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Annual review of immunology最新文献

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TGF-β Regulation of T Cells. TGF-β对T细胞的调控。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-045939
WanJun Chen
{"title":"TGF-β Regulation of T Cells.","authors":"WanJun Chen","doi":"10.1146/annurev-immunol-101921-045939","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-045939","url":null,"abstract":"<p><p>Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4<sup>+</sup> T cells, TGF-β maintains the quiescence and controls the activation of naive T cells. While inhibiting the differentiation and function of Th1 and Th2 cells, TGF-β promotes the differentiation of Th17 and Th9 cells. TGF-β is required for the induction of Foxp3 in naive T cells and the development of regulatory T cells. TGF-β is crucial in the differentiation of tissue-resident memory CD8<sup>+</sup> T cells and their retention in the tissue, whereas it suppresses effector T cell function. In addition, TGF-β also regulates the generation or function of natural killer T cells, γδ T cells, innate lymphoid cells, and gut intraepithelial lymphocytes. Here I highlight the major findings and recent advances in our understanding of TGF-β regulation of T cells and provide a personal perspective of the field.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"483-512"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9412424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation. NLRP3 炎症小体组装和激活的结构机制
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-02-07 DOI: 10.1146/annurev-immunol-081022-021207
Jianing Fu, Hao Wu
{"title":"Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.","authors":"Jianing Fu, Hao Wu","doi":"10.1146/annurev-immunol-081022-021207","DOIUrl":"10.1146/annurev-immunol-081022-021207","url":null,"abstract":"<p><p>As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1. The three major components of the NLRP3 inflammasome are NLRP3, which captures the danger signals and recruits downstream molecules; caspase-1, which elicits maturation of the cytokines IL-1β and IL-18 and processing of gasdermin D to mediate cytokine release and pyroptosis; and ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), which functions as a bridge connecting NLRP3 and caspase-1. In this article, we review the structural information that has been obtained on the NLRP3 inflammasome and its components or subcomplexes, with special focus on the inactive NLRP3 cage, the active NLRP3-NEK7 (NIMA-related kinase 7)-ASC inflammasome disk, and the PYD-PYD and CARD-CARD homotypic filamentous scaffolds of the inflammasome. We further implicate structure-derived mechanisms for the assembly and activation of the NLRP3 inflammasome.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"301-316"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9417635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing Cancer Immunotherapies That Engage T Cells and NK Cells. 设计能吸引 T 细胞和 NK 细胞的癌症免疫疗法。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2022-11-29 DOI: 10.1146/annurev-immunol-101921-044122
Oleksandr Kyrysyuk, Kai W Wucherpfennig
{"title":"Designing Cancer Immunotherapies That Engage T Cells and NK Cells.","authors":"Oleksandr Kyrysyuk, Kai W Wucherpfennig","doi":"10.1146/annurev-immunol-101921-044122","DOIUrl":"10.1146/annurev-immunol-101921-044122","url":null,"abstract":"<p><p>T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy. Recent work has also shown that NK cells play an important role in recruiting dendritic cells to tumors and thus enhance induction of CD8 T cell responses, while IL-2 secreted by T cells activates NK cells. Targeting of immune evasion mechanisms from the activating NKG2D receptor and its MICA and MICB ligands on tumor cells offers opportunities for therapeutic intervention. Interestingly, T cells and NK cells share several important inhibitory and activating receptors that can be targeted to enhance T cell- and NK cell-mediated immunity. These inhibitory receptor-ligand systems include CD161-CLEC2D, TIGIT-CD155, and NKG2A/CD94-HLA-E. We also discuss emerging therapeutic strategies based on inhibitory and activating cytokines that profoundly impact the function of both lymphocyte populations within tumors.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"17-38"},"PeriodicalIF":26.9,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159905/pdf/nihms-1873672.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9426625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging. 极度分化的T细胞亚群有助于衰老过程中的组织退化。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-064501
Gonzalo Soto-Heredero, Manuel M Gómez de Las Heras, J Ignacio Escrig-Larena, María Mittelbrunn
{"title":"Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging.","authors":"Gonzalo Soto-Heredero,&nbsp;Manuel M Gómez de Las Heras,&nbsp;J Ignacio Escrig-Larena,&nbsp;María Mittelbrunn","doi":"10.1146/annurev-immunol-101721-064501","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101721-064501","url":null,"abstract":"<p><p>There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"181-205"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils. 组织髓样细胞的起源和异质性:关注gmp衍生的单核细胞和中性粒细胞。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-081022-113627
Lai Guan Ng, Zhaoyuan Liu, Immanuel Kwok, Florent Ginhoux
{"title":"Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils.","authors":"Lai Guan Ng,&nbsp;Zhaoyuan Liu,&nbsp;Immanuel Kwok,&nbsp;Florent Ginhoux","doi":"10.1146/annurev-immunol-081022-113627","DOIUrl":"https://doi.org/10.1146/annurev-immunol-081022-113627","url":null,"abstract":"<p><p>Myeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various myeloid cells that perform separate but complementary functions during homeostasis and disease, our understanding of tissue myeloid cells has evolved significantly. Exciting findings from transcriptomics profiling and fate-mapping mouse models have facilitated the identification of their developmental origins, maturation, and tissue-specific specializations. This review highlights the current understanding of tissue myeloid cells and the contributing factors of functional heterogeneity to better comprehend the complex and dynamic immune interactions within the healthy or inflamed tissue. Specifically, we discuss the new understanding of the contributions of granulocyte-monocyte progenitor-derived phagocytes to tissue myeloid cell heterogeneity as well as the impact of niche-specific factors on monocyte and neutrophil phenotype and function. Lastly, we explore the developing paradigm of myeloid cell heterogeneity during inflammation and disease.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"375-404"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
RNA Modification in the Immune System. 免疫系统中的RNA修饰。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-045401
Dali Han, Meng Michelle Xu
{"title":"RNA Modification in the Immune System.","authors":"Dali Han,&nbsp;Meng Michelle Xu","doi":"10.1146/annurev-immunol-101921-045401","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-045401","url":null,"abstract":"<p><p>Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of these diverse, dynamic RNA modifications in various immune cells within healthy and diseased contexts. Further, we explore our current understanding of the mechanisms whereby aberrant RNA modifications modulate the immune milieu of the tumor microenvironment and point out outstanding research questions.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"73-98"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Modeling T Cell Fate. T 细胞命运建模
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-040924
Rob J De Boer, Andrew J Yates
{"title":"Modeling T Cell Fate.","authors":"Rob J De Boer, Andrew J Yates","doi":"10.1146/annurev-immunol-101721-040924","DOIUrl":"10.1146/annurev-immunol-101721-040924","url":null,"abstract":"<p><p>Many of the pathways that underlie the diversification of naive T cells into effector and memory subsets, and the maintenance of these populations, remain controversial. In recent years a variety of experimental tools have been developed that allow us to follow the fates of cells and their descendants. In this review we describe how mathematical models provide a natural language for describing the growth, loss, and differentiation of cell populations. By encoding mechanistic descriptions of cell behavior, models can help us interpret these new datasets and reveal the rules underpinning T cell fate decisions, both at steady state and during immune responses.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"513-532"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-Epithelial Cross Talk in Regeneration and Repair. 再生和修复中的免疫-上皮串扰。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-01-25 DOI: 10.1146/annurev-immunol-101721-062818
Laure Guenin-Mace, Piotr Konieczny, Shruti Naik
{"title":"Immune-Epithelial Cross Talk in Regeneration and Repair.","authors":"Laure Guenin-Mace, Piotr Konieczny, Shruti Naik","doi":"10.1146/annurev-immunol-101721-062818","DOIUrl":"10.1146/annurev-immunol-101721-062818","url":null,"abstract":"<p><p>The epithelial tissues that line our body, such as the skin and gut, have remarkable regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier function, these tissues have also evolved sophisticated repair mechanisms to swiftly heal and limit the penetration of harmful agents following injury. Researchers now appreciate that epithelial regeneration and repair are not autonomous processes but rely on a dynamic cross talk with immunity. A wealth of clinical and experimental data point to the functional coupling of reparative and inflammatory responses as two sides of the same coin. Here we bring to the fore the immunological signals that underlie homeostatic epithelial regeneration and restitution following damage. We review our current understanding of how immune cells contribute to distinct phases of repair. When unchecked, immune-mediated repair programs are co-opted to fuel epithelial pathologies such as cancer, psoriasis, and inflammatory bowel diseases. Thus, understanding the reparative functions of immunity may advance therapeutic innovation in regenerative medicine and epithelial inflammatory diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"207-228"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10088099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation. 大脑中的补体：大脑中的补体：对神经保护、神经元可塑性和神经炎症的贡献》（Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation.
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-02-07 DOI: 10.1146/annurev-immunol-101921-035639
Suzanne S Bohlson, Andrea J Tenner
{"title":"Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation.","authors":"Suzanne S Bohlson, Andrea J Tenner","doi":"10.1146/annurev-immunol-101921-035639","DOIUrl":"10.1146/annurev-immunol-101921-035639","url":null,"abstract":"<p><p>The complement system is an ancient collection of proteolytic cascades with well-described roles in regulation of innate and adaptive immunity. With the convergence of a revolution in complement-directed clinical therapeutics, the discovery of specific complement-associated targetable pathways in the central nervous system, and the development of integrated multi-omic technologies that have all emerged over the last 15 years, precision therapeutic targeting in Alzheimer disease and other neurodegenerative diseases and processes appears to be within reach. As a sensor of tissue distress, the complement system protects the brain from microbial challenge as well as the accumulation of dead and/or damaged molecules and cells. Additional more recently discovered diverse functions of complement make it of paramount importance to design complement-directed neurotherapeutics such that the beneficial roles in neurodevelopment, adult neural plasticity, and neuroprotective functions of the complement system are retained.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"431-452"},"PeriodicalIF":26.9,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9454198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host Recovery from Respiratory Viral Infection. 宿主从呼吸道病毒感染中恢复。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-040450
Xiaoqin Wei, Harish Narasimhan, Bibo Zhu, Jie Sun
{"title":"Host Recovery from Respiratory Viral Infection.","authors":"Xiaoqin Wei,&nbsp;Harish Narasimhan,&nbsp;Bibo Zhu,&nbsp;Jie Sun","doi":"10.1146/annurev-immunol-101921-040450","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-040450","url":null,"abstract":"<p><p>Emerging and re-emerging respiratory viral infections pose a tremendous threat to human society, as exemplified by the ongoing COVID-19 pandemic. Upon viral invasion of the respiratory tract, the host initiates coordinated innate and adaptive immune responses to defend against the virus and to promote repair of the damaged tissue. However, dysregulated host immunity can also cause acute morbidity, hamper lung regeneration, and/or lead to chronic tissue sequelae. Here, we review our current knowledge of the immune mechanisms regulating antiviral protection, host pathogenesis, inflammation resolution, and lung regeneration following respiratory viral infections, mainly using influenza virus and SARS-CoV-2 infections as examples. We hope that this review sheds light on future research directions to elucidate the cellular and molecular cross talk regulating host recovery and to pave the way to the development of pro-repair therapeutics to augment lung regeneration following viral injury.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"277-300"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9396213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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