local environmental cues, such as the release of epithelium-derived type 2 initiator cytokines/alarmins, producing type 2 effector cytokines such as IL-4, IL-5, and IL-13 in response to tissue damage and infection. ILC2s are associated with the severity of allergic asthma, and experimental models of lung inflammation have shown how they act as playmakers, receiving signals variously from stromal and immune cells as well as the nervous system and then distributing cytokine cues to elicit type 2 immune effector functions and potentiate CD4+ T helper cell activation, both of which characterize the pathology of allergic asthma. Recent breakthroughs identifying stromal- and neuronal-derived microenvironmental cues that regulate ILC2s, along with studies recognizing the potential plasticity of ILC2s, have improved our understanding of the immunoregulation of asthma and opened new avenues for drug discovery.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"39 ","pages":"167-198"},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614118/pdf/EMS163166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10632778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Obsessive-Compulsive Behavior Isn't Necessarily a Bad Thing. 强迫行为不一定是坏事。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2020-04-26 DOI: 10.1146/annurev-immunol-072319-033325

P. Marrack

引用次数: 1

Innate Lymphocyte Mechanisms in Skin Diseases. 皮肤病中的先天性淋巴细胞机制

IF 29.7 1区医学

Annual review of immunology Pub Date : 2020-04-26 DOI: 10.1146/annurev-immunol-082919-093554

Yi-Ling Chen, Clare S Hardman, Koshika Yadava, Graham Ogg

引用次数: 0

Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases. 细胞质DNA的先天免疫反应：机制和疾病。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2019-12-04 DOI: 10.1146/annurev-immunol-070119-115052

Ming-Ming Hu, H. Shu

{"title":"Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases.","authors":"Ming-Ming Hu, H. Shu","doi":"10.1146/annurev-immunol-070119-115052","DOIUrl":"https://doi.org/10.1146/annurev-immunol-070119-115052","url":null,"abstract":"DNA has been known to be a potent immune stimulus for more than half a century. However, the underlying molecular mechanisms of DNA-triggered immune response have remained elusive until recent years. Cyclic GMP-AMP synthase (cGAS) is a major cytoplasmic DNA senor in various types of cells that detect either invaded foreign DNA or aberrantly located self-DNA. Upon sensing of DNA, cGAS catalyzes the formation of cyclic GMP-AMP (cGAMP), which in turn activates the ER-localized adaptor protein MITA (also named STING) to elicit the innate immune response. The cGAS-MITA axis not only plays a central role in host defense against pathogen-derived DNA but also acts as a cellular stress response pathway by sensing aberrantly located self-DNA, which is linked to the pathogenesis of various human diseases. In this review, we summarize the spatial and temporal mechanisms of host defense to cytoplasmic DNA mediated by the cGAS-MITA axis and discuss the association of malfunctions of this axis with autoimmune and other diseases. Expected final online publication date for the Annual Review of Immunology, Volume 38 is April 26, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"1 1","pages":""},"PeriodicalIF":29.7,"publicationDate":"2019-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-070119-115052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47386889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 72

The Microbiome and Food Allergy. 微生物群和食物过敏。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2019-04-26 DOI: 10.1146/annurev-immunol-042718-041621

Onyinye I Iweala, Cathryn R Nagler

引用次数: 109

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons. hiv -1合并感染者对结核分枝杆菌的免疫应答

IF 29.7 1区医学

Annual review of immunology Pub Date : 2018-04-26 DOI: 10.1146/annurev-immunol-042617-053420

Hanif Esmail, Catherine Riou, Elsa du Bruyn, Rachel Pei-Jen Lai, Yolande X R Harley, Graeme Meintjes, Katalin A Wilkinson, Robert J Wilkinson

{"title":"The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons.","authors":"Hanif Esmail, Catherine Riou, Elsa du Bruyn, Rachel Pei-Jen Lai, Yolande X R Harley, Graeme Meintjes, Katalin A Wilkinson, Robert J Wilkinson","doi":"10.1146/annurev-immunol-042617-053420","DOIUrl":"https://doi.org/10.1146/annurev-immunol-042617-053420","url":null,"abstract":"Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis-374,000 deaths per annum are attributable to HIV-tuberculosis, 75% of those occurring in Africa. HIV-1 infection increases the risk of tuberculosis by a factor of up to 26 and alters its clinical presentation, complicates diagnosis and treatment, and worsens outcome. Although HIV-1-induced depletion of CD4+ T cells underlies all these effects, more widespread immune deficits also contribute to susceptibility and pathogenesis. These defects present a challenge to understand and ameliorate, but also an opportunity to learn and optimize mechanisms that normally protect people against tuberculosis. The most effective means to prevent and ameliorate tuberculosis in HIV-1-infected people is antiretroviral therapy, but this may be complicated by pathological immune deterioration that in turn requires more effective host-directed anti-inflammatory therapies to be derived.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"36 ","pages":"603-638"},"PeriodicalIF":29.7,"publicationDate":"2018-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-042617-053420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10746469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 87

Antigen-Presenting Cells in the Skin. 皮肤中的抗原呈递细胞。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-06 DOI: 10.1146/annurev-immunol-051116-052215

Sakeen W Kashem, Muzlifah Haniffa, Daniel H Kaplan

引用次数: 233