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Annual review of immunology最新文献

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Modeling T Cell Fate. T 细胞命运建模
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-040924
Rob J De Boer, Andrew J Yates
{"title":"Modeling T Cell Fate.","authors":"Rob J De Boer, Andrew J Yates","doi":"10.1146/annurev-immunol-101721-040924","DOIUrl":"10.1146/annurev-immunol-101721-040924","url":null,"abstract":"<p><p>Many of the pathways that underlie the diversification of naive T cells into effector and memory subsets, and the maintenance of these populations, remain controversial. In recent years a variety of experimental tools have been developed that allow us to follow the fates of cells and their descendants. In this review we describe how mathematical models provide a natural language for describing the growth, loss, and differentiation of cell populations. By encoding mechanistic descriptions of cell behavior, models can help us interpret these new datasets and reveal the rules underpinning T cell fate decisions, both at steady state and during immune responses.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"513-532"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-Epithelial Cross Talk in Regeneration and Repair. 再生和修复中的免疫-上皮串扰。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-01-25 DOI: 10.1146/annurev-immunol-101721-062818
Laure Guenin-Mace, Piotr Konieczny, Shruti Naik
{"title":"Immune-Epithelial Cross Talk in Regeneration and Repair.","authors":"Laure Guenin-Mace, Piotr Konieczny, Shruti Naik","doi":"10.1146/annurev-immunol-101721-062818","DOIUrl":"10.1146/annurev-immunol-101721-062818","url":null,"abstract":"<p><p>The epithelial tissues that line our body, such as the skin and gut, have remarkable regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier function, these tissues have also evolved sophisticated repair mechanisms to swiftly heal and limit the penetration of harmful agents following injury. Researchers now appreciate that epithelial regeneration and repair are not autonomous processes but rely on a dynamic cross talk with immunity. A wealth of clinical and experimental data point to the functional coupling of reparative and inflammatory responses as two sides of the same coin. Here we bring to the fore the immunological signals that underlie homeostatic epithelial regeneration and restitution following damage. We review our current understanding of how immune cells contribute to distinct phases of repair. When unchecked, immune-mediated repair programs are co-opted to fuel epithelial pathologies such as cancer, psoriasis, and inflammatory bowel diseases. Thus, understanding the reparative functions of immunity may advance therapeutic innovation in regenerative medicine and epithelial inflammatory diseases.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"207-228"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10088099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation. 大脑中的补体：大脑中的补体：对神经保护、神经元可塑性和神经炎症的贡献》（Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation.
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-02-07 DOI: 10.1146/annurev-immunol-101921-035639
Suzanne S Bohlson, Andrea J Tenner
{"title":"Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation.","authors":"Suzanne S Bohlson, Andrea J Tenner","doi":"10.1146/annurev-immunol-101921-035639","DOIUrl":"10.1146/annurev-immunol-101921-035639","url":null,"abstract":"<p><p>The complement system is an ancient collection of proteolytic cascades with well-described roles in regulation of innate and adaptive immunity. With the convergence of a revolution in complement-directed clinical therapeutics, the discovery of specific complement-associated targetable pathways in the central nervous system, and the development of integrated multi-omic technologies that have all emerged over the last 15 years, precision therapeutic targeting in Alzheimer disease and other neurodegenerative diseases and processes appears to be within reach. As a sensor of tissue distress, the complement system protects the brain from microbial challenge as well as the accumulation of dead and/or damaged molecules and cells. Additional more recently discovered diverse functions of complement make it of paramount importance to design complement-directed neurotherapeutics such that the beneficial roles in neurodevelopment, adult neural plasticity, and neuroprotective functions of the complement system are retained.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"431-452"},"PeriodicalIF":26.9,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9454198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host Recovery from Respiratory Viral Infection. 宿主从呼吸道病毒感染中恢复。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-040450
Xiaoqin Wei, Harish Narasimhan, Bibo Zhu, Jie Sun
{"title":"Host Recovery from Respiratory Viral Infection.","authors":"Xiaoqin Wei,&nbsp;Harish Narasimhan,&nbsp;Bibo Zhu,&nbsp;Jie Sun","doi":"10.1146/annurev-immunol-101921-040450","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-040450","url":null,"abstract":"<p><p>Emerging and re-emerging respiratory viral infections pose a tremendous threat to human society, as exemplified by the ongoing COVID-19 pandemic. Upon viral invasion of the respiratory tract, the host initiates coordinated innate and adaptive immune responses to defend against the virus and to promote repair of the damaged tissue. However, dysregulated host immunity can also cause acute morbidity, hamper lung regeneration, and/or lead to chronic tissue sequelae. Here, we review our current knowledge of the immune mechanisms regulating antiviral protection, host pathogenesis, inflammation resolution, and lung regeneration following respiratory viral infections, mainly using influenza virus and SARS-CoV-2 infections as examples. We hope that this review sheds light on future research directions to elucidate the cellular and molecular cross talk regulating host recovery and to pave the way to the development of pro-repair therapeutics to augment lung regeneration following viral injury.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"277-300"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9396213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Not Dead Yet. 还没死。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-065214
Betty Diamond
{"title":"Not Dead Yet.","authors":"Betty Diamond","doi":"10.1146/annurev-immunol-101721-065214","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101721-065214","url":null,"abstract":"I have been a scientific grasshopper throughout my career, moving from question to question within the domain of lupus. This has proven to be immensely gratifying. Scientific exploration is endlessly fascinating, and succeeding in studies you care about with colleagues and trainees leads to strong and lasting bonds. Science isn't easy; being a woman in science presents challenges, but the drive to understand a disease remains strong.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"1-15"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T Cell Responses to SARS-CoV-2. T细胞对新冠病毒的反应
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-061120
Alessandro Sette, John Sidney, Shane Crotty
{"title":"T Cell Responses to SARS-CoV-2.","authors":"Alessandro Sette,&nbsp;John Sidney,&nbsp;Shane Crotty","doi":"10.1146/annurev-immunol-101721-061120","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101721-061120","url":null,"abstract":"<p><p>A large body of evidence generated in the last two and a half years addresses the roles of T cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces multi-epitope CD4 and CD8 T cell responses with polyfunctionality. Early T cell responses have been associated with mild COVID-19 outcomes. In concert with animal model data, these results suggest that while antibody responses are key to prevent infection, T cell responses may also play valuable roles in reducing disease severity and controlling infection. T cell memory after vaccination is sustained for at least six months. While neutralizing antibody responses are impacted by SARS-CoV-2 variants, most CD4 and CD8 T cell responses are preserved. This review highlights the extensive progress made, and the data and knowledge gaps that remain, in our understanding of T cell responses to SARS-CoV-2 and COVID-19 vaccines.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"343-373"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9750288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
IL-4 and IL-13: Regulators and Effectors of Wound Repair. IL-4 和 IL-13：伤口修复的调节因子和效应因子
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-02-03 DOI: 10.1146/annurev-immunol-101921-041206
Judith E Allen
{"title":"IL-4 and IL-13: Regulators and Effectors of Wound Repair.","authors":"Judith E Allen","doi":"10.1146/annurev-immunol-101921-041206","DOIUrl":"10.1146/annurev-immunol-101921-041206","url":null,"abstract":"<p><p>Type 2 immunity mediates protective responses to helminths and pathological responses to allergens, but it also has broad roles in the maintenance of tissue integrity, including wound repair. Type 2 cytokines are known to promote fibrosis, an overzealous repair response, but their contribution to healthy wound repair is less well understood. This review discusses the evidence that the canonical type 2 cytokines, IL-4 and IL-13, are integral to the tissue repair process through two main pathways. First, essential for the progression of effective tissue repair, IL-4 and IL-13 suppress the initial inflammatory response to injury. Second, these cytokines regulate how the extracellular matrix is modified, broken down, and rebuilt for effective repair. IL-4 and/or IL-13 amplifies multiple aspects of the tissue repair response, but many of these pathways are highly redundant and can be induced by other signals. Therefore, the exact contribution of IL-4Rα signaling remains difficult to unravel.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"229-254"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9468347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia. 干扰素干扰:COVID-19重症肺炎的关键机制
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101921-050835
Helen C Su, Huie Jing, Yu Zhang, Jean-Laurent Casanova
{"title":"Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia.","authors":"Helen C Su,&nbsp;Huie Jing,&nbsp;Yu Zhang,&nbsp;Jean-Laurent Casanova","doi":"10.1146/annurev-immunol-101921-050835","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-050835","url":null,"abstract":"<p><p>Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign infection in most individuals to critical pneumonia and death in a few. Genetic studies in patients have established that critical cases can result from inborn errors of TLR3- or TLR7-dependent type I interferon immunity, or from preexisting autoantibodies neutralizing primarily IFN-α and/or IFN-ω. These findings are consistent with virological studies showing that multiple SARS-CoV-2 proteins interfere with pathways of induction of, or response to, type I interferons. They are also congruent with cellular studies and mouse models that found that type I interferons can limit SARS-CoV-2 replication in vitro and in vivo, while their absence or diminution unleashes viral growth. Collectively, these findings point to insufficient type I interferon during the first days of infection as a general mechanism underlying critical COVID-19 pneumonia, with implications for treatment and directions for future research.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"561-585"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9474265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Effector-Triggered Immunity. Effector-Triggered免疫力。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-031732
Brenna C Remick, Moritz M Gaidt, Russell E Vance
{"title":"Effector-Triggered Immunity.","authors":"Brenna C Remick,&nbsp;Moritz M Gaidt,&nbsp;Russell E Vance","doi":"10.1146/annurev-immunol-101721-031732","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101721-031732","url":null,"abstract":"<p><p>The innate immune system detects pathogens via germline-encoded receptors that bind to conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here we consider an additional strategy of pathogen sensing called effector-triggered immunity (ETI). ETI involves detection of pathogen-encoded virulence factors, also called effectors. Pathogens produce effectors to manipulate hosts to create a replicative niche and/or block host immunity. Unlike PAMPs, effectors are often diverse and rapidly evolving and can thus be unsuitable targets for direct detection by germline-encoded receptors. Effectors are instead often sensed indirectly via detection of their virulence activities. ETI is a viable strategy for pathogen sensing and is used across diverse phyla, including plants, but the molecular mechanisms of ETI are complex compared to simple receptor/ligand-based PAMP detection. Here we survey the mechanisms and functions of ETI, with a particular focus on emerging insights from animal studies. We suggest that many examples of ETI may remain to be discovered, hiding in plain sight throughout immunology.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"453-481"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9750289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The Immunological Conundrum of Endogenous Retroelements. 内源性逆转录因子的免疫学难题。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2023-04-26 DOI: 10.1146/annurev-immunol-101721-033341
George Kassiotis
{"title":"The Immunological Conundrum of Endogenous Retroelements.","authors":"George Kassiotis","doi":"10.1146/annurev-immunol-101721-033341","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101721-033341","url":null,"abstract":"<p><p>Our defenses against infection rely on the ability of the immune system to distinguish invading pathogens from self. This task is exceptionally challenging, if not seemingly impossible, in the case of retroviruses that have integrated almost seamlessly into the host. This review examines the limits of innate and adaptive immune responses elicited by endogenous retroviruses and other retroelements, the targets of immune recognition, and the consequences for host health and disease. Contrary to theoretical expectation, endogenous retroelements retain substantial immunogenicity, which manifests most profoundly when their epigenetic repression is compromised, contributing to autoinflammatory and autoimmune disease and age-related inflammation. Nevertheless, recent evidence suggests that regulated immune reactivity to endogenous retroelements is integral to immune system development and function, underpinning cancer immunosurveillance, resistance to infection, and responses to the microbiota. Elucidation of the interaction points with endogenous retroelements will therefore deepen our understanding of immune system function and contribution to disease.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"41 ","pages":"99-125"},"PeriodicalIF":29.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10660474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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