免疫系统中的RNA修饰。

IF 26.9 1区医学 Q1 IMMUNOLOGY

Annual review of immunology Pub Date : 2023-04-26 DOI:10.1146/annurev-immunol-101921-045401

Dali Han, Meng Michelle Xu

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引用次数: 2

摘要

RNA修饰的表征已经确定了它们的分布特征和分子功能。各种形式RNA修饰的动态变化对免疫系统的发育和功能至关重要。在这篇综述中，我们讨论了创新的RNA修饰分析技术的价值，以揭示这些不同的、动态的RNA修饰在健康和疾病背景下的各种免疫细胞中的功能。此外，我们探讨了我们目前对异常RNA修饰调节肿瘤微环境免疫环境的机制的理解，并指出了突出的研究问题。

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RNA Modification in the Immune System.

Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of these diverse, dynamic RNA modifications in various immune cells within healthy and diseased contexts. Further, we explore our current understanding of the mechanisms whereby aberrant RNA modifications modulate the immune milieu of the tumor microenvironment and point out outstanding research questions.

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来源期刊

Annual review of immunology 医学-免疫学

CiteScore

57.20

自引率

0.70%

发文量

期刊介绍： The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.