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Annual review of immunology最新文献

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Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases. 细胞质DNA的先天免疫反应：机制和疾病。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2019-12-04 DOI: 10.1146/annurev-immunol-070119-115052
Ming-Ming Hu, H. Shu
{"title":"Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases.","authors":"Ming-Ming Hu, H. Shu","doi":"10.1146/annurev-immunol-070119-115052","DOIUrl":"https://doi.org/10.1146/annurev-immunol-070119-115052","url":null,"abstract":"DNA has been known to be a potent immune stimulus for more than half a century. However, the underlying molecular mechanisms of DNA-triggered immune response have remained elusive until recent years. Cyclic GMP-AMP synthase (cGAS) is a major cytoplasmic DNA senor in various types of cells that detect either invaded foreign DNA or aberrantly located self-DNA. Upon sensing of DNA, cGAS catalyzes the formation of cyclic GMP-AMP (cGAMP), which in turn activates the ER-localized adaptor protein MITA (also named STING) to elicit the innate immune response. The cGAS-MITA axis not only plays a central role in host defense against pathogen-derived DNA but also acts as a cellular stress response pathway by sensing aberrantly located self-DNA, which is linked to the pathogenesis of various human diseases. In this review, we summarize the spatial and temporal mechanisms of host defense to cytoplasmic DNA mediated by the cGAS-MITA axis and discuss the association of malfunctions of this axis with autoimmune and other diseases. Expected final online publication date for the Annual Review of Immunology, Volume 38 is April 26, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"1 1","pages":""},"PeriodicalIF":29.7,"publicationDate":"2019-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-070119-115052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47386889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 72
The Microbiome and Food Allergy. 微生物群和食物过敏。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2019-04-26 DOI: 10.1146/annurev-immunol-042718-041621
Onyinye I Iweala, Cathryn R Nagler
{"title":"The Microbiome and Food Allergy.","authors":"Onyinye I Iweala,&nbsp;Cathryn R Nagler","doi":"10.1146/annurev-immunol-042718-041621","DOIUrl":"https://doi.org/10.1146/annurev-immunol-042718-041621","url":null,"abstract":"<p><p>The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters antigens derived from an estimated 10<sup>14</sup> commensal microbes and greater than 30 kg of food proteins yearly. It must distinguish these harmless antigens from potential pathogens and mount the appropriate host immune response. Local and systemic hyporesponsiveness to dietary antigens, classically referred to as oral tolerance, comprises a distinct complement of adaptive cellular and humoral immune responses. It is increasingly evident that a functional epithelial barrier engaged in intimate interplay with innate immune cells and the resident microbiota is critical to establishing and maintaining oral tolerance. Moreover, innate immune cells serve as a bridge between the microbiota, epithelium, and the adaptive immune system, parlaying tonic microbial stimulation into signals critical for mucosal homeostasis. Dysregulation of gut homeostasis and the subsequent disruption of tolerance therefore have clinically significant consequences for the development of food allergy.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"37 ","pages":"377-403"},"PeriodicalIF":29.7,"publicationDate":"2019-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-042718-041621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10051935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 109
The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons. hiv -1合并感染者对结核分枝杆菌的免疫应答
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2018-04-26 DOI: 10.1146/annurev-immunol-042617-053420
Hanif Esmail, Catherine Riou, Elsa du Bruyn, Rachel Pei-Jen Lai, Yolande X R Harley, Graeme Meintjes, Katalin A Wilkinson, Robert J Wilkinson
{"title":"The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons.","authors":"Hanif Esmail,&nbsp;Catherine Riou,&nbsp;Elsa du Bruyn,&nbsp;Rachel Pei-Jen Lai,&nbsp;Yolande X R Harley,&nbsp;Graeme Meintjes,&nbsp;Katalin A Wilkinson,&nbsp;Robert J Wilkinson","doi":"10.1146/annurev-immunol-042617-053420","DOIUrl":"https://doi.org/10.1146/annurev-immunol-042617-053420","url":null,"abstract":"<p><p>Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis-374,000 deaths per annum are attributable to HIV-tuberculosis, 75% of those occurring in Africa. HIV-1 infection increases the risk of tuberculosis by a factor of up to 26 and alters its clinical presentation, complicates diagnosis and treatment, and worsens outcome. Although HIV-1-induced depletion of CD4<sup>+</sup> T cells underlies all these effects, more widespread immune deficits also contribute to susceptibility and pathogenesis. These defects present a challenge to understand and ameliorate, but also an opportunity to learn and optimize mechanisms that normally protect people against tuberculosis. The most effective means to prevent and ameliorate tuberculosis in HIV-1-infected people is antiretroviral therapy, but this may be complicated by pathological immune deterioration that in turn requires more effective host-directed anti-inflammatory therapies to be derived.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"36 ","pages":"603-638"},"PeriodicalIF":29.7,"publicationDate":"2018-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-042617-053420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10746469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 87
Antigen-Presenting Cells in the Skin. 皮肤中的抗原呈递细胞。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-06 DOI: 10.1146/annurev-immunol-051116-052215
Sakeen W Kashem, Muzlifah Haniffa, Daniel H Kaplan
{"title":"Antigen-Presenting Cells in the Skin.","authors":"Sakeen W Kashem,&nbsp;Muzlifah Haniffa,&nbsp;Daniel H Kaplan","doi":"10.1146/annurev-immunol-051116-052215","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052215","url":null,"abstract":"<p><p>Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes, and macrophages. They are highly dynamic, with the capacity to enter skin from the peripheral circulation, patrol within tissue, and migrate through lymphatics to draining lymph nodes. Skin APCs are endowed with antigen-sensing, -processing, and -presenting machinery and play key roles in initiating, modulating, and resolving cutaneous inflammation. Skin APCs are a highly heterogeneous population with functionally specialized subsets that are developmentally imprinted and modulated by local tissue microenvironmental and inflammatory cues. This review explores recent advances that have allowed for a more accurate taxonomy of APC subsets found in both mouse and human skin. It also examines the functional specificity of individual APC subsets and their collaboration with other immune cell types that together promote adaptive T cell and regional cutaneous immune responses during homeostasis, inflammation, and disease.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"469-499"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34756160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 233
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. 合成免疫学:入侵免疫细胞以扩大其治疗能力。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052302
Kole T Roybal, Wendell A Lim
{"title":"Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.","authors":"Kole T Roybal,&nbsp;Wendell A Lim","doi":"10.1146/annurev-immunol-051116-052302","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052302","url":null,"abstract":"<p><p>The ability of immune cells to survey tissues and sense pathologic insults and deviations makes them a unique platform for interfacing with the body and disease. With the rapid advancement of synthetic biology, we can now engineer and equip immune cells with new sensors and controllable therapeutic response programs to sense and treat diseases that our natural immune system cannot normally handle. Here we review the current state of engineered immune cell therapeutics and their unique capabilities compared to small molecules and biologics. We then discuss how engineered immune cells are being designed to combat cancer, focusing on how new synthetic biology tools are providing potential ways to overcome the major roadblocks for treatment. Finally, we give a long-term vision for the use of synthetic biology to engineer immune cells as a general sensor-response platform to precisely detect disease, to remodel disease microenvironments, and to treat a potentially wide range of challenging diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"229-253"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34945306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 88
Th2 Cells in Health and Disease. Th2细胞在健康和疾病中的作用。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052350
T. Nakayama, K. Hirahara, A. Onodera, Yusuke Endo, H. Hosokawa, K. Shinoda, D. Tumes, Y. Okamoto
{"title":"Th2 Cells in Health and Disease.","authors":"T. Nakayama, K. Hirahara, A. Onodera, Yusuke Endo, H. Hosokawa, K. Shinoda, D. Tumes, Y. Okamoto","doi":"10.1146/annurev-immunol-051116-052350","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052350","url":null,"abstract":"Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases. Molecular analysis of Th2 cell differentiation and maintenance of function has led to recent discoveries that have refined our understanding of Th2 cell biology. Epigenetic regulation of Gata3 expression by chromatin remodeling complexes such as Polycomb and Trithorax is crucial for maintaining Th2 cell identity. In the context of allergic diseases, memory-type pathogenic Th2 cells have been identified in both mice and humans. To better understand these disease-driving cell populations, we have developed a model called the pathogenic Th population disease induction model. The concept of defined subsets of pathogenic Th cells may spur new, effective strategies for treating intractable chronic inflammatory disorders.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"53-84"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44399775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 240
Memory B Cells of Mice and Humans. 小鼠和人类的记忆B细胞。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-041015-055531
Florian J. Weisel, M. Shlomchik
{"title":"Memory B Cells of Mice and Humans.","authors":"Florian J. Weisel, M. Shlomchik","doi":"10.1146/annurev-immunol-041015-055531","DOIUrl":"https://doi.org/10.1146/annurev-immunol-041015-055531","url":null,"abstract":"We comprehensively review memory B cells (MBCs), covering the definition of MBCs and their identities and subsets, how MBCs are generated, where they are localized, how they are maintained, and how they are reactivated. Whereas naive B cells adopt multiple fates upon stimulation, MBCs are more restricted in their responses. Evolving work reveals that the MBC compartment in mice and humans consists of distinct subpopulations with differing effector functions. We discuss the various approaches to define subsets and subset-specific roles. A major theme is the need to both deliver faster effector function upon reexposure and readapt to antigenically variant pathogens while avoiding burnout, which would be the result if all MBCs generated only terminal effector function. We discuss cell-intrinsic differences in gene expression and signaling that underlie differences in function between MBCs and naive B cells and among MBC subsets and how this leads to memory responses.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"255-284"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-041015-055531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47161913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 210
Thymic Epithelial Cells. 胸腺上皮细胞。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-02-10 DOI: 10.1146/annurev-immunol-051116-052320
Jakub Abramson, Graham Anderson
{"title":"Thymic Epithelial Cells.","authors":"Jakub Abramson, Graham Anderson","doi":"10.1146/annurev-immunol-051116-052320","DOIUrl":"10.1146/annurev-immunol-051116-052320","url":null,"abstract":"<p><p>Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity. These properties are collectively required to bias thymocyte development toward production of self-tolerant and functionally competent T cells. The importance of thymic epithelial cells (TECs) is evidenced by clear links between their dysfunction and multiple diseases where autoimmunity and immunodeficiency are major components. Consequently, TECs are an attractive target for cell therapies to restore effective immune system function. The pathways and molecular regulators that control TEC development are becoming clearer, as are their influences on particular stages of T cell development. Here, we review both historical and the most recent advances in our understanding of the cellular and molecular mechanisms controlling TEC development, function, dysfunction, and regeneration.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"85-118"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34756158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signaling by Antibodies: Recent Progress. 抗体信号传导:最新进展。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 DOI: 10.1146/annurev-immunol-051116-052433
Stylianos Bournazos, Taia T Wang, Rony Dahan, Jad Maamary, Jeffrey V Ravetch
{"title":"Signaling by Antibodies: Recent Progress.","authors":"Stylianos Bournazos,&nbsp;Taia T Wang,&nbsp;Rony Dahan,&nbsp;Jad Maamary,&nbsp;Jeffrey V Ravetch","doi":"10.1146/annurev-immunol-051116-052433","DOIUrl":"https://doi.org/10.1146/annurev-immunol-051116-052433","url":null,"abstract":"<p><p>IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 ","pages":"285-311"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-immunol-051116-052433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34945304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 156
The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules. 外源抗原在mhc - 1分子上交叉呈递的生物学和潜在机制。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2017-04-26 Epub Date: 2017-01-11 DOI: 10.1146/annurev-immunol-041015-055254
Freidrich M Cruz, Jeff D Colbert, Elena Merino, Barry A Kriegsman, Kenneth L Rock
{"title":"The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.","authors":"Freidrich M Cruz, Jeff D Colbert, Elena Merino, Barry A Kriegsman, Kenneth L Rock","doi":"10.1146/annurev-immunol-041015-055254","DOIUrl":"10.1146/annurev-immunol-041015-055254","url":null,"abstract":"<p><p>To monitor the health of cells, the immune system tasks antigen-presenting cells with gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides bound to MHC-I molecules. Most cells would be unable to perform this function because they use their MHC-I molecules to exclusively present peptides derived from the cell's own proteins. However, the immune system evolved mechanisms for dendritic cells and some other phagocytes to sample and present antigens from the extracellular milieu on MHC-I through a process called cross-presentation. How this important task is accomplished, its role in health and disease, and its potential for exploitation are the subject of this review.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"35 1","pages":"149-176"},"PeriodicalIF":29.7,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47726078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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