Annual review of immunology最新文献_第7页

Distinct Cellular Tropism and Immune Responses to Alphavirus Infection. 不同的细胞趋向性和对甲病毒感染的免疫反应。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2022-04-26 DOI: 10.1146/annurev-immunol-101220-014952

Natasha M Kafai, Michael S Diamond, Julie M Fox

引用次数: 6

Instructive Cues of Thymic T Cell Selection. 胸腺T细胞选择的指导性提示。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2022-04-26 DOI: 10.1146/annurev-immunol-101320-022432

Magali Irla

引用次数: 17

Emerging Paradigms in Type 2 Immunity. 2型免疫的新范式。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2022-04-26 DOI: 10.1146/annurev-immunol-101320-030339

H. Hammad, Nincy Debeuf, H. Aegerter, A. Brown, B. Lambrecht

引用次数: 12

Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance. 健康巨噬细胞反应的功能标志：它们的调节基础和疾病相关性

IF 29.7 1区医学

Annual review of immunology Pub Date : 2022-04-26 DOI: 10.1146/annurev-immunol-101320-031555

Katherine M Sheu, Alexander Hoffmann

{"title":"Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance.","authors":"Katherine M Sheu, Alexander Hoffmann","doi":"10.1146/annurev-immunol-101320-031555","DOIUrl":"10.1146/annurev-immunol-101320-031555","url":null,"abstract":"Macrophages are first responders for the immune system. In this role, they have both effector functions for neutralizing pathogens and sentinel functions for alerting other immune cells of diverse pathologic threats, thereby initiating and coordinating a multipronged immune response. Macrophages are distributed throughout the body-they circulate in the blood, line the mucosal membranes, reside within organs, and survey the connective tissue. Several reviews have summarized their diverse roles in different physiological scenarios and in the initiation or amplification of different pathologies. In this review, we propose that both the effector and the sentinel functions of healthy macrophages rely on three hallmark properties: response specificity, context dependence, and stimulus memory. When these hallmark properties are diminished, the macrophage's biological functions are impaired, which in turn results in increased risk for immune dysregulation, manifested by immune deficiency or autoimmunity. We review the evidence and the molecular mechanisms supporting these functional hallmarks.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"40 ","pages":"295-321"},"PeriodicalIF":29.7,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074967/pdf/nihms-1878081.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9271460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T Cell Responses to the Microbiota. T 细胞对微生物群的反应。

IF 26.9 1区医学

Annual review of immunology Pub Date : 2022-04-26 Epub Date: 2022-02-03 DOI: 10.1146/annurev-immunol-101320-011829

Ivaylo I Ivanov, Timur Tuganbaev, Ashwin N Skelly, Kenya Honda

{"title":"T Cell Responses to the Microbiota.","authors":"Ivaylo I Ivanov, Timur Tuganbaev, Ashwin N Skelly, Kenya Honda","doi":"10.1146/annurev-immunol-101320-011829","DOIUrl":"10.1146/annurev-immunol-101320-011829","url":null,"abstract":"The immune system employs recognition tools to communicate with its microbial evolutionary partner. Among all the methods of microbial perception, T cells enable the widest spectrum of microbial recognition resolution, ranging from the crudest detection of whole groups of microbes to the finest detection of specific antigens. The application of this recognition capability to the crucial task of combatting infections has been the focus of classical immunology. We now appreciate that the coevolution of the immune system and the microbiota has led to development of a lush immunological decision tree downstream of microbial recognition, of which an inflammatory response is but one branch. In this review we discuss known T cell-microbe interactions in the gut and place them in the context of an algorithmic framework of recognition, context-dependent interpretation, and response circuits across multiple levels of microbial recognition resolution. The malleability of T cells in response to the microbiota presents an opportunity to edit immune response cellularity, identity, and functionality by utilizing microbiota-controlled pathways to promote human health.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"40 ","pages":"559-587"},"PeriodicalIF":26.9,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296687/pdf/nihms-1823890.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9354672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies. 嗜酸性粒细胞敲除人类:通过嗜酸性粒细胞导向的生物疗法揭示嗜酸性粒细胞的作用。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-093019-125918

Elizabeth A Jacobsen, David J Jackson, Enrico Heffler, Sameer K Mathur, Albert J Bredenoord, Ian D Pavord, Praveen Akuthota, Florence Roufosse, Marc E Rothenberg

{"title":"Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies.","authors":"Elizabeth A Jacobsen, David J Jackson, Enrico Heffler, Sameer K Mathur, Albert J Bredenoord, Ian D Pavord, Praveen Akuthota, Florence Roufosse, Marc E Rothenberg","doi":"10.1146/annurev-immunol-093019-125918","DOIUrl":"https://doi.org/10.1146/annurev-immunol-093019-125918","url":null,"abstract":"The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"39 ","pages":"719-757"},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317994/pdf/nihms-1721148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9517653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity. T细胞介导免疫的线粒体代谢调控。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-101819-082015

Elizabeth M Steinert, Karthik Vasan, Navdeep S Chandel

引用次数: 26

Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma. 先天淋巴样细胞:调节哮喘的团队成员。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2021-04-26 DOI: 10.1146/annurev-immunol-110119-091711

Noe Rodriguez-Rodriguez, Mayuri Gogoi, Andrew N J McKenzie

{"title":"Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma.","authors":"Noe Rodriguez-Rodriguez, Mayuri Gogoi, Andrew N J McKenzie","doi":"10.1146/annurev-immunol-110119-091711","DOIUrl":"https://doi.org/10.1146/annurev-immunol-110119-091711","url":null,"abstract":"Type 2 immunity helps protect the host from infection, but it also plays key roles in tissue homeostasis, metabolism, and repair. Unfortunately, inappropriate type 2 immune reactions may lead to allergy and asthma. Group 2 innate lymphoid cells (ILC2s) in the lungs respond rapidly to local environmental cues, such as the release of epithelium-derived type 2 initiator cytokines/alarmins, producing type 2 effector cytokines such as IL-4, IL-5, and IL-13 in response to tissue damage and infection. ILC2s are associated with the severity of allergic asthma, and experimental models of lung inflammation have shown how they act as playmakers, receiving signals variously from stromal and immune cells as well as the nervous system and then distributing cytokine cues to elicit type 2 immune effector functions and potentiate CD4+ T helper cell activation, both of which characterize the pathology of allergic asthma. Recent breakthroughs identifying stromal- and neuronal-derived microenvironmental cues that regulate ILC2s, along with studies recognizing the potential plasticity of ILC2s, have improved our understanding of the immunoregulation of asthma and opened new avenues for drug discovery.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"39 ","pages":"167-198"},"PeriodicalIF":29.7,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614118/pdf/EMS163166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10632778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Obsessive-Compulsive Behavior Isn't Necessarily a Bad Thing. 强迫行为不一定是坏事。

IF 29.7 1区医学

Annual review of immunology Pub Date : 2020-04-26 DOI: 10.1146/annurev-immunol-072319-033325

P. Marrack

引用次数: 1

Innate Lymphocyte Mechanisms in Skin Diseases. 皮肤病中的先天性淋巴细胞机制

IF 29.7 1区医学

Annual review of immunology Pub Date : 2020-04-26 DOI: 10.1146/annurev-immunol-082919-093554

Yi-Ling Chen, Clare S Hardman, Koshika Yadava, Graham Ogg

引用次数: 0